179 results about "Diseases skin" patented technology

Camera and / or other sensor analysis of skin, used to diagnose and monitor health conditions. A computer, receiving skin data from a user, where the skin data is images and / or other data of the skin. The computer processes the skin data identify skin conditions, their status, and to compare the skin data with information indicative of health conditions that are not skin diseases. This can be done by finding similar skin data to other data received from other people who have specified health conditions and / or by looking for changes from previous images. The skin data can be captured by a smart phone camera (alone or with digital peripheral attachments) or a dedicated capture device such as a periscope, one way mirror, or cubicle. An augmented reality marking system can be used to mark areas on the user's skin to compare against other previous skin images and / or data.

The invention discloses a cationic super-deformation liposome capable of realizing gene transdermal transfection as well as preparation and application of the cationic super-deformation liposome, and belongs to the field of gene transdermal delivery. Materials such as low-molecular-weight polyethyleneimine, lipidosome and Tween 80 are adopted, and the components are safe and simple; polyethyleneimine is used as a conjugation carrier of the gene to improve the binding capacity of the gene, liposome is used as a delivery carrier to improve the skin delivery capacity of the gene, and Tween 80 is used for improving the stability and transdermal transfection capacity of the carrier again, so that non-invasive targeted transdermal delivery of the gene is realized; in vitro stability is high, gene degradation can be effectively inhibited, and meanwhile in vitro cell experiments, high transfection efficiency and low toxicity are achieved; the cationic super-deformed liposome can successfully realize high-efficiency transdermal penetration of the gene and effectively promote transfection expression of the gene in the skin at the same time, a new idea is provided for gene delivery, and the advantage of treating skin diseases through non-invasive delivery of the gene is expected to be fully exerted.

Provided are methods and composition for treating skin barrier functions and associated disorders. Formulated compositions may be applied on human skin to maintain a desired skin surface pH over an extended period of time without irritating the skin. Maintaining the desired surface pH aids in treatment of eczema, in addition to other skin conditions.

The instant disclosure relates to lipid particles that harbor cationic lipids, the particles found to be capable of delivering associated cargoes - particularly nucleic acid cargoes when formulated as nucleic acid-lipid particles - intracellularly to skin tissue cells when administered topically to a subject. The instant disclosure provides compositions comprising such lipid particles, optionally in association with a therapeutic agent (e.g., a therapeutic mRNA and / or nucleic acid controller system), as well as methods and kits for delivering a lipid particle-associated therapeutic agent and / or for treating or preventing a disease or disorder, e.g., a skin disease or disorder, in a subject, using one or more lipid particle compositions provided herein.

The invention relates to a multi-modal skin disease analysis method based on deep learning, and relates to the technical field of auxiliary diagnosis. A photoacoustic imaging device is used for scanning, a dermatoscope is used for shooting a skin disease affected part, and photoacoustic imaging data and a skin image of the affected part are obtained; aligning the photoacoustic image with a skin image, filling according to a skin image space, and combining with the skin image to obtain multi-modal skin data; constructing and pre-training a skin analysis model based on the multi-modal skin data; the pre-trained skin analysis model analyzes the collected multi-modal skin data to obtain a skin disease analysis result. The multi-modal skin data is constructed, multivariate data support is provided, and it is ensured that disease analysis is accurate and reliable. The skin analysis model extracts different scales of skin image feature maps and photoacoustic imaging feature maps so as to cover correlation between different sizes of features and different specifications of skin diseases; the other modal data is used to reinforce the own modal, and the two modal features are better combined; and the interpretability is high.

