114 results about "Photodynamic diagnosis" patented technology

A system configured for photodynamic or photothermal therapy and photodynamic diagnosis of a tissue is 5 disclosed. The system comprises in combination an assembly of: a proximal end adapter for a catheter comprising an adapter body (32), having proximal and distal ends, defining an axial lumen extending between the proximal and distal ends, a catheter mounting element at the distal end 10 of the adapter body (32) for sealingly mounting a catheter to the adapter body, and a hollow catheter (31), wherein the catheter mounting element connects a catheter body to the hollow catheter so that the hollow catheter extends from the distal end of the catheter body; a first light 15 guide (36) having proximal and distal ends, wherein said first light guide is sealingly contained in said axial lumen defining an axial optical path extending between the proximal and distal ends of the adapter body (32) towards said tissue (8) and into close proximity thereof or 20 interstitially into said tissue; an optical connector mounting element at the proximal end having mounted an optical connector (37) to the adapter body, and wherein said optical connector (37) is coupled to a light source via a second light guide (38), such that light from said 25 light source is transmittable from said light source via said second light guide (38) and further via said optical connector (37) to said first light guide (36) via said proximal end adapter towards said tissue (8) through said catheter (31).

The invention discloses a gold nanocage-manganese dioxide composite nanoparticle as well as a preparation method and application thereof, and relates to the technical field of nanoparticle photodynamic therapy. The composite nanoparticle comprises a gold nanocage inner core and a manganese dioxide shell layer. The preparation method is characterized in that potassium permanganate is reduced by a one-step reduction method; the manganese dioxide shell layer covers the surface of the gold nanocage, wherein the gold nanocage inner core achieves a photodynamic curative effect under the triggering of near-infrared light; the manganese dioxide shell layer is degraded in tumor microenvironment and releases oxygen, so that the tumor oxygen deficiency is relieved, and the photodynamic curative effect is enhanced; on the other hand, the opto-acoustic and magnetic resonance bimodule imaging can also be realized. The problem of insufficient photodynamic curative effect caused by factors such as tumor oxygen deficiency and photodynamic oxygen consumption of a nanometer photosensitizer used in the prior art is solved. The photodynamic curative effect of the gold nanocage-manganese dioxide composite nanoparticle is obvious; the gold nanocage-manganese dioxide composite nanoparticle can be applied to tumor targeted oxygenation photodynamic diagnosis and treatment integration.

An apparatus that includes a surgical telescopic device having a distal end and a proximal end; a camera coupled to the proximal end of the surgical telescopic device; and a holographic notch filter interposed between the camera and the proximal end of the surgical telescopic device. The camera preferably is a charge-coupled-device camera ("CCD camera"). The apparatus may also include a focusing lens or an alternative type of filter such as a long-pass filter or an infrared filter. The surgical telescopic device may be used by illuminating the material with non-white light and detecting the emitted fluorescence, phosphorescence or luminescence.

An endoscopic or microscopic apparatus for diagnosis by means of a light-induced reaction in biologic tissue "in vivo" which is created by a photo-amboceptor or by autofluorescence is provided. The inventive apparatus is characterized by the feature that at least one reference wavelength lambdar is provided which is longer by up to 2Deltalambda at maximum or smaller than the wavelength lambdas at the point of intersection.

The invention discloses several non-peripherial substituted phthalocyanine metal complexes and making method, which introduces functional group into position a (position 1(4), 8(11), 15(18) and 22(25)) of phthalocyanine complex.

A device for testing and/or adjusting a PDD or PDT system and/or for training on such a system comprises an illumination system emitting light which serves at least to stimulate a fluorescent dye and which may be directed to this end onto a tissue zone to be diagnosed and/or therapeutically treated, and an imaging unit which images the light arriving from the stimulated tissue zone. The invention is characterized by the provisions that a target is provided which reflects the light of the illumination system, and that the target comprises at least one light source which emits light within the wavelength range of the fluorescence spectrum of the dye.

