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Metabalomics and viral diagnostics suite

A metabolite, virus technology, applied in the field of evaluating the gene editing treatment of viruses, can solve the problem that antiviral drugs cannot solve the latent virus, and it is difficult to determine whether an individual is free from the virus, etc.

Inactive Publication Date: 2019-01-04
EXCISION BIOTHERAPEUTICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antiviral drugs are routinely given to people with the virus, but antiviral drugs do not address latent virus
Therefore, it may be difficult to determine whether an individual is free of the virus after treatment

Method used

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Examples

Experimental program
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Embodiment Construction

[0012] The present invention is generally directed to diagnostic panels and methods for determining the presence of a virus by determining the level of at least one metabolite or biomarker and determining the metabolic state of an individual. Diagnostic panels can determine disease status and viral suppression or rebound during various treatments.

[0013] The term "assay" as used herein refers to the procedure of determining the amount of a particular component of a mixture or sample. "Assay" is used interchangeably with the term "test" herein.

[0014] The term "biomarker" as used herein refers to a substance, such as, but not limited to, a protein, DNA sequence, RNA sequence, metabolite, or other biological substance or substance that, when detected, indicates a particular state of health or unhealthiness of an individual with respect to a disease. substances, and especially viruses in active and / or inactive states.

[0015] The term "healthy" as used herein refers to the...

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PUM

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Abstract

A diagnostic panel includes a test for detecting at least one biomarker that indicates the presence of a virus. A kit includes the diagnostic panel, instructions for use, materials to take and apply samples to the panel, and descriptions of biomarker levels and their meaning. A method of detecting the presence of disease, by taking a sample of an individual, applies the sample to the diagnostic panel including at least one biomarker indicative of disease, detects the presence of at least one biomarker, compares levels of the biomarker to a baseline, and determines if the individual has a disease. Methods of determining the stage of a disease, monitoring the progress of disease treatments, determining viral suppression or rebound, and detecting latent virus are also provided.

Description

technical field [0001] The present invention relates to methods and diagnostics for determining the disease state of a virus-infected individual based on a biomarker profile. More precisely, the present invention relates to methods and diagnostics for evaluating gene editing therapies for viruses. Background technique [0002] Many people suffer from viral infections (such as HIV and hepatitis) in which viruses replicate within the individual's cells. The virus can be latent inside the cell, meaning it is inactive and does not produce disease symptoms, but can become active at a later time. Antiviral drugs are routinely given to people with the virus, but antiviral drugs do not address the problem of latent virus. Therefore, it may be difficult to determine whether an individual is free of the virus after treatment. [0003] PCT / US 2013 / 068592 to Slupsky discloses a method of determining a disease state in a subject by obtaining first and second sets of biological samples...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/573G01N33/574
CPCG01N33/56983G01N2800/26G01N2800/52G01N2800/56Y02A50/30
Inventor 托马斯·马尔科姆
Owner EXCISION BIOTHERAPEUTICS INC
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