45 results about "Lower blood cholesterol" patented technology

The invention provides formulations and methods for mediating inflammation, in particular an inflammatory bowel disorder such as necrotizing enterocolitis, and for. Further, the formulations are effective in lowering blood cholesterol and decreasing blood cholesterol absorption. The formulations comprise at least one ganglioside, which may be selected from the group consisting of: GD3, GM1, GM2, GM3, and GD1b. The invention provides a method of treating or preventing inflammatory diseases, such as necrotizing enterocolitis by delivery of at least one ganglioside to a subject in need thereof. Supplementation of foods or liquids with gangliosides, fore example infant formula or infant foods, can be employed according to the invention.

The invention relates to a preparation method and application of tea polyphenol chitosan nanoparticles, in particular to novel tea polyphenol nanoparticles. The nanoparticles are prepared from the following components in parts by weight: 3 to 6 parts of chitosan, 1 to 2 parts of porous silicon dioxide and 1 to 4 parts of tea polyphenol. The porous silicon dioxide is added into the tea polyphenol nanoparticles, so that the tea polyphenol content of the nanoparticles can be remarkably increased. The tea polyphenol chitosan nanoparticles are prepared by a sodium tripolyphosphate (TPP) ionic gel method. The nanoparticles can be widely applied to various fields of biomedicine and health care products, and can be used for lowering blood cholesterol, treating obesity, resisting oxidation, clearing free radicals and preventing and treating tumors.

The invention disclosed a kind of lactobacillus casei Bd-II, the accession number of the deposit of which is CGMCC NO.0849, and also disclosed a use of it for reducing blood lipid level. Further, a composition for reducing blood lipid level containing it and an acceptable carrier is disclosed. The carrier can be skimmed milk.

A method of lowering blood cholesterol in a non-diabetic patient by at least 30% is described. The method involves orally administering for 30 consecutive days a fenugreek seed extract composition. Various methods of preparation and various formulations are described. Physiologically effective pharmaceutical compositions and beverages containing fenugreek seed extracts and other active components are also disclosed.

A method of lowering blood cholesterol in a non-diabetic patient by at least 30% is described. The method involves orally administering for 30 consecutive days a fenugreek seed extract composition. Various methods of preparation and various formulations are described. Physiologically effective pharmaceutical compositions and beverages containing fenugreek seed extracts and other active components are also disclosed.

The sustained release formulation for oral administration of an HMG-CoA reductase inhibitor of the present invention can be easily and economically prepared and is capable of maintaining a constant drug level in blood by slowly releasing the HMG-CoA reductase inhibitor at a uniform rate for 24 hrs. Accordingly, the sustained release formulation of the present invention can be effectively used for lowering blood cholesterol and triglyceride levels.

The invention provides formulations and methods for mediating inflammation, in particular an inflammatory bowel disorder such as necrotizing enterocolitis, and for. Further, the formulations are effective in lowering blood cholesterol and decreasing blood cholesterol absorption. The formulations comprise at least one ganglioside, which may be selected from the group consisting of: GD3, GM1, GM2, GM3, and GD1b. The invention provides a method of treating or preventing inflammatory diseases, such as necrotizing enterocolitis by delivery of at least one ganglioside to a subject in need thereof. Supplementation of foods or liquids with gangliosides, fore example infant formula or infant foods, can be employed according to the invention.

The invention discloses a food formula benficial to weight control and reduction of three highs (hihg blood pressure, high blood fat and high sugar). The food formula comprises, by weight, 18-22 partsof inulin, 16-20 parts of whey protein powder, 10-12 parts of skimmed milk powder, 9-11 parts of soybeam dietary fiber, 9-11 parts of oat meal, 5.4-5.8 parts of maltodextrin, 2.5-3.5 parts of maca powder, 1.8-2.2 parts of barley leave green juice, 1.3-1.7 parts of konjac powder, 1.4-1.6 parts of psylliumseedhusk, 1.4-1.6 parts of potassium citrate, 0.4-0.6 part of chia seeds, 0.03-0.05 part of stevioside, 0.4-0.6 part of concentrated vanilla and 0.3-0.5 part of fresh milk flavored essence. By the above technical scheme, the inulin, oat meal, soybean dietary fiber, barley leave green juice, konjac powder and psylliumseedhusk which are rich in dietary fiber have the functions of relaxing bowls, regulating constipation, lowering blood cholesterol and triglycerides, controlling body weight and blood sugar and the like, protein needed by the body can be implemented by the addition of the whey protein powder and skinned milk powder which are rich in good protein, and the balanced nutritional diet is achieved in the premise of weight control and reduction of the three highs.

