211 results about "Bone calcium" patented technology

The invention discloses a health product for increasing bone density and a preparation method of the health product. Chinese dwarf cherries, Chinese herbal medicine extracts refined by adopting a modern extraction technology and other raw materials having the function of increasing the bone density are scientifically compounded and are scientifically combined omnibearingly to play a synergistic effect, so as to effectively promote the calcium absorption in multiple aspects, repair and reconstruct the cartilago articularis, promote the generation of synovial fluid, promote the synthesis of collagen in cartilago articularis substrates, prevent the further degradation of cartilage, indirectly reduce the osteoclast function, inhibit the re-absorption of bones, increase the content of bone calcium and perfect the biomechanical properties of the bones, so that the product has a good function of increasing the bone density. A microwave drying technology in the preparation method can be used for further improving the integration and biological stability of the health product, and by means of the antioxidant activity of a grape seed extract in the raw materials, the strong adsorption and inclusion functions of modified dietary fibers and the antifungal propertie of the Chinese herbal medicine extracts, an efficient, safe, nutritional and stable health product having the function of increasing the bone density is prepared finally.

The invention provides an omeprazole sodium lyophilized powder for injection (pH of 10.8-11.2), comprising omeprazole sodium as the main active component, as well as excipient, metal ion complexing agent, stabilizer, antioxidant and pH regulator. The omeprazole sodium lyophilized powder for injection has higher active component content than that of the conventional omeprazole sodium injection, solves solution clarity problem, and effectively prevents loss of bone calcium due to complexation with calcium ion. The omeprazole sodium lyophilized powder for injection also has the advantages of stable color and properties, low side effects, good stability, good redissolution, and convenient application.

A solid implantable bone construct (12) shaped like a cylinder, a cone, or a frustum, for anchoring ligament implants. The bone construct (12) can include a bone component and a biocompatible solid component. The bone component can include particulate bone of between 75 and 600 microns, powdered bone of 75 microns or smaller in size, or both. The biocompatible solid component can include calcium sulfate hemihydrate, a calcium phosphate product, or both. The bone component can be between 5 and 50 wt-% of the construct (12) and the biocompatible solid component can be at least 50 wt-% of the construct (12). Also disclosed is a composite graft (10) comprising a first bone dowel (12) and a ligament (20) and a method of securing one bone to another using the composite graft (10).

The invention relates to a nutritional biscuit with high bone calcium and a making method thereof, belonging to a processing and making technique of foods required by the life of human beings. The nutritional biscuit is formed by preparing and processing the following raw materials according to a certain proportion formula and a certain production technology and comprises the following raw materials according to the formula and the mixture ratio: 950g of flour, 50g of corn starch, 350g to 450g of cattle bone powder hydrolyzing substance, 240g to 260g of flavoring agent, 140g to 160g of flavoring taste-retaining agent, 280g to 300g of nutritional extender, 80g to 100g of calcium absorption promoter, 6g to 8g of foaming agent and 1ml of butter essence. The product contains high effective calcium and abundant nutrition, the color of the surface of the biscuit is bright, and the biscuit has a deep red brown color, has the special flavor of bone, is soft, savory and crisp and has no peculiar odor. The processing procedure of the invention is shown as the attached drawing of the abstract.

The invention relates to a method for preparing low-molecular-weight sheep bone collagen polypeptide calcium chelate microcapsules, which comprises the following steps of: 1, preparing sheep bone meal, namely grinding fresh sheep bones, degreasing, drying, and grinding to prepare sheep bone paste; 2, performing enzymolysis on the sheep bone paste to prepare bone collagen polypeptides; 3, separating and extracting by using an ultrafiltration membrane to obtain low-molecular-weight bone collagen polypeptides; 4, chelating the low-molecular-weight bone collagen polypeptides and a calcium source to prepare low-molecular-weight collagen polypeptide calcium chelates; and 5, preparing the low-molecular-weight sheep bone collagen polypeptide calcium chelate microcapsules. By the method, the addedvalue of sheep bone resources is improved, the comprehensive development and utilization of collagen and bone calcium in pig bones is realized, and the prepared microcapsule calcium supplement has high solubility in water, and has the highest solubility in a range close to human body temperature; and the microcapsule product can cover the peculiar smell of calcium salt.

