This invention provides a pharmaceutical composition for promoting fracture healing, its preparation method, and its application. The composition, by weight, comprises 25-50 parts of an
active core component, 8-25 parts of an osteogenic synergistic bioactive component, 3-15 parts of a bone-targeting
transdermal penetration enhancer, and 5-15 parts of a moisturizing dispersant. The
active core component is based on bone-healing traditional Chinese medicines such as calcined natural
copper nanoparticles and
Eupolyphaga sinensis polypeptides. The osteogenic synergistic component is based on collagen peptides of specific molecular weights and graded
sodium hyaluronate. The bone-targeting
transdermal penetration enhancer is a compound of
eugenol and
limonene. This invention utilizes a three-dimensional synergistic formulation structure and a phase-separated low-temperature preparation process, overcoming the shortcomings of traditional topical medications, such as poor transdermal targeting, weak
efficacy, easy inactivation, and low safety. It can achieve targeted enrichment at fracture ends, synergistically promoting fracture healing throughout its
entire life cycle, and simultaneously repairing bone and
soft tissue. It is suitable for promoting the repair of various fractures and possesses extremely high
clinical value and promising prospects for widespread application.