75 results about "Latent Virus" patented technology

The invention discloses an application of a benzamide histone deacetylase inhibitor in preparation of virus reservoir reactivation drugs as well as a composition containing the benzamide histone deacetylase inhibitor. The composition has an obvious effect of activating a reservoir of multiple persistent infection viruses such as human immunodeficiency virus, hepatitis B virus and hepatitis C virus and can be combined with an antiviral agent to obtain a better treatment effect.

The disclosure relates to methods of controlling the state of a virus (lytic or lysogenic) in an individual, such as a method of reactivating a latent virus in an individual, comprising administering one or more agents that modulates the activity of signal transducer and activator of transcription 3 (STAT3) or any of p300, CBP or p300 / CBP. Also contemplated are methods further comprising administering an HDAC modulating agent, such as an HDAC inhibiting agent or an HDAC activating agent.

The invention provides a HIV latency-resistant effective part of euphorbia and a use thereof. Through an ingenious activity screening method, it is found that a traditional Chinese medicine euphorbia has effects of resisting AIDS. Through solvent extraction, extraction and column chromatography processes and the combination with activity screening, the HIV latency-resistant effective part of euphorbia is determined and is prepared; and the HIV latency-resistant effective part of euphorbia can be used as an active ingredient having effects of resisting AIDS. The HIV latency-resistant effective part of euphorbia has effects of HIV latency intervention, can be combined with antiretroviral drugs thereby promoting removal of latent virus reservoirs, and provides a novel approach for thorough curing of AIDS.

The invention discloses a human source anti-tetanus exotoxin antibody (HTAT-Fab) and preparation method, comprising: constructing human immunity phage antibody bank, screening phage positive clone, further getting HTAT-Fab gene with a specific neutralization activity and high affinity. The gene can be expressed in the procaryotic cell such as E.coli, eukaryotic cell such as microzyme, or mammalian cell such as CHO, purifying to get highly purified HTAT-Fab with a strong tissue penetrability, a high affinity. The HTAT-Fab product can not only eliminate the allergic reaction generated by horse serum anti-tatanus antitoxin (TAT) (foreign protein), but also avoid the blood source for producing human tetanus immunoglobulin (HTIG) and the latent virus pollution.

A diagnostic panel includes a test for detecting at least one biomarker that indicates the presence of a virus. A kit includes the diagnostic panel, instructions for use, materials to take and apply samples to the panel, and descriptions of biomarker levels and their meaning. A method of detecting the presence of disease, by taking a sample of an individual, applies the sample to the diagnostic panel including at least one biomarker indicative of disease, detects the presence of at least one biomarker, compares levels of the biomarker to a baseline, and determines if the individual has a disease. Methods of determining the stage of a disease, monitoring the progress of disease treatments, determining viral suppression or rebound, and detecting latent virus are also provided.

The invention relates to a network cooperative defense system and method based on a community structure, wherein the system divides the whole network into a plurality of autonomous communities, and each autonomous community comprises a user host, a cooperative control center and a community internal security system; wherein the community internal security system comprises an intrusion detection module which is used for intrusion detection and notifying a cooperative control center if abnormal information exists; an information honeypot and honeynet module which is used for responding to a command sent by the cooperative control center and storing and continuously monitoring abnormal information so as to obtain virus characteristics; a firewall module which is used for access control and identity authentication in the user host and the router; an intrusion protection module which is used for assisting the intrusion detection module to clear data packets containing viruses; a collaborative defense strategy library module which is used for storing node defense strategies or security defense strategies; a cooperative control center which is used for generating an optimal defense strategy according to a detection analysis result. The systems and methods provided by the present disclosure inhibit latent virus propagation.

The invention provides isatin compounds as well as a preparation method and an application thereof. The compounds have the structure shown in a formula (I) and have good BRD4 protein inhibition activity, have huge application potential in the antitumor and anti-virus aspects and can be applied to preparation of BRD4 inhibitor drugs; meanwhile, the compounds have good HIV latent virus activation capability, have greatly reduced in-vitro cytotoxicity as compared with known HIV latent activators JQ1, are safer to use and have good tolerance.

The invention provides isatin compounds as well as a preparation method and an application thereof. The compounds have the structure shown in a formula (I) and have good BRD4 protein inhibition activity, have huge application potential in the antitumor and anti-virus aspects and can be applied to preparation of BRD4 inhibitor drugs; meanwhile, the compounds have good HIV latent virus activation capability, have greatly reduced in-vitro cytotoxicity as compared with known HIV latent activators JQ1, are safer to use and have good tolerance.

The invention discloses a human source anti-tetanus exotoxin antibody (HTAT-Fab) and preparation method, comprising: constructing human immunity phage antibody bank, screening phage positive clone, further getting HTAT-Fab gene with a specific neutralization activity and high affinity. The gene can be expressed in the procaryotic cell such as E.coli, eukaryotic cell such as microzyme, or mammalian cell such as CHO, purifying to get highly purified HTAT-Fab with a strong tissue penetrability, a high affinity. The HTAT-Fab product can not only eliminate the allergic reaction generated by horse serum anti-tatanus antitoxin (TAT) (foreign protein), but also avoid the blood source for producing human tetanus immunoglobulin (HTIG) and the latent virus pollution.

Compositions that bind viral proteins that are specifically expressed during the latent stage of the viral life cycle are disclosed. These compositions bind the latent viral proteins while the viral proteins are expressed in their cellular host, and provide a means for targeting cells that harbor latent virus. In a preferred embodiment the compositions are antibodies which bind the extracellular region of the latent viral protein, most preferably LMP-2A, an EBV latent protein, which are conjugated to a diagnostic or cytotoxic agent or immobilized to a solid support for removal of the infected cells. These antibodies are capable of distinguishing cells expressing EBV DNA from cells which are not expressing EBV DNA. Compositions that can be used to elicit production of these antibodies, or as a vaccine, are also disclosed. Methods for generating diagnostic or cytotoxic reagents and vaccines based on the viral epitopes that identify cells harboring latent virus are also disclosed. The antibody conjugates can be used in diagnostic assays to identify cells expressing latent viral protein and people who are harboring latent viral particles. The antibody conjugates can also be used to remove the infected cells or to kill the infected the cells. Alternatively, or in addition, the viral proteins or portions thereof can be used as a vaccine to induce an immune reaction by the host to kill the infected cells. These methods can be used to detect or treat patients harboring latent viruses like EBV and who are at risk of developing a disease such as an autoimmune disease like systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).

The invention provides a multiple RT-PCR detection method, which can simultaneously detect whether leaves, twigs, flowers or fruits of an apple tree bring three latent viruses namely apple chlorotic leaf spot virus, apple stem grooving virus, and apple stem pitting virus, and three apple scar skin viroids namely apple scar skin viroid, apple dimple fruit viroid, and apple fruit crinkle viroid or not. The detection method has the advantages of clear detection result, convenient operation, rapid reaction, and high sensitivity, and overcomes the shortages of time consuming, tedious steps, difficulty in distinguishing the stripes, and low sensitivity in the prior art. The invention provides a rapid detection method, which is easy for promotion and application, for detecting apple viruses.