The invention belongs to the technical field of veterinary drug preparations, and particularly relates to a compound external ointment for treating parasites of dogs and cats and skin tinea and a preparation method, the compound external ointment comprises the following components by mass percent: 2%-12% of selamectin, 3%-20% of imidacloprid, 0.5%-2% of terbinafine hydrochloride, 2%-12% of dipropylene glycol monomethyl ether, 10%-50% of isopropanol, 9%-45% of polyethylene glycol 400 and the balance of water. The adhesive is prepared from, by weight, 9%-45% of polyethylene glycol 3350, 5%-15% of caprylic / capric polyethylene glycol glyceride, 1%-8% of oleyl alcohol, 0.5%-5% of dimeticone, 0.01%-0.1% of butylated hydroxytoluene and 1%-5% of cassava starch polymethylsesquioxane. The preparation method comprises the following steps: uniformly stirring the selamectin, the imidacloprid, the terbinafine hydrochloride and the mixed solvent, then mixing with the matrix (the polyethylene glycol 400 and the polyethylene glycol 3350 are heated and uniformly mixed in advance), the emulsifier and other components, and homogenizing. The compound selamectin ointment prepared by the invention can realize accurate administration at the edge of the auricle of an animal, and not only can ensure that the medicine is fully absorbed, but also can improve the compliance of animal administration; the composition not only can expel parasites in a broad spectrum, but also has broad-spectrum antifungal activity, and can prevent and treat a plurality of skin diseases of pets.

The present invention relates to skin moisturizing external compositions containing a ceramide, a cholesterol, and a fatty acid, and more particularly, to skin moisturizing external compositions capable of preventing skin troubles such as atopy by forming a dense lamellar structure, which is an intercellular lipid structure, and improving the skin barrier, and may include a ceramide having long-chain fatty acids, a cholesterol, a long-chain fatty acid, and purified water as active ingredients.

1. Name of the product of this design: Ultraviolet light therapy pen (CN‑308P II). 2. Purpose of the product of this design: UV irradiation treatment for skin diseases such as vitiligo, psoriasis, pityriasis rosea, eczema, etc. 3. Key points of the design of this product: The combination of shape and pattern. 4. The picture or photo that best illustrates the key points of the design: Stereoscopic picture.

The present disclosure provides crystalline forms of the compound having formula (I): (I), wherein the crystalline forms are crystalline Forms A, B, C, E, F, and H, each of which is characterized by an X-ray powder diffraction (XRPD) pattern. The present disclosure also provides methods for preparing crystalline forms, in particular Form A. The present disclosure further provides methods of treating various skin disorders using the crystalline forms of the disclosure or a pharmaceutical composition thereof.

The invention belongs to the field of skin care and skin disease treatment, and provides a skin care composition and application thereof, and the skin care composition is in a liquid form and comprises recombinant collagen and glycolic acid. The specific low-concentration glycolic acid in the skin care composition disclosed by the invention ensures the mild keratin metabolism capability; the recombinant collagen with high transdermal property can quickly permeate into the deep layer of the skin, and can immediately provide a repairing raw material for the skin while the glycolic acid acts, so that discomforts such as redness and stabbing pain are remarkably relieved, and synchronous skin care and repairing is realized.

Select substituted lysine and branched amino acid salts, compositions containing the same and the use of the foregoing in treating the adverse physiological effects of various diseases, especially skin diseases; in mitigating the effects of aging and environmental factors on skin; and in improving and rejuvenating skin.

METHODS FOR GEOLOCATION-BASED SKIN SCIENCE-BASED ENVIRONMENTAL EXPOSURE METRICS Methods for communicating the risk of skin conditions due to exposure to sunlight and environmental conditions to individuals. These methods leverage geolocation and environmental data to provide guidance and enable consumers to make informed decisions regarding outdoor activities, healthcare, and skincare. A photopollution metric is a function of the ultraviolet index (UVI) and the level of a pollutant such as particulate matter (PM) and allows for the communication of an individual's risk of exposome-induced skin conditions based on environmental exposure. Figure for abstract: none

This disclosure relates to compositions and methods using genetically modified bacteria that express superoxide dismutase (SOD) and catalase enzymes to reduce oxidative stress in the skin, and can be used for various skin conditions. In some embodiments of this disclosure, the genetically modified bacteria are Gram-positive bacteria, for example, of the genus Corynebacterium.

