105 results about "Blood calcium" patented technology

The invention discloses a postpartum new dairy cow drenching nutritious supplementary and application thereof in a nutritious supplementary for treating postpartum hypocalcemia, abomasum displacement or ketosis disease of dairy cow. The nutritious supplementary provided by the invention is capable of effectively maintaining the levels of blood calcium, blood magnesium and glucose and reducing the levels of NEFA (Non-Esterified Fatty Acid) and beta-hydroxybutyric acid, thereby effectively reducing the occurrence rate of metabolic diseases of postpartum paralysis, ketosis, abomasum displacement and the like of new dairy cow. As a result, the dairy cow can be rehabilitated in physical power and food intake quickly, and the health condition of the dairy cow can be improved and the milk yield of the dairy cow can be increased; and good economic benefit can be achieved.

The invention provides L-calcium aspartate. The L-calcium aspartate comprises the following components, by weight, 0.9-1.1 parts of L-aspartic acid, 0.4-0.5 part of calcium carbonate and 4.2 parts of pure water. The L-calcium aspartate the invention, which is used as a nutrition intensifying agent, enters the small intestine after stably going through the stomach, and slowly releases calcium ions for being absorbed by human bodies, the molecular structure of the L-calcium aspartate is similar to the molecular structure of dipeptide protein calcium which is in natural foods and is most easily absorbed by the intestinal tract, and results of Shanghai disease control center detection show that the content of blood calcium in the L-calcium aspartate is 84.5mug/ml and the content of blood calcium in a blank control group is 6.6mug/ml. By statistical processing, the difference has a significance (P is less than 0.005). The method has the advantages of less relating equipment and simplicity, and allows the yield of the L-calcium aspartate to reach 99.50%; and the calcium content is 12.1-12.6%, so the method is suitable for industrialized production and has a large application value.

The invention discloses a vitamin D and vitamin K soft capsule with a good calcium supplementing effect. The vitamin D and vitamin K soft capsule is prepared from the following raw materials in partsby weight: 60-70 parts of calcium carbonate; 0.1-2 part of vitamin D3; 1-3 parts of vitamin K2; 20-30 parts of vegetable oil; 0.1-3 part of phospholipid; and 100-150 parts of a capsule material. Traditional calcium supplementation needs to be accurately migrated to bones to achieve bone supplementation, and it is neglected that real calcium supplementation of blood calcium has three major elementsthat firstly, a sufficient calcium source is provided; secondly, the vitamin D3 is used for promoting good intestinal calcium absorption; and thirdly, sufficient vitamin K2 plays a role of leading calcium into bones. Calcium carbonate, vitamin D3 and vitamin K2 are adopted to form the soft capsule, the synergistic effect is good, and the calcium supplementing effect is better. The calcium-supplementing soft capsule disclosed by the invention not only can promote calcium absorption and prevent waist and leg pains of a patient, but also can play a role in improving sleep and regulating emotion.

The invention discloses a gelatinized anionic salt additive special for cows at early perinatal period and a preparation method thereof. The additive is composed of the following components by weight: 35-40 parts of corn flour, 0.5-1.0 part of sucrose, 15-20 parts of calcium chloride, 10-15 parts of calcium sulfate, 15-20 parts of ammonium chloride, 3-5 parts of ammonium sulfate, 0.5-1 part of magnesium oxide, and 8-10 parts of rumen-protected choline, wherein the calcium chloride, calcium sulfate, ammonium chloride, ammonium sulfate and magnesium oxide are gelatinized by corn flour and are then coated. Without affecting or lowering the dry matter intake of cows, the gelatinized anionic salt additive provided by the invention can effectively control postnatal hypocalcemia and other metabolic diseases caused by the content decrease of blood calcium in blood after cow labor onset and lactation, improve lipid metabolism, strengthen immunity, and relieve negative energy balance.

The present invention discloses a low value fish bone polypeptide chelated calcium. The low value fish bone polypeptide chelated calcium is prepared from low value fish bones and prepared by fish bone meal coarse preparing, fish bone meal fermenting, stepwise enzymolyzing, isoelectric point precipitating, chelating and freeze-drying. Beneficial effects are as follows: small molecule bone polypeptides are prepared by using a synergetic enzymatic hydrolysis of marine protease and terrestrial protease. The prepared bone polypeptides are small in molecular weight, chelated with calcium ions to obtain the bone polypeptide chelated calcium, and high in an absorption rate in human body, and do not produce blood calcium symptoms. The human body is good in an absorption effect for calcium in the bone polypeptide chelated calcium. After a long term consumption, a calcium apparent absorption rate, a calcium retention rate, a bone density, a bone mineral salt content, a bone cortex area, a bone energy absorption, etc. all show an obvious increasing trend.