The invention discloses a method for preparing crocodile ossein chelated calcium. The method includes the following process steps: (1) materials are obtained; (2) freezing is carried out; (3) normal-temperature processing is carried out; (4) stewing is carried out; (5) microwave processing is carried out; (6) smashing is carried out; (7) superfine grinding is carried out; (8) first-time enzymolysis is carried out; (9) second-time compounded enzymolysis is carried out; (10) the materials obtained after two times of enzymolysis are placed into a centrifugal machine for separation; (11) concentration and spraying drying are carried out to obtain ossein protein peptide powder; (12) separated bone powder is taken out for acidolysis for extracting calcium powder; (13) centrifugation is carried out to obtain bone calcium powder; (14) water bath chelation is carried out; and (15) powdered crocodile ossein chelated calcium is obtained. The crocodile ossein chelated calcium is high in quality and can be widely applied to the fields of medicines, foods, health care and the like.

A flavouring bone extract rich in bone calcium, amino acids, trace elements, etc is proportionally prepared from fresh chicken bone, nucleotide disodium, gourmet powder, granular white sugar, natural spices, starch, yeast extract, ginger powder, garlic powder, pepper, onion powder, edible salt and chicken fat through breaking chicken bone, heating, enzymolyzing, concentrating, mixing with others, granulating, drying, classifying, and packing.

The invention relates to natural total nutrient rice crust and a production method of the natural total nutrient rice crust. The rice crust adopts rice as main material, and beans, nuts, dried small shrimp powder, vegetable protein powder, cereal germ powder, fresh bone calcium powder, livestock and poultry liver powder, seaweed powder and spirulina powder for supplementing nutrition and seasoning, and has balanced and comprehensive nutrition. During production, the rice and bean materials are cooked and aged at two times, natural nutrition supplementation and seasoning is carried out at three times in different processing stages, and rice crust sheet and rice crust cake finished product, and rice crust sheet blank and rice crust cake blank semi-finished products subjected to baking are provided. Due to the characteristics of the special dietary value and rich amino acids and vitamins of rice, the rice crust has health care effects, and is sweet and delicious, and natural in color.

The invention discloses fermented sauced bone meal and a preparation method thereof. The fermented sauced bone meal is prepared by adopting a way of fermenting after enzymolysis. Livestock and poultry bone protein and polysaccharide are degraded by adopting mixed bacteria and composite enzyme, so that bone calcium can be adequately separated, the bone calcium is interacted with amino acid to generate soluble calcium ammonium, the absorption and the utilization on the calcium can be promoted, and the content of soluble protein is increased. The developed fermented sauced bone meal is not only rich in nutrients, proteins, collagen polypeptide, amino acid, nucleotide, polysaccharide substances and minerals, but also full and strong in taste, thick in sauce fragrance, durable in fragrance, natural in flavor and easy to carry and store.

The invention relates to a method for processing a high calcium fish meat blended sausage, belonging to the technical field of food processing. With fish flesh, meat of poultry and livestock or meat paste as well as calcium (calcium sources of fish bone calcium, beef bone calcium, pig bone calcium and the like) as raw materials, the method comprises the following steps: firstly cleaning the fish flesh and meat, removing bones, tendons and myolemma of the meat of poultry and livestock, scaling and decaptitating on the fish flesh, removing fish bone, removing fish skin, removing viscera, and removing the fish odour; and then slicing, pickling, mincing, chopping and uniformly stirring the meat of poultry and livestock or meat paste, minced fish, calcium powder and condiment according to the ratio, carrying out vacuum chopping and stirring and vacuum filling, and carrying out curing, sterilizing, cooling and storing. By applying the method in the invention, the taste of the sausage is improved, the sausage has the flavours of fish and meat, and the processed calcium sources are added during the processing process, thus high quality high calcium fish meat blended sausage can be produced.