The invention belongs to the technical field of skin disease treatment and medicine, and particularly relates to an external pharmaceutical composition for treating atopic dermatitis and a preparation method and application thereof. The medicine composition is liquid medicine composed of blumea balsamifera oil, perfoliote knotweed herb and piper cubeba extract and is specially used for treating the atopic dermatitis (AD). According to the composition, the blumea balsamifera oil is innovatively used as a main component and cooperates with the perfoliote knotweed herb and the piper cubeba extract to form an efficient treatment scheme, and the curative effect of the composition is remarkably superior to that of a traditional method for singly using the blumea balsamifera oil. Experiments prove that the composition can effectively improve the skin barrier function, regulate immune disorder, reduce the levels of serum IgE and TSLP and inflammatory factors IL-4 and IFN-gamma, and reduce inflammatory cell infiltration, so that the AD symptom is relieved, and the recurrence rate is reduced.

The present invention relates generally to maqui berry for use in the treatment or prevention of skin diseases, wherein maqui berry may be the primary natural active ingredient. Particular embodiments as disclosed herein find application in, inter alia, the prophylaxis and the treatment of skin diseases, in particular, dermatitis, atopic dermatitis (neurodermatitis), dermatitis solaris, eczema, hand eczema, lichen planus, lupus erythematosus, psoriasis, urticaria, itching, scabies, age spot, freckles and dry / atopic skin of humans. In particular, the present invention relates to the use of maqui berry extract in the manufacture of a medicament or dietary supplement for use in treating or preventing said skin diseases or defects.

The invention belongs to the technical field of biological medicines, and particularly relates to application of a marine small molecule peptide and an active variant thereof in preparation of a medicine for treating skin diseases, the marine small molecule peptide and the active variant thereof can effectively inhibit keratinocyte pan apoptosis induced by TNF-alpha and IFN-gamma, the formation of a PANoptosome complex is blocked through a multi-target synergistic effect, and the effect of treating the skin diseases is achieved. The oxidative stress is reduced, and mitochondria is stabilized, so that a skin inflammatory cell death network is inhibited from the source. The variant has the same high sequence as the peptide, retains the activity of inhibiting cell pan-apoptosis, and has enhanced stability, skin permeability, in vivo half-life or efficacy. Based on the action mechanism, the peptide and the variant thereof can be used for preparing medicines for preventing and treating intractable skin diseases such as epidermis necrolysis, psoriasis, atopic dermatitis, skin lupus erythematosus and lichen planus. The invention also provides a composition containing the peptide or the variant thereof, and dosage forms comprise an external preparation and an injection.

The present invention relates to a multimodal skin disease analysis method based on deep learning, and relates to the field of auxiliary diagnosis technology. The present invention uses a photoacoustic imaging device to scan, and a dermatoscope to photograph the affected area of the skin disease to obtain photoacoustic imaging data and skin images of the affected area; aligns the photoacoustic imaging with the skin image, fills the space according to the skin image, and then combines it with the skin image to obtain multimodal skin data; constructs and pre-trains a skin analysis model based on multimodal skin data; the pre-trained skin analysis model analyzes the collected multimodal skin data to obtain skin disease analysis results. The present application constructs multimodal skin data, provides multivariate data support, and ensures that disease analysis is accurate and reliable. The skin analysis model extracts skin image feature maps and photoacoustic imaging feature maps of different scales to cover the association between features of different sizes and skin diseases of different specifications; uses another modality data to strengthen its own modality to better combine the two modality features; and has strong interpretability.

The invention provides bacillus mojavensis and belongs to the technical field of microorganisms. The preservation number of the bacillus mojavensis VT275 is CGMCC (China General Microbiological Culture Collection Center) No.29974. The bacillus mojavensis VT275 can be used for effectively inhibiting common skin pathogenic bacteria and food-borne pathogenic bacteria, such as staphylococcus aureus, methicillin-resistant staphylococcus aureus, staphylococcus epidermidis, listeria monocytogenes, shigella, enterococcus faecalis and the like. The bacillus mojavensis VT275 disclosed by the invention can be used for preventing or treating skin diseases such as specific dermatitis or controlling food-borne infection, and has a good application prospect in the fields of medicines, cosmetics, edible microorganisms, feed microorganisms and the like.

