87 results about "Shark cartilage" patented technology

The patent relates to health foods containing natural astaxanthin, which is made into liquid capsule containing natural astaxanthin with natural astaxanthin oil, edible oil and fat and natural antioxidant as raw materials by conventional processing; or which is made into power capsule or tables containing natural astaxanthin with natural astaxanthin, natural antioxidant and other health food as raw materials by conventional processing. In comparison with present technology, the advantage of the invention includes, (1) the health food provided in present patent takes natural astaxanthin as main raw material, has the strongest antioxidant, capable of improving human immunity and anti-aging and ranking first in terms of health foods containing natural antioxidant; (2) the health food is made from pure natural materials and without any compound materials and side-effect; (3) the natural astaxanthin of health food coordinately used with shark cartilage, glucosamine hydrochloride, chitosan, propolis and paclitaxel etc as function material, which is capable of enhancing astaxanthin function; (4) adding antioxidant of natural tea-pigment and tea polyphenols is capable of avoiding oxidation of astaxanthin, thus prolonging shelf life more than one year.

Compositions with synergistic anti-inflammatory effects in inflammatory diseases resulting from activation and consequent degranulation of mast cells and followed by secretion of inflammatory biomolecules from the activated mast cells, composed of a heavily sulfated, non-bovine proteoglycan such as shark cartilage chondroitin sulfate C, an unrefined olive kernel oil / extract that increases absorption of these compositions in various routes of administration, and one or more of a hexosamine sulfate such as D-glucosamine sulfate, a flavone such as quercetin, S-adenosylmethionine, a histamine-1 receptor antagonist, a histamine-3 receptor agonist, an antagonist of the actions of CRH, caffeine, and a polyamine.

The invention provides a nutritional composition suitable for patients suffering from bone and joint diseases. The nutritional composition is prepared from 20%-40% of marine fish oligopeptides, 10%-30% of ossein protein peptides, 1%-5% of organic calcium, 1%-5% of casein phosphopeptides, 0.1%-1% of a saussurea involucrate culture, 1%-5% of shark cartilage powder, 5%-20% of inulin, 5%-30% of oligopeptides, 0.1%-1% of vitamins, 1%-3% of mineral substances and the like. The marine food which is used for special dietary uses, is suitable for being eaten by the patients suffering from the bone and joint diseases and contains the marine fish oligopeptides and the ossein protein peptides is provided according to physiological characteristics, nutritional requirements and conventional diet defects of the patients suffering from the bone and joint diseases, and the food has the effects of improving the nutritional condition of the organism, promoting rehabilitation of bones and joints, assisting in controlling blood glucose and conditioning the intestinal functions of the organism and the like.

The invention relates to a solid beverage and the preparation method thereof. In the invention a plurality of novel nutritive additives which are blended in reasonable proportions are adopted to achieve the needed effect. The detailed ingredients and the weight proportions (percent) thereof are as follows: 30 to 40 percents of concentrated lactalbumin, 28 to 32 percent of whole milk powder, 5 to 10 percent of oligermerized isomaltiooligosaccharide (IMO), 3.5 to 5 percent of water soluble dietary fiber, 12 to 19 percent of natural fruit powder, 0.8 to 1.5 percent of medium chain triglyceride, 0.9 to 1.5 percent of premix of vitamins and minerals, 0.8 to 1.5 percent of glutamine, 0.7 to 1.2 percent of L-carnitine, 0.2 to 0.5 percent of conjugated linoleic acid, 1 to 1.5 percent of shark cartilage, 3.8 to 5.9 percent of dimethyl sulfone, 0.2 to 0.5 percent of hexadecadienoic acid, 1.5 to 2 percent of amino glucose and 0.5 to 1 percento of glycoprotein. Made by adopting quality protein and carbohydrate as major preferred materials, and adding various novel functional nutritive raw materials properly, the solid beverage is suitable for the population involving with sports.

