34 results about "Intrinsic factor" patented technology

PCT No. PCT/AU92/00141 Sec. 371 Date Nov. 30, 1992 Sec. 102(e) Date Nov. 30, 1992 PCT Filed Apr. 2, 1992 PCT Pub. No. WO92/17167 PCT Pub. Date Oct. 15, 1992There are disclosed complexes and compositions for oral delivery of a substance or substances to the circulation or lymphatic drainage system of a host. The complexes of the invention comprise a microparticle coupled to at least one carrier, the carrier being capable of enabling the complex to be transported to the circulation or lymphatic drainage system via the mucosal epithelium of the host, and the microparticle entrapping or encapsulating, or being capable of entrapping or encapsulating, the substance(s). Examples of suitable carriers are mucosal binding proteins, bacterial adhesins, viral adhesins, toxin binding subunits, lectins, Vitamin B12 and analogues or derivatives of Vitamin B12 possessing binding activity to Castle's intrinsic factor.

Compositions and methods for prevent, stabilize, reverse or treat disorders related to iron deficiency in a human or other animal. In a first embodiment, the composition includes about 10 mg to about 500 mg of one or more forms of iron, wherein at least one form of iron is an aspartic acid-glycine chelate of iron; and about 5 mg to about 500 mg of one or more forms of an organic acid. In another embodiment, the composition includes about 50 to about 150 mg of one or more forms of iron, wherein at least one form of iron is an aspartic acid-glycine chelate of iron; about 50 to about 250 mg of one or more forms of an organic acid; about 150 to about 250 mg of one or more forms of ascorbic acid; about 0.5 mg to about 1.5 mg vitamin B12; about 50 to about 150 mg intrinsic factor; and about 0.5 mg to about 1.5 mg folic acid.

The invention discloses a method for detecting the pollution grade of an insultor, which is characterized by comprising the steps of: 1. obtaining ultraviolet discharge pulse x1<0>, temperature valuex3<0> and humidity value x4<0>, and obtaining weather conditions; 2. determining the value of each parameter after normalization; 3. determining the constant weight value of each index factor; 4. obtaining the variable weight value of each index facor; 5. generating the membership function lists of discharge pulse and running age limit, and the membership function lists of the temperature value, the humidity value and the weather conditions; 6. generating the single factor judgement matrix A and matrix B of the index layer under intrinsic factors and enviromental factors; 7. obtaining the evaluating matrix S of the intrinsic factors; 8. obtaining the evaluating matrix Z of the enviromental facors Z; and 9. obtaining the status evaluation v of the insulator. The method has the obvious effects of: replacing the traditional method of climbing the rod for examination by workers and realizing continuous real-time detection. The method effectively conducts accurate and reliable grade analysis to the current running state of the insulator, and is convenient for monitoring and changing the insulator reasonably by the workers.

The invention discloses a Chinese medicinal preparation for treating infantile upper respiratory tract infection and a preparation method thereof. The Chinese medicinal preparation comprises the following raw material medicaments: Indian buead, ephedra herb, kudzuvine root, white mustard seed, schizonepeta spike, cicada slough, platycodon root, astragalus, gypsum, mint, tangerine peel, divaricate saposhnikovia root, baical skullcap root and heartleaf houttuynia herb. For infants accompanied by sore throat and antiadoncus, watermelon frost and honeysuckle flower are added into the raw material medicaments; for infants accompanied by pyrexia and high fever, weeping forsythia, indigowoad root and gardenia are added into the raw material medicaments; for infants accompanied by poor appetite and indigestion, charred triplet and chicken's gizzard-membrane are added into the raw material medicaments; and for infants accompanied by cough with excessive phlegm, sessile stemona root and unibract fritillary bulb are added into the raw material medicaments. In the Chinese medicinal preparation, pungent warm is matched with acrid cold to dredge sweat pores and cleanse intrinsic heat; and the intrinsic heat is expelled by aiding with pivoting and elevating, and sour-sweet medicaments are subjected to compatibility to nourish yin, clear yingfen and remove the intrinsic heat. The infantile upper respiratory tract infection is caused by exogenous pathogens and seasonal pathogenic factors due to abnormal changes in temperature, and is easy to produce the intrinsic heat, so heat syndromes are common clinically, and quick defervescence is the main treatment aim. The Chinese medicinal preparation has the strong effects of resisting virus, allaying the fever, resisting inflammation and enhancing organism immunity.

