Multi-targeted photodynamic therapy polymer carrier and preparation method thereof

Abstract

The invention discloses a preparation method of a multi-targeted photodynamic therapy polymer carrier. The preparation method comprises the following steps of: firstly, preparing a thermosensitive prepolymer: carrying out reversible addition-fragmentation chain transfer polymerization on diethylene glycol dimethacrylate, polyethylene glycol methacrylate and methacrylic-2-ethyl hydroxyl as reactants to obtain the thermosensitive prepolymer; and secondly, by taking the thermosensitive prepolymer and silicon phthalocyanine dichloride as reactants, connecting the silicon phthalocyanine dichloride onto a thermosensitive prepolymer chain segment by a chemical bond method to obtain the multi-targeted photodynamic therapy polymer carrier. According to the preparation method disclosed by the invention, the multi-targeted photodynamic therapy polymer carrier is synthesized and is a water-soluble thermosensitive nano-carrier; the multi-targeted photodynamic therapy polymer carrier can be gathered in cells by regulating and controlling the temperature and a high-transparent retention effect of solid tumors in a targeted manner and further the photodynamic therapy is carried out; and singlet oxygen has quantum yield as high as 0.55 and can be used for further photodynamic therapy.

Description

technical field [0001] The present invention relates to a polymer carrier, in particular to a multi-targeted photodynamic therapy polymer carrier and a preparation method thereof. Background technique [0002] Photodynamic therapy (PDI) has developed rapidly in recent years and has been applied to the treatment of various diseases including cancer. The basic process of this reaction is based on the fact that when a photodynamic sensitive substance or photosensitizer (PS) is irradiated with light of the corresponding wavelength, it absorbs photon energy and changes from the ground state to the excited state, and its physical de-excitation process produces fluorescence, which is analyzed by fluorescence spectroscopy. It can be used for disease diagnosis; its chemical de-stimulation process can generate a large amount of reactive oxygen species (ROS), the most important of which is singlet oxygen. Reactive oxygen species can interact with a variety of biological macromolecules...

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Problems solved by technology

[0003] However, due to the generally poor water solubility of photosensitizers, they are easy to deposit in blood vessels, which limits the application of photodynamic therapy.

[0004] The existing traditional method is to physically entrap the drug through nanoparticles, but it cannot avoid the problem of partial release of the drug before reaching the treatment area, resulting in toxic side effects and affecting the curative effect

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