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A method for rapidly inducing an alcoholic fatty liver model with a single factor

A technology of alcoholic fatty liver and factors, applied in the direction of additional food elements, applications, animal feed, etc., to achieve the effect of speeding up the molding speed, reducing the cost of modeling, and stabilizing the model

Active Publication Date: 2022-04-22
GUANGXI UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0005] The present invention aims at the deficiencies of the above-mentioned alcoholic fatty liver model, especially the deficiency of the alcoholic fatty liver disease model induced by a single factor similar to human beings. Alcoholic fatty liver model method, the method takes non-human primates as objects, induces by alcohol single factor, obtains an animal model that can completely simulate the occurrence and development of human alcoholic fatty liver with significant B-ultrasound and pathological detection results, Provide a good model carrier for the study of the pathogenesis of alcoholic fatty liver, the screening of preventive or therapeutic drugs, and the evaluation of pharmacodynamics

Method used

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  • A method for rapidly inducing an alcoholic fatty liver model with a single factor
  • A method for rapidly inducing an alcoholic fatty liver model with a single factor
  • A method for rapidly inducing an alcoholic fatty liver model with a single factor

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Embodiment Construction

[0038] The present invention will be further described below in conjunction with specific examples, but the protection scope and application scope of the present invention will not be limited.

[0039] 1. Main instruments and test materials

[0040] 1. Main instruments:

[0041] (1) Biochemical analyzer: Hitachi 7180 automatic biochemical analyzer, purchased from Hitachi, Japan.

[0042] (2) Blood cell analyzer: Sysmex XN-1000, purchased from Sysmex Medical Electronics (Shanghai) Co., Ltd.

[0043] (3) B-ultrasound machine: Mindray portable B-ultrasound machine.

[0044] 2. Test material:

[0045] (1) All are commercially available quality wines. They are 16% Vol Ta brand aged tribute wine dry type (yellow wine), 40% Vol Royal Louis X.O (brandy), 56% Vol Red Star Erguotou Qingxiang type (white wine), and 48% Vol Xinghuacun Fenjiu (white wine).

[0046] Preparation of wine concentration: The concentration of wine is the volume percentage concentration, that is, the percent...

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Abstract

The invention discloses a method for rapidly inducing an alcoholic fatty liver model by a single factor. According to the method, non-human primates are given alcohol containing 10-35% ethanol every day according to the amount of ethanol of 4-5.7g / kg body weight, At the same time, the basal feed was given free feeding for 50‑90 days to obtain a stable model of alcoholic fatty liver. The present invention can obtain a stable animal model of alcoholic fatty liver that is close to the natural occurrence of human beings. It provides a good model carrier for the study of the pathogenesis of chronic fatty liver, the screening of therapeutic drugs, and the evaluation of pharmacodynamics.

Description

technical field [0001] The invention relates to a method for establishing an animal disease model, in particular to a method for rapidly inducing an alcoholic fatty liver model by a single factor. Background technique [0002] Alcoholic fatty liver disease (AFLD) is a type of fatty liver disease, and it is a special kind of clinical liver disease. Most of the patients are long-term drinkers, usually more than 5 years, and they are caused by long-term and heavy drinking. Liver cells produce a large number of toxic substances such as acetaldehyde, secrete a large number of free radicals and hydroxyl groups, and cause metabolic disorders. In recent years, with the change of lifestyle, liver disease and related diseases induced by alcohol and or metabolic factors have increased rapidly, and the incidence of fatty liver has been increasing year by year and showing a younger trend. Fatty liver in my country has risen to the second place among liver diseases . Among the long-term ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01K67/02A23K20/105
CPCA01K67/02A23K20/105
Inventor 冷静梁丹唐海波吴展帅李晓红肖健唐耀平
Owner GUANGXI UNIV OF CHINESE MEDICINE
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