Methods are described for the development of monoclonal antibodies to intrinsic factor and the application of said antibodies in the development of B12 immunoassays. In particular, antibodies are described that are capable of binding to intrinsic factor only in the absence of vitamin B12, and that are released from binding in the presence, and upon the binding, of vitamin B12 to intrinsic factor. Assays may be formatted such that either antibody or intrinsic factor is immobilized or labeled.

The invention provides bullacta exarata health-care fine dried noodles and a preparation method of the bullacta exarata health-care fine dried noodles. The fine dried noodles comprise the following raw materials in percentage by weight: 65-85 percent of flour, 5-15 percent of bullacta exarata protein powder, 3-10 percent of artemisia songarica schrenk seed powder, 2.5-5 percent of celery seeds and 2.5-5 percent of rorippa indica seeds, wherein the raw materials are uniformly mixed to be prepared into a dough, and the dough is aged, pressed and cut into noodles; the noodles have fine and smooth mouthfeel, and are aromatic, mellow and delicious. The original flavor and the bioactive constituents of the bullacta exarata are remained at a full rate and are not lost; the problems that the bullacta exarata has fishy smell and the eating environment and the eating mode are limited are solved; a new approach for deep processing of the bullacta exarata is developed. The boiling fastness of the noodles is increased, the toughness is improved, the strength is high, the noodles do not break, the soup does not become milky, the intrinsic factors for high probability of deterioration are reduced, and the guarantee period is greatly prolonged. The noodles have complete and rich nutrients and a prominent health-care function and enable a better digestive absorption function. The immunity can be enhanced and various focuses of the human bodies can be eliminated after a person frequently eats the noodles, so that the effects of building the body and prolonging the life are achieved.

The invention discloses a gene detection kit for myopia risk assessment and a detection method thereof. The gene detection kit comprises a kit body and a reagent individually stored in the kit body, wherein the individually stored reagent contains 1 a PCR reaction primer group targeted to SNP polymorphic sites of two genes, 2 a PCR amplification reagents and 3 an agarose gel electrophoresis analysis reagent. The gene detection kit makes multiple PCR amplification reactions simultaneously performed on the same PCR instrument by adopting the design of PCR primers, detects related genes of subjects, achieves high efficiency and specificity of detection, analyzes the risks of tending to high myopia of the subjects through, finds myopic heredities and genetic intrinsic factors of the subjects, can well provide scientific references for the subjects, helps the subjects to improve and change living and working habits so as to prevent or reduce the myopia risk of, and meanwhile adopts corresponding strategies in daily life to avoid invalid or even harmful methods.

An immunoassay method and test kit for detecting autoantibody in a patient sample, such as autoantibodies that interferes with the complexation of intrinsic factor with vitamin B12. A labeled receptor, i.e., intrinsic factor, is mixed with the sample and then with an anti-intrinsic factor antibody that binds competitively with the autoantibody to intrinsic factor bound to a solid phase is added and presence of autoantibody in the sample is determined.

The invention discloses a traditional Chinese medicinal composition for treating infant suppurative tonsillitis. Traditional Chinese medicine holds that infant suppurative tonsillitis is mainly caused by wind heat evil invasion and excessive interior heat, and can be caused by eating more spicy foods, intrinsic heat of spleen and stomach, heat toxin attacking and throat node obstructing as well. Therefore, the traditional Chinese medicinal composition disclosed by the invention is prepared from traditional Chinese medicines having functions of dispelling wind and clearing heat, cooling blood and relieving sore throat, such as java speedwell, bidens biternata, kyllinga monocephala, marshy willowweed herb, Yunnan cowpea root, small-leaved pea treat fruit, aeginetia indica, copper alternanthera, liparis nervosa and patrinia rupestris, and the traditional Chinese medicinal composition is decocted into a decoction. Clinical tests show that total effective rate is 97.1% and the curative effect is significant; moreover, the composition is free from toxic and side effect, and is low in treatment cost.

The present disclosure relates to pharmaceutical compositions for mammalian consumption containing essential fatty acids, protein, vitamins and choline, or combinations thereof, so constituted to optimize absorption and/or transport and/or efficiency of the co-ingredients of the composition. The pharmaceutical compositions are useful as supplements to provide nutrients to nutritionally deficient patients. The composition can contain essential fatty acids, such as EPA, DHA and/or ALA, cobalamin binding protein, such as Intrinsic Factor, vitamin B12 or a synthetic form thereof, choline, such as choline bitartrate, or combinations thereof.

