141 results about "Diseases skin" patented technology

Provided are methods and composition for treating skin barrier functions and associated disorders. Formulated compositions may be applied on human skin to maintain a desired skin surface pH over an extended period of time without irritating the skin. Maintaining the desired surface pH aids in treatment of eczema, in addition to other skin conditions.

The instant disclosure relates to lipid particles that harbor cationic lipids, the particles found to be capable of delivering associated cargoes - particularly nucleic acid cargoes when formulated as nucleic acid-lipid particles - intracellularly to skin tissue cells when administered topically to a subject. The instant disclosure provides compositions comprising such lipid particles, optionally in association with a therapeutic agent (e.g., a therapeutic mRNA and / or nucleic acid controller system), as well as methods and kits for delivering a lipid particle-associated therapeutic agent and / or for treating or preventing a disease or disorder, e.g., a skin disease or disorder, in a subject, using one or more lipid particle compositions provided herein.

The invention belongs to the technical field of veterinary drug preparations, and particularly relates to a compound external ointment for treating parasites of dogs and cats and skin tinea and a preparation method, the compound external ointment comprises the following components by mass percent: 2%-12% of selamectin, 3%-20% of imidacloprid, 0.5%-2% of terbinafine hydrochloride, 2%-12% of dipropylene glycol monomethyl ether, 10%-50% of isopropanol, 9%-45% of polyethylene glycol 400 and the balance of water. The adhesive is prepared from, by weight, 9%-45% of polyethylene glycol 3350, 5%-15% of caprylic / capric polyethylene glycol glyceride, 1%-8% of oleyl alcohol, 0.5%-5% of dimeticone, 0.01%-0.1% of butylated hydroxytoluene and 1%-5% of cassava starch polymethylsesquioxane. The preparation method comprises the following steps: uniformly stirring the selamectin, the imidacloprid, the terbinafine hydrochloride and the mixed solvent, then mixing with the matrix (the polyethylene glycol 400 and the polyethylene glycol 3350 are heated and uniformly mixed in advance), the emulsifier and other components, and homogenizing. The compound selamectin ointment prepared by the invention can realize accurate administration at the edge of the auricle of an animal, and not only can ensure that the medicine is fully absorbed, but also can improve the compliance of animal administration; the composition not only can expel parasites in a broad spectrum, but also has broad-spectrum antifungal activity, and can prevent and treat a plurality of skin diseases of pets.

The invention belongs to the field of skin care and skin disease treatment, and provides a skin care composition and application thereof, and the skin care composition is in a liquid form and comprises recombinant collagen and glycolic acid. The specific low-concentration glycolic acid in the skin care composition disclosed by the invention ensures the mild keratin metabolism capability; the recombinant collagen with high transdermal property can quickly permeate into the deep layer of the skin, and can immediately provide a repairing raw material for the skin while the glycolic acid acts, so that discomforts such as redness and stabbing pain are remarkably relieved, and synchronous skin care and repairing is realized.

Select substituted lysine and branched amino acid salts, compositions containing the same and the use of the foregoing in treating the adverse physiological effects of various diseases, especially skin diseases; in mitigating the effects of aging and environmental factors on skin; and in improving and rejuvenating skin.

METHODS FOR GEOLOCATION-BASED SKIN SCIENCE-BASED ENVIRONMENTAL EXPOSURE METRICS Methods for communicating the risk of skin conditions due to exposure to sunlight and environmental conditions to individuals. These methods leverage geolocation and environmental data to provide guidance and enable consumers to make informed decisions regarding outdoor activities, healthcare, and skincare. A photopollution metric is a function of the ultraviolet index (UVI) and the level of a pollutant such as particulate matter (PM) and allows for the communication of an individual's risk of exposome-induced skin conditions based on environmental exposure. Figure for abstract: none

This disclosure relates to compositions and methods using genetically modified bacteria that express superoxide dismutase (SOD) and catalase enzymes to reduce oxidative stress in the skin, and can be used for various skin conditions. In some embodiments of this disclosure, the genetically modified bacteria are Gram-positive bacteria, for example, of the genus Corynebacterium.