The present invention provides an apparatus for white light observation and fluorescence diagnosis of skin diseases. More particularly, the present invention provides an apparatus for photodynamic diagnosis in which a plurality of excitation light emitting diodes (LEDs) is provided in an image pick-up head, the excitation LEDs being arranged to illuminate the entire examination region in the form of a mosaic by setting respective illumination light axes of the excitation LEDs to illuminate preassigned individual areas of the examination region, thus uniformly illuminating the examination region in a wide field of view with excitation light. In the apparatus for photodynamic diagnosis, the respective excitation LEDs are provided at the same or different angles based on the light axis of the object lens, and thereby it is possible that the beams of the light sources composed of the LEDs illuminate the field of view of the examination region uniformly, thus improving the uniformity of illumination. Moreover, the present invention provides an apparatus for photodynamic diagnosis in which warm white LEDs and cold white LEDs as white light sources are appropriately arranged so as to deliver natural colors and thereby to reproduce natural color images.

The invention discloses a port wine stains photodynamic diagnosis and treatment instrument, which includes a photodynamic cure device and an OCT scan device. One industrial control mainboard and one operation system are shared for the OCT scan device and the photodynamic cure device, the OCT scan device is equipped with a data interface for connecting an external computer. By cooperation of the OCT scan device and the photodynamic treatment device, the diagnosis and cure instrument detects microscopic section of processed pathological change skin tissue and confirms treatment effect on microscopic view, wherein imaging scan resolution can be in micron-level and exceeds traditional detection way far and away. The diagnosis and treatment instrument can real-time display section tissue structure images of detected position by using the OCT scan device, realize image processing functions to make the images more clear and provide scientific evidence for pathological change diagnosis and estimation of therapeutic effect. The diagnosis and cure instrument resolves problem in prior art that estimations of skin pathological change part by visual observation and experience and to therapy results are inaccurate.

A medicinal carrier composition suitable for the locally transferring bioactive compound, especially the 5-aminolaevulinic acid (ALA) for photodynamic diagnosing or therapy, contains mucosa adhering polymer and thermoresponsive polymer.

The invention discloses axial end hydroxyl substituted silicon phthalocyanine, a self-assembling body of silicon phthalocyanine, as well as a preparation method and application of silicon phthalocyanine, and belongs to the field of preparation of photodynamic medicines or photosensitizers. The axial end hydroxyl substituted silicon phthalocyanine disclosed by the invention can be used as a photosensitizer for photodynamic treatment, photodynamic diagnosis or photodynamic sterilization, and is high in photodynamic activity.

In photodynamic diagnosis and photodynamic therapy, the oscillating wavelength of laser light from a light source is fitted to a plurality of different kinds of photosensitizers and exciting conditions thereof. Moreover, diagnosis and treatment are achieved using concurrent diagnosis during treatment is realized as well. A semiconductor laser generates laser light having an oscillating wavelength which is variable and a full width at half maximum which is narrow. A light transmission line guides an irradiated laser light to the vicinity of a focus, an image transmission line observes the focus and the periphery thereof, a fluorescence light extracting device extracts only the fluorescence light emitted from a photosensitizer excited by the irradiated laser light, an image-pick-up/analyzing device picks up and analyzes an image of the extracted fluorescence light and an image display device displays the analyzing result.

