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Vascellum esoderma growth factor sustained-release corpuscle and method for preparing the same

A growth factor, vascular endothelium technology, applied in the field of sustained-release microparticles and their preparation, can solve the problems of increasing the number of administrations and doses, the expected effect is far from the expected, easy to lose activity, etc., to reduce the number of administrations and increase stability. Sex, reducing the effect of drug inactivation

Inactive Publication Date: 2008-04-02
THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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  • Summary
  • Abstract
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AI Technical Summary

Problems solved by technology

[0004] Although vascular endothelial growth factor has such an important role, in actual medical use, there are shortcomings of short half-life and easy loss of activity. These shortcomings make the physiological effect of vascular endothelial growth factor in practice far from the expected effect. High frequency and dose of administration, resulting in toxic and side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0026] Implementation one:

[0027] Weigh 1.6g~2.0g of polylactic acid / glycolic acid copolymer and put it into a beaker, add 32ml~40ml of dichloromethane into the beaker, then add 2.5ml~3ml of acetone, start stirring at a steady speed of 1000r / min, drop Add 12ml to 16ml of rabbit anti-human vascular endothelial growth factor polyclonal antibody working solution to make the solution uniformly emulsified. After emulsification, add 32ml to 36ml of an aqueous solution of 2.5% polyvinyl alcohol (PVA) emulsifier, and continue stirring for 4 hours. After the time is up, take out the above-mentioned emulsified solution and add 100ml of 0.5% polyvinyl alcohol (PVA) emulsifier aqueous solution, then continue stirring at 500r / min for 24h, volatilize and remove the dichloromethane solvent, and finally remove all The organic solvent and the solute are vascular endothelial growth factor sustained-release particles. Measured with a laser particle size analyzer, the average particle size of ...

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PUM

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Abstract

The present invention relates to a slow-released granule, in particular to a vascular endothelial growth factor slow-released granule. Polylactic acid / glycolic acid and rabbit anti-human growth factor polyclonal antibody working fluid are emulsified and dispersed in different solvent and finally the slow-released granule comprising polylactic acid / glycolic acid vascular intrinsic factor is obtained. The present invention is capable of slowing down the enervation of vascular endothelial growth factor and extending the activity. The present invention has the advantages of convenient medication, improved vascular intrinsic factor efficacy and stability and innocuity.

Description

【Technical field】 [0001] The invention relates to a sustained-release microparticle and a preparation method thereof, in particular to a sustained-release microparticle for slowing down the weakening of vascular endothelial growth factor and prolonging the activity time. 【Background technique】 [0002] Polylactic acid has a unique biodegradability. The intermediate product lactic acid is the same as the sugar metabolite in the body, and the final product is water and carbon dioxide, which is harmless to the human body. However, polylactic acid / glycolic acid copolymer has been used as a biodegradable implant material in vivo. [0003] Vascular endothelial growth factor (English: vascular endothelial growth factor, abbreviated: VEGF) is a heparin-binding growth factor specific for vascular endothelial cells, which can induce angiogenesis in vivo. VEGF is a highly conserved homodimeric glycoprotein. Two single chains with a molecular weight of 24 kDa each form a dimer with dis...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/34A61K38/18A61P9/10A61P43/00
Inventor 陈扬李振宇王大平闫洪印郭悦青
Owner THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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