48 results about "Silicon phthalocyanine" patented technology

The invention discloses axial end hydroxyl substituted silicon phthalocyanine, a self-assembling body of silicon phthalocyanine, as well as a preparation method and application of silicon phthalocyanine, and belongs to the field of preparation of photodynamic medicines or photosensitizers. The axial end hydroxyl substituted silicon phthalocyanine disclosed by the invention can be used as a photosensitizer for photodynamic treatment, photodynamic diagnosis or photodynamic sterilization, and is high in photodynamic activity.

The invention discloses a triphenylamine-based branch ligand substituted silicon phthalocyanine, a preparation method and an application thereof. 4-bromotriphenylamine and 4-hydroxy phenylboronic acidare catalytically coupled through tetrakis (triphenylphosphine) palladium, so as to acquire a branch precursor 4'-(diphenyl amino)-[1,1'-biphenyl]-4-alcohol; the 4'-(diphenyl amino)-[1,1'-biphenyl]-4-alcohol (TPA-OH) reacts with SiPcCl2 in the presence of methylbenzene and K2CO3, so as to acquire bi-(4-(diphenyl amino)-1-biphenylyloxy) axially substituted silicon phthalocyanine; steric hindranceof a triphenylamine substituted branch structure is capable of restraining the gathering of phthalocyanine to some extent; the triphenylamine with an aggregation-induced emission characteristic is introduced into the branch structure, so that the 'aggregation-induced quenching' effect of phthalocyanine is improved, the optical physical property of phthalocyanine is regulated and the simultaneous execution of fluorescence imaging and photodynamic therapy is realized; the triphenylamine-based branch ligand substituted silicon phthalocyanine can be used as a fluorescence imaging agent and a photodynamic therapy photosensitizer.

The invention discloses axial nucleoside asymmetrically-modified silicon phthalocyanine and a preparation method and application thereof, belonging to the preparation field of a photodynamic medicine or a photosensitizer. The axial nucleoside asymmetrically-modified silicon phthalocyanine disclosed by the invention can be applied to photodynamic treatment, photodynamic diagnosis or photodynamic disinfection as a photosensitizer, has the structural characteristic of axial asymmetric substitution, and shows good amphipathicity and excellent photodynamic activity.

The invention discloses axial ALA-modified silicon phthalocyanine and a preparation method and an application thereof, and belongs to the field of photodynamic drug or photosensitizer preparation. The silicon phthalocyanine provided by the invention can be used in photodynamic treatment, photodynamic diagnosis or photodynamic disinfection as a photosensitizer. The silicon phthalocyanine has a structure containing a second-generation photosensitizer ALA. Cells can release two photosensitizers, namely ALA and silicon phthalocyanine. Photodynamic therapy window is expanded. The silicon phthalocyanine provided by the invention shows a good synergistic anticancer effect and a high photodynamic activity.

The invention relates to a SiPc (silicon phthalocyanine) photosensitizer using RGD polypeptide as a targeted group, a preparation method of the SiPc photosensitizer and application of the SiPc photosensitizer to an aspect of tumor photodynamics therapy. The SiPc is used as a photosensitive part to be connected with an RGD polypeptide ligand; PEG (polyethylene glycol) and fragments containing carboxy groups are introduced into the structure; a series of novel photosensitizers with the tumor targeting performance can be prepared. One coupling compound RGD-(Linker)2-Glue-SiPc has good optical physic and photodynamic performance; the EC50 value on the receptor positive tumor cells is 10 to 20nm; under the condition of once medication, the spongioblastoma on the mouse body can be cured; after the continuous observation for 35 days, recurrence does not occur; good application prospects are shown in the field of tumor photodynamics therapy.

The invention discloses silicon phthalocyanine modified by a cytidine derivative and a preparation method and an application thereof, which belong to the field of preparation of photodynamic medicaments or photosensitizers. The silicon phthalocyanine modified by the cytidine derivative provided by the invention can be taken as a photosensitizer for use in photodynamic therapy, photodynamic diagnosis or photodynamic disinfection, has the advantages of high selectivity, high photodynamic activity and the like, has definite constitution, is easy and convenient to prepare, and is easy to be industrialized.