Compositions with synergistic anti-inflammatory effects in inflammatory diseases resulting from activation and consequent degranulation of mast cells and followed by secretion of inflammatory biomolecules from the activated mast cells, composed of a heavily sulfated, non-bovine proteoglycan such as shark cartilage chondroitin sulfate C, an unrefined olive kernel oil / extract that increases absorption of these compositions in various routes of administration, and one or more of a hexosamine sulfate such as D-glucosamine sulfate, a flavone such as quercetin, S-adenosylmethionine, a histamine-1 receptor antagonist, a histamine-3 receptor agonist, an antagonist of the actions of CRH, caffeine, and a polyamine.

A health-care food for increasing human bone density is proportionally prepared from shark cartilage powder, Ca supplement, VD, epimedium, aminoglucose D-hydrochloride, and chondroitin sulfate. Its preparing process is also disclosed.

A method for extracting shark calcium chondroitin sulfate from a shark cartilage comprises the processes in sequence such as curing, alkalization, enzymatic hydrolysis, deproteinization, crystallization, resin pretreatment, resin exchange, ultrafiltration dehydration, calcification of filtrate and crystallization dehydration dying. Because secondary crystallization is adopted, the covalent binding of protein and shark chondroitin sulfate is broken by hydrogen peroxide to enable the chondroitin sulfate in the protein to be dissociated, impurities such as the protein and the like can be effectively removed to improve the purity and the content of shark sodium chondroitin sulfate; cation resin is adopted to complete the sodium removal process by column chromatography, the exchanged shark chondroitin sulfate is high in concentration and the shark chondroitin sulfate which is produced during ion exchange can be accurately controlled, and the sodium content in the product is low; with dehydration of ultrafiltration, not only the concentration can be realized, but also the small molecular impurities can be removed to improve the purity of the shark chondroitin sulfate, at the same time, to improve the content of calcium. The method also can save the using amount of ethanol and reduce the production cost.

Compositions with synergistic anti-inflammatory effects in inflammatory diseases resulting from activation and consequent degranulation of mast cells and followed by secretion of inflammatory biomolecules from the activated mast cells, composed of a heavily sulfated, non-bovine proteoglycan such as shark cartilage chondroitin sulfate C, and one or more of a hexosamine sulfate such as D-glucosamine sulfate, a flavone such as quercetin, an unrefined kernel olive oil that increases absorption of these compositions in various routes of administration, S-adenosylmethionine, a histamine-1 receptor antagonist, a histamine-3 receptor agonist, an antagonist of the actions of CRH, caffeine, and a polyamine.

The invention provides a health-care medicament and tablet with functions of strengthening immunity, relieving physical fatigue and resisting tumor, as well as a preparation method of the tablet. The medicament comprises the following components: 13 to 20g of broccoli extract, 2 to 8 parts of garlic powder, 1.8 to 6g of shark cartilage, 5.5 to 12g of mushroom extract, 9 to 15g of sea cucumber powder, 0.0005 to 0.001g of seleno-k-carrageenan, 3.6 to 9g of microcrystalline cellulose, 3 to 8g of sorbitol, 6 to 15 parts of mannitol, 0.45 to 1g of sucralose, and 0.3 to 0.8g of magnesium stearate. The preparation method comprises the following steps: crushing the shark cartilage and the sea cucumber powder, screening through a sieve of 80-100 meshes, respectively weighing with other raw and auxiliary materials in certain proportion, and mixing the raw and auxiliary materials for 45 to 50 minutes; tabletting; screening, polishing, and packing the inner part and outer part; and inspecting according to an inspection standard, and putting in storage. The medicament can be used for assisting people to strengthen immunity, relieve physical fatigue and resist tumor, and can be used for improving the living quality of people without side effect or adverse reactions; and the product is safe and stable and has controllable quality by using a modern preparation technology and an advanced quality control method.