The invention belongs to the technical field of skin disease treatment and medicine, and particularly relates to an external pharmaceutical composition for treating atopic dermatitis and a preparation method and application thereof. The medicine composition is liquid medicine composed of blumea balsamifera oil, perfoliote knotweed herb and piper cubeba extract and is specially used for treating the atopic dermatitis (AD). According to the composition, the blumea balsamifera oil is innovatively used as a main component and cooperates with the perfoliote knotweed herb and the piper cubeba extract to form an efficient treatment scheme, and the curative effect of the composition is remarkably superior to that of a traditional method for singly using the blumea balsamifera oil. Experiments prove that the composition can effectively improve the skin barrier function, regulate immune disorder, reduce the levels of serum IgE and TSLP and inflammatory factors IL-4 and IFN-gamma, and reduce inflammatory cell infiltration, so that the AD symptom is relieved, and the recurrence rate is reduced.

The present invention relates generally to maqui berry for use in the treatment or prevention of skin diseases, wherein maqui berry may be the primary natural active ingredient. Particular embodiments as disclosed herein find application in, inter alia, the prophylaxis and the treatment of skin diseases, in particular, dermatitis, atopic dermatitis (neurodermatitis), dermatitis solaris, eczema, hand eczema, lichen planus, lupus erythematosus, psoriasis, urticaria, itching, scabies, age spot, freckles and dry / atopic skin of humans. In particular, the present invention relates to the use of maqui berry extract in the manufacture of a medicament or dietary supplement for use in treating or preventing said skin diseases or defects.

The invention belongs to the technical field of biological medicines, and particularly relates to application of a marine small molecule peptide and an active variant thereof in preparation of a medicine for treating skin diseases, the marine small molecule peptide and the active variant thereof can effectively inhibit keratinocyte pan apoptosis induced by TNF-alpha and IFN-gamma, the formation of a PANoptosome complex is blocked through a multi-target synergistic effect, and the effect of treating the skin diseases is achieved. The oxidative stress is reduced, and mitochondria is stabilized, so that a skin inflammatory cell death network is inhibited from the source. The variant has the same high sequence as the peptide, retains the activity of inhibiting cell pan-apoptosis, and has enhanced stability, skin permeability, in vivo half-life or efficacy. Based on the action mechanism, the peptide and the variant thereof can be used for preparing medicines for preventing and treating intractable skin diseases such as epidermis necrolysis, psoriasis, atopic dermatitis, skin lupus erythematosus and lichen planus. The invention also provides a composition containing the peptide or the variant thereof, and dosage forms comprise an external preparation and an injection.

The application belongs to the technical field of medicines, and specifically provides application of Phanginin A in preparation of medicines for preventing and / or treating skin diseases. The skin diseases include atopic dermatitis and skin epidermal barrier damage. The application finds that Phanginin A can reduce atopic dermatitis lesion scores, improve atopic dermatitis skin pathological thickening and inflammatory cell infiltration, reduce spleen inflammatory response, inhibit volume increase, promote thymus function recovery, down-regulate expression of atopic dermatitis related inflammatory factors IL-6 and TNF-alpha, and can be used for preventing and / or treating atopic dermatitis. In addition, the application also finds that Phanginin A can promote keratinocyte scratch healing, and can be used for repairing skin epidermal barrier damage.

To provide compounds and compositions for use in treating skin disorders.SOLUTION: There is provided herein a compound of formula (XXXII) or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer thereof or a physiologically functional derivative thereof, wherein R1, R2, R3, G, A, E, n, p, and q are defined herein. There are also provided herein compositions comprising a compound of formula (XXXII), and methods of using a compound of formula (XXXII), e.g., in the treatment or prevention of skin disorders.SELECTED DRAWING: Figure 1

The present invention relates to a polymer self-assembly nanocarrier and a method of preparing same, the nanocarrier binding a peptide that targets a specific cell and, simultaneously, carrying an active ingredient that has been verified. The present invention can exhibit various effects such as a moisturizing effect, an increase in filaggrin production, whitening, skin barrier reinforcement and the like by selectively and efficiently delivering a drug through a targeting peptide, can be applied to skin diseases such as atopy or psoriasis, and is expected to enable the maximum effect of an active substance in the pharmaceutical and cosmetic fields to be obtained.

