260 results about "Diseases skin" patented technology

Methods of treating, preventing, correcting and / or managing skin diseases or disorders characterized by overgrowths of the epidermis, keratoses, scleroderma, cutaneous vasculitis, acne or wrinkles are disclosed. Specific embodiments encompass the administration of an immunomodulatory compound, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent. Specific second active ingredients are capable of affecting or inhibiting cell growth or proliferation, removing or improving acne scars, or reducing or correcting wrinkle lines. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

Biocompatible materials are propelled at the skin with sufficient velocity to cause desired resurfacing of skin layers to the desired penetration depth. The materials, such as dry ice or water ice, are harmonious with the human body and thus eliminate foreign body reactions. Various materials may be used in combination, including local anesthetics and vasoconstrictors in solid or liquid form. The biocompatible solid or liquid particles are suspended in a cold carrier fluid and propelled through an insulated delivery system to the surface of the skin. The treatment of diseased skin lesions may be accomplished using the present invention as a drug delivery system.

The present invention provides an apparatus and method for photodynamic diagnosis and therapy of skin diseases and a light source system thereof that can improve the efficiency of skin diagnosis by accurately analyzing skin conditions using fluorescence and white light simultaneously and further carry out fluorescent diagnosis and photodynamic therapy in the same skin region simultaneously. The apparatus for photodynamic diagnosis and therapy of skin diseases of the present invention includes: a camera head including a case having a view hole, provided in front thereof, to be in contact with a skin region, a white light source provided so as to irradiate a white light from the inside of the case through the view hole onto the skin region, a digital color TV camera provided in the rear of the case, the camera head being provided to irradiate the white light, a fluorescence excitation light and a therapeutic light for the photodynamic therapy from the inside of the case onto the skin region being in contact with the view hole, and the digital color TV camera collecting the light from the skin region and outputting a generated image signal; a light source system, connected to the case of the camera head through a light guide capable of light transmission, for providing the fluorescence excitation light, the therapeutic light for the photodynamic therapy and the white light to be irradiated onto the skin region to the camera head; and an image processing and analysis system for receiving the image signal from the camera head to process, analyze and store to same, for displaying a color image by the white light, a fluorescence image by the excitation light and the therapeutic light for the photodynamic therapy, obtained by the digital color TV camera, and a synthesized image thereof, and for controlling the general operations of the camera head and the light source system.

The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and / or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and / or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto. The method for preventing and treating diseases and conditions related to binuclear enzyme function and melanin overproduction is comprised of administering to a host in need thereof an effective amount of a composition comprising one or more diarylalkanes and / or diarylalkanols synthesized and / or isolated from one or more plants together with a pharmaceutically acceptable carrier.

The invention relates to an apparatus for skin imaging, a system for skin analysis and a method for skin analysis, using a combination of near-field and far-field skin images under different angles of illumination. The apparatus provides a tool that may be employed for rapid screening of the skin for lesions that may be indicative of skin diseases, in particular skin cancers such as melanoma.

The present invention provides compositions containing one or more antimicrobial peptide sequestering compounds and methods for topical application of such compositions to the skin to treat skin diseases and disorders such as rosacea in humans.

The invention discloses a skin model and application. The method comprises separately culturing epidermal cells and dermal cells derived from fetus scalp, newborn prepuce or adult scalp, and subculturing, wherein the used culture medium and culture method can maintain multiple functions of skin cells; separately digesting the cultured and proliferated multifunctional epidermal cells and dermal cells into single cells, and mixing to obtain suspension; transferring onto a semipermeable polymer or silica gel membrane substrate for incubation; transplanting cells on adhesive film to a receptor. The method can regenerate human intact functional skin and hair, the regenerated skin contains an epidermal layer, a dermal layer and a subcutaneous tissue as well as skin appendant organs. The skin model regenerated by the method disclosed by the invention can be used for study of human skin diseases, screening of skin drugs, and development of cell products for treating wound and other skin diseases.

Medical apparatus for diagnosing of a diseased condition of the skin of a subject. The apparatus comprises an electrically conducting probe including a plurality of electrodes, each electrode comprising a plurality of micro-needles, wherein each electrode comprises a base substrate, said micro-needles being integrally formed with said substrate and arranged in a laterally spaced relationship apart from each other and having a length being sufficient to penetrate the stratum corneum, said micro-needles being arranged with an at least partially oblique shape. Furthermore, the present invention relates to an electrode for use in the device, arrays of micro-needle and method for the diagnostics of biological conditions using impedance measurements. The diagnostics is in particular related to cancer, and preferably skin cancer, wherein skin cancer is a basal cell carcinoma, a malignant melanoma, a squamous cell carcinoma, or precursors of such lesions.