The present disclosure relates to an illumination system for endoscopic applications comprising at least one substantially monochromatic light source having a predefined central wavelength between 400 and 500 nm or between 500 and 550 nm, an optical transmission path adapted to guide light emanating from the light source to an endoscopic region of examination, and an optical band-rejection filter, wherein the illumination system is adapted to illuminate at least a part of the region of examination by generating autofluorescence in surrounding tissue, and the band-rejection filter is adapted to attenuate at least said light source wavelength to a viewer and wherein said light source is the single light source in the illumination system. A further embodiment relates to an endoscope for examining a body cavity comprising tissue, the endoscope comprising a source of light consisting of a substantially monochromatic light source having a predefined central wavelength between 400 and 550 nm, means for guiding light from the substantially monochromatic light source towards at least a part of the tissue, and at least one band-rejection filter adapted to attenuate at least said central wavelength, wherein the substantially monochromatic light source is configured to generate autofluorescence in the irradiated tissue such that the irradiated tissue is observable, and wherein the endoscope is configured to display at least a part of the irradiated tissue through said band-rejection filter. A system for photodynamic diagnosis and/or therapy of bladder cancer is further disclosed herein.

An object of the present invention is to provide a PDD diagnosis apparatus that even if there is a distance from an irradiation portion of an optical fiber to a diseased tissue, enables provision of a fluorescence detection sensitivity equivalent to that in a case where irradiation is provided in such a manner that the irradiation portion of the optical fiber is brought close to the diseased tissue. A diagnosis apparatus including: a light source unit that emits excitation light to a photosensitizing substance accumulated in a diseased tissue; a detection unit that detects fluorescence produced from the photosensitizing substance; and an excitation light irradiation/fluorescence detection optical fiber including an output/input end with a collimator connected thereto, in which the excitation light emitted from the light source unit is guided to the excitation light irradiation/fluorescence detection optical fiber, and the excitation light output from the output/input end is provided in such a manner that the excitation light is collimated by the collimator and excites the photosensitizing substance accumulated in the diseased tissue; and the fluorescence produced by the photosensitizing substance excited by the excitation light is input from the output/input end via the collimator, and the input fluorescence is guided to the excitation light irradiation/fluorescence detection optical fiber and the fluorescence produced from the photosensitizing substance is detected in the detection unit is used.

An apparatus for performing photodynamic diagnosis and photodynamic therapy on a target region that is pre-given with a photosensitizer precursor includes a display unit, an excitation light source operable to irradiate the target region with exciting light so as to excite emission of fluorescence from the target region as a result of fluorescence response of the photosensitizer precursor, an image capturing unit operable to capture a white light image and a fluorescent image of the target region, an image processing unit operable to superimpose the white light image and the fluorescent image into a synthesized image and to provide at least one of the white light image, the fluorescent image and the synthesized image thereto for display on the display unit, and a curing light source operable to irradiate a specified portion of the target region with curing light for treating the specified portion.

The invention provides a photosensitizer prodrug compound, and a preparation method and an application thereof. The compound has a structure represented by formula (I). A disulfide bond is introduced at the N end of 5-ALA or its ester derivative, the disulfide bond is a GSH responsive group, the group containing the disulfide bond undergoes self-immolative reaction under the condition of linking urethane to the beta position of the disulfide bond in order to release the connected 5-ALA or its ester derivative, protoporphyrin is generated in an intracellular metabolism manner, and the photosensitizer plays a role in photodynamic diagnosis, so dimerization induced inactivation of the 5-ALA is avoided, and the drug stability is increased; and the overexpression of the GSH in various tumor cells and the response of the prodrug compound to the GSH enhance the tumor targeting property of the drug. The invention also provides the application of the photosensitizer prodrug compound in the preparation of the drug for photodynamic diagnosis and treatment.

The invention discloses axial nucleoside asymmetrically-modified silicon phthalocyanine and a preparation method and application thereof, belonging to the preparation field of a photodynamic medicine or a photosensitizer. The axial nucleoside asymmetrically-modified silicon phthalocyanine disclosed by the invention can be applied to photodynamic treatment, photodynamic diagnosis or photodynamic disinfection as a photosensitizer, has the structural characteristic of axial asymmetric substitution, and shows good amphipathicity and excellent photodynamic activity.