Cosmetic composition comprising an endolysin derived from a Staphylococcus aureus phage and a mineral filler. The present invention relates to a composition, particularly a cosmetic one, comprising, in a physiologically acceptable medium, at least one endolysin derived from a Staphylococcus aureus phage and at least one mineral filler selected from hydrophilic fumed silicas and spherical porous silica particles. It also relates to the use of such a composition to prevent and / or treat a skin disorder related to colonization by Staphylococcus aureus in an individual in need, and in particular to prevent and / or treat acne and / or eczema in an individual in need, and a non-therapeutic cosmetic process for the care of keratinous materials, particularly skin, comprising at least one step of topical application of such a composition to said keratinous materials.

The invention belongs to the technical field of skin microorganism regulation and control and daily chemical products, and relates to application of alkyl oxazolidinone in regulation and control of skin microbial flora and a product containing the alkyl oxazolidinone. The invention finds that the alkyl oxazolidinone, especially C8-14 alkyl oxazolidinone, has a remarkable inhibition effect on regulating and controlling skin microbial flora, especially on malassezia furfur and propionibacterium acnes; the compound is widely applied to preparation of products for removing dandruff, relieving itching and / or relieving acne and preparation of medicines for treating and / or preventing skin diseases caused by imbalance of skin microbial flora.

The present disclosure relates to the treatment of a skin condition in a subject, including but not limited to one or more of luminosity, brightness, skin pore size, skin pore count, sebum production, sebum composition, overall skin quality, eyelid laxity, fine lines under the eye, fine lines on the face, laxity on the face, perioral rhytids, moderate to severe facial folds and wrinkles such as nasolabial folds, moderate to severe facial wrinkles such as smile lines or marionette lines, age-related midface contour deficiencies, dorsal hand to correct volume deficit, glabellar lines, correction of facila depressions, either due to injury or age-related, perioral wrinkles, lip commissures, crow's feet, facial rhytides, and forehead wrinkles, comprising applying to the skin of the subject a first composition derived from one or more sponges, and a second composition comprising one or more botulinum toxins. Also provided are compositions for use in the treatment of a skin condition in a subject, including but not limited to hyperhidrosis, comprising a first composition and a second composition, wherein (a) the first composition comprises Spongilla; and (b) the second composition comprises one or more botulinum toxins. Also provided are kits, including kits for the treatment of a skin condition in a subject including but not limited to hyperhidrosis, comprising a first composition and a second composition, wherein the first composition comprises Spongilla, and the second composition comprises one or more botulinum toxins.

A topical composition for treating diabetic skin conditions is disclosed, comprising a non-steroidal, non-comedogenic, and fragrance-free formulation. The composition includes a synergistic blend of emollients, humectants & occlusives for intense moisturization; emulsifying agents for stabilization; moisturizing agents for enhanced hydration; antioxidants for reducing oxidative stress; anti-inflammatory agents for alleviating inflammation; anti-itching agents for relieving the itching; skin conditioners for improved barrier function; Filaggrin improver and agents for stimulating collagen production. The composition provides relief from dry skin, itching, and redness associated with diabetic skin conditions.

The present invention provides an anti-OX40L / IL-31Rot bispecific antibody and uses thereof. Specifically, the present invention provides for the first time a bispecific antibody that simultaneously targets OX40L and IL-31Rot for the treatment of skin diseases such as atopic 5 dermatitis (AD). The anti-OX40L / IL-31Rot bispecific antibody of the present invention exhibits high binding activity to both OX40L and IL-31Rot, synergistically regulates pathogenic T cells, effectively suppresses pruritus while providing long-lasting therapeutic efficacy, thereby offering patients a better treatment experience. The bispecific antibody of the present invention has promising applications in the treatment of skin diseases.