The present invention relates to a new method of producing functionally active recombinant porcine Intrinsic Factor as well as the protein (i.e., porcine Intrinsic Factor) produced thereby. In particular, the vector comprising the DNA encoding the protein is introduced into a Chinese Hamster Ovary (CHO) host cell under conditions sufficient for optimal expression of functional protein. The expressed protein may then be subjected to three methods ultimately resulting in a protein having at least 97% purity.

The invention discloses a traditional Chinese medicine preparation for treating infant suppurative tonsillitis. In traditional Chinese medicine, the infant suppurative tonsillitis is mostly caused by wind-heat pathogenic toxin invasion and excessive interior heat, and also can be caused by eating spicy food, intrinsic heat of spleen and stomach, heat toxin attack on node of throat. The traditional Chinese medicine preparation is decocted with water into decoction by selecting the following traditional Chinese medicines with the effects of clearing away heat and toxic materials, eliminating swelling and removing stasis, benefiting throat and relieving pain, namely franchet groundcherry, all-grass of manyflower bugle, philippine violet herb, hairy holly leaf, morinda parvifolia, rattlesnake plantain, carpesium divaricatum, north china iris root, trollflower and tibetan thistle. According to the clinical test, the traditional Chinese medicine preparation is remarkable in curative effect, and has the total effective rate of 93.3% which is obviously higher than that of a control group. And moreover, the traditional Chinese medicine preparation is free of toxic and side effect, low in treatment cost and worthy of clinical popularization and application.

An isolated nucleotide sequence or fragment thereof encoding the porcine intrinsic factor, wherein the porcine intrinsic factor comprises an amino acid sequence having at least 85% amino acid sequence identity to an amino acid sequence selected from the group consisting of SEQ ID NO: 3, SEQ ID NO: 6, and SEQ ID NO: 9. The invention also encompasses an isolated nucleic acid sequence or fragment thereof comprising, or complementary to, a nucleotide sequence having at least 85% nucleotide sequence identity to a nucleotide sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 4, and SEQ ID NO: 7. The porcine intrinsic factor can be use is an assay to determine the quantity of vitamin B₁₂ in a biological sample.

Improved delivery of zinc using haptocorrin or intrinsic factor modified to include a zinc binding sequence that can outcompete dietary zinc inhibitors such as phytin. Known zinc binding sequences can be assayed to determine competitiveness with respect to phytin and, if successful, incorporated into the B₁₂ binding site of haptocorrin or intrinsic factor. Thus a method of producing functional human haptocorrin or intrinsic factor which binds to zinc includes the steps of modifying human TCN1 or GIF to comprise one or more zinc-binding site sequences, constructing a vector containing the modified human TCN1 or GIF sequence, and introducing the vector into a host cell for a time and under conditions sufficient for expression of the functional human haptocorrin or intrinsic factor. The resulting zinc binding complex can be orally administered to zinc deficient individuals to improve the amount of dietary zinc available to the individuals.

Vitamin B-12 deficiency is very common among population. The main causes of B- 12 deficiency include lack of intrinsic factors and other intestinal factors (e.g. malabsorption), rare genetic disorders, and inadequate intake. The present invention relates to intranasal formulations of vitamin B derivatives such as methylcobalamin, Cyanocobalamin which provide enhanced transnasal absorption.

The present invention relates to a slow-released granule, in particular to a vascular endothelial growth factor slow-released granule. Polylactic acid/ glycolic acid and rabbit anti-human growth factor polyclonal antibody working fluid are emulsified and dispersed in different solvent and finally the slow-released granule comprising polylactic acid/ glycolic acid vascular intrinsic factor is obtained. The present invention is capable of slowing down the enervation of vascular endothelial growth factor and extending the activity. The present invention has the advantages of convenient medication, improved vascular intrinsic factor efficacy and stability and innocuity.

