254results about How to "Achieve targeted" patented technology

The invention relates to a natural active drug-polysaccharide targeted compound with antitumor activity and targeting property. A natural active drug is introduced onto a polysaccharide framework by chemical grafting, and physically mixed with a ligand distearoylphosphatidyl ethanolamine-polyethyleneglycol-anisoyl amine with targeted transmission capacity to form a natural active drug-polysaccharide targeted compound, and the natural active drug-polysaccharide targeted compound can be self-assembled in water to form a nano micelle. The method is characterized in that the natural active drug-polysaccharide targeted compound has targeted transmission capacity, enhances the tumor transfer efficiency of the preparation, reduces the untoward reaction and enhances the tolerance of the patient; the hydrophobic inner core formed by the hydrophobic group can physically wrap the antineoplastic drug, thereby obviously improving the water solubility of the antineoplastic drug; and the antineoplastic drug which is physically wrapped by the chemically coupled ursolic acid can implement combined treatment of tumors and lower the toxic or side effect. The preparation method is simple and easy to operate, has the advantage of higher yield, and can easily implement industrialization.

The invention discloses a directional induced polarization real-time advance water detecting device while drilling for tunnel construction. The device comprises a drill bit, a high-strength insulated sleeve while drilling, and a directional induced polarization detection system, wherein the drill bit is connected with the high-strength insulated sleeve while drilling through a connecting bearing, and the directional induced polarization detection system is distributed at the periphery of the high-strength insulated sleeve while drilling. The invention also provides a corresponding directional induced polarization real-time advance water detecting method while drilling for tunnel construction. According to the device and the method disclosed by the invention, the interference of the construction environment is avoided, the detection effect is better, the utilization efficiency of an advance borehole is improved, current orientation is realized, the low resistance at the borehole wall is broken through, the detection range is enlarged, an electrode is protected, and a better coupling contact between the electrode and a rock-soil body is guaranteed.

An encoder within a video transmission system controls the bit allocation at a sub-frame level. A frame is divided into smaller blocks, known as rate control blocks. Rate control blocks are used as the basic unit for bit allocation. This bit allocation achieves the target bit rate desired by the system as well as meet latency constraints. The encoder uses the slice partitioning capabilities to generate the rate control blocks using one or more slices of the image frame. This feature allows the decoder to decode the rate control blocks independently and ensures that the encoded data size for each rate control block is allocated. The encoder also detects the overflow condition for the buffer and performing an operation to avoid the overflow condition based on whether the image frame is an inter-frame or a intra-frame.

The invention relates to a neo-gambogic acid SLN (solid lipid nanoparticle) and a preparation method thereof. The neo-gambogic acid SLN comprises a therapeutically effective amount of neo-gambogic acid, medicinal phosphatide, a surfactant and a lipid material. In the invention, the neo-gambogic acid is prepared into SLNs (solid lipid nanoparticles), thereby improving the solubility of the neo-gambogic acid, reducing the irritability, improving the bioavailability, and prolonging the action time of medicaments in a human body, in addition, the neo-gambogic acid SLNs can be gathered partially in the human body so as to play the targeted action of the SLNs and exert the anti-cancer therapeutic action of the SLNs better.

The invention discloses a system and a method for ventilating stacks and collecting exhaust gases and percolate of compost. At least one air tube is laid in a base at the bottom of each stack along a length direction of the stack; grooves are reserved on the bases above vents of the air tubes; ventilation protecting layers are laid in the grooves above the vents; one end of each air tube is connected with a main air tube connected with a blower, while the other end is sealed with a pipe closer; a percolate outlet is downwards reserved at the closed end of each air tube; cleaning grooves are reserved on the peripheries of the pipe closers and the percolate outlets; percolate buffering and discharging devices connected with the percolate outlets are arranged in the cleaning grooves; an exhaust pipeline is arranged above each stack along the length direction; exhaust openings are distributed at the bottom of the exhaust pipeline; and each exhaust pipeline is connected with a main exhausttube. The system and the method have the advantages of greatly reducing the quantity of civil engineering at the same time of ensuring relatively better oxygenation state in the whole composting body, and simultaneously realizing the directed and highly-efficient collection of the exhaust gases produced in a composting process; and the system has a simpler structure and is convenient to operate.

The invention provides a brain delivery method for a nano-medicament carrier. Brain delivery of the nano-medicament carrier carrying a diagnosis and treatment medicament is mediated by using ultrasonic waves and micro-vesicles together; the nano-medicament carrier and the micro-vesicles are administrated separately or administrated simultaneously after being mixed easily or administrated simultaneously through non-covalent and covalent connection; and in the brain delivery of the nano-medicament carrier carrying the diagnosis and treatment medicament under the mediation of ultrasonic waves and micro-vesicles, ultrasonic treatment is performed immediately or a certain time interval after micro-vesicles are applied to a mechanism. Compared with the conventional brain delivery of a medicament under the mediation of ultrasonic waves and micro-vesicles, the method has the advantages that: poor in-vivo properties (poor stability, easiness in clearing by the organism and the like) of the medicament can be eliminated, the diagnosis molecular signal strength is enhanced, the detection sensitivity is enhanced, and focus targeting can be realized; and compared with the conventional brain delivery technology for the nano-medicament carrier, the method has the advantage that: external ultrasonic waves are applied in a technology, so that more efficient and more specific brain medicament delivery can be realized.

