Method for rapidly inducing alcoholic fatty liver disease (AFLD) model by single factor

Abstract

The invention discloses a method for rapidly inducing an alcoholic fatty liver disease (AFLD) model by a single factor. According to the method, a non-human primate drinks alcohol containing 10-35% ethanol according to an ethanol quantity of 4-5.7 g for every one kilogram of body weight, meanwhile, the non-human primate is freely fed with basal feed for 50-90 days, and the stable AFLD model can beobtained. The method can obtain the stable AFLD animal model similar to human and occurring naturally, the compliance of the non-human primate is better, operation or animal killing for examination is not required in a test, the modeling time is short, the modeling cost is low, and a good model carrier is provided for research on AFLD pathogenesis, screening of treatment drugs and pharmacodynamicevaluation.

Description

technical field [0001] The invention relates to a method for establishing an animal disease model, in particular to a method for rapidly inducing an alcoholic fatty liver model by a single factor. Background technique [0002] Alcoholic fatty liver disease (AFLD) is a type of fatty liver disease, and it is a special kind of clinical liver disease. Most of the patients are long-term drinkers, usually more than 5 years, and they are caused by long-term and heavy drinking. Liver cells produce a large number of toxic substances such as acetaldehyde, secrete a large number of free radicals and hydroxyl groups, and cause metabolic disorders. In recent years, with the change of lifestyle, liver disease and related diseases induced by alcohol and or metabolic factors have increased rapidly, and the incidence of fatty liver has been increasing year by year and showing a younger trend. Fatty liver in my country has risen to the second place among liver diseases . Among the long-term ...

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Problems solved by technology

[0005] The present invention aims at the deficiencies of the above-mentioned alcoholic fatty liver model, especially the deficiency of the alcoholic fatty liver disease model induced by a single factor similar to human beings. Alcoholic fatty liver model method, the method takes non-human primates as objects, induces by alcohol single factor, obtains an animal model that can completely simulate the occurrence and development of human alcoholic fatty liver with significant B-ultrasound and pathological detection results, Provide a good model carrier for the study of the pathogenesis of alcoholic fatty liver, the screening of preventive or therapeutic drugs, and the evaluation of pharmacodynamics

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