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Composition for increasing bone mineral density and preparation method thereof

A technology for increasing bone density and composition, applied in the field of compositions for increasing bone density and preparation thereof, can solve the problems of hunched over, loss of bone calcium, vertebral compression fracture, etc., and achieves the promotion of utilization and the increase of bone calcium level. , the effect of alleviating osteoporosis

Active Publication Date: 2011-06-08
BEIJING TONGRENTANG HEALTH PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term insufficient calcium intake requires continuous extraction of "deposits" from the bone bank to ensure a constant blood calcium. Bone calcium is constantly lost. Although there is no performance when young, osteoporosis will occur earlier in old age, leading to spinal cord damage. Compression fractures, causing hunched over

Method used

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  • Composition for increasing bone mineral density and preparation method thereof
  • Composition for increasing bone mineral density and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Raw materials: 180kg of calcium carbonate, 23kg of D-glucosamine hydrochloride, 15kg of collagen, 5kg of polyvinylpyrrolidone, 2kg of magnesium stearate.

[0033] Preparation method of capsules:

[0034] 1) Calcium carbonate, D-glucosamine hydrochloride, collagen, polyvinylpyrrolidone, and magnesium stearate are removed from the outer packaging and sent to a clean area. Take the formula amount of calcium carbonate, D-glucosamine hydrochloride, and collagen respectively through a 100-mesh sieve in a high-efficiency sieving machine, and mix them in a three-dimensional swing mixer for 20 minutes to obtain mixed powder.

[0035] 2) Dissolving polyvinylpyrrolidone in purified water to make an 8% aqueous solution as a binder.

[0036] 3) Put the mixed powder into a wet granulator, add an appropriate amount of the above-mentioned binder to make a soft material, add water appropriately, and granulate with a 30-mesh sieve to obtain wet granules. The wet granules are dried in a spray-dr...

Embodiment 2

[0041] Raw materials: 360kg of calcium carbonate, 46kg of D-glucosamine hydrochloride, 30kg of collagen, 10kg of polyvinylpyrrolidone, 4kg of magnesium stearate.

[0042] Preparation method of capsules:

[0043] 1) Calcium carbonate, D-glucosamine hydrochloride, collagen, polyvinylpyrrolidone, and magnesium stearate are removed from the outer packaging and sent to a clean area. Take the formula amount of calcium carbonate, D-glucosamine hydrochloride, and collagen, respectively, pass through an 80-mesh sieve in a high-efficiency powder sieving machine, and mix them in a three-dimensional swing mixer for 30 minutes to obtain mixed powder.

[0044] 2) Dissolve polyvinylpyrrolidone in purified water to prepare a 10% aqueous solution as a binder.

[0045] 3) Put the mixed powder into a wet granulator, add an appropriate amount of the above-mentioned binder to make a soft material, add water appropriately, and granulate with a 20-mesh sieve to obtain wet granules. The wet granules are dri...

Embodiment 3

[0050] Raw materials: 540kg calcium carbonate, 69kg D-glucosamine hydrochloride, 45kg collagen, 15kg polyvinylpyrrolidone, 6kg magnesium stearate.

[0051] Preparation method of capsules:

[0052] 1) Calcium carbonate, D-glucosamine hydrochloride, collagen, polyvinylpyrrolidone, and magnesium stearate are removed from the outer packaging and sent to a clean area. Take the formula amount of calcium carbonate, D-glucosamine hydrochloride and collagen respectively through a 60-mesh sieve in a high-efficiency sieving machine, and mix in a three-dimensional swing mixer for 40 minutes to obtain a mixed powder.

[0053] 2) Polyvinylpyrrolidone is dissolved in purified water to prepare a 12% aqueous solution as a binder.

[0054] 3) Put the mixed powder into a wet granulator, add an appropriate amount of the above-mentioned binder to make a soft material, add water appropriately, and granulate with a 10 mesh sieve to obtain wet granules. The wet granules are dried in a spray-drying granulato...

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Abstract

The invention provides a composition for increasing the bone mineral density. The composition mainly comprises the following raw materials in parts by weight: 180-540 percent of calcium carbonate, 23-69 percent of D-glucosamine hydrochloride and 15-45 percent of collagen. The invention also provides a preparation method of the composition. The raw materials adopted by the composition for increasing the bone mineral density have no toxic and side effects, health and safety, has the effects of promoting calcium absorption and relieving osteoporosis and can safely and effectively supplement calcium of the human body and ensure that the calcium level is improved so as to prevent fractures and bone loss and has improvement effect on bone formation. Moreover, the invention adopts scientific andreasonable production process and better retains active constituents in various raw materials.

Description

Technical field [0001] The invention relates to a composition, in particular to a composition for increasing bone density and a preparation method thereof. Background technique [0002] Osteoporosis is a bone metabolism disease that seriously endangers the health of the elderly. It is caused by the decrease in the density of the bone substance. With the aging of the social population, the incidence of the disease is getting higher and higher. It is characterized by bone loss and easy fracture, which brings harm to society and families. The measurement of bone density is a necessary means to evaluate osteoporosis. There are many reasons for osteoporosis, one of which is the lack of calcium in food. Calcium is an important element of the human body. 99% of the calcium in the human body is stored in hard tissues, namely bones and teeth, and the remaining 1% is distributed in blood, muscles and other tissues. The calcium in bones is important for bone minerals. The ingredients giv...

Claims

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Application Information

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IPC IPC(8): A61K38/39A61P19/08A61P19/10A23L1/304A23L1/305A61K33/10A61K31/7008
Inventor 张宏查圣华
Owner BEIJING TONGRENTANG HEALTH PHARMA
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