The invention relates to extraction of an active ingredient exosome from a human umbilical cordmesenchymal stem cell and application thereof in preparation of medicaments for treating liver and kidney injury and skin diseases. The human umbilical cordmesenchymal stem cell-derived exosome is prepared by the following steps of: (1) culturing a human umbilical cordmesenchymal stem cell; (2) preparing a cordmesenchymal stem cell conditioned medium; and (3) separating and purifying the exosome. The experiments for infusing the human umbilical cordmesenchymal stem cell exosome serving as a medicament into a mice acute liver injury model, a rat kidney injury model and a rat skin scald model show that the medicament can improve the liver function, the kidney function and the skin condition, promote the pathological recovery of the liver, the kidney and the skin, reduce the death rate, fulfill the aims of blocking and reversing the development of the liver and kidney injury and open up a new approach for clinical treating of the liver and kidney injury.

The present invention provides impedance data having an improved spatial resolution, both with regard to depth and lateral extension, which enables a detection of diseased skin conditions, such a malignant melanoma, at an early stage. Specifically, the present invention is implemented in a probe, medical devices and medical systems including such a probe, and methods using such a probe for measuring electrical impedance of tissue of a subject. A switching circuit is arranged for selectively activate electrode pairs of the probe in accordance with a predetermined activation scheme, the predetermined activation scheme including to activate adjacent electrodes in a successive manner, to gradually scan tissue of the subject at a first tissue depth so as to obtain a sequence of impedance signals from the tissue depth.

A near-permanent skin treatment includes photothermolysis of reddened facial skin to induce ischemia. Reperfusion of the photothermolysis treated skin is inhibited by following with regular applications of phenyl-epinephrine carried in a lotion until vascular necrosis is complete. Alternatively, a temporary treatment for reddened facial skin includes only cosmetic as-needed applications of phenyl-epinephrine carried in lotion to induce vasoconstriction in Rosacea and other similarly embarrassing skin disorders.

The invention relates to a Chinese medicinal composition for treating skin itch and a preparation method thereof. The Chinese medicinal composition mainly comprises the following raw material medicaments: figwort root, root of red-rooted salvia, cortex dictamni, natural indigo, divaricate saposhnikovia root, safflower, peach seed, radix rehmanniae preparata, mint, cicada slough, kudzu-vine root, Mongolian snakegourd root, radix rehmanniae preparata, simpleleaf shrub chastetree fruit, reed rhizome, lalang grass rhizome, common lophatherum herb, gardenia, lightyellow sophora root, ash bark, red paeony root, tree peony bark, sinkiang arnebia root, dahurian patrinia herb, glandularstalk St. paulswort herb, erythrina indica lam, tangerine peel, combined spicebush root, areca peel and the like. The Chinese medicinal composition can be prepared into any common oral preparation by the conventional Chinese medicinal preparation method. The Chinese medicinal composition can obviously improve symptoms such as local or general skin itch caused by various skin diseases, food allergy, medicament allergy and the like. The Chinese medicinal composition has the advantages of exact clinical effects, obvious curative effect, quick response, low cost, basically no toxic or side effects and the like.

A cleanser composition composed of purified water, sodium laureth sulfate, zinc pyrithione, cocamidopropyl betaine, glycerol cocoate, polyquaternium-7, and a cross-linked polyacrylic acid polymer for topical application to an area affected by a skin disorder such as seborrheic dermatitis, perioral dermatitis, rosacea, acne, tinea versicolor, eczema and psoriasis.

The invention relates to a device for the treatment of free-form areas and zones of human or animal skin areas or plant surfaces by means of cold atmospheric-pressure plasma. The core of the device is a specific, preferably gas-permeable, electrode arrangement for generating a dielectrically impeded surface discharge where the earthed electrode is composed of electrically conductive textile material and the high-voltage electrode consists of a thin wire or electrically conductive thread which is sheathed with an insulting layer which has to meet specific requirements. On the basis of the present invention, it is possible to generate, in the area of diseased skin parts of the human body, in direct proximity to the skin surface or to wounds, a flat plasma for the treatment of the diseased areas which is acceptable in respect of the stress on the skin caused by temperature and electric potentials. The advantage of the gas-permeable textile sheet-like structure consists especially in that the arrangement can be placed flexibly onto variously curved surfaces and, in addition, offers the possibility of a gas exchange with the environment and / or the targeted dosing of a specific process gas mixture across the textile material into the active plasma zone.

