Nasal compositions of vitamin B12

Abstract

Vitamin B-12 deficiency is very common among population. The main causes of B- 12 deficiency include lack of intrinsic factors and other intestinal factors (e.g. malabsorption), rare genetic disorders, and inadequate intake. The present invention relates to intranasal formulations of vitamin B derivatives such as methylcobalamin, Cyanocobalamin which provide enhanced transnasal absorption.

Description

technical field [0001] The present invention relates to intranasal compositions of vitamin B-12 derivatives such as methylcobalamin, cyanocobalamin and hydroxocobalamin and methods for their preparation. Background technique [0002] Vitamin B-12 deficiency is very common in the population. Large surveys in the US and UK revealed that about 6% of people aged 60 or older are deficient in vitamin B-12. Furthermore, in developing countries such as India, this deficiency is more common, starts early in life and persists throughout life. A study of 441 middle-aged men in Pune (India) revealed that 67% had low vitamin B-12 concentrations (<150 pmol / L). Among the urban middle class, 81% had lower vitamin B-12 concentrations, and vegetarians had a 4.4-fold higher risk of developing low vitamin B-12 concentrations. [0003] The main causes of B-12 deficiency include lack of intrinsic factor and other intestinal factors (eg, malabsorption), rare genetic disorders, and insufficie...

AI Technical Summary

Problems solved by technology

[0011] Although the prior art discloses intranasal formulations of cyanocobalamin and some methods of using methylcobalamin, there are concerns regarding the low solubility of methylcobalamin, its instability, and thus its bioavailability for optimal therapeutic effect The impact of the still unresolved

Additionally, optimized viscosity and pH of formulations for effective intranasal delivery remains a challenge, and thus therapeutically effective commercial methylcobalamin formulations are not available on the market

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