The invention relates to the technical field of cosmetics, in particular to a cosmetic or skin care preparation rich in growth factors and a preparation method thereof. The invention provides a growth factor-rich cosmetic or skin care product preparation composed of cell growth factor, small molecule peptide, water, oil, surfactant, moisturizer, antioxidant and preservative and its preparation method. The combination of the formulations of the composition can not only accelerate the metabolism of skin cells, repair the broken superficial dermal fibroblasts, have outstanding and rapid repair functions on skin wounds, but also have the functions of whitening and wrinkle removal, calming and anti-allergic, skin softening, Anti-wrinkle, whitening, refreshing, anti-aging, anti-radiation, prevention and lightening of spots and other functions.