This invention relates to pharmaceuticals and methods for clearing
hepatitis B
virus (HBV)
cccDNA from the livers of
hepatitis B
virus-infected individuals. Specifically, this invention provides the use of HBV entry inhibitors that inhibit HBV entry into hepatocytes and, optionally, immunomodulatory agents that regulate anti-HBV
immunity in the preparation of pharmaceutical combinations or kits used in methods for clearing HBV
cccDNA from
hepatitis B patients. This invention also provides corresponding pharmaceutical combinations and kits for the above-mentioned uses.