The invention discloses a mesoporous silica drug-loaded nanoparticle. Mesoporous silica is used as a drug carrier, and is wrapped with a polydopamine layer; through a Schiff base addition reaction, the raw material is connected to tumor-directed osmotic peptide iRGD and poly (2-ethyl-2-oxazoline) so as to obtain the mesoporous silica drug-loaded nanoparticle MSN (at) PDA-PEOz-iRGD. The invention also discloses a preparation method of the above drug-loaded nanoparticle. By loading the prepared drug-loaded nanoparticle on an anti-cancer drug, the drug has obvious pH-responsive release, obvious tumor cell targeting ability and good photothermal treatment effect and good antitumor effect in vivo and in vitro, and provides theoretical basis for the research of novel targeted drug delivery system.

The invention provides a multi-data center based natural resource geospatial data organization method and system. The method comprises a data type identification step, a feature class model establishment step, a relation class data model establishment step and an auxiliary information acquisition step. Firstly, the type of natural resource geospatial data is identified and data centers, a database, a data set and an auxiliary information set are established; secondly, according to the identified data type, establishing a feature class data integration organization model and establishing a relation class data model; and finally, according to the identified data type and a relation class data calculation result, acquiring auxiliary information and storing the auxiliary information in the auxiliary information set. According to the organization method provided by the invention, unification of different data types in a conception layer based on a plurality of data centers and integration organization management of different data types are realized; orderly data management and data tracking and backtracking are realized; and the application convenience and flexibility of the natural resource geospatial data are satisfied.

The invention provides a long-circulating preparation which is an invisible nano particle, a stealth lipidosome, or an invisible micelle containing docetaxle, carrier materials and additive. The long-circulating preparation is prepared by wrapping the docetaxle with the carrier materials that are modified by polyethylene glycol, a hydrotropic substance. The long-circulating preparation of the docetaxel can avoid being captured or swallowed by the hepatolienal reticular endothelial system in the body, thus prolonging circulation time in blood. Compared with the common injection of the docetaxel or the non-stealth lipidosome of the docetaxel, the long-circulating preparation of the docetaxel provided by the invention has stronger inhibit function on a tumor.

The invention discloses a management context-based human resource assessment system and a method thereof. The management context-based human resource assessment system includes a basic data management module, a question bank management module, an assessment information module, an assessment generation module and an analysis module, wherein the basic data management module, the assessment information module and the question bank management module are respectively connected with the analysis module through the assessment generation module. With the management context-based human resource assessment system and the method thereof of the invention adopted, the pertinence and accuracy of human resource assessment organization and effectiveness of organizational decision making can be improved, and launch of work such as human resource selection, training and development, and human resource check can be facilitated for enterprises.

Relating to cyclotriphosphazene and its fluorescent nano-microsphere as well as a preparation method, the invention provides hexaminoacid ester phenoxyl cyclotriphosphazene, its fluorescent nano-microsphere and a preparation method thereof. Hexaminoacid ester phenoxyl cyclotriphosphazene has a general structural formula as shown in the picture, wherein, M is amino acid x ester. And hexaminoacid ester phenoxyl cyclotriphosphazene is prepared by first reacting 6 pairs of carboxyphenoxyl cyclotriphosphazene with thionyl chloride, and then adding amino-acid ester hydrochloride and an acid binding agent for reaction. Composed of hexaminoacid ester phenoxyl cyclotriphosphazene, the fluorescent nano-microsphere is prepared by the steps of: dissolving hexaminoacid ester phenoxyl cyclotriphosphazene in an organic solvent, then adding distilled water dropwisely, and pouring water, then conducting dialysis and freeze-drying, thus obtaining the fluorescent nano-microsphere. Hexaminoacid ester phenoxyl cyclotriphosphazene has stable structure, good biocompatibility, easy degradation, degradation product free of toxicity and inflammatory response, and its preparation method has a yield up to over 80%, mild reaction conditions, and a simple process, thus boasting very good industrial application prospects. Under ultraviolet excitation, the fluorescent nano-microsphere can generate a fluorescence phenomenon, and can serve as a carrier of targeting drug delivery.

The invention discloses a content recommendation method and device, and electronic equipment. One specific embodiment of the content recommendation method comprises the following steps of: obtaining attribute information of at least one candidate terminal; filtering the candidate terminal based on the attribute information so as to determine a target terminal; and recommending a content according to stored interest point information corresponding to the target terminal. By means of the embodiment, the content recommendation accuracy is improved; and targeted content recommendation is realized.

