Skeletal muscle mechanical behavior multiscale modeling method
A technology of skeletal muscle mechanics and modeling methods, which is applied in the field of multi-scale modeling of skeletal muscle mechanical behavior, and can solve problems such as unrealization and simulation
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specific Embodiment approach 1
[0026] Specific embodiment 1: A method for multi-scale modeling of skeletal muscle mechanical behavior includes the following steps:
[0027] Step 1: Determine the position and posture of muscle fibers;
[0028] Step 2: Establish the skeletal muscle macroscopic geometric model and the skeletal muscle micro geometric model according to step one;
[0029] Step 3: Mesh the geometric model established in Step 2;
[0030] Step 4: Model the electrophysiological characteristics of skeletal muscle according to Step 3.
[0031] Step 5: Perform multi-scale calculations between cells and muscle tissues according to Steps 3 and 4;
[0032] Step 6: Establish a multi-scale biomechanical model of skeletal muscle according to Step 5;
[0033] Step 7: Perform muscle strength prediction according to Step 6.
[0034] The skeletal muscle multi-scale model and simulation overall design plan of the present invention is as Figure 5 Shown.
specific Embodiment approach 2
[0035] Specific embodiment two: This embodiment is different from the specific embodiment one in that the specific process of determining the position and posture of the muscle fiber in the step one is:
[0036] In the model analysis, the material and the direction of the muscle fibers are defined by the element coordinate system. Establish a rectangular coordinate system on the muscle fiber voxel. The radial direction of the voxel is along the axial direction of the muscle fiber. The other two coordinate axes of the voxel are in a plane perpendicular to the muscle fiber. The rectangular coordinate system is the local coordinate system of the geometric model. Such as figure 2 As shown; the global coordinate system is placed at the geometric center of the skeletal muscle, and the position and posture of the muscle fiber are determined by the connection relationship between the local coordinate system and the global coordinate system, such as image 3 Shown.
[0037] Other steps and...
specific Embodiment approach 3
[0038] Specific embodiment three: This embodiment is different from specific embodiment one or two in that the specific process of establishing the skeletal muscle macroscopic geometric model and the skeletal muscle micro geometric model in the second step is:
[0039] Step 2: Build a macroscopic geometric model of skeletal muscle
[0040] The volumetric data of the medical image of muscle is acquired by MRI equipment. After the medical image is acquired, image preprocessing is performed, the preprocessed image is segmented, and three-dimensional reconstruction is performed after image segmentation to obtain the skeletal muscle macroscopic geometric model; perform skeletal muscle geometric modeling The steps are as figure 1 Shown.
[0041] Step 2: Build a microscopic geometric model of skeletal muscle
[0042] Through diffusion tensor magnetic resonance DT-MRI, microscopic information such as fiber angle can be obtained, and the actual fiber distribution in the pinnate muscle can be d...
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