The invention discloses a special compound feed for crayfishes capable of preventing and curing parasitic infection of crayfishes. The special compound feed consists of the following raw materials: flour, soya bean meal, rapeseed meal, cottonseed meal, fish meal, meat and bone meal, monocalcium phosphate, zeolite powder, shrimp premix, soybean oil, bentonite, DDGS, corn, areca-nut, verbena, pumpkin seed, radix bupleuri, Astragalus membranaceus, Mangnolia officinalis, Chinese lobelia, Poria cocos and liquorice. The product formula is scientific, balance in nutritional ingredients and high in palatability, the added traditional Chinese medicine ingredients can effectively promote the feeding capacity of crayfishes and improve the resistance of crayfishes, and the crayfishes further can be prevented from being infected by parasites effectively; and the crayfishes fed by using the compound feed is green and environmentally-friendly and excellent in quality, the market competitiveness of crayfishes is greatly strengthened, and the special compound feed is applicable for abroad popularization and application.