The embodiment of the invention discloses a video playing method and method. The method has a concrete embodiment with the steps of responding to a received message of a user for requesting the targetvideo watching; obtaining the face information of the user, wherein the target video corresponds to the permissible age interval; inputting the face image into a pretrained age classifier to obtain the age of the user, wherein the age classifier is used for expressing whether the corresponding relationship of the face image and the age; determining whether the age of the user is in the permissible age interval range corresponding to the target video or not; if so, playing the target video; obtaining the physiological parameter of when the user watches the target video; regulating the video playing effect according to the physiological parameter. The video playing effect regulation comprises at least one of the follows: regulation on the sound volume of the target video, regulation of image brightness of the target video, target video closing, and video content switching. The embodiment has the advantages that the video playing effect can be regulated in a self adaptive way according to the physiological parameter of the user; the targeted video playing is realized.

A solid lipoid nanoparticle of tanshinone is prepared from tanshinone, medicinal phosphatide, emulsifier, lipoid material and additive. Its advantages are high dissolving speed and biological utilization rate, high target property to myocardial tissue, high curative effect, low dosage and low toxic by-effect.

The invention relates to a method for synthesizing dextran-magnetic LDH-fluorouracil magnetic targeting sustained and controlled release tripolymer, comprising the following steps of: finishing the synthesis of magnetic layered composite hydroxide and the intercalation assembly of fluorouracil to the magnetic layered composite hydroxide under the condition of nitrogen protection; performing the in-situ composite process of magnetic LDH-fluorouracil under the condition of nitrogen protection with the dextran as the wrapping material; and finally separating the product through the solvent conversion technology. The invention realizes the merging and unification of the targeting and the sustained release of a magnetic targeting drug, thereby solving the problems of the preparation of magnetic LDH-Drugs and protection against oxidation, and synthesizing a magnetic targeting sustained and controlled release drug delivery system which has good biocompatibility and high storage stability and fits for transport in vivo; and the invention is suitable for the chemical synthesis of various magnetic targeting sustained and controlled release drugs, and has the advantages of simple and rapid preparation technology, high product purity, energy consumption saving, no environment pollution, wide application range and the like.

The invention provides a substrate of a traditional Chinese medicine biochip formed by a silanizated slide and an organic active group connected through -O-. The substrate of the traditional Chinese medicine biochip is characterized in that the organic active group is -(CH2)2SO2CHCH2, an active ethenyl is at the end of the group and can be in cross-linking reaction with micromolecular organic matters such as carbonyls, glycosides and alkaloids and the like so that the organic micromolecule can be fixed on the substrate to prepare the traditional Chinese medicine biochip using the micromolecular organic matters as a probe, for example, a high throughput biochip which screens active ingredients of Chinese medicinal herb.

The invention discloses an antharcycline antitumor antibiotics loaded nano-micelle preparation, which comprises antharcycline antitumor antibiotics, A-B-C type triblock polymer and assisting agents, wherein the antharcycline antitumor antibiotics is one or more of adriamycin, daunorubicin, pharmorubicin, perarubicin or lacinomycin; and the A-B-C type triblock polymer is polyethylene glycol-polyethylene glycol containing carboxyl on side chain-polyester. According to the preparation, drugs are coated in the nano-micelle by virtue of the coaction of self-assembly of segmented copolymer and electrostatic adsorption, the nano-micelle has uniform and stable grain diameter, the encapsulation efficiency reaches 99 percent, and the prepared nano-micelle preparation is of a spherical structure with grain diameter between 20 and 300nm; and the shell of the micelle is made from polyethylene glycol molecules, so that drugs are prevented from being contacted with enzyme and other protein molecules in blood or identified and swallowed by a reticuloendothelial system in the body, so that the circulating period of micelle in the body can be prolonged.

The invention relates to NIR-II conjugated nano particles and a preparation method and application thereof. The NIR-II conjugated nano particles comprise NIR-II conjugated small molecules and amphiphilic polymers; a structural formula of the NIR-II conjugated small molecules is as follows; and the amphiphilic polymers are self-assembled and encapsulated on the NIR-II conjugated small molecules. The nanoparticles have good biocompatibility, high NIR-II photothermal conversion efficiency, good photoacoustic imaging effect and NIR-II tumor photothermal therapy effect.

The present invention relates to the technical field of biology, and in particular to a block copolymer and a synthesis method thereof, and a preparation method of nano particles. The block copolymer provided by invention comprises a first block, a second block and a third block, which are connected successively. The first block and the third block are hydrophilic blocks, and the second block is a hydrophobic block. Compared with prior art, the block copolymer provided by the invention can effectively shield surface charges of cationic particles like polycation gene complex particles, exclude in vivo circulation barriers of cationic particles, and improve in vivo circulation efficiency, and also can be grafted to a target group to realize pathological cell targeting in vivo, and effectively improve the targeting effect.