The invention discloses a process for co-production of collagen calcium and polypeptide in chondroitin sulfate production. The production process includes: conducting coarse crushing on shark cartilage to a massive size, performing soaking in an acid solution and then conducting filtering, subjecting the filtrate to calcification treatment and alcohol precipitation, conducting secondary washing with alcohol, and then carrying out spin-drying and drying to obtain collagen chelated calcium; subjecting the soaked cartilage to enzymolysis and filtration to obtain a chondroitin sulfate and collagen polypeptide aqueous solution and bone dreg, subjecting the aqueous solution to ultrafiltration separation to obtain a chondroitin sulfate concentrated solution, and performing alcohol precipitation to obtain chondroitin sulfate; and concentrating the ultrafiltrate, and then carrying out spray drying, thus obtaining collagen polypeptide. On the basis of co-production of chondroitin sulfate and collagen polypeptide, the invention also produces another high benefit product at the same time, i.e. collagen chelated calcium, makes full use of the resources in cartilage, performs high value utilization of bone calcium powder in treatment process, and improves the economic value.

The invention discloses low molecular weight peptide of a shark cartilage angiogenesis inhibiting factor, a production purifying method and application thereof. The amino acid sequence of the low molecular weight peptide of the shark cartilage angiogenesis inhibiting factor is shown as SEQ ID NO: 1, and the DNA sequence for coding the low molecular weight peptide is shown as SEQ ID NO:2. The low molecular weight peptide of the shark cartilage angiogenesis inhibiting factor can inhibit generation or growth of vessels or vascular endothelial cells, can inhibit proliferation of tumor cells, can be used for preparing related medicaments for inhibiting generation or growth of the vessels or preparing anti-tumor medicaments.

Compositions with synergistic anti-inflammatory effects in inflammatory diseases resulting from activation and consequent degranulation of mast cells and followed by secretion of inflammatory biomolecules from the activated mast cells, composed of a heavily sulfated, non-bovine proteoglycan such as shark cartilage chondroitin sulfate C, an unrefined olive kernel oillextract that increases absorption of these compositions in various routes of administration, and one or more of a hexosamine sulfate such as D-glucosamine sulfate, a flavone such as quercetin, S-adenosylmethionine, a histamine-1 receptor antagonist, a histamine-3 receptor agonist, an antagonist of the actions of CRH, caffeine, and a polyamine.

The invention discloses a shark cartilage angiogenesis inhibiting factor and a production and purification method and an application. The amino acid sequence of the shark cartilage angiogenesis inhibiting factor of the invention is shown as SEQ ID NO:1, and the cDNA sequence coding the amino acid sequence of the shark cartilage angiogenesis inhibiting factor is shown as SEQ ID NO:2. The shark cartilage angiogenesis inhibiting factor has the effects of inhibiting the growth of vascular endothelial cells and the blood vessel, and can be applied to the preparation of medicines for inhibiting the angiogenesis or vessel growth, in particular the tumor angiogenesis or tumor vessel growth.

Compositions with synergistic anti-inflammatory effects in inflammatory diseases resulting from activation and consequent degranulation of mast cells and followed by secretion of inflammatory biomolecules from the activated mast cells, composed of a heavily sulfated, non-bovine proteoglycan such as shark cartilage chondroitin sulfate C, an unrefined olive kernel oil / extract that increases absorption of these compositions in various routes of administration, and one or more of a hexosamine sulfate such as D-glucosamine sulfate, a flavone such as quercetin, S-adenosylmethionine, a histamine-1 receptor antagonist, a histamine-3 receptor agonist, an antagonist of the actions of CRH, caffeine, and a polyamine.

A process for obtaining an angiogenesis inhibitor and an angiogenesis activator from shark cartilage comprising, as the key step, the aqueous extraction of dried shark cartilage. The angiogenesis inhibitor obtained is more potent than shark cartilage not subjected to the extraction step. The angiogenesis inhibitor is particularly useful for the prevention or treatment of cancer. The angiogenesis activator is particularly useful for stimulating wound healing.

The invention discloses colza oil with calcium supplement and health care functions, and relates to the technical field of biological medicines. The colza oil is composed of the following raw materials like rap oil, rapeseeds, tea oil, walnut oil, corn oil, broad beans, oysters, shark cartilage, loquat seeds, sorghums and raisins. The preparation method comprises the steps of A oyster preparation and tea oil preprocessing, B shark cartilage preprocessing, C loquat seed preprocessing, D squeezing, E alkali washing, F washing, G refined filtration, H mixing and I freezing. The colza oil has the advantages that nutrition is complete, calcium can be supplemented, and the colza oil is edible fat and oil, and is suitable for people lacking calcium, children and the old.

