2 results about "Scavenger receptor" patented technology

The application discloses a monoclonal antibody for identifying human soluble scavenger receptor A, and the amino acid sequences of the heavy chain and the light chain variable region are shown as SEQ ID NO. 1 and SEQ ID NO. 5. A double antibody sandwich detection method is established by using the monoclonal antibody as a capture antibody, the whole operation time is shortened from the conventional 4 hours to 1.5 hours, the detection P / N value is significantly improved, the minimum detection limit reaches 15 pg / mL, and the detectable range is 15-7680 ng / mL. The method is suitable for human soluble scavenger receptor A detection.

Compositions and kits for diagnosing and prognosing Alzheimer's Disease (AD) in a human patient include a binding agent such as a monoclonal antibody for a biomarker conjugated to a detectable moiety such as a fluorophore, wherein the biomarker is chosen from CD163, CD91, CD59, MerTK and other phagocytosis-related molecules. Further compositions and kits employ panels of fluorophore-conjugated monoclonal antibodies for biomarkers including scavenger receptors. Methods for determining the relative expression of biomarkers, diagnosing AD, and determining the efficacy of AD therapeutic candidates such as phagocytosis-promoting agents and scavenger receptor agonists also appear.