A multi-ply technical composite, usable in particular for making medical aids, garments and medical articles, includes at least two layers (2, 3), the first of which (2), in contact with the skin, is a cotton fabric (elasticised to a greater or lesser extent) or silk, or fabrics to which chitosan, silver or another antibacterial substance or active constituent is added, and the second, outer layer (3) is constituted by a semipermeable membrane, such as polyurethane between 5 and 80 microns thick, with considerable elasticity in order to ensure the user's comfort. Receptors rechargeable with active constituents are inserted into fabric (2) and protected by the polyurethane membrane.

The dermopathic blood poison treating capsule for treating dermopathy is prepared with madder and other 38 kinds of Chinese medicinal materials, and through washing, drying, crushing, grinding into fine powder, mixing with proper amount of talc powder and encapsulating. It can cleare away blood heat and toxic matter, eliminating swelling and stopping itching. Grinding the materials into fine powder of size below 47 micron can speed the absorption of skin on the effective medicine components and raise the healing effect greatly.

The present invention relates to method(s) of treating a subject afflicted with a skin disease or condition, the method comprising administering to the subject or patient in need a composition comprising a therapeutically effective amount of a substituted cis or trans-stilbene or a stilbene hybrid. A method of treating or reducing the likelihood of a skin disease or condition in a patient is an additional embodiment of the present invention. Preferred pharmaceutical compositions of the invention include nanoemulsions comprising a therapeutically effective amount of a substituted cis or trans-stilbene or stilbene hybrid and at least one antibiotic.

The present invention discloses a new application of pig skin which can be substituted for human skin and its preparation method. Said preparation method includes the following steps: killing health living while pig with about 50 kg, shaving hair and cleaning pigskin, skinning and chipping to obtain skin sheet, cross-linking with glutaraldehyde, cleaning with balanced salt solution phosphate, soaking it in IM physiological saline containing trypsase, vibrating with Triton-100, more washing it with balanced salt solution phosphate and storing it in refrigerator with 4 deg.C for stand-by. Said invented product has the functional characteristics of two skin substitutes of Integra artificial skin and ADM, so that it not only can be used as temporary wound surface covering material for protecting surface of wound, but also can be used as permanent substitute for dermis for repairing surface of the wound.

The invention discloses a sonchus plant extract used for curing skin diseases and application thereof in preparing medicament for treating skin diseases; the extract is obtained by taking sonchus plants as raw material, extracting by water, filtering and sterilizing the filtrate at high temperature. For water extracting, the temperature is 80-100 DEG C, the period is 1-5 hours, and the extract is filtered with a non-metal filter screen of 200-1,000 meshes. Both the extract of sonchus common sow thistle and the extract of sonchus brachyotus have the functions of antimycotic, antianaphylaxis, antiphlogosis, itch relieving and the like. The extract can be used for curing allergic dermatitis, eczema, skin itch, pimple, scar itch, dermatitis caused by mosquito bite, mycotic infection and other skin diseases. The effective rate and the cure ratio for curing allergic dermatitis, eczema, skin itch, pimple, scar itch, and dermatitis caused by mosquito bite are both 100%, the effective rate for curing dermatophytosis cuased by mycotic is 100% and the cure ration therefor is 70-75%.

The present invention relates to a method for treating dermal inflammation and dermal diseases by local or systemic delivery, in a subject in need of such treatment, which comprises administering a pharmaceutical composition comprising a therapeutically effective amount of at least one agonist of Formyl peptide receptor 2 (FPR2).

The invention provides a multimode imaging detection system for skin disease, characterized in that a supercontinuum laser is adopted, different wavelengths for specific skin tissues are selected to acquire hyperspectral and high-resolution confocal imaging, simultaneously the characteristic of deep depth of photoacoustic technique imaging is combined, and system integration of a hyperspectral imaging technique, a reflection type confocal imaging technique and a photoacoustic imaging technique is carried out to form the multimode optical imaging system. The multimode imaging detection system repairs the shortcoming of single-mode imaging in skin diagnosis, and compared with the single-modal technique, the multimode technique provides more complete information, improves the sensibility, accuracy and specificity in skin disease diagnosis, realizes hyperspectral, high-resolution and high-speed multimode optical molecular images for deep level skin disease diagnosis, provides a new technical means for diagnosis and clinical research on skin disease, is favorable for improving the diagnosis level of skin disease, and simultaneously can guide operation on skin disease and provide objective evaluation on medication of skin disease.