The invention belongs to the field of food, and discloses a composition for preventing or treating joint diseases. The composition is mainly prepared from the following raw materials: zaocys dhumnade,eucommia flower, pawpaw, coix lacryma-jobi, pseudo-ginseng, beautiful millettia root, ginseng, cartilage, sugar and peptide. The prepared composition taking zaocys dhumnade, eucommia flower, coix lacryma-jobi, pawpaw, pseudo-ginseng, beautiful millettia root and ginseng as raw materials integrally has the effects of strengthening tendons and activating collaterals, expelling wind-damp and relieving arthralgia, tonifying liver and kidney and strengthening tendons and bones; shark cartilage powder, chitosan oligosaccharide and bovine bone collagen peptide are adopted for matching to lubricate joints. The composition has a good prevention or treatment effect on joint diseases, especially joint diseases caused by knee joint degenerative changes, can effectively improve symptoms such as ankylosis and aching pain, and has no side effect after long-term administration.

The invention relates to an extraction method of chondroitin, particularly to an extraction process of shark chondroitin, and belongs to the technical field of natural product extraction. According to the extraction process, an enzymic method, membrane separation and carbon dioxide supercritical extraction are integrated. The extraction process comprises the steps as follows: taking fresh shark cartilage, washing the shark cartilage clean, crushing the shark cartilage into fine powder, and extracting the fine powder in a NaOH solution to obtain an extract liquid; adjusting the pH of the extract liquid, and then adding trypsin for enzymolysis to obtain enzymatic hydrolysate; performing enzyme deactivation on the enzymatic hydrolysate, filtering the enzymatic hydrolysate with an ultra-filtration membrane to obtain an ultra-filtration permeate, and filtering the permeate with a nanofiltration membrane to obtain a concentrated solution; and spray-drying the concentrated solution into powder, feeding the powder into an extraction kettle for carbon dioxide supercritical extraction to obtain chondroitin solids. An integrated extraction process of the shark chondroitin is adopted, and the extraction process has the characteristics of high yield and high product purity.

The present pertains to the field of traditional Chinese medicine, more specifically a capsule for increasing compact bone substance density and delaying senescence, which is prepared from soybean isoflavones, shark cartilage micropowder, calcium carbonate, vitamin B6, folic acid and medicinal auxiliary materials.

The invention discloses a sugar-free shark fin bone meal tablet candy for preventing tumors and improving immunity, and a production technology thereof. Raw materials of the tablet candy comprise, by mass, 30-50 parts of shark cartilage meal, 5-10 parts of sorbitol, 5-10 parts of magnesium stearate, 20-30 parts of soybean protein powder, 4-6 parts of spirulina, and 2-3 parts of composite Chinese herbal medicine extract, wherein the composite Chinese herbal medicine extract is aqueous extract of a mixture of Herba Houttuyniae, Herba Taraxaci, hawthorn fruit, purslane, sea-tangle, Radix Scutellariae, fig, dark plum, wild chrysanthemum flower, Sarcandra glabra, licorice root and Stevia Rebaudiana Bertoni. The tablet candy has the advantages of synergism of the shark cartilage meal and other raw materials due to scientific compatibility, tumor and fatigue preventing efficacy, safety, no side effects, convenient eating, and good market application prospect.

Compositions for primarily addressing degenerative complaints, in particular joint related conditions such as arthritis and rheumatism, in which there may also be associated inflammation, are provided. Other potential uses are also discussed, as well as prophylactic and curative applications. Preferred embodiments incorporate green-lip mussel products (particularly GLME) with shark cartilage or chondroitin compounds, and plant and bark based antioxidants are employed in a number of embodiments.