The invention relates to a medicinal composition for treating osteoporosis and a preparation method thereof. With increasingly clear trend of China's aging population, osteoporosis becomes a common disease and a frequently encountered disease among the middle-aged and old people, and the traditional treatment has high treatment cost and has no quite ideal treatment effect. The invention provides the medicinal composition for treating the osteoporosis and the preparation method thereof, wherein the medicinal composition comprises the following raw materials in part by weight: 140 to 180 parts of D-glucosamine hydrochloride, 80 to 120 parts of calcium carbonate, 0.0008 to 0.0012 part of vitamin, 40 to 80 parts of chondroitin sulfate, 40 to 80 parts of starch, 10 to 30 parts of dextrin and 2 to 4 parts of magnesium stearate. The vitamin D added into the composition regulates the bone metabolic hormone, and ensures stable internal environment of bone and calcium; the predominant crushing and mixing conditions can improve the absorption of calcium and other active ingredients, and the mixing mode is more scientific; after the starch is selected and ground and the surface is saturated, the vitamin D is added, so the bioactivity of the vitamin D is ensured; and after the tabletting is finished, a coating is coated on the vitamin so that the vitamin D is more stable.

The invention relates to a compound for preventing osteoporosis and osteoarthrosis. The compound relates to a compound for preventing osteonosuses. The compound for preventing osteoporosis and osteoarthrosis solves the problem that: the prior calcium replenishing agent can purely replenish calcium, while the replenished calcium cannot be fully absorbed and utilized by the human body. The compound for preventing osteoporosis and osteoarthrosis comprises the following components by weight portion: 10 to 90 portions of glucosamine, 10 to 90 portions of calcium agent, 0.1 to 40 portions of casein phosphopeptide, 0.1 to 40 portions of drynaria rhizome extract, 0.0001 to 0.09 portion of vitamin K and 0.81 to 208 portions of supplementary materials. The compound for preventing osteoporosis and osteoarthrosis can obviously improve the bone calcium content and bone density; and the replenished calcium agent can be fully absorbed and utilized.

The invention discloses a method for preparing bone calcium and bone gla protein prepared by means of the method. The method comprises the following steps of three-time defatting, two-time centrifugation, two-time fermentation and secondary protease hydrolysis. Fat in bone meal prepared by adopting a defatting process is completely removed basically, so that the fat content in calcium obtained by means of enzymolysis is lower than 0.1%. The bone gla protein is safe and healthy to consumers with cardiovascular disease, and economical burden to the consumers is not increased.

Inhibitors of bone calcium resorption are administered to allow high doses of vitamin D compounds or mimetics to be given with the intent of treating non-calcium related diseases such as cancer, psoriasis, and autoimmune disease without the dangers of calcification of kidney, heart, and aorta. Inhibitors of bone calcium resorption include the bis-phosphonates, OPG (osteoprotegerin) or the soluble RANKL (receptor activator of NF-κB ligand) receptor known as sRANK (soluble RANK which is the protein expressed by the NF-κB gene), and function to block the availability of calcium from bone thereby preventing hypercalcemia and the resulting calcification of soft tissues. Thus, high doses of 1α,25-dihydroxyvitamin D₃ (1,25-(OH)₂D₃), its analogs, prodrugs, or mimetics can be utilized with minimal risk to a patient. Specifically, alendronate is shown to block the bone calcium mobilization activity of both 1,25-(OH)₂D₃ and its very potent analog, 2-methylene -19-nor-(20S)-1α,25-dihydroxyvitamin D_3.

A composite Ca-supplementing food for the astronaut is prepared from calcium carbonate, collagen peptide, stachyose and VD3. Its advantage is efficient absorption by intestine and stomach.

