The invention relates to a pesticide composition with spirotetramat and dinotefuran. The effective components of the pesticide composition are the spirotetramat and the dinotefuran. The mass ratio of the spirotetramat to the dinotefuran is (1-40):(40-1); and the total mass of the effective components, namely the spirotetramat and the dinotefuran, in the preparation accounts for 1-80 percent of the mass of the whole preparation, and the rests are auxiliary components which are allowed to be used and are accepted in pesticides. The pesticide composition can be missible oil, a suspending agent, wettable powder, a water scattering agent, water emulsion, microemulsion, granula and micro capsules, can effectively prevent and treat insects such as aphids, leafhopper, plant hopper, thrips, aleyrodid, phylloxera, mealybug and scale insect and is mainly used for treating and preventing insects on various crops such as wheat, rice, cotton, vegetables, fruit trees, tobaccos, soy beans, oranges, tropical fruit trees, nuts, grapes, hops and potatoes.