Fracture heal dynamic process simulation method based on biological mechanism

A fracture healing and dynamic process technology, applied in computer-aided medical procedures, informatics, medical simulation, etc., can solve problems such as the inability to comprehensively simulate the dynamic change of callus shape, the complex relationship between mechanical environment changes and biological environment changes, and achieve relief. Socioeconomic burden, cost saving, and time saving effects

Inactive Publication Date: 2016-12-14
HARBIN UNIV OF SCI & TECH
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Problems solved by technology

[0004] The purpose of the present invention is to solve the shortcoming that the existing fracture healing dynamic process model cannot comprehensively simulate the complex relationship between the dynamic change of the callus shape, the mechanical environment change and the biological environment change in the fracture healing process, and propose a biological Simulation method of fracture healing dynamic process based on scientific mechanism

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  • Fracture heal dynamic process simulation method based on biological mechanism
  • Fracture heal dynamic process simulation method based on biological mechanism
  • Fracture heal dynamic process simulation method based on biological mechanism

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specific Embodiment approach 1

[0039] Embodiment 1: A method for simulating the dynamic process of fracture healing based on biological mechanisms in this embodiment is specifically carried out in accordance with the following steps:

[0040] Step 1, the establishment of three-dimensional geometric model;

[0041] Step 2, importing the obtained three-dimensional geometric model into meshing software for meshing;

[0042] Step 3, establishing a biomechanical model of bone and callus on the basis of grid division;

[0043] Step 4, on the basis of the biomechanical model of bone and callus, determine the initial parameters of the simulation and apply the load and boundary conditions;

[0044] Step five, on the basis of step four, carry out the simulation design of the dynamic change of callus shape;

[0045] Step 6. Establish a deterministic mathematical model of bone density and cartilage density over time in different initial bone internal stress environments in normal blood supply areas;

[0046] Step 7,...

specific Embodiment approach 2

[0048] Specific embodiment two: the difference between this embodiment and specific embodiment one is: the establishment of the three-dimensional geometric model in the step one; the specific process is:

[0049] Using the segmentation-based 3D medical image surface reconstruction algorithm to reconstruct the 3D surface of the image to obtain a 3D geometric model;

[0050] The image is obtained by imaging equipment CT, and the data storage format is DICOM.

[0051]The process of constructing the solid model from the surface model is to construct the surface list of the solid model from the triangular slice sequence of the surface model and the upper and lower bottom surfaces, and construct the vertex list of the solid model from the vertex sequence of the surface model, and simultaneously establish the body, ring, edge and half edge The linked list and the pointing relationship of the nodes in each linked list. The solid construction process expressed by the boundary model is...

specific Embodiment approach 3

[0053] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is: the three-dimensional geometric model obtained in the described step 2 is imported into the grid division software to carry out grid division; the specific process is:

[0054] Because the grid division software will generate a lot of data, the present invention only needs node coordinates and unit numbers, imports the obtained 3D geometric model into MATLAB for preprocessing, only extracts the target data, and generates the required data for subsequent finite element calculations based on the target data. Two files of unit number and node coordinates;

[0055] The two files of the unit number and node coordinates are files in txt text format;

[0056] The node coordinate file contains three columns of data, and the three columns of data represent the spatial coordinate values ​​of each node;

[0057] The unit number file contains four columns of data, which are the...

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Abstract

A fracture heal dynamic process simulation method based on a biological mechanism aims solve the problems that an existing fracture heal dynamic process model cannot integrally simulate complex relations between dynamic changes, mechanics environment changes and biology environment changes of a callus shape in a fracture healing process; the novel method comprises the following steps: 1, building a three dimensional geometry model; 2, dividing grids; 3, building a bone and callus biomechanics model; 4, determining simulation initial parameters and application loads, and boundary conditions; 5, deciding a normal blood supply unit and an non-normal blood supply unit, executing step6 for a normal blood supply zone, and executing step7 for a non-normal blood supply zone; 6, building a normal blood supply zone determinacy mathematics model; 7, building a non-normal blood supply zone fuzzy mathematics model; 8, building a bone fracture healing simulation process according to steps 6 and 7. The fracture heal dynamic process simulation method is applied to the biomedical engineering field.

Description

technical field [0001] The invention relates to a method for simulating the dynamic process of fracture healing based on biological mechanism. Background technique [0002] In fact, not all fractures can be repaired, sometimes there will be non-repair or delayed repair, delayed union or non-union of fractures will cause pain in the affected limb, dysfunction, and cause unemployment for patients. Due to the large number of fracture accidents per year, fractures The number of people with delayed or non-healing is considerable, and the resulting socioeconomic burden will be substantial. Fracture delayed union or nonunion is affected by specific geometric factors, mechanical factors, and biological factors. Therefore, the research on the fracture healing process and its influence on the speed and quality of fracture healing has been receiving much attention, and some achievements have been made. However, due to the limitations of research methods and the complexity of the fract...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/00
CPCG16H50/50
Inventor 王沫楠
Owner HARBIN UNIV OF SCI & TECH
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