A probiotic and its application in secondary osteoporosis

An osteoporosis and secondary technology, applied in the field of microorganisms, can solve the problems of huge economic burden for patients, and achieve the effect of promoting bone formation in vivo and improving expression

Active Publication Date: 2022-07-12
安徽善和生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these drugs may have safety, tolerability and other issues, and bring huge economic burden to patients

Method used

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  • A probiotic and its application in secondary osteoporosis
  • A probiotic and its application in secondary osteoporosis
  • A probiotic and its application in secondary osteoporosis

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Experimental program
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Embodiment 1

[0024] 1. Materials and methods

[0025] 1.1 Laboratory Strain

[0026] Lactobacillus plantarum HFY15 was isolated from yak yogurt in Sichuan Province, China. It was identified as lactic acid bacteria, LAB by 16S rDNA sequence. The center (abbreviated as CGMCC, the address is: Institute of Microbiology, Chinese Academy of Sciences, No. 3, No. 1 Beichen West Road, Chaoyang District, Beijing), and the deposit registration number is CGMCC No.16648.

[0027] Lactobacillus plantarum HFY15 isolated and purified from yak yogurt samples showed positive Gram staining; the colonies were mostly white or milky white in color, round in shape, neat in edges, and moist and smooth on the surface. There are long rods, short rods, spherical shapes, and there is no budding.

[0028] The 16S rDNA base sequence of the strain HFY15 of the present invention is shown in SEQ ID No. 1; the sequencing results are compared on the NCBI website (http: / / blast.ncbi.nlm.nih.gov / Blast.cgi) . Same as Lactob...

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Abstract

The invention discloses a probiotic and its application in secondary osteoporosis, belonging to the technical field of microorganisms. The Lactobacillus plantarum HFY15 belongs to the genus of lactic acid bacteria (LAB), and the preservation number is CGMCC No. 16648; The present invention separates and identifies Lactobacillus plantarum HFY15 from natural yak yogurt; the present invention establishes a rat secondary osteoporosis (OP) model by using retinoic acid, and studies the preventive effect of HFY15 on OP; the results show that HFY15 Supplementation of Osteoarthritis increased the expression of osteogenic marker genes, inhibited the expression of osteoclast genes, and stimulated bone formation; the findings provided a new and effective strategy for the prevention and treatment of OP.

Description

technical field [0001] The invention relates to the technical field of microorganisms, in particular to a probiotic and its application in secondary osteoporosis. Background technique [0002] Secondary osteoporosis (OP) is caused by certain diseases and treatments that interfere with bone density and lead to bone loss. As many as 30% of postmenopausal women and 50% of men may be at potential risk for osteoporosis. People with early-stage osteoporosis generally have no symptoms, and osteoporosis often goes undetected for years until a person breaks a bone. Common fractures associated with osteoporosis include hip, wrist or spine fractures. Osteoporosis occasionally causes symptoms, and the underlying pathogenesis of secondary osteoporosis is often multifactorial. Proper treatment of osteoporosis can reduce the risk of fractures and prevent unnecessary treatment with anti-resorptive drugs. [0003] Many diseases, medications, and lifestyle factors can cause secondary oste...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/20A61K35/747A61P19/10C12R1/25
CPCC12N1/20A61K35/747A61P19/10C12R2001/25C12N1/205Y02A50/30
Inventor 赵欣刘新红
Owner 安徽善和生物科技有限公司
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