The present invention discloses uses of treating, preventing or improving bone diseases by Lactobacillus or a composition including the Lactobacillus. The Lactobacillus and compositions can increase the blood calcium concentration, the trabecular bone volume density (BV/TV ratio), the trabecular thickness (Tb.Th), the trabecular number (Tb.N) and the bone mineral density (BMD) of a subject, and reduce trabecular spacing (Tb.Sp) of the subject. Further, the present invention discloses a method for treating a subject diagnosed with a bone disease, comprises steps of identifying the subject having the bone disease, and administering to the subject an effective amount of a composition including at least one of Lactobacillus plantarum GKM3 and Lactobacillus paracasei GKS6, wherein the Lactobacillus plantarum GKM3 is deposited in China General Microbiological Culture Collection Center (CGMCC) with a deposition number of CGMCC 14565 on Aug. 25, 2017, and the Lactobacillus paracasei GKS6 is deposited in CGMCC with a deposition number of CGMCC 14566 on Aug. 25, 2017.

The invention provides bifidobacterium lactis (Bifidobacterium lactis) capable of preventing osteoporosis and an application of the bifidobacterium lactis capable of preventing osteoporosis, and belongs to the technical field of microorganisms. The bifidobacterium lactis provided by the invention has properties of being resistant to gastric acid and intestinal juice, when the bifidobacterium lactis is treated for 30min in gastric acid liquid having pH being 2.5, the survival rate of viable bacteria is 62% or above, when the bifidobacterium lactis is treated for 2 hours, the survival rate of the viable bacteria is 61% or above, and when the bifidobacterium lactis is treated for 2 hours in small intestine liquid having pH being 6.8, the survival rate of the viable bacteria is 70% or above. The bifidobacterium lactis can significantly reduce loss of bone mass caused by lack of estrogen, promote blood calcium and blood phosphorus, restrain the number of in vivo osteoclasts, restrain the absorption effects of the in vivo osteoclasts on bones, and increase the level of protein through promoting the expression protein of bone synthesis and metabolism correlation factor genes so as to promote formation of new bones. The strain disclosed by the invention can be used for preparing foods and the like capable of preventing osteoporosis, and has great application prospects.

The invention provides compound premix feed for laying hens in due date. The compound premix feed for the laying hens in due date is prepared from components in parts by mass as follows: 88-120 parts of mountain flour, 200-350 parts of zeolite powder, 150-190 parts of calcium hydrophosphate, 60-70 parts of sodium chloride, 10-20 parts of sodium bicarbonate, 150-200 parts of rice hull powder, 30-36 parts of DL-methionine, 24-28 parts of choline chloride, 22-28 parts of L-lysine hydrochloride, 30 parts of composite microelements, 8 parts of compound vitamins, 2-4 parts of VC-2-phosphate powder, 2-4 parts of phytase, 2-4 parts of microbial composite coats, 2-3 parts of an antioxidant, 2-4 parts of an anti-stress agent and 2-3 parts of a mould adsorbent. By the aid of the complete ration prepared from the compound premix feed, smooth transition of ration nutrition from young chicken to laying hens can be effectively guaranteed, a calcium source is stored for hens beginning laying and hens in the egg laying peak stage, and soft egg shells and paralysis of the hens due to lack of calcium and phosphorus as well as kidney swelling and intractable diarrhea caused by overhigh blood calcium are effectively avoided.

The invention discloses a new purpose of N-(2)-L-alanyl-L-glutamine. The new purpose is characterized in that the purpose is an application of the N-(2)-L-alanyl-L-glutamine or the pharmaceuticaly-acceptable salt, ester and solvate to preparation of medicines for resisting osteoporosis. Through in vivo experiment, the inventor finds that the N-(2)-L-alanyl-L-glutamine can reduce the length of thigh bones, increase the diameter of the thigh bones and reduce the indexes of blood calcium concentration and the like. The new purpose of the N-(2)-L-alanyl-L-glutamine has the advantages that medicines can be applied to treatment for resisting osteoporosis, and have treatment protective effects on primary osteoporosis, secondary osteoporosis and idiopathic osteoporosis.

The invention relates to the field of dietary supplements, and specifically relates to a biological bone calcium health product and a preparation method thereof. The biological bone calcium health product comprises the following raw materials in parts by weight: 80 to 120 parts of livestock bone paste, 4*10<-8>-6*10<-8> parts of vitamin D, 0.2 to 0.4 part of casein phosphopeptides, and 8 to 12 parts of filler. According to the biological bone calcium health product, calcium to be supplemented appears in the livestock bone paste (organic substance) and is easily digested and absorbed by a human body, the vitamin D and casein phosphopeptides which are of given mixing ratio bring the effects of maintaining stabile blood calcium concentration and benefiting absorbing or calcium utilization; therefore, the biological bone calcium health product is rich in nutrition, has a good health product, and can be used as a good calcium supplementing health product for a patient suffering from osteoporosis.