The invention relates to a method for preparing a pig bone collagen polypeptide chelated calcium supplement. The method comprises the following steps of: 1, preparing pig bone paste, namely crushing, defatting and grinding fresh pig bones to obtain the pig bone paste; 2, preparing bone collagen polypeptide, namely preparing a pig bone paste culture solution, inoculating mixed strains of serratia marcescens and lactobacillus bulgaricus, fermenting, centrifuging, filtering and drying to obtain the bone collagen polypeptide; 3, preparing soluble bone calcium by mixing bone paste residue left after fermentation and hydrochloric acid; and 4, preparing the bone collagen polypeptide chelated calcium supplement, namely chelating the bone collagen polypeptide and the soluble bone calcium to obtainthe bone collagen polypeptide chelated calcium supplement. By the method, the added value of a pig bone resource is improved, the collagen and bone calcium in the pig bones are comprehensively developed and utilized, and the prepared chelated calcium supplement has high solubility in water, is favorable for a human body to absorb and utilize calcium element in the chelate, and can be applied to various fields such as chemical engineering, foods, cosmetics and the like.

The invention discloses a method for extracting bone calcium by fermentation, and osteocalcin. The method comprises the steps of crushing the bone, fermenting lactic acid bacteria, heating for sterilization, enzymolizing, adding alkali to neutralize an enzymatic hydrolysate, inactivating and drying to obtain the osteocalcin. Compared with the osteocalcin prepared by a convention technology, the osteocalcin prepared by the enzymolysis technology has greatly increased free calcium content. The final prepared product has better balanced nutrition.

The invention discloses a bone calcium extraction method by double fermentation. The bone calcium extraction method by double fermentation includes the steps of fermenting before enzymolysis, enzymolysis and fermenting after enzymolysis. Free calcium content of bone gla protein made by the bone calcium extraction method compared with the prior art is increased greatly. The obtained bone gla protein has fine taste and fragrance, and peculiar odors in extract are removed.

The invention relates to deep processing technology of yak bones, in particular to a preparation method for successively producing yak bone marrow oil and ultramicro polypeptide bone calcium powder once. The preparation method is characterized by comprising the following steps: (1) washing; (2) autoclaving; (3) separating: after freezing and centrifugal separation, taking away the upper fat as bone oil; (4) grinding and secondarily autoclaving: after filtering the lower contents, separating and grinding the bone and meat, continuously cooking for 30 minutes under the conditions of pressure of0.2-0.3MPa and temperature of 105-110 DEG C, similarly, after freezing and centrifuging, collecting the upper fat and merging the upper fat with the first collected bone oil, thus preparing the bone marrow oil product; (5) carrying out enzymolysis; (6) carrying out powder injection; (7) carrying out ultramicro grinding; and (8) mixing polypeptide bone powder obtained through spraying with ultramicro bone calcium powder, thus preparing the polypeptide bone calcium powder.

This invention provides pharmaceutical uses for 2-methylene-19-nor-20(S)-1α,25-dihydroxyvitamin D₃. This compound is characterized by high bone calcium mobilization activity demonstrating preferential activity on bone. This results in a novel therapeutic agent for the treatment and prophylaxis of diseases where bone formation is desired, particularly osteoporosis. This compound also increases both breaking strength and crushing strength of bones evidencing use in conjunction with bone replacement surgery such as hip and knee replacements, as well as use by normal subjects when high bone mass is desired.

The invention discloses a bone calcium extraction method and osteocalcin prepared by the bone calcium. The extraction method comprises the steps of composite enzymatic hydrolysis and fermentation. Free calcium content in the osteocalcin prepared by the invention is increased by 5%-25% than that in the osteocalcin prepared by enzymatic hydrolysis with a conventional technology. The final prepared product has good mouthfeel and is aromatic; and the peculiar smell in the extract product is removed.

