Process for co-production of collagen calcium and polypeptide in chondroitin sulfate production

Abstract

The invention discloses a process for co-production of collagen calcium and polypeptide in chondroitin sulfate production. The production process includes: conducting coarse crushing on shark cartilage to a massive size, performing soaking in an acid solution and then conducting filtering, subjecting the filtrate to calcification treatment and alcohol precipitation, conducting secondary washing with alcohol, and then carrying out spin-drying and drying to obtain collagen chelated calcium; subjecting the soaked cartilage to enzymolysis and filtration to obtain a chondroitin sulfate and collagen polypeptide aqueous solution and bone dreg, subjecting the aqueous solution to ultrafiltration separation to obtain a chondroitin sulfate concentrated solution, and performing alcohol precipitation to obtain chondroitin sulfate; and concentrating the ultrafiltrate, and then carrying out spray drying, thus obtaining collagen polypeptide. On the basis of co-production of chondroitin sulfate and collagen polypeptide, the invention also produces another high benefit product at the same time, i.e. collagen chelated calcium, makes full use of the resources in cartilage, performs high value utilization of bone calcium powder in treatment process, and improves the economic value.

Description

technical field

[0001] The invention belongs to the field of biomedicine, and more specifically relates to a production process for co-producing collagen chelated calcium and small molecule polypeptides in the production process of chondroitin sulfate. Background technique:

[0002] Chinese patent 201310027690.5 discloses a method for producing chondroitin sulfate and co-producing peptone, collagen peptide, and cartilage calcium powder. Temperature destroys the activity of collagen peptides. In addition, in the production process of this patent, the inorganic salt content in the collagen peptide solution is high, and the nanofiltration desalination needs repeated water addition, which will generate a large amount of waste water.

[0003] At present, the by-products co-produced in the chondroitin sulfate production industry are mostly collagen polypeptide, peptone and bone calcium powder, and among the by-products, only collagen polypeptide is the most valuable. Therefore, ...