An animal model has been developed where the animals can survive myocardial infarctions caused by diet-induced coronary atherosclerosis, and live with chronic heart failure. This animal model is a result of reduced activity of scavenger receptor class BI (SR-BI) and ApoE and the inducible activity of the Mx1-Cre gene. In a preferred embodiment, the model is a result of crossbreeding two transgenic mouse lines: a knockout of SR-BI (SRBI− / −) and an impaired ApoE expressor (Apoeh / h) to generate a strain referred to as Apoeh / hSRB1− / − mice, which is then crossbred to mice that carry the inducible Mx1-Cre transgene. The Apoeh / hSRB1− / − mouse model is genetically modified, enabling the offspring to rapidly and permanently lower their high blood cholesterol levels caused by dietary challenge. The ability to rapidly and permanently lower blood cholesterol levels in these mice stops and may cause the regression of occlusive coronary atherosclerosis restoring blood flow to the heart, allowing the mice to survive from myocardial infarction and live with chronic heart failure.

The present invention relates to an extract of mixed herb medicine, and a pharmaceutical composition for the prevention and treatment of obesity containing the extract as an effective ingredient or health food containing the same, more precisely, an extract of mixed herb medicine extracted from the mixture of cassia seeds (Cassia obtusifolia L.), green tea (Thea sinensis L.), eucommia bark (Eucommia ulmoides Oliver), garlic (Allium sativum var. pekinense), hawthorn (Crataegus Pinnatifida Bunge), fresh pine needle (Pinus densiflora Siebold et Zuccarini) and wormwood (Artemisia capillaris Thunberg) using water or aqueous alcohol solution, a pharmaceutical composition for the prevention and treatment of obesity containing the above extract and a fermented extract extracted after adding rice, malt and yeast to the above mixture, or health food containing the same. The extract of the present invention can be effectively used for the prevention and the treatment of obesity by inhibiting weight gain by high-fat diet, lowering blood cholesterol and decreasing neutral fat (triglyceride).

Disclosed are batter-based baked goods which comprise oats, psyllium, and phytosterol esters. Also disclosed is a method for making these baked goods. The baked goods, preferably cookies, provide an effective method for lowering blood cholesterol levels in humans. The batter-based product of the present invention also provide an effective method for administering these cholesterol-lowering ingredients in a form which tastes good and makes it easier for a patient to consume sufficient quantities of soluble fiber and phytosterol esters.

The invention discloses a fermentation method of banana-flavor beer. According to the fermentation method, a traditional flavor beer fermentation process is changed, pulp and the like are not added in a hydrolytic process of malt, homogenized banana pulp which is subjected to pasteurization is added into sterilized beer fermented malt juice, and common fermentation is carried out, so that the fermented beer has a banana flavor. By increasing the banana flavor to the banana-flavor beer based on original beer flavors, the banana-flavor beer has good color, aroma, bitter taste and taste and is rich in vitamin, mineral substances, organic acid and amino acid, and the content of ethanol is 3%-6%, so that the banana-flavor beer is helpful for maintaining the health of human bodies, has the efficacies of reducing blood pressure, moistening lung, arresting cough and reducing cholesterol in blood, meets the consumption needs of different crowds at present and has wide market promotion prospect.

An animal model has been developed where the animals can survive myocardial infarctions caused by diet-induced coronary atherosclerosis, and live with chronic heart failure. This animal model is a result of reduced activity of scavenger receptor class BI (SR-BI) and ApoE and the inducible activity of the Mx1-Cre gene. In a preferred embodiment, the model is a result of crossbreeding two transgenic mouse lines: a knockout of SR-BI (SRBI− / −) and an impaired ApoE expressor (Apoeh / h) to generate a strain referred to as Apoeh / hSRB1− / − mice, which is then crossbred to mice that carry the inducible Mx1-Cre transgene. The Apoeh / hSRB1− / − mouse model is genetically modified, enabling the offspring to rapidly and permanently lower their high blood cholesterol levels caused by dietary challenge. The ability to rapidly and permanently lower blood cholesterol levels in these mice stops and may cause the regression of occlusive coronary atherosclerosis restoring blood flow to the heart, allowing the mice to survive from myocardial infarction and live with chronic heart failure.