The invention relates to a solid beverage and the preparation method thereof. In the invention a plurality of novel nutritive additives which are blended in reasonable proportions are adopted to achieve the needed effect. The detailed ingredients and the weight proportions (percent) thereof are as follows: 30 to 40 percents of concentrated lactalbumin, 28 to 32 percent of whole milk powder, 5 to 10 percent of oligermerized isomaltiooligosaccharide (IMO), 3.5 to 5 percent of water soluble dietary fiber, 12 to 19 percent of natural fruit powder, 0.8 to 1.5 percent of medium chain triglyceride, 0.9 to 1.5 percent of premix of vitamins and minerals, 0.8 to 1.5 percent of glutamine, 0.7 to 1.2 percent of L-carnitine, 0.2 to 0.5 percent of conjugated linoleic acid, 1 to 1.5 percent of shark cartilage, 3.8 to 5.9 percent of dimethyl sulfone, 0.2 to 0.5 percent of hexadecadienoic acid, 1.5 to 2 percent of amino glucose and 0.5 to 1 percento of glycoprotein. Made by adopting quality protein and carbohydrate as major preferred materials, and adding various novel functional nutritive raw materials properly, the solid beverage is suitable for the population involving with sports.

The invention discloses a coarse cereal electuary with effects of tonifying deficiency, fending off cold and benefiting intelligence and a preparation method of the coarse cereal electuary. The coarse cereal electuary is made of main materials and auxiliary materials, comprises the following main materials in parts by weight: 6-11 parts of cassawa, 5-10 parts of henry steudnera tubers, 8-14 parts of black soya beans, 4-8 parts of sorghum, 5-10 parts of semen euryales and 6-12 parts of broom corn millet, and comprises the following auxiliary materials in parts by weight: 3-5 parts of red dates, 2-5 parts of fructus lycii, 2-6 parts of maltose, 6-9 parts of raisin, 5-10 parts of shrimp meal, 10-16 parts of bean curd powder, 7-13 parts of shark cartilage, 3-6 parts of colza oil and 6-9 parts of fish meal. The coarse cereal electuary with the effects of tonifying the deficiency, fending off the cold and benefiting the intelligence is rich in elements, and has the effects of hematogenesis, beautifying, intelligence benefiting, brain reinforcing a and faint scent and smooth taste.

The invention provides a health-care product for promoting the development of cat head bone and cheek muscles. The health-care product comprises the following components: quinoa, flaxseeds, broccoli,pumpkin seed powder, rhizoma dioscoreae, semen armeniacae, xanthophyll, haematococcus pluvialis, chlorella, astragalus polysaccharide, bromelain, ganoderan, fucoidin, ginseng polypeptide, green lippedmussel, oyster peptide, sea cucumber peptide, fish collagen peptide, bovine bone protein peptide, deep sea fish oil DHA, shark chondroitin, whey protein, astaxanthin, vitamin A, vitamin B1, vitamin B3, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, zinc gluconate, calcium caseinate, taurine, lysine, methionine, lysine, threonine, leucine, valine, isoleucine, animal-type compound aminoacid, chicken meal, cod meal, lactic acid bacteria, hawthorn yeast powder and fruit and vegetable enzyme powder. The health-care product is balanced in nutrition and quick to absorb; and various nutrient substances promote the development of cat head and face bones and cat muscles.

The invention provides a composition for improving bone health and application thereof, and the composition comprises the following components in parts by mass: 10 to 30 parts of shark cartilage powder, 1 to 5 parts of collagen, 30 to 60 parts of coconut powder and 1 to 5 parts of milk mineral salt. The composition provided by the invention is different from the traditional health care product formula chondroitin sulfate + collagen + calcium carbonate, and milk mineral salts are added as a calcium source, cucumber seed powder and coconut powder are further added, a reasonable combination is achieved, a synergistic effect among various components is realized so that the composition can effectively supplement calcium, promote calcium absorption and deposition, increase bone weight and bone density, and significantly increase bone calcium content to 200 mg / g or more, thereby preventing and treating diseases including osteoporosis, bone health is improved, the quality of life of middle-aged and elderly people is improved.

