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Optimized dengue virus entry inhibitory peptide (DN81)

A technology for dengue virus, entry inhibitors, domain-binding inhibitors, in vivo antiviral compound candidates, for the treatment of diseases induced by dengue viruses

Inactive Publication Date: 2010-08-11
FLORIDA GULF COAST UNIV BOARD OF TRUSTEES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The fusion mechanism of class II viral fusion proteins is not clearly understood, nor is there a theory for specifically inhibiting the fusion of these proteins

Method used

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  • Optimized dengue virus entry inhibitory peptide (DN81)
  • Optimized dengue virus entry inhibitory peptide (DN81)
  • Optimized dengue virus entry inhibitory peptide (DN81)

Examples

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Embodiment Construction

[0019] One embodiment of the present invention relates to a method for inhibiting dengue infection, comprising inhibiting the fusion of the virion envelope with the cell membrane, and delivering the viral genome into the cytoplasm.

[0020] According to the present invention, any peptide or protein (including those dengue viruses that infect human as well as non-human hosts) that inhibits the fusion of the dengue virus envelope with the cell membrane can be used. In various embodiments of the invention, these dengue peptide entry inhibitors may include, but are not limited to, peptides associated with membrane-interacting binding regions of several dengue virus proteins. The genome structure of dengue virus is as figure 1 shown.

[0021] The term "binding region", when applied to a peptide, nucleic acid, complex, etc., refers to a region of the dengue virus E protein or other class II E protein that is a target or likely to bind an agent that reduces or inhibits viral infecti...

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Abstract

Abstract The invention relates peptide entry inhibitors and methods of determining such inhibitors that are bindable to regions of viruses having class II E proteins, such as the dengue virus E protein, as candidates for in vivo anti-viral compounds.

Description

[0001] Cross References to Related Applications [0002] This International Patent Application claims the benefit of and priority to US Provisional Application No. 60 / 949,710, filed July 13, 2007, which is incorporated herein by reference. [0003] The present invention relates to inhibitors that bind to domains of viruses. More specifically, the present invention relates to inhibitors that bind to regions of the dengue virus envelope glycoprotein or the dengue virus E protein, a type II virus E protein. Still more particularly, the present invention relates to peptide entry inhibitors and methods for identifying these inhibitors that bind to regions of the Dengue virus E protein as candidates for antiviral compounds in vivo. Background of the invention [0004] Dengue viruses, members of the flavivirus family, impose one of the greatest social and economic burdens of any mosquito-borne viral pathogen. Control of dengue virus through vaccination has proven elusive without an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/00A61K38/16C07K14/005
CPCC12N2770/24122A61K38/00C07K14/005A61P31/12Y02A50/30
Inventor S·F·迈克尔S·伊塞尔恩R·加里R·萨穆德拉拉J·科斯丁E·延维蒂苏克
Owner FLORIDA GULF COAST UNIV BOARD OF TRUSTEES
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