The invention discloses a process for co-production of collagen calcium and polypeptide in chondroitin sulfate production. The production process includes: conducting coarse crushing on shark cartilage to a massive size, performing soaking in an acid solution and then conducting filtering, subjecting the filtrate to calcification treatment and alcohol precipitation, conducting secondary washing with alcohol, and then carrying out spin-drying and drying to obtain collagen chelated calcium; subjecting the soaked cartilage to enzymolysis and filtration to obtain a chondroitin sulfate and collagen polypeptide aqueous solution and bone dreg, subjecting the aqueous solution to ultrafiltration separation to obtain a chondroitin sulfate concentrated solution, and performing alcohol precipitation to obtain chondroitin sulfate; and concentrating the ultrafiltrate, and then carrying out spray drying, thus obtaining collagen polypeptide. On the basis of co-production of chondroitin sulfate and collagen polypeptide, the invention also produces another high benefit product at the same time, i.e. collagen chelated calcium, makes full use of the resources in cartilage, performs high value utilization of bone calcium powder in treatment process, and improves the economic value.

The invention relates to buckwheat rice crust, which relates to natural total nutrient rice crust and a production method thereof. Buckwheat is adopted as a main ingredient, and natural nutritious materials such as beans, nutlets, shrimp bran powder, plant protein powder, grain germ flour, fresh bone calcium powder, livestock and poultry liver powder, dried marine algae powder and spirulina powder are used for nutrition supplementing and seasoning, so that nutrition is balanced and comprehensive. In production, the beans are boiled and cured twice, natural nutrition supplementing and seasoning are carried out three times in different processing stages, and rice crust slices, rice crust cake products, baked rice crust piece blanks and baked rice crust cake blank semi-finished products are provided. The buckwheat rice crust has the beneficial effects that: the buckwheat has unique edibleness and is rich in various amino acid, vitamins and the like; and the rice crust has a health care function, so that the buckwheat rice crust is more delicious and is natural in color.

The invention provides a composition for increasing the bone mineral density. The composition mainly comprises the following raw materials in parts by weight: 180-540 percent of calcium carbonate, 23-69 percent of D-glucosamine hydrochloride and 15-45 percent of collagen. The invention also provides a preparation method of the composition. The raw materials adopted by the composition for increasing the bone mineral density have no toxic and side effects, health and safety, has the effects of promoting calcium absorption and relieving osteoporosis and can safely and effectively supplement calcium of the human body and ensure that the calcium level is improved so as to prevent fractures and bone loss and has improvement effect on bone formation. Moreover, the invention adopts scientific andreasonable production process and better retains active constituents in various raw materials.

The invention discloses an animal bone calcium extraction method and bone gla protein made thereby. The animal bone calcium extraction method includes the steps of triple defatting, double centrifuging, fermenting, and compound protease hydrolysis. Fat in the bone powder made by the defatting process is substantially removed, so that fat content of calcium agent obtained by enzymolysis is smaller than 0.1%. The bone gla protein is safer and healthier for consumers with cardiovascular diseases but causes no increase in financial burden.

The invention provides a high-efficiency calcium supplement capsule and a preparation method of the high-efficiency calcium supplement capsule. According to the specification of 0.45g/capsule, 1000 calcium supplement capsules comprise the following components by weight: 45-55g of calcium carbonate, 126-154g of calcium citrate malate, 108-132g of D-glucosamine hydrochloride, 90-110g of chondroitin sulfate, 18-22g of casein phosphopeptides and 18-22g of vitamin C. The preparation method comprises the following steps of: respectively sieving the D-glucosamine hydrochloride, the chondroitin sulfate, the calcium carbonate, the calcium citrate malate, the casein phosphopeptides and the vitamin C by 80 screen meshes, mixing according to proportion, and filling into a hollow capsule. The high-efficiency calcium supplement capsule provided by the invention not only can promote the absorption of calcium, but also can increase the deposition of bone calcium salt, so that the use of the bone on the calcium can be improved.