Gold nanocage-manganese dioxide composite nanoparticle as well as preparation method and application thereof

A composite nanoparticle and gold nanocages technology, which is applied in the field of gold nanocages-manganese dioxide composite nanoparticles and their preparation, can solve the problems of reducing the effect of photodynamic therapy, aggravating local hypoxia of tumors, poor photodynamic effect and the like , to achieve good photoacoustic imaging ability, improve tumor hypoxic microenvironment, and enhance the effect of photodynamic efficacy

Active Publication Date: 2018-02-09
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, tumor hypoxia will lead to insufficient photodynamic efficacy, and photodynamic oxygen depletion intensifies tumor local hypoxia, thereby further reducing the effect of photodynamic therapy.
[0007] The nano-photosensitizers currently used can exert photodynamic efficacy under the

Method used

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  • Gold nanocage-manganese dioxide composite nanoparticle as well as preparation method and application thereof
  • Gold nanocage-manganese dioxide composite nanoparticle as well as preparation method and application thereof
  • Gold nanocage-manganese dioxide composite nanoparticle as well as preparation method and application thereof

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preparation example Construction

[0072] The preparation method of the composite nanoparticle of the present invention is to reduce potassium permanganate with a reducing agent, and grow a manganese dioxide shell layer on the surface of the gold nanocage to form a gold nanocage-manganese dioxide composite nanoparticle with a core-shell structure.

[0073] The preparation method of the composite nano particle of the present invention is simple and easy, has strong operability, good controllability, and is easy to implement and popularize.

[0074] As a further embodiment, the preparation method of gold nanocage-manganese dioxide composite nanoparticles comprises the following steps:

[0075] adding potassium permanganate solution and a reducing agent to the gold nanocage-water dispersion to react, and growing a manganese dioxide shell on the surface of the gold nanocage to obtain gold nanocage-manganese dioxide composite nanoparticles;

[0076] Preferably, the reducing agent is selected from one or more of poly...

Embodiment approach

[0111] A specific embodiment, the step of preparing silver nanocubes comprises:

[0112] Inject 0.05-0.1mL of sodium hydrosulfide-ethylene glycol solution with a concentration of 2-4mmol / L into 3-8mL of ethylene glycol at a temperature of 145-160°C and mix for 2-5min; then add 0.2-0.8mL, Mix 2-4mmol / L hydrochloric acid-ethylene glycol solution with 1-2mL polyvinylpyrrolidone-ethylene glycol solution with a concentration of 15-25mg / mL for 2-5min; then add 0.2-0.8mL 250-300mmol / L silver trifluoroacetate-ethylene glycol solution, react at 145-160°C for 30-60 minutes, and obtain silver nanocubes with edge lengths of 40-80nm after separation and washing.

[0113] Silver nanocubes are prepared by the polyol reduction method. The polyol is selected from ethylene glycol, and hydrochloric acid and sulfide (sodium hydrogen sulfide) are added to assist in the preparation. By adjusting the specific reagent addition amount and reaction parameters, the edge length is 40~ 80nm silver nanocu...

Embodiment 1

[0131] A gold nanocage-manganese dioxide composite nanoparticle with a core-shell structure comprises a gold nanocage core and a manganese dioxide shell, the edge length of the gold nanocage is 55nm, and the manganese dioxide shell is 10nm thick.

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Abstract

The invention discloses a gold nanocage-manganese dioxide composite nanoparticle as well as a preparation method and application thereof, and relates to the technical field of nanoparticle photodynamic therapy. The composite nanoparticle comprises a gold nanocage inner core and a manganese dioxide shell layer. The preparation method is characterized in that potassium permanganate is reduced by a one-step reduction method; the manganese dioxide shell layer covers the surface of the gold nanocage, wherein the gold nanocage inner core achieves a photodynamic curative effect under the triggering of near-infrared light; the manganese dioxide shell layer is degraded in tumor microenvironment and releases oxygen, so that the tumor oxygen deficiency is relieved, and the photodynamic curative effect is enhanced; on the other hand, the opto-acoustic and magnetic resonance bimodule imaging can also be realized. The problem of insufficient photodynamic curative effect caused by factors such as tumor oxygen deficiency and photodynamic oxygen consumption of a nanometer photosensitizer used in the prior art is solved. The photodynamic curative effect of the gold nanocage-manganese dioxide composite nanoparticle is obvious; the gold nanocage-manganese dioxide composite nanoparticle can be applied to tumor targeted oxygenation photodynamic diagnosis and treatment integration.

Description

technical field [0001] The invention relates to the technical field of nanoparticle photodynamic therapy, in particular to a gold nanocage-manganese dioxide composite nanoparticle and its preparation method and application. Background technique [0002] In recent years, photodynamic therapy has become a research hotspot in the field of tumor treatment due to its non-invasive and space-time controllable advantages. The energy converts oxygen into cytotoxic reactive oxygen species, thereby inducing tumor cell apoptosis or necrosis. Therefore, the efficacy of photodynamic therapy depends on the synergistic effect of photosensitizer, light and oxygen. [0003] On the one hand, currently clinically available photosensitizers are mainly small molecule photosensitizers such as phthalocyanine, porphine or derivatives of porphyrin compounds. These photosensitizers generally have problems such as poor targeting, low water solubility, fast metabolism, photobleaching, phototoxicity, a...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K9/51A61K47/02A61K49/22A61K49/18A61P35/00
CPCA61K9/5115A61K41/0057A61K49/0002A61K49/1878A61K49/225
Inventor 蔡林涛梁锐晶刘兰兰韩志群何华美郑明彬
Owner SHENZHEN INST OF ADVANCED TECH
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