The application belongs to the technical field of medicines, and specifically provides application of Phanginin A in preparation of medicines for preventing and / or treating skin diseases. The skin diseases include atopic dermatitis and skin epidermal barrier damage. The application finds that Phanginin A can reduce atopic dermatitis lesion scores, improve atopic dermatitis skin pathological thickening and inflammatory cell infiltration, reduce spleen inflammatory response, inhibit volume increase, promote thymus function recovery, down-regulate expression of atopic dermatitis related inflammatory factors IL-6 and TNF-alpha, and can be used for preventing and / or treating atopic dermatitis. In addition, the application also finds that Phanginin A can promote keratinocyte scratch healing, and can be used for repairing skin epidermal barrier damage.

To provide compounds and compositions for use in treating skin disorders.SOLUTION: There is provided herein a compound of formula (XXXII) or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer thereof or a physiologically functional derivative thereof, wherein R1, R2, R3, G, A, E, n, p, and q are defined herein. There are also provided herein compositions comprising a compound of formula (XXXII), and methods of using a compound of formula (XXXII), e.g., in the treatment or prevention of skin disorders.SELECTED DRAWING: Figure 1

The present invention relates to a polymer self-assembly nanocarrier and a method of preparing same, the nanocarrier binding a peptide that targets a specific cell and, simultaneously, carrying an active ingredient that has been verified. The present invention can exhibit various effects such as a moisturizing effect, an increase in filaggrin production, whitening, skin barrier reinforcement and the like by selectively and efficiently delivering a drug through a targeting peptide, can be applied to skin diseases such as atopy or psoriasis, and is expected to enable the maximum effect of an active substance in the pharmaceutical and cosmetic fields to be obtained.

Cosmetic composition comprising an endolysin derived from a Staphylococcus aureus phage and a mineral filler. The present invention relates to a composition, particularly a cosmetic one, comprising, in a physiologically acceptable medium, at least one endolysin derived from a Staphylococcus aureus phage and at least one mineral filler selected from hydrophilic fumed silicas and spherical porous silica particles. It also relates to the use of such a composition to prevent and / or treat a skin disorder related to colonization by Staphylococcus aureus in an individual in need, and in particular to prevent and / or treat acne and / or eczema in an individual in need, and a non-therapeutic cosmetic process for the care of keratinous materials, particularly skin, comprising at least one step of topical application of such a composition to said keratinous materials.

The invention belongs to the technical field of skin microorganism regulation and control and daily chemical products, and relates to application of alkyl oxazolidinone in regulation and control of skin microbial flora and a product containing the alkyl oxazolidinone. The invention finds that the alkyl oxazolidinone, especially C8-14 alkyl oxazolidinone, has a remarkable inhibition effect on regulating and controlling skin microbial flora, especially on malassezia furfur and propionibacterium acnes; the compound is widely applied to preparation of products for removing dandruff, relieving itching and / or relieving acne and preparation of medicines for treating and / or preventing skin diseases caused by imbalance of skin microbial flora.

The present invention relates to a pharmaceutical composition comprising a tubulin inhibitor as an active ingredient for preventing or treating skin diseases. In addition, the present invention relates to a quasi-drug composition or cosmetic composition comprising a tubulin inhibitor as an active ingredient for preventing or alleviating skin diseases. In addition, the present invention relates to a cosmetic composition comprising a tubulin inhibitor as an active ingredient for skin moisturization, whitening, wrinkle alleviation, acne relief, skin barrier strengthening, or skin keratinocyte differentiation. The tubulin inhibitor of the present invention increases the expression level of filaggrin in epidermal cells, promotes skin differentiation, inhibits NF S-kB signaling induced by TNF-α, and exhibits photo-aging inhibition and wrinkle alleviation effects as well as whitening effects. Accordingly, the tubulin inhibitor of the present invention can be utilized as an active ingredient that exhibits activities, such as skin moisturization, whitening, wrinkle alleviation, acne relief, skin barrier strengthening, or skin keratinocyte differentiation, along with the prevention, treatment, or alleviation of skin diseases.

