The invention relates to an object deformation real-time simulation graphic processing technique, particularly a soft tissue deformation simulation method based on coupling of mesh-free Galerkin and mass spring, which comprises the following steps: in the pretreatment process, establishing a linear viscoelasticity biomechanical model for soft tissues; in the deformation computation process, dynamically partitioning a mesh-free region and a mass spring region according to the load carried by the soft tissues, establishing a transitional unit of the connection region between the mesh-free region and mass spring region, and constructing a transitional unit approximation displacement function, thereby implementing self-adapting coupling of a mesh-free Galerkin method and a mass spring method;and in the after-treatment process, outputting the state of the mass or node of each time step in the deformation process onto a screen, carrying out illumination rendering, and finally displaying the real-time deformation process of the soft tissue organ under stressed conditions on the screen, thereby implementing visualization effect of dynamic deformation. By utilizing the advantage of high efficiency in the mass spring method and the advantages of high precision and no need of mesh reconstruction in the mesh-free Galerkin method, the invention overcomes the defect that the Galerkin method is not suitable for solving a large-scale problem, thereby effectively lowering the complexity of computation in the soft tissue deformation simulation and enhancing the operation efficiency.