Gold nanocage-manganese dioxide composite nanoparticle as well as preparation method and application thereof

Abstract

The invention discloses a gold nanocage-manganese dioxide composite nanoparticle as well as a preparation method and application thereof, and relates to the technical field of nanoparticle photodynamic therapy. The composite nanoparticle comprises a gold nanocage inner core and a manganese dioxide shell layer. The preparation method is characterized in that potassium permanganate is reduced by a one-step reduction method; the manganese dioxide shell layer covers the surface of the gold nanocage, wherein the gold nanocage inner core achieves a photodynamic curative effect under the triggering of near-infrared light; the manganese dioxide shell layer is degraded in tumor microenvironment and releases oxygen, so that the tumor oxygen deficiency is relieved, and the photodynamic curative effect is enhanced; on the other hand, the opto-acoustic and magnetic resonance bimodule imaging can also be realized. The problem of insufficient photodynamic curative effect caused by factors such as tumor oxygen deficiency and photodynamic oxygen consumption of a nanometer photosensitizer used in the prior art is solved. The photodynamic curative effect of the gold nanocage-manganese dioxide composite nanoparticle is obvious; the gold nanocage-manganese dioxide composite nanoparticle can be applied to tumor targeted oxygenation photodynamic diagnosis and treatment integration.

Description

technical field [0001] The invention relates to the technical field of nanoparticle photodynamic therapy, in particular to a gold nanocage-manganese dioxide composite nanoparticle and its preparation method and application. Background technique [0002] In recent years, photodynamic therapy has become a research hotspot in the field of tumor treatment due to its non-invasive and space-time controllable advantages. The energy converts oxygen into cytotoxic reactive oxygen species, thereby inducing tumor cell apoptosis or necrosis. Therefore, the efficacy of photodynamic therapy depends on the synergistic effect of photosensitizer, light and oxygen. [0003] On the one hand, currently clinically available photosensitizers are mainly small molecule photosensitizers such as phthalocyanine, porphine or derivatives of porphyrin compounds. These photosensitizers generally have problems such as poor targeting, low water solubility, fast metabolism, photobleaching, phototoxicity, a...

AI Technical Summary

Problems solved by technology

Therefore, tumor hypoxia will lead to insufficient photodynamic efficacy, and photodynamic oxygen depletion intensifies tumor local hypoxia, thereby further reducing the effect of photodynamic therapy.

[0007] The nano-photosensitizers currently used can exert photodynamic efficacy under the trigger of near-infrared light, but the efficacy needs to be further improved. At the same time, due to factors such as tumor hypoxia and photodynamic oxygen consumption in tumor photodynamic therapy, the effect of photodynamic therapy is reduced. , resulting in poor photodynamic efficacy

Images