The invention discloses concentrate supplement for dairy cows in early peripartum and a using method thereof. A formula of the concentrate supplement contains 17.5% of protein, 4% of fiber, 2.5% of fat, 12% of ash, 3% of calcium, 0.5% of phosphorus, 0.6% of magnesium, 0.8% of potassium, 0.6% of sulphur, 0.1% of sodium and 0.9% of chlorine, wherein the percentages are mass percentages of all the components in the total weight of the concentrate supplement for dairy cows in early peripartum; and the formula also contains 75mg/kg of manganese, 120mg/kg of iron, 32mg/kg of copper, 2.5mg/kg of cobalt, 125mg/kg of zinc, 0.5mg/kg of selenium, 3mg/kg of iodine, 42000IU of vitamin A, 10000IU of vitamin D, 420IU of vitamin E and 50ppm of rumensin. The using method is that the concentrate supplement for dairy cows in early peripartum is used together with corn silage and tall oat grass or hay. The concentrate supplement can improve the blood calcium concentration of cows, provide available energy, reduce energy negative balance, improve fat metabolism, and reduce blood NEFA (Non Esterified Fatty Acid) concentration so as to effectively guarantee the smooth transition of the production phase of the cows.

The invention is a method to peculiarly absorb low-density fat-cholesterin in high-fat blood plasm. The absorption is completed by water-insoluble carrier coupled with heparin as sorbentó±and water-insoluble carrier graft bivalent cation as sorbentó�. The reaction steps: 1) adding sorbentó±, 5-10g and sorbentó�3-5g in each 100ml of blood plasm in lipid blood plasm collector to shake lightly for 10-15 minutes under room temperature; 2) placing on high-capacity centrifuger to centrifuge for 10-20 minutes at 2000-3500rpm, and collecting clear defatted blood plasm; 3) using lipid filter to eliminate floating lipid suspension substrate in the clear defatted blood plasm; 4) absorbing excessive bivalent cation to adjust blood calcium to normal physiological concentration.

The invention relates to the technical field of health-care food, in particular to a vitamin K2 (MK-7) soft capsule for promoting blood calcium to enter bones and a preparation method. The vitamin K2(MK-7) soft capsule comprises a capsule liquid and a capsule skin, wherein the capsule liquid is prepared from the following raw materials in parts by weight: 30 to 60 parts of vitamin K2, 440 to 530parts of vegetable oil and 0.1 to 0.2 part of an antioxidant; the capsule skin is prepared from the following raw materials in parts by weight: 150 to 220 parts of gelatin and hydroxypropyl methyl cellulose, 110 to 180 parts of purified water, 45 to 80 parts of a plasticizer and 1 to 6 parts of an opacifying agent; the vitamin K2 (MK-7) soft capsule is prepared from the capsule liquid and the capsule skin through a certain preparation method. The composition has high activity and high stability, and can promote blood calcium to enter bones.

The invention discloses health-care granules for preventing the negative balance of energy metabolism of cows and a using method of the health-care granules. The health-care granules disclosed by the invention are mainly prepared from the following raw materials: calcium propionate, brown sugar, magnesium chloride, yeast, sodium chloride and corn flour. The health-care granules for feeding the cows, disclosed by the invention, have the advantages of being convenient to use, low in cost, good in palatability, notable in effects and the like. After the postnatal cows are fed with the health-care granules, physical strength can be quickly restored, the quantity of rumen microbial populations can be maintained, the food consumption is restored, the milk yield is increased, and the ability of resisting diseases is improved. Feeding experiments for the postnatal cows confirm that the health-care granules can effectively maintain the level of blood calcium (Ga), serum phosphate (P), blood magnesium (Mg) and blood sugar (GLU), and can reduce the level of beta-hydroxybutyric acid (BHBA), free fatty acid (NEFA), and aspartate aminotransferase (AST). The attack rate of nutrient metabolic disease-ketosis of the postnatal cows can be effectively reduced.

The invention provides calcium tablets special for cows. The calcium tablets comprise the following components in percentage by weight: 50-60% of calcium ions, 2-5% of vitamins, 5-10% of cane sugar, 6-12% of starch, 5-10% of saturated fatty acid, 3-6% of zeolite powder and 15-20% of spirulina, wherein the saturated fatty acid is used as coatings of the calcium tablets. Through adoption of the calcium tablets disclosed by the invention, the situation that after prenatal cows eat the calcium tablets, the rise of blood calcium concentration is too fast so that the calcium regulating ability of the cows is influenced can be prevented, the immunity of the cows can be enhanced, and parturient paresis caused by hypocalcemia after parturition of the cows can be prevented and treated.