The invention provides a composition comprising glucomannan, carrageenan, xanthan gum and a monovalent or divalent cation salt. The composition is suitable for use in managing weight, combating obesity, combating metabolic syndrome, promoting satiety, reducing appetite, combating diabetes, lowering blood cholesterol, lowering blood pressure, reducing postpranial glycaemia, or increasing insulin sensitivity.

The invention provides formulations for mediating inflammation and for lowering blood cholesterol. For example, inflammation of the intestine, retina or neural tissues, may be mediated. Further the formulations are effective in decreasing blood cholesterol absorption. The formulations comprise at least one ganglioside, which may be selected from the group consisting of: GD3, GM1, GM2, GM3, GD1b, NANA, and sialic acid. The invention further provides a method of treating or preventing inflammatory diseases by delivery of at least one ganglioside to a subject in need thereof, and a method of reducing blood cholesterol in a subject be delivery of a ganglioside-containing formulation. The formulation of the invention may be used to supplement foods or liquids, and may for example be used in preparation of infant formula or foods.

The invention discloses Lactobacillus plantarum and its use, specifically discloses Lactobacillus plantarum and its use in the preparation of medicine or food, medicine and food. The address of the preservation unit is Wuhan University, Wuhan, China, the preservation number is CCTCC NO: M2013391, and the preservation name is Lactobacillus plantarum Y‑9Lactobacillus plantarum Y‑9. The plantarum lactobacillus of the present invention has excellent probiotic effect, acid resistance and bile salt resistance, can be preserved for a long time, and can be effectively used for lowering blood cholesterol, lowering blood pressure, improving immunity, losing weight or regulating intestinal flora.

A vaccine construct comprising an antigenic PCSK9 peptide and an immunogenic carrier, and methods of using the same that are effective to lower blood cholesterol levels in a mammal and treat dyslipidemias and related disease states in a mammal without the frequency of administration required by passive immunity strategies.

Provided herein are methods for reducing levels of blood cholesterol, low-density lipoprotein (LDL), and / or the treatment of diseases associated with high cholesterol, hyperlipidemia, dyslipidemia, or high levels of low-density lipoprotein (LDL), wherein the methods comprise administering a DRP1 inhibitor to a subject in need thereof. In certain embodiments, the subject is selected for treatment as described herein when the subject exhibits intolerance to conventional statin therapy. Also contemplated herein are the use of DRP1 inhibitors in the treatment of cancer and inflammatory disease.

The present invention is related to naturally occurring immunoglobulin to cholesterol found in bovine milk that binds to cholesterol, LDL, IDL, and VLDL cholesterol. Milk and dairy-derived products containing immunoglobulin to cholesterol is internally administered to animals including humans. The composition is effective in lowering blood cholesterol and phospholipids by preventing the absorption of dietary sources of cholesterol in the gastrointestinal tract.

The invention relates to compositions comprising Pinus pinaster stem bark extract, papain, and Aloe vera extract, and methods of manufacturing same. There are also described methods of treating or preventing a variety of conditions, including treating or preventing elevated blood glucose, pre-diabetes, type 2 diabetes, autoimmune diseases, reducing or decreasing inflammation, treating or preventing diseases characterised by elevated levels of inflammation, and lowering blood cholesterol, said methods comprising administering an effective amount of a composition according to the invention to a subject in need thereof. Uses of the composition of the invention for the manufacture of a medicament for treating or preventing a variety of conditions are also described.

The invention discloses a method for tissue culture of Xungen tea to obtain tissue culture seedlings of tea trees with roots and a making method for the Xungen tea. The making method is used for making the Xungen tea through the tissue culture seedlings of the tea trees with the roots in combination with a rolling device or manual rolling and other processes. The Xungen tea can be planted indoorsin a three-dimensional, multi-layered and continuous manner, and the yield of the Xungen tea is ensured; the fresh beauty of the mini plants of the tea trees can be fully displayed in the brewing process, the ornamental property is better, and the quality of tea drinking is significantly improved; the Xungen tea has active ingredients of roots such as stachyose and raffinose besides active ingredients of tender shoots, and has a unique health-care effect of tea tree roots of lowering blood cholesterol, triglyceride and the like; the innovative Xungen tea based on a production and brewing process can enrich products on the existing tea market.