The present invention discloses a multi-classification system for children's skin diseases based on an improved ResNet, which includes a computer memory and a classification model stored in the computer memory; the classification model includes a feature extraction unit and a prediction unit; the feature extraction unit includes a residual module structure, a medium-scale dilated convolution structure, a wide-scale dilated convolution structure, and a multi-scale fusion dilated convolution structure; the image sequentially passes through a convolutional layer, a max pooling layer, a convolutional layer, and a batch normalization layer to extract features, enters the above four structures used in parallel, and outputs their respective feature maps; the prediction unit fuses the feature maps output by each structure and inputs them into a batch normalization layer to standardize the fused features; then, the standardized feature maps are downsampled through an average pooling layer; finally, the features are transformed into a classification probability distribution of skin diseases through a softmax layer. By using the present invention, the recognition and classification accuracy of common children's skin diseases can be improved.

The present disclosure relates to the treatment of a skin condition in a subject, including but not limited to one or more of luminosity, brightness, skin pore size, skin pore count, sebum production, sebum composition, overall skin quality, eyelid laxity, fine lines under the eye, fine lines on the face, laxity on the face, perioral rhytids, moderate to severe facial folds and wrinkles such as nasolabial folds, moderate to severe facial wrinkles such as smile lines or marionette lines, age-related midface contour deficiencies, dorsal hand to correct volume deficit, glabellar lines, correction of facila depressions, either due to injury or age-related, perioral wrinkles, lip commissures, crow's feet, facial rhytides, and forehead wrinkles, comprising applying to the skin of the subject a first composition derived from one or more sponges, and a second composition comprising one or more botulinum toxins. Also provided are compositions for use in the treatment of a skin condition in a subject, including but not limited to hyperhidrosis, comprising a first composition and a second composition, wherein (a) the first composition comprises Spongilla; and (b) the second composition comprises one or more botulinum toxins. Also provided are kits, including kits for the treatment of a skin condition in a subject including but not limited to hyperhidrosis, comprising a first composition and a second composition, wherein the first composition comprises Spongilla, and the second composition comprises one or more botulinum toxins.

A topical composition for treating diabetic skin conditions is disclosed, comprising a non-steroidal, non-comedogenic, and fragrance-free formulation. The composition includes a synergistic blend of emollients, humectants & occlusives for intense moisturization; emulsifying agents for stabilization; moisturizing agents for enhanced hydration; antioxidants for reducing oxidative stress; anti-inflammatory agents for alleviating inflammation; anti-itching agents for relieving the itching; skin conditioners for improved barrier function; Filaggrin improver and agents for stimulating collagen production. The composition provides relief from dry skin, itching, and redness associated with diabetic skin conditions.

A skin care product comprising one or more cannabinoids and one or more triglyceride oils is disclosed. The cannabinoids used in the product may be CBD, THC, or a mixture thereof. The triglyceride oil used in the product may be squalene, meadowfoam seed oil, or a mixture thereof. The cannabinoid and triglyceride compounds may be naturally derived products. The skin care product exhibits beneficial anti-microbial and / or skin rejuvenating properties and may be used to treat a human or an animal. Some skin disorders that may be treated with the product include acne, xerosis and wrinkled skin.

The invention relates to the technical field of preparation of medicines for treating skin diseases, in particular to application of a water-soluble BODIPY photosensitizer to preparation of medicines for photodynamically treating skin diseases. The BODIPY photosensitizer has the beneficial effect that the BODIPY photosensitizer has good water solubility. A water-soluble BODIPY compound can be directly prepared into a high-concentration drug aqueous solution of 4.9-7.8 mM, or can be conveniently prepared into external hydrophilic preparations such as gel and the like, so that mass production and clinical transformation are facilitated, and the requirements of photodynamic therapy of different skin diseases are met.