The invention belongs to a Zhuyeqing beauty and health care tea for reducing lipid and intrinsic heat and production processes thereof. The Zhuyeqing beauty and health care tea for reducing lipid andintrinsic heat is prepared from following raw materials in corresponding parts by weight: 15-25 parts of Zhuyeqing tea, 15-25 parts of oolong tea, 10-20 parts of semen cassiae, 10-15 parts of radix astragali seu hedysari, 5-7 parts of grapefruit and 5-7 parts of papaya; the production processes include material selection, grinding, extraction, granulation, drying and other steps; the Zhuyeqing beauty and health care tea for reducing lipid and intrinsic heat is appropriate in material proportion, and has the abilities of clearing away heat and toxic materials, relaxing bowel and promoting metabolism, with an obvious effect in improving constipation, as well as abilities of improving intestinal tract movement and preventing constipation after drinking the tea for a long time, so as to realize the effects of slimming and reducing lipid, maintaining beauty and keeping young and brightening skin.

The invention provides mode configuration/control method/system of electronic equipment, medium and electronic equipment. The mode control method comprises the following steps: when a user needs to switch the application mode of the electronic equipment, receiving the incoming identifier matching with the switched application mode; configuring an intrinsic factor in the application mode for the electronic equipment according to the identifier, and synthesizing a location path; and analyzing the location path to find a correction template file located in the location path. According to the invention, the expansibility of mode configuration of a dynamic detector is improved, a better image is provided to help a doctor perform more accurate diagnosis, and the mode recognizability of the dynamic detector is enhanced.

The invention discloses a medicine for treating cardiovascular and cerebrovascular diseases and a preparation method of the medicine. The medicine is prepared from 16 traditional Chinese medicines including ginkgo leaves, pseudo-ginseng, earthworms, desertliving cistanche, epimedium brevicornu and the like. The medicine has a good effect on heart diseases such as coronary heart disease, myocardial infarction, ischemic heart disease, atrial fibrillation with ventricular premature beat and tachycardia, and cerebrovascular diseases such as cerebral infarction, cerebral thrombosis, cerebral hemorrhage and encephalatrophy. The clinical observation shows that in the early stage (within 6 hours) of cerebrovascular diseases, the effect of the medicine can be taken into play immediately, symptoms of hemiplegia, hemiparalysis and aphasia from apoplexy can be relieved after the medicine is taken for about 20min, and the diseases can be fundamentally treated when the medicine is taken for a long time. The medicine has the effects of activating blood and removing fatigue, dredging blood vessels, removing atheromatous plaque, clearing and activating the channels and collaterals, improving micro-circulation, improving blood vessel toughness, protecting blood vessels, connecting tendons and generating vessels, can fundamentally relieve and remove intrinsic factors of cardiovascular and cerebrovascular diseases, and is an ideal medicine for treating cardiovascular and cerebrovascular diseases. The clinical observation shows that the effective rate of the medicine is greater than 98%, and the recovery rate is as high as 95%.

This invention comprises a method of transmucosal delivery of process of Vitamin B12 without the need of intrinsic factor comprising administering a solid composition comprising a Vitamin B12 and at least one bifunctional macromolecule with hydrophilic exterior and with hydrophobic pockets capable of pocketing Vitamin B12 material, illustrated by cyclodextrin, at least one permeation enhancer, illustrated by Isopropyl Myristate and at least one agent that is mucoadhessive as well as penetration enhancer, illustrated by chitosan. The solid composition of Vitamin B12 of claim 2 may comprise a lozenge, a candy, a wafer, a tablet, a patch, a film, a spray, a lip balm, or gum.

Disclosed are treatment compositions including a polycarbodiimide together with a carboxylic acid to enhance the quality of keratinous substrates, including keratinous fibers such as hair. In particular, compositions and methods for protecting hair from damage or adverse effects caused by extrinsic and intrinsic factors and for improving the condition of or repairing damaged hair are disclosed.

The invention relates to a solid-state fermentation tank for brewing edible vinegar. The solid-state fermentation tank for brewing the edible vinegar is characterized by being of a multilayer type; the solid-state fermentation tank provided by the invention overcomes the defects of the traditional edible vinegar solid state fermentation brewing method that a large amount of rice husk, sorghum shell and the like which have no nutritional value and can produce harmful substances in a fermentation process need to be added in a fermented material; pentosan contained in the rice husk can produce furfural during fermentation, so that the obtained vinegar tastes scorched bitter; pectin substances can be decomposed to generate methyl alcohol which influences the quality of the vinegar in a fermentation process and is the main source of various foreign flavours in the edible vinegar; even the rice husk is steamed in clear soup before use, only bran smell and soil smell can be removed, and external factors are avoided but intrinsic factors are not avoided, so that the quality of the edible vinegar is influenced.