The invention discloses a shepherd's purse health-care noodle, which comprises the following raw materials in parts by weight: 70-100 parts of wheat flour, 20-30 parts of yellow rice flour, 10-40 parts of shepherd's purse juice, and 5-8 parts of egg liquid , 2-10 parts of modified starch, 2-6 parts of chicken essence, 0.3-1.5 parts of flour alkali, 0.5-2 parts of table salt, 1-4 parts of calcium propionate and appropriate amount of water. The invention adopts a kind of shepherd's purse health-care noodles, which can help the three-high elderly to play a health care effect to a certain extent, and has a delicate taste, rich nutrition and good taste; because the invention adds shepherd's purse juice, the shepherd's purse juice can reduce cholesterol and glycerin in blood and liver Triester content and health care effects such as lowering blood pressure, these health care noodles not only meet the needs of the elderly’s eating habits and health care, but also the nutrition, health care and environmental protection food that people are pursuing in life, and can also produce good social benefits and benefits. economic benefits.

Blood cholesterol levels are correlated with production of amyloid β protein (Aβ), and are predictors of populations at risk of developing AD. Methods for lowering blood cholesterol levels can be used to decrease production of Aβ, thereby decreasing the risk of developing AD. The same methods and compositions can also be used for treating individuals diagnosed with AD. Methods include administration of compounds which increase uptake of cholesterol by the liver, such as the administration of HMG CoA reductase inhibitors, administration of compounds which block endogenous cholesterol production, such as administration of HMG CoA reductase inhibitors, administration of compositions which prevent uptake of dietary cholesterol, and administration of combinations of any of these which are effective to lower blood cholesterol levels. Methods have also been developed to predict populations at risk, based on the role of cholesterol in production of Aβ. For example, individuals with Apo E4 and high cholesterol, defined as a blood cholesterol level of greater than 200 mg / dl, post menopausal women with high cholesterol levels—especially those who are not taking estrogen, or individuals which high blood cholesterol levels who are not obese are all at risk of developing AD if blood cholesterol levels are not decreased.

The invention belongs to the technical field of traditional Chinese medicines and particularly relates to a traditional Chinese medicine which is prepared from Chinese herbal medicines and is used for treating cardiovascular and cerebrovascular diseases. The traditional Chinese medicine is prepared from the raw materials in parts by weight: 5-10 parts of hawksbill turtle, 10-15 parts of radix curcumae, 10-13 parts of fructus aurantii, 8-15 parts of cowherb seed, 8-15 parts of zedoary, 8-12 parts of bupleurum root, 9-17 parts of sea buckthorn, 9-13 parts of winged euony twigs, 12-15 parts of radix clematidis, 10-16 parts of ligustrum lucidum, 5-8 parts of gecko, 5-8 parts of panax pseudo-ginseng, 12-17 parts of lycopus lucidus, 12-16 parts of fenugreek, 10-15 parts of potentilla discolor, 13-25 parts of wild jujube seed, 10-20 parts of rhizoma cibotii, 10-15 parts of schisandra fruit, 10-25 parts of red raspberry, 20-30 parts of giant knotweed and 5-15 parts of ants. According to the traditional Chinese medicine disclosed by the invention, in accordance with the pathogenesis of the cardiovascular and cerebrovascular diseases that the cardiovascular and cerebrovascular diseases are caused by cerebral hemorrhagic or ischemic injury resulting from blood vessel narrowing, insufficient blood supply or cerebral blood vessel thrombosis due to the atherosclerosis of heart and brain blood vessels, methods such as promoting blood circulation to dispel blood stasis, resisting thrombosis and dissolving fat, softening blood vessels and the like must be adopted during the treatment of the diseases so as to improve the conditions of spasm and stiffening of cardio-cerebral vessels, lower the content of cholesterol in blood, block thrombosis, dilate coronary arteries and increase blood flow volume, and thus the radical cure effect of treating both symptoms and root causes and preventing the disease to recurrence is achieved.