The invention relates to an extraction process of shark chondroitin, which comprises the following steps: (1) pretreatment of shark cartilage: boiling the shark cartilage in clear water for 3-4 hours, cooling the boiled shark cartilage, washing away protein and grease on the surface of the shark cartilage with clear water, drying the cleaned shark cartilage in an air-blowing dryer until the weight of the shark cartilage is constant, crushing the dried shark cartilage by using a crusher, and further crushing the crushed shark cartilage by using an ultrafine crusher to obtain shark cartilage ultrafine powder; (2) alkali extraction: weighing the shark cartilage ultrafine powder, adding a sodium hydroxide solution for soaking according to a solid-to-liquid ratio of 1: 30, and placing the soaked shark cartilage ultrafine powder in a shaking table for oscillation; and (3) centrifuging: putting the mixed solution subjected to oscillation hydrolysis into a centrifugal machine for centrifuging, and reserving supernate for later use after centrifuging. By using an enzymolysis-resin extraction method, the yield and purity of chondroitin sulfate are improved, and processing leftovers of shark fins and related products are fully utilized.

The invention relates to a medicament for treating liver cancer, in particular to a medicament for treating liver cancer by combining traditional Chinese medicine and western medicine. The medicament is prepared from the following raw medicine materials: 20g of shark cartilage, 10g of basil polysaccharide, 10g of puerarin, 10g of vitamin C, 20g of pulvis corn, 20g of antelope horn powder, 20g of centipede, and 20g of American ginseng. A preparation method of the medicament adopts the following steps of: preparing the antelope horn powder, the centipede and the American ginseng and uniformly mixing; pulverizing by using an ultramicro pulverizer; sieving by a sieve of 100 meshes to obtain fine powder; uniformly mixing the fine powder and rest of raw medicine materials; and finally encapsulating. The preparation method has the characteristics of simple preparation process, small medicament loss and easy industrial production.

The invention relates to a shark cartilage glycoprotein and an anti-cancer application thereof. The shark cartilage glycoprotein is prepared by crushing shark cartilage; extracting the shark cartilagewith alkaline water; and salting out, removing free proteins and purifying the shark cartilage to obtain an active component of the shark cartilage. A pharmacological experiment displays that the shark cartilage glycoprotein has remarkable anti-angiogenesis action and also can inhibit proliferation of cells such as skin cancer, breast cancer, non-small cell lung cancer, liver cancer, gastric cancer and ovarian cancer. An in vivo experiment also shows an excellent anti-tumor effect, and the shark cartilage glycoprotein can be widely applied to preventing and treating cancers.

The invention discloses a shark fin bone meal solid beverage with blood fat lowering efficacy. The solid beverage comprises 40-60 parts of shark fin bone meal, 20-30 parts of blueberry powder, 5-10 parts of calcium gluconate, 3-5 parts of xylitol and 1-2 parts of composite Chinese herbal medicine extract; and the composite Chinese herbal medicine extract is a water extract prepared from 8-12 parts of saffron, 10-15 parts of Polygonum multiflorum, 15-20 parts of radix bupleuri, 10-13 parts of Rhizoma Alismatis, 8-12 parts of Rhizoma Polygoni Cuspidati, 10-15 parts of rheum officinale, 10-16 parts of hawthorn fruit, 10-18 parts of Artemisia capillaris, 5-10 parts of Rhizoma curcumae longae, 5-10 parts of Mythic Fungus, 10-15 parts of licorice root and 10-15 parts of Stevia Rebaudiana Bertoni through an ultrasonic wave assisted enzymatic hydrolysis + water decoction technology. The solid beverage has the advantages of good blood fat lowering efficacy, safety, no side effects and convenient drinking.

The invention relates to a composition for inhibiting alopecia and / or promoting hair growth, which is characterized in that the composition comprises the following components by part: 1 to 50 parts of shark cartilage extractive, 1 to 50 parts of muntingia calabura extractive, 1 to 50 parts of equisetum extractive, 1 to 50 parts of cod liver oil and 1 to 50 parts of frenugreek extractive, and other nutrition compositions, such as vitamin C, vitamin E, chondroitin sulfate, immune globulin, etc., can be optionally added. The composition can be prepared into various preparations for oral administration by compounding with pharmaceutically acceptable carriers and additives. Animal experiments prove that the composition has good curative effects of inhibiting alopecia and / or promoting hair growth.