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Composite nano-enzyme synergistic catalysis fiber material as well as preparation method and application thereof

A technology of synergistic catalysis and fiber materials, applied in dressings for diabetic chronic wound healing, composite nano-enzyme synergistically catalyzed fiber materials and its preparation, and preparation of dressings to promote wound healing, which can solve the problem of high storage conditions of hydrogels and neovascular damage , difficult clinical use and other problems, to achieve the effect of improving the hypoxic microenvironment, preventing infection, and overcoming the difficulty of clinical use

Pending Publication Date: 2022-08-02
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, the dressings that promote wound healing in diabetic patients are mainly hydrogel dressings. The principle is generally to promote wound healing by improving the antibacterial ability of the wound, but it cannot solve the problem of neovascular injury caused by hypoxia at the wound, and the hydrogel dressing Glue has disadvantages such as high storage conditions and difficulty in clinical use.

Method used

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  • Composite nano-enzyme synergistic catalysis fiber material as well as preparation method and application thereof
  • Composite nano-enzyme synergistic catalysis fiber material as well as preparation method and application thereof
  • Composite nano-enzyme synergistic catalysis fiber material as well as preparation method and application thereof

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preparation example Construction

[0056] The present invention also provides a method for preparing the above-mentioned composite nano-enzyme synergistically catalyzing fiber material, the steps are as follows:

[0057] Step 1: Mixing calcium peroxide, manganese dioxide nanozyme, polylactic acid-glycolic acid copolymer and spinning solvent uniformly to obtain spinning solution A;

[0058] Step 2: Mixing calcium peroxide, ferric oxide nanozyme, benzoic acid, polylactic acid-glycolic acid copolymer and spinning solvent uniformly to obtain spinning solution B;

[0059] Step 3: Electrospinning the spinning solution A and the spinning solution B through two parallel nozzles, and drying the product to obtain a composite nano-enzyme synergistic catalytic fiber material.

[0060] In the above technical solution, in step 1 and step 2, the method of mixing is uniform mixing, and the stirring time is 4-6h.

[0061] The present invention also provides the application of the composite nano-enzyme synergistically catalyzin...

Embodiment 1

[0066] Mix 0.1 g of calcium chloride and 0.35 g of polyvinylpyrrolidone in 15 mL of ethanol, ultrasonically treat for 0.5 h, first add 1 mL of ammonia water (0.8 M) to the above solution, continue stirring for 0.5 h, and then add 0.6 mL of hydrogen peroxide (1 M) Add to the above solution at a speed of 0.2 mL / min, continue stirring until a light blue milky solution is obtained, and finally wash with ethanol 3 times and dry at 60 ° C. The obtained product is a monodispersed calcium peroxide sphere with a diameter of 70 nm.

[0067] Dissolve 0.325g of ferric chloride and 0.2g of trisodium citrate in 20mL of ethylene glycol, first add 1.2g of anhydrous sodium acetate to the above solution, stir for 0.5h, and then add the obtained mixed solution into a 50mL reaction kettle, Heating at 200 °C for 10 h, and finally cooling to room temperature, washing with ethanol for 3 times, then washing with deionized water for 3 times, and drying at 60 °C, the obtained black product is a spherica...

Embodiment 2

[0070] Step 1. Dissolve 0.1 PLGA (molar ratio of lactic acid to glycolic acid=50:50, molecular weight is 100000 Da) in 0.89 g of hexafluoroisopropanol to obtain a PLGA solution;

[0071] Step 2. According to the mass ratio of the inner mixture to PLGA of 1:10, mix the inner mixture with the PLGA solution of step 1 to obtain spinning solution A;

[0072] Wherein, the inner admixture is composed of manganese dioxide nanozyme (prepared in Example 1) and calcium peroxide (prepared in Example 1) in mass ratios of 0:10, 1:9, 5:5, and 9:1;

[0073] Step 3: Electrospin the spinning solution A and dry it to prepare a hybrid fiber. The conditions for electrospinning are: a spinning voltage of 20 kV, a perfusion speed of 0.5 mL / h, a receiving distance of 20 cm, and a spinning chamber of 20 cm. The temperature is 25°C; the drying conditions are: temperature 25°C, humidity 20%, time 24h.

[0074] Take 0.08 g of the four types of hybrid fibers prepared in Example 2, respectively, place the...

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Abstract

The invention relates to a composite nano-enzyme concerted catalysis fiber material as well as a preparation method and application thereof, and belongs to the technical field of wound dressings. The composite nano-enzyme concerted catalysis fiber material is prepared from a spinning solution A and a spinning solution B through electrostatic spinning and drying, the spinning solution A is composed of a polylactic acid-glycolic acid copolymer, manganese dioxide nano-enzyme, calcium peroxide and a spinning solvent, and the spinning solution B is composed of a polylactic acid-glycolic acid copolymer, ferroferric oxide nano-enzyme, calcium peroxide, benzoic acid and a spinning solvent. The composite nano-enzyme synergetic catalytic fiber material can efficiently and continuously generate oxygen and hydroxyl radicals at the same time, so that the catalytic fiber material has the effects of oxygen supply and antibiosis, wound healing is remarkably promoted, especially the healing speed of diabetic chronic wounds is remarkably increased, and the composite nano-enzyme synergetic catalytic fiber material has the advantages of being convenient to use, easy to prepare and store and capable of absorbing seepage.

Description

technical field [0001] The invention belongs to the technical field of wound dressings, in particular to a composite nano-enzyme synergistic catalysis fiber material and a preparation method and application thereof, in particular to the composite nano-enzyme synergistic catalysis fibrous material in the preparation of dressings for promoting wound healing, especially the healing of chronic diabetic wounds application of dressings. Background technique [0002] People with diabetes face the risk of chronic non-healing wounds and even amputation throughout their lives. Studies have shown that the main cause of chronic trauma in diabetes is the damage of neovascularization caused by hypoxia at the wound. Under the condition of high glucose content, the processes of hydroxylation, degradation and translation of hypoxia-inducible factor in chronic wounds are severely disturbed, resulting in the inability of wounds in diabetic patients to respond to soft tissue ischemia by upregu...

Claims

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Application Information

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IPC IPC(8): B01J23/889B01J35/06B01J37/34A61L15/18A61L15/20A61L15/26A61L15/42A61L15/44A61L15/46D04H1/728
CPCB01J23/8892B01J23/002B01J37/342A61L15/26A61L15/18A61L15/20A61L15/42A61L15/44A61L15/46D04H1/728A61L2300/412A61L2300/102A61L2300/404B01J35/40B01J35/58C08L67/04
Inventor 任劲松李光明曲晓刚刘昊伊加岱
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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