Disclosed herein includes a drug delivery system comprising at least one peptide and a targeting ligand for bone fracture and/or for bone healing. Some embodiments include a peptide delivery system comprising at least an acidic, basic, hydrophilic, hydrophobic or neutral peptide linked to an acidic peptide or nonpeptidic polyanion for use in targeting the aforementioned attached peptide to a bone fracture surface. In some embodiments, a conjugated peptide expresses an anabolic function that acts through PTH receptor 1, and various formats of targeting ligands guide the drug to raw hydroxyapatite. This system offsets some side effects caused by free anabolic drug, such as high blood calcium concentration

The invention provides a supermicro calcium antibacterial health care wet wipe and a preparation method thereof, and solves the problems that health care wet wipes in the prior art do not have the effects of stopping bleeding and supplementing loss of calcium in blood, the supermicro calcium antibacterial health care wet wipe includes skin-friendly antibacterial cloth and a soaking liquid; the skin-friendly antibacterial cloth is prepared by compounding composite supermicro calcium far infrared mixed powder onto plant fiber and polylactic acid fiber and spinning, the soaking liquid comprises 2 to 10 parts by weight of radix sophorae flavescentis, 6 to 18 parts by weight of scutellaria baicalensis, 4 to 6 parts by weight of calamine and 20 to 30 parts by weight of pure water, the skin-friendly antibacterial cloth is prepared by compounding the composite supermicro calcium powder onto supermicro fiber by electrostatic spinning technology, has strong antibacterial activity, can activate cells, relieves spasm phenomenons caused by low blood calcium, and has the effects of stopping bleeding and supplementing the loss of the calcium in the blood, and the supermicro calcium antibacterial health care wet wipe also contains traditional Chinese medicine ingredients and has the effects of disinfection and sterilization.

The invention discloses capsules for treating eye diseases. The capsules are prepared from the following component extractives in percentage by weight: 10-15% of active polypeptide, 10-15% of arillus longan, 8-10% of medlar, 8-12% of semen cuscutae, 8-12% of radix rehmanniae praeparata, 8-10% of semen cassiae, 3-7% of equisetum hiemale linne, 3-7% of schisandra chinensis, 3-7% of angelica, 5-8% of semen plantaginis, 4-6% of fructus broussonetiae, 2-5% of zanthoxylum, 2-5% of haws, 2-5% of silybum marianum and 2-5% of vitamin A. The capsules provided by the invention have the advantages that active polypeptide can be utilized for tonifying kidney, nourishing liver, supplementing the blood calcium content of a human body, and enhancing the toughness of eyeball walls; arillus longan, equisetum hiemale linne and other components can be utilized for inducing resuscitation and improving eyesight, preventing eyeballs from protruding, lowering the blood sugar content of the human body, improving the crystal osmotic pressure of aqueous humor, and eliminating the fatigue of ciliary muscles of eyes; animal liver extractives and vitamin A can be utilized for supplementing various microelements for the human body, so as to ensure balanced nutritional ingredients of the eyes; after the capsules are taken by a patient, the eye diseases of the patient can be treated fundamentally; the treatment course is short, and the therapeutic effect is instant.

The invention relates to a medicine composite injection for treating osteoporosis and a preparation method thereof. In particular, active constituents of the injection comprise one or more constituents out of teriparatide combined with bisphosphonate series, calcitonin series and estrogen, and besides, pH regulating agents and excipient with the amount acceptable to pharmacy are added. According to the preparation method, the preparation process is investigated, the rat urinary calcium content, the blood calcium conent, the serum phosphate content and the thighbone mineral matter content further serve as indexes, the treatment effect of the injection on osteoporosis model rats is further investigated, the prepared composite injection is remarkable in effect, and the practical significance is achieved.

The invention discloses a preparation method of high-valued fishbone polypeptide chelated calcium. The preparation method comprises the steps of rough preparation of fishbone meal, fermentation of thefishbone meal, step-by-step enzymolysis, isoelectric precipitation, chelating and freeze drying. The preparation method has the following beneficial effects: small-molecular-weight bone polypeptide is prepared with a marine protease and terrestrial protease coordinated enzymolysis method, the prepared bone polypeptide has small molecular weight, the absorptivity of bone polypeptide chelated calcium prepared from the bone polypeptide and calcium ions by chelating in a human body is high, and the phenomenon of blood calcium is avoided. The human body has a good bone polypeptide chelated calciumabsorbing effect, and after long-term taking, the calcium apparent absorption rate, the calcium retention rate, the bone mineral density, the bone mineral salt content, the bone cortex area, femoralenergy absorption and the like show an obviously increasing trend.