Skeletal muscle mechanical behavior multiscale modeling method

A technology of skeletal muscle mechanics and modeling methods, which is applied in the field of multi-scale modeling of skeletal muscle mechanical behavior, and can solve problems such as unrealization and simulation

Inactive Publication Date: 2016-12-07
HARBIN UNIV OF SCI & TECH
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  • Abstract
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  • Application Information

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Problems solved by technology

[0003] The present invention proposes a multi-scale modeling method for skeletal muscle mechanical behavior in order to solve the problem that the prior art cannot realize the complete process simulation from cell electrophysiological action potential activation to skeletal muscle mechanical output

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  • Skeletal muscle mechanical behavior multiscale modeling method
  • Skeletal muscle mechanical behavior multiscale modeling method
  • Skeletal muscle mechanical behavior multiscale modeling method

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specific Embodiment approach 1

[0026] Specific embodiment 1: A method for multi-scale modeling of skeletal muscle mechanical behavior includes the following steps:

[0027] Step 1: Determine the position and posture of muscle fibers;

[0028] Step 2: Establish the skeletal muscle macroscopic geometric model and the skeletal muscle micro geometric model according to step one;

[0029] Step 3: Mesh the geometric model established in Step 2;

[0030] Step 4: Model the electrophysiological characteristics of skeletal muscle according to Step 3.

[0031] Step 5: Perform multi-scale calculations between cells and muscle tissues according to Steps 3 and 4;

[0032] Step 6: Establish a multi-scale biomechanical model of skeletal muscle according to Step 5;

[0033] Step 7: Perform muscle strength prediction according to Step 6.

[0034] The skeletal muscle multi-scale model and simulation overall design plan of the present invention is as Figure 5 Shown.

specific Embodiment approach 2

[0035] Specific embodiment two: This embodiment is different from the specific embodiment one in that the specific process of determining the position and posture of the muscle fiber in the step one is:

[0036] In the model analysis, the material and the direction of the muscle fibers are defined by the element coordinate system. Establish a rectangular coordinate system on the muscle fiber voxel. The radial direction of the voxel is along the axial direction of the muscle fiber. The other two coordinate axes of the voxel are in a plane perpendicular to the muscle fiber. The rectangular coordinate system is the local coordinate system of the geometric model. Such as figure 2 As shown; the global coordinate system is placed at the geometric center of the skeletal muscle, and the position and posture of the muscle fiber are determined by the connection relationship between the local coordinate system and the global coordinate system, such as image 3 Shown.

[0037] Other steps and...

specific Embodiment approach 3

[0038] Specific embodiment three: This embodiment is different from specific embodiment one or two in that the specific process of establishing the skeletal muscle macroscopic geometric model and the skeletal muscle micro geometric model in the second step is:

[0039] Step 2: Build a macroscopic geometric model of skeletal muscle

[0040] The volumetric data of the medical image of muscle is acquired by MRI equipment. After the medical image is acquired, image preprocessing is performed, the preprocessed image is segmented, and three-dimensional reconstruction is performed after image segmentation to obtain the skeletal muscle macroscopic geometric model; perform skeletal muscle geometric modeling The steps are as figure 1 Shown.

[0041] Step 2: Build a microscopic geometric model of skeletal muscle

[0042] Through diffusion tensor magnetic resonance DT-MRI, microscopic information such as fiber angle can be obtained, and the actual fiber distribution in the pinnate muscle can be d...

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Abstract

The invention relates to a skeletal muscle mechanical behavior multiscale modeling method and aims at solving the problem in the prior art that a complete process from cell electrophysiologic action potential activation to skeletal muscle mechanical output cannot be simulated. The method comprises the steps of S1, determining positions and attitudes of muscle fibers; S2, establishing a skeletal muscle macroscopic geometric model and a skeletal muscle microcosmic geometric model according to the S1; S3, carrying out grid division on the geometric models established in the S2; S4, carrying out skeletal muscle electrophysiologic property modeling according to the S3; S5, carrying out multiscale calculation between cells and muscle tissues according to the S3 and S4; S6, establishing a skeletal muscle multiscale biomechanics model according to the S5; and S7, predicting muscular force according to the S6. The method is applied to the field of biomedical engineering.

Description

Technical field [0001] The invention relates to a multi-scale modeling method of skeletal muscle mechanical behavior. Background technique [0002] For the analysis and exploration of skeletal muscle function, the current research is almost entirely focused on in vivo and in vitro experimental tests, or using anatomical inference algorithms to judge the role of muscles based on the start and end points of the muscles and the positional relationship between them and the joints; or use muscles The electrogram is combined with telemetry technology and rapid photography to determine the function of the muscles by measuring the muscle activity of different parts when the human body does various exercises. Due to the complex anatomical properties of skeletal muscle and the limitations of experimental methods, the experimental results can only reflect the macroscopic and comprehensive characteristics of skeletal muscle function, and cannot objectively judge the microscopic origin of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F17/50G06F19/00
CPCG06F19/34G06F30/20
Inventor 王沫楠
Owner HARBIN UNIV OF SCI & TECH
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