The invention discloses silicon phthalocyanine axially modified by aminoethyl phenoxyl and polyethylene glycol oligomer as well as a preparation method and application of silicon phthalocyanine, belonging to the field of preparation of photodynamic medicaments or photosensitizers. The silicon phthalocyanine provided by the invention can be used as a photosensitizer for photodynamic treatment, photodynamic diagnosis or photodynamic sterilization, has the structural characteristic of axially asymmetrical substitution and shows favorable amphipathy and extremely high photodynamic activity.

The invention discloses silicon phthalocyanine modified by uridine derivatives and a preparation method and application of the silicon phthalocyanine, and belongs to the field of preparation of photodynamic drugs or photosensitizer. The silicon phthalocyanine modified by the uridine derivatives can be used as a photosensitizer for photodynamic therapy, photodynamic diagnosis or photodynamic disinfection, has the advantages of high selectivity, high photodynamic activity and the like, and is explicit in composition and easy to prepare and industrialize.

The invention relates to a pH sensitive ketal connection cholesterol-silicon phthalocyanine complex, a preparing method of the pH sensitive ketal connection cholesterol-silicon phthalocyanine complex and application of the pH sensitive ketal connection cholesterol-silicon phthalocyanine complex to medicines. In particular, the invention relates to a silicon phthalocyanine complex shown in the general formula (I), a preparing method of the silicon phthalocyanine complex, a medicine component containing the complex and application of the silicon phthalocyanine complex as a photosensitizer, in particular to application to cancer treatment. All substituting groups in the general formula (I) are the same as definitions in the specification. Due to existence of cholesterol groups, the complex in the series are difficultly taken by cancer cells and normal cells, but in the cancer tissue extracellular micro acid environment, ketal keys are subject to hydrolysis reactions, hydrolysis derivatives of silicon phthalocyanine can be easily taken by the cancer cells, and the extremely-high photosensitive activity is shown; and the complex and the component can be prepared into cancer cell extracellular micro acid environment target photosensitive medicines.

A method for preparing a silica particle incorporating at least one phthalocyanine derivative is provided. In the method, the particle may be prepared from at least one silicon phthalocyanine derivative via an inverse micro-emulsion. In addition, the silica particles and their uses are provided.

The invention discloses axial galactose/lactose modified silicon phthalocyanine as well as a preparation method and an application thereof, which belong to the field of preparation of photodynamic drugs or photosensitizers. The axial galactose/lactose modified silicon phthalocyanine provided by the invention has the advantages of non-aggregation in a physiological solution, high activity, high biological safety and the like, and can be used as a photosensitizer for photodynamic therapy, photodynamic diagnosis or photodynamic disinfection.

The invention discloses application of piperazidine substituted silicon phthalocyanine and application thereof to photothermal therapy, and belongs to the field of a photothermal agent or photothermaltherapy medicine. A solution containing the silicon phthalocyanine provided by the invention has the obvious photoinduced temperature rising effect under the illumination of near infrared laser; thephotothermal therapy can be realized; meanwhile, the photodynamic active oxygen generation effect is also achieved; the cooperated effect of photodynamic therapy and photodynamic therapy can be achieved.

The present invention relates to a silicon phthalocyanine complex, the preparation method and the medicinal application thereof. The present invention particularly relates to a silicon phthalocyanine complex of formula (I), the preparation method thereof and a pharmaceutical composition comprising the same, as well as the use thereof as a photosensitizer, in particular the use in the treatment of cancers, wherein each substituent in formula (I) is the same as defined in the description.

Provided is a production process for a colorant which contains a silicon phthalocyanine compound making it possible to reach a targeted particle diameter even by a conventional dispersing method and which is excellent in performances such as a color reproducibility, a light fastness, an electrostatic property, a transparency and the like, and a colorant composition, a toner, an ink for ink jet recording and a color filter which are excellent in the above performances.

The above production process is a production process for a colorant containing a silicon phthalocyanine compound and a copper phthalocyanine compound and is characterized by having a preparing step of reacting raw materials of a silicon compound and phthalocyanine under the presence of a copper salt or the copper phthalocyanine compound described above to prepare the silicon phthalocyanine compound described above.