The present invention is directed to compositions of nicotinamide derivatives combined with wakame seaweed, wakame extracts, or glycosaminoglycans, and their use in treating skin diseases and disorders.

Methods of treatment and dosage regimes using hydrophobic gel or foam compositions comprising a tetracycline antibiotic for accelorating the return of skin integrity and or in treating or alleviating a disorder including impetigo, acne, rosacea, a skin disease caused by a bacteria or a tetracycline antibiotic responsive disease, wherein the foam composition or gel is administered topically to a target area on a subject having the disorder and wherein the target area comprises an area of skin, or mucosa or an eye.

The present invention describes cosmetic nanotechnology, comprising polymeric nanoparticles containing oil and UV filter, photoprotective compositions comprising polymeric nanoparticles described herein, methods of prevention of diseases of the skin, and processes for the preparation of the polymeric nanoparticles described herein.

The invention discloses a traditional Chinese medicine for treating skin diseases and a preparation method thereof, which pertain to the technical field of Chinese medical pharmaceutical technology. The traditional Chinese medicine comprises 9 to 11 portions of kuh-seng, 9 to 11 portions of cyrtomium fortunei, 9 to 11 portions of honeysuckle, 9 to 11 portions of chrysanthemum, 4 to 6 portions of cicada skins, 4 to 6 portions of fresh licorice, 4 to 6 portions of fructus xanthii, 2 to 4 portions of amoorcorn tree bark and 2 to 4 portions of fructus kochiae, wherein the mixture ratio of the components is weight ratio. The preparation method of the traditional Chinese medicine is vinegar processing method. The traditional Chinese medicine has the functions of clearing heat and drying damp, clearing away heat and toxic materials, cooling blood, dispelling wind and removing heat, removing damp and relieving itching and has great treatment effect on the skin diseases such as whelk, eczema, skin itch, psoriasis, purpura, dermatophytosis, lupus sebaceus and the like, is the good medicine for treating skin diseases and can be used for treating the skin diseases.

The invention provides for methods of detecting and treating diseased tissue, particularly in skin diseases or disorders, such as psoriasis, scleroderma, eczema or atopic dermatitis tissue. The method involves administrating a composition comprising an antibody specific to the diseased tissue to a patient. After administration, the antibody in the composition binds to the exposed cell surface antigen (epitope) and allows the detection and / or disrupts the growth of the diseased tissue. In addition, this invention provides methods of treating psoriasis, scleroderma, eczema or atopic dermatitis by eliciting an immune response in an individual against an antigen which is only exposed to antibody detection in tissues affected by these disorders

The invention relates to a medicine composition for treating skin diseases, in particular to a composition which is prepared with Chinese medicinal materials including radix sophorae flavescentis, rhizoma smilacis glabrae, oriental wormwood, golden cypress, rough gentian, cortex dictamni, purslane, broom cypress fruit, stemona, raw liquorice and optional menthol and borneol. The composition remarkably increases an itch irritating field, can effectively suppress mouse ear swelling, and has high expected safety. In addition, the composition can effectively suppress mouse ear swelling caused by dimethylbenzene, and can effectively suppress rat egg white induced paw swelling.

The present invention relates to the preparation and use of compositions for the treatment of skin disorders itchy and / or infected skin such as impetigo, acne (on face, forehead scalp and on the back of the body) and fungal infection of skin and nails. Whether the infection may be acute or chronic or sub-acute or acute on chronic. As well as for the promotion of non carrier state of the human beings and animals from some pathogenic bacteria such as staphylococci. The compositions are based on extracts from the plants Cassia tora, Centratherum anthelminticum and / or Melia azadirachta. A variety of other herbal extracts may be included and the composition may take the form of a freeze dried or a spray dried powder or presence of this in a cream or ointment based on Ghee, or in a cream or ointment form developed with any other vehicle, or they may be in a powdered form without spray drying. That spray dried or freeze dried powder may be suspended in a suitable mouth wash or nasal drops. The herbs may be in a powdered form of suitable for preparing decoctions in hot water. Laboratory results are of Specimen Example 2. Specimen Example 1 I have found working on the patients clinically as broad spectrum covering pustules as well as fungal infections.