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80 results about "Biomechanical model" patented technology

Simulation Method of Soft Tissue Deformation Based on Meshless Galerkin and Particle Spring Coupling

The invention relates to an object deformation real-time simulation graphic processing technique, particularly a soft tissue deformation simulation method based on coupling of mesh-free Galerkin and mass spring, which comprises the following steps: in the pretreatment process, establishing a linear viscoelasticity biomechanical model for soft tissues; in the deformation computation process, dynamically partitioning a mesh-free region and a mass spring region according to the load carried by the soft tissues, establishing a transitional unit of the connection region between the mesh-free region and mass spring region, and constructing a transitional unit approximation displacement function, thereby implementing self-adapting coupling of a mesh-free Galerkin method and a mass spring method;and in the after-treatment process, outputting the state of the mass or node of each time step in the deformation process onto a screen, carrying out illumination rendering, and finally displaying the real-time deformation process of the soft tissue organ under stressed conditions on the screen, thereby implementing visualization effect of dynamic deformation. By utilizing the advantage of high efficiency in the mass spring method and the advantages of high precision and no need of mesh reconstruction in the mesh-free Galerkin method, the invention overcomes the defect that the Galerkin method is not suitable for solving a large-scale problem, thereby effectively lowering the complexity of computation in the soft tissue deformation simulation and enhancing the operation efficiency.
Owner:NORTH CHINA UNIV OF WATER RESOURCES & ELECTRIC POWER

Use of an in vitro hemodynamic endothelial/smooth muscle cell co-culture model to identify new therapeutic targets for vascular disease

An in vitro biomechanical model used to applied hemodynamic (i.e., blood flow) patterns modeled after the human circulation to human / animal cells in culture. This model replicates hemodynamic flow patterns that are measured directly from the human circulation using non-invasive magnetic resonance imaging and translated to the motor that controls the rotation of the cone. The cone is submerged in fluid (i.e., cell culture media) and brought into close proximity to the surface of the cells that are grown on the plate surface. The rotation of the cone transduces momentum on the fluid and creates time-varying shear stresses on the plate or cellular surface. This model most closely mimics the physiological hemodynamic forces imparted on endothelial cells (cell lining blood vessels) in vivo and overcomes previous flow devices limited in applying more simplified nonphysiological flow patterns. Another aspect of this invention is directed to incorporate a transwell co-cultured dish. This permits two to three or more different cell types to be physically separated within the culture dish environment, while the inner cellular surface is exposed to the simulated hemodynamic flow patterns. Other significant modifications include custom in-flow and out-flow tubing to supply media, drugs, etc. separately and independently to both the inner and outer chambers of the coculture model. External components are used to control for physiological temperature and gas concentration. The physical separation of adherent cells by the artificial transwell membrane and the bottom of the Petri dish permits each cell layer, or surface to be separately isolated for an array of biological analyses (i.e., protein, gene, etc.).
Owner:HEMOSHEAR LLC +1

Semi-on-body biomechanical experimental method using cervical structure to simulate extensor muscles behind the neck

ActiveCN101853599AAvoid interferenceEducational modelsHuman bodySecond dorsal vertebra
The invention discloses a semi-on-body biomechanical experimental method using a cervical structure to simulate extensor muscles behind the neck. The method comprises the following steps: cutting out the first to seventh cervical vertebra, the first dorsal vertebra and the second dorsal vertebra from the body of a person who died within 2 hours, removing muscles while avoiding damaging ligaments and facet joints; fixing an upper bearing tray on the first cervical vertebra, fixing a lower bearing tray under the second dorsal vertebra, installing a loading weight on the upper bearing tray; opening 2-3mm of incisions separately at the front junctions and back joints of the third/fourth dorsal vertebra, the fourth/fifth dorsal vertebra, the fifth/sixth dorsal vertebra and the sixth/seventh dorsal vertebra, inserting miniature pressure sensors respectively, sewing with silk threads; connecting a tension sensor and a tension spring between the upper and lower bearing trays to prepare a cervical vertebra biomechanical model; and fixing a pulling-extending force sensor on a cervical vertebra experimental loading table, connecting a wedge-shaped metal block with the upper bearing tray through screws, using the loading table to apply a pulling-extending force and a loading force on the cervical vertebra biomechanical model, and recording the measured values.
Owner:YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE

Method and system for interactive computation of cardiac electromechanics

A method and system for simulating cardiac function of a patient is disclosed. A patient-specific anatomical model of at least a portion of the patient's heart is generated from medical image data of the patient. Cardiac electrophysiology potentials are calculated over a computational domain defined by the patient-specific anatomical model for each of a plurality of time steps using a patient-specific cardiac electrophysiology model. The electrophysiology potentials acting on a plurality of nodes of the computational domain are calculated in parallel for each time step. Biomechanical forces over the computational domain for each of the plurality of time steps using a cardiac biomechanical model coupled to the cardiac electrophysiology model. The biomechanical forces acting on a plurality of nodes of the mesh domain are estimated in parallel for each time step. Blood flow and cardiac movement are computed at each of the plurality of time steps based on the calculated biomechanical forces. Computed electrophysiology potentials, biomechanical forces and cardiac parameters are displayed, user input is interactively received to change at least one of the parameters of the patient-specific models, and the electrophysiology potentials, the biomechanical forces, and the blood flow and cardiac movement are recalculated.
Owner:SIEMENS HEALTHCARE GMBH

Manufacturing method of three-dimensional fixation plate for repairing fracture lower jawbone and three-dimensional fixation plate

The invention discloses a manufacturing method of a three-dimensional fixation plate for repairing a fracture lower jawbone and the three-dimensional fixation plate. The manufacturing method comprises the following steps: constructing a biomechanical model of a standard lower jawbone, and making a regional fracture fixation principle; and for the to-be-reconstructed lower jawbone, acquiring CT data of the to-be-reconstructed lower jawbone, conducting three-dimensional reconstruction and manufacturing the three-dimensional fixation plate. The three-dimensional fixation plate comprises a main connecting plate and a plurality of auxiliary connecting plates for connecting the fracture part of the to-be-repaired lower jawbone, wherein both the main connecting plate and the auxiliary connecting plates fit to the outer surface of the fracture part of the to-be-repaired lower jawbone; and the main connecting plate and the auxiliary connecting plates are fixedly connected to the to-be-repaired lower jawbone by virtue of titanium nails. The three-dimensional fixation plate disclosed by the invention has the beneficial effects that the three-dimensional fixation plate, which can achieve good matching with bones of a patient, is good in retention force and stability, so that the accuracy of lower jawbone fracture rigid internal fixation treatment is improved.
Owner:ZHEJIANG UNIV OF TECH
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