The invention provides children spleen invigorating powder. The children spleen invigorating powder is prepared from the following raw materials in parts by weight of 14.3% of plantain herbs, 11.4% ofpericarpium arecae, 14.3% of herba portulacae, 10% of wrinkled gianthyssop herbs, 14.3% of radish seeds, 10% of perilla frutescens, 7.1% of haws, 12.9% of argy wormwood leaves and 5.7% of rhizoma coptidis. According to the children spleen invigorating powder disclosed by the invention, a given quantity of the purslane herbs are added, so that the content of nutrient components in the children spleen invigorating powder can be enriched, the concentration of cholesterol in blood can be reduced, the efficacy of improving the elasticity of vascular wall during bath of babies can be achieved, andthe children spleen invigorating powder facilitates prevention and treatment of cardiovascular diseases; and a given amount of the perilla frutescens is added, so that the children spleen invigoratingpowder can induce perspiration and disperse cold qi to relieve exterior syndromes and evil, can also promote the circulation of qi, relieve epigastric distention, resolve stagnation and relieve vomiting, can be used for treating diseases of cold, chill, chest distress, vomiting, evil and the like during bath of the babies, and can also be used for symptoms of qi stagnation of spleen and stomach,chest distress, vomiting, evil and the like.

The invention discloses intestine-nourishing ointment and a preparation method thereof. The intestine-nourishing ointment is made from the following materials according to parts by weight: 20-30 parts of xylo-oligosaccharide, 30-40 parts of galacto-oligosaccharide, 10-20 parts of yacon concentrate or black garlic extract, 20-30 parts of coconut milk, 10-20 parts of fermented glutinous rice re-fermented concentrate, 0.1-1.0 part of vitamin C, 0.1-1.0 part of citric acid, and 10-20 parts of resistant dextrin. The intestine-nourishing ointment can moisten intestines to relax bowels, improve intestinal health, improve body immunity, lower blood cholesterol, promote mineral absorption, prevent and treat appendicitis and prevent colon cancerization, and can also produce various vitamins to promote body health.

The invention discloses a Filipendula glaberrima alcoholic extract and solvent fractions fractionated therefrom or novel compounds 1 and 2 purely isolated from a Filipendula glaberrima ethyl acetate fraction that have an excellent inhibitory effect against HMG-CoA reductase activity, an excellent antioxidant effect and a remarkably excellent effect of suppressing the formation of foam cells in macrophages. Also, disclosed is a pharmaceutical composition or health food composition for treating, preventing and ameliorating vascular diseases, hypercholesterolemia, or heart diseases caused by hypercholesterolemia, or lowering blood cholesterol levels, containing, as active ingredients, the Filipendula glaberrima alcoholic extract and the solvent fractions or the novel compounds 1 and 2.

The invention belongs to the technical field of traditional Chinese medicine, and relates to a traditional Chinese medicine preparation for regulating hyperlipidemia, which is composed of silver rattan tea, crucian jujube, notoginseng flower, hawthorn, kudzu root, turmeric, Yuanhu, astragalus, aconite, puhuang and radix japonicus 7-, Danshen, Maodongqing, white peony, the present invention is based on the secret recipe handed down from the ancestors, combined with the summary of his many years of clinical experience, obtained through repeated experiments, so the medicine has a unique effect on intractable hyperlipidemia. It adopts multi-drug scientific compatibility and comprehensive treatment so that the active ingredients of the drug can quickly enter the blood circulation, lower blood cholesterol, block thrombosis, expand coronary arteries, increase blood flow, improve the tolerance of myocardial ischemia, improve Cerebral infarction, repair damaged brain nerves, and quickly recover from hyperlipidemia. The medicine of the invention has unique curative effects on hypertension, hyperlipidemia, diabetes, brain atrophy, cerebral thrombosis, coronary heart disease, cerebral arteriosclerosis and stroke sequelae. Moreover, it has the advantages of quick effect, short course of treatment, high cure rate and low cost.

The invention belongs to the technical field of natto production, particularly relates to black chickpea natto granules and a production process thereof, and provides a scheme for solving the problem that cholesterol and blood pressure are easy to rise in the prior art. The black chickpea particles comprise the following main materials in parts by weight: 45-50 parts of natto powder, 5-10 parts of a corn material, 1-5 parts of a millet extract, 1-3 parts of red date powder, 1-2 parts of chrysanthemum, 5-10 parts of mixed tea and 15-20 parts of maltodextrin, and the corn material is rich in calcium, so that the effect of reducing blood pressure can be achieved; the corn oil can be used for reducing blood cholesterol and softening blood vessels, the red dates have the effects of reducing cholesterol and triglyceride in blood, and the chrysanthemum, the green tea and the ground tea can be used for reducing blood fat and gently reducing blood pressure, so that the health-care tea has a good health-care effect on heart blood vessels.