Skin aging resisting composition, soluble micro-needle patch and preparation method thereof

An anti-aging skin composition technology, applied in the field of anti-aging composition, can solve the problems of inability to effectively penetrate the stratum corneum of the skin, and the effect is not obvious, so as to resist ultraviolet damage, reduce skin looseness, and increase the content of Effect

Active Publication Date: 2017-12-08
GUANGZHOU NEWORLD PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Most of the skin care products on the market add exogenous active substances, such as moisturizers, free radical scavengers, sunscreens, etc., to partially delay skin aging, but most of the products have no obvious effect, because skin care products for external use cannot effectively penetrate The stratum corneum of the skin reaches the epidermis and dermis to play its due role

Method used

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  • Skin aging resisting composition, soluble micro-needle patch and preparation method thereof
  • Skin aging resisting composition, soluble micro-needle patch and preparation method thereof
  • Skin aging resisting composition, soluble micro-needle patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0047] (1) Preparation of the positive mold: use computer-aided design (CAD) to design the positive mold, convert the design drawings into digital information of digital machine tools through digital-to-analog conversion, and select brass as the processing material to process and shape according to the design size.

[0048] (2) Preparation of female mold: Take polydimethylsiloxane and monomer curing agent at a ratio of 11:1 (w / w), mix them with a vortex mixer, and place them in a vacuum box for vacuum degassing for 15 minutes. After the air bubbles are exhausted, pour the liquid into the prepared brass male mold slowly, avoid the generation of air bubbles during the pouring process, place it in the oven, set the oven temperature to 100°C, keep it warm for 1.5 hours, take it out, and demould , that is, the negative mold of PMDS is obtained.

Embodiment 1

[0049] Example 1 Preparation of Dissolvable Microneedle Patch for Anti-aging Skin

[0050] (1) Preparation of needle body preparation solution: Dissolve 0.5g of blue copper peptide in 5ml of water, weigh 0.4g of sodium hyaluronate (molecular weight: 7775), 0.25g of hydroxyethyl starch, and 0.25g of β-glucan , collagen (fish collagen, molecular weight: 1500) 0.25g, added to the blue copper peptide aqueous solution, vortexed to mix, fully swollen, placed overnight to dissolve, and the needle preparation solution was obtained.

[0051] (2) Preparation of substrate preparation solution: weigh 1.0 g of high molecular weight sodium hyaluronate (molecular weight: 1.90×10 6 ), 2.0g medium molecular weight sodium hyaluronate (molecular weight: 0.37×10 6 ), and add 60ml of water, mix well, leave overnight and then centrifuge to remove excess air bubbles to obtain the substrate preparation solution.

[0052] (3) Take 200 μl of the needle body preparation solution and inject it into a 7...

Embodiment 2

[0054] Example 2 Preparation of Dissolvable Microneedle Patch for Anti-aging Skin

[0055] (1) Preparation of needle body preparation solution: Dissolve 0.46g of blue copper peptide in 5ml of water, weigh 0.33g of sodium hyaluronate, 0.34g of hydroxyethyl starch, 0.21g of β-glucan, and 0.17g of collagen , added to the blue copper peptide aqueous solution, vortexed to mix, fully swelled, left overnight to dissolve, and the needle preparation solution was obtained.

[0056] (2) Preparation of substrate preparation solution: same as in Example 1.

[0057] (3) with embodiment 1.

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Abstract

The invention relates to a skin aging resisting composition, a soluble micro-needle patch and a preparation method thereof. The skin aging resisting composition consists of the following components in percentages by weight: 5-50% of copper peptide, 8-25% of hydroxyethyl starch 19-32% of sodium hyaluronate, 9-21% of [beta]-glucan and 8-22% of collagen. The composition has a synergistic effect of resisting skin aging; and the composition has good effects of resisting wrinkles, removing freckles and removing dark skin. The composition can be prepared into the soluble micro-needle patch which is good in mechanical intensity, so that a skin-care effect is further enhanced; and in comparison with a smearing mode, the micro-needle patch is capable of effectively improving epidermal penetration rate of an active ingredient, reducing dosage, accelerating speed of taking effects and improving the utilization rate of the copper peptide.

Description

technical field [0001] The invention relates to the field of skin care products, in particular to an anti-aging skin composition, a soluble microneedle patch and a preparation method thereof. Background technique [0002] The skin is a part of the body. When the body ages due to factors such as stress and ultraviolet radiation, the skin inevitably ages, resulting in wrinkles, spots, dullness, and sagging. The aging of the skin has two factors, intrinsic and extrinsic. The intrinsic factor is the natural aging process that occurs when the body lacks the ability to maintain a sufficient regeneration rate of cells as the age increases; while the extrinsic factors include life stress, environmental pollution, and ultraviolet radiation. Photoaging, external stimuli and inflammation. [0003] The typical external symptoms of skin aging are as follows: (1) Wrinkles of different depths appear, skin elasticity becomes poor, sagging; (2) The skin is dull and dull, and pigmentation oc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/65A61K8/02A61K8/64A61Q19/00A61Q19/02A61Q19/08
CPCA61K8/0204A61K8/64A61K8/65A61K8/73A61K8/732A61K8/735A61K2800/87A61Q19/00A61Q19/02A61Q19/08
Inventor 陈航平李革任春艳
Owner GUANGZHOU NEWORLD PHARMA CO LTD
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