A medical luminaire for photodynamic diagnosis. The medical luminaire including: a broad-band lamp for generating broad-band background light; a semiconductor lamp for generating short-wave excitation light, wherein the semiconductor lamp comprises a laser diode, the light from which is fed alternatively or additionally into a light path of the broad-band lamp, and a light fibre bundle for transporting the light, wherein the excitation light is transported in a partial bundle.

The present invention relates to amphiphilic squaraine dyes of the general formula (1) as shown below Formula (1) wherein, R¹=—(CH₂—CH₂—O)_n—CH₃, n=4-8, or —(CH₂)_n—CO₂X, n=3-6, X=H, succinamide and R²=—CH₃ or —(CH₂—CH₂—O)_n—CH₃, n=4-8 and pharmaceutically acceptable derivatives thereof, for use as near infrared fluorescence probes in photodynamic diagnostic and biological, biochemical and industrial applications.

The invention discloses axial ALA-modified silicon phthalocyanine and a preparation method and an application thereof, and belongs to the field of photodynamic drug or photosensitizer preparation. The silicon phthalocyanine provided by the invention can be used in photodynamic treatment, photodynamic diagnosis or photodynamic disinfection as a photosensitizer. The silicon phthalocyanine has a structure containing a second-generation photosensitizer ALA. Cells can release two photosensitizers, namely ALA and silicon phthalocyanine. Photodynamic therapy window is expanded. The silicon phthalocyanine provided by the invention shows a good synergistic anticancer effect and a high photodynamic activity.

This invention relates to a medicament-carrier composition for use in delivering medicaments or fixing the action site of biological active compounds, which mainly comprises a mucoadhesive polymer and a thermoresponsive polymer. The medicament-carrier composition according to this invention is quite suitable for use in topically delivering biological active compounds, especially those useful in photodynamic diagnosis or therapy, e.g. 5-aminolevulinic acid (called as “ALA” for short).

The invention discloses phthalocyanine-chitosan oligosaccharide conjugates as well as a preparation method and an application thereof, and belongs to the field of drug preparation. The phthalocyanine-chitosan oligosaccharide conjugates are monosubstituted carboxyl zinc phthalocyanine and chitosan oligosaccharide conjugates or quaternization derivatives of the conjugates, and can be applied to photodynamic bacterial resistance, photodynamic cancer resistance, photodynamic diagnosis and photodynamic disinfection. The phthalocyanine-chitosan oligosaccharide conjugates have double functional groups of phthalocyanine and chitosan oligosaccharide or chitosan oligosaccharide quaternary ammonium salt, thereby being capable of realizing a synergistic treatment effect while realizing photodynamic bacterial resistance; meanwhile, chitosan oligosaccharide has excellent water solubility and biocompatibility, accordingly, amphiphilic property and biocompatibility of phthalocyanine can be improved effectively, toxicity of phthalocyanine can be reduced, and clinical application value of phthalocyanine can be increased.

The invention discloses phthalocyanine silicon modified by amino ethyl groups and phenoxy groups as well as a preparation method and application thereof, which belong to the field of the preparation of photodynamic medicines or photosensitizers. The phthalocyanine silicon modified by the amino ethyl groups and the phenoxy groups, which is provided by the invention, can be used as a photosensitizer for photodynamic therapy, photodynamic diagnosis or photodynamic disinfection, has the advantages of definite composition, simple and convenient preparation, high photodynamic activity and the like, is easy to realize industrialization and has obvious economic and social benefits.

This invention relates to solid compositions and solid pharmaceutical products for use in methods of photodynamic diagnosis of cancer, pre-cancerous and non-cancerous conditions in the lower part of the gastrointestinal system. The solid pharmaceutical compositions and pharmaceutical products comprise an active ingredient which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative of 5-ALA or pharmaceutically acceptable salts thereof. The invention relates further to methods of photodynamic diagnosis of cancer, pre-cancerous and non-cancerous conditions of the lower gastrointestinal tract, wherein the solid pharmaceutical compositions and pharmaceutical products are used.