A diagnostic imaging system for analysing skin tissue image data received from a remote user for evaluating the image data for screening for a skin disease or skin condition, the system comprising: a manipulator arm and slider system of a robot, the manipulator arm moving on the slider along a patient body and comprising a plurality of elements interconnected to each other by a plurality of joints whereby each element is rotatable relative to an adjoining element of the manipulator arm; a non-invasive dermatoscope module comprising one or more dermatoscopes arranged to acquire tissue image data, the dermatoscope module being coupled to one of the elements of the manipulator arm by a coupling arrangement to allow movement of the dermatoscope module relative to said one of the elements of the manipulator arm; and a controller coupled to the manipulator arm and a coupling arrangement to employ the manipulator arm to move the dermatoscope module relative to the subject's anatomy; a server in communication with a distribution network for receiving tissue image data from the dermatoscope module, the tissue image data; a processor for executing a learning machine algorithm, wherein the algorithm is trained using image data sets having known outcomes for a plurality of skin diseases or skin conditions, the processor being operable for receiving image data from the dermatoscope module and processing the image data to produce processed image data and introducing the processed image data into the learning machine to provide an output indication of whether the tissue image data is associated with a skin condition or skin disease.

The present disclosure includes methods of treating a disease or condition that produces skin inflammation and / or itch. More specifically the present disclosure relates to treating skin inflammation and itch caused by diseases or disorders of the skin such as psoriasis by administering a peptide fragment of the MARCKS protein. Peptide fragments and variants thereof as disclosed in the present disclosure are useful in such methods.

The present invention relates to the technical field of microorganisms. Disclosed in the present invention are Lacticaseibacillus casei VB179 for inhibiting Malassezia, and a culture device and the use thereof. Specifically, disclosed in the present invention is Lacticaseibacillus casei VB179, wherein the Lacticaseibacillus casei VB179 is deposited in the China General Microbiological Culture Collection Center with a deposit number of CGMCC No. 28623 and a deposit date of 12 October 2023. The Lacticaseibacillus casei VB179 of the present invention can significantly inhibit the growth of Malassezia, and can further be used for treating skin diseases caused by the excessive reproduction of Malassezia, such as tinea versicolor, Malassezia folliculitis, seborrheic dermatitis and atopic dermatitis.

Cosmetic Use of a Composition for the Care of Keratinous Materials Comprising at Least of Indole-3-Pyruvic Acid. The present invention relates to the cosmetic, particularly topical, non-therapeutic use of a composition comprising, in a physiologically acceptable medium, indole-3-pyruvic acid, one of its isomers, or one of its salts, to prevent a decrease in the skin barrier function and / or to strengthen the skin barrier function in an individual, particularly in dry skin. It also relates to the use of such a composition to prevent and / or treat a skin disorder in sensitive skin in an individual, as well as the use of such a composition to prevent and / or treat pruritus and / or inflammation of the skin in an individual.A non-therapeutic cosmetic process for the care of keratinous materials, particularly of the skin, comprising the topical application of such a composition to these keratinous materials. Figure for the abstract: None.

The present invention provides a method and a pharmaceutical composition for treatment of skin diseases associated with accelerated comeodesmosomes degradation and / or weaker cell-cell adhesion, such as a peeling skin syndrome, Netherton syndrome, and atopic dermatitis.

The technical objective of this invention is to provide a protective pad against skin conditions. Destroyed by extreme cold for the cryolipolysis process, where the component... Waterproofing may be provided to prevent tearing or with waterproof components and base parts. It may be prevented from separating during the negative pressure process and Waterproof components can be easily attached to the base components without defects. In this case, a protective pad is used to prevent skin damage from extreme cold during the fat breakdown process. This invention's cooling agent is a protective pad against frostbite that is designed to prevent skin damage. The design is intended for use in cryolipolysis (fat freezing) procedures utilizing a fat-dissolving device. Cooling and protective padding against frostbite will include a base component made of... Made from fibrous materials, one or more waterproof components made from resin materials, and... It is placed by overlapping the base components and one or more stitched sections that are made by... Sew the base assembly and the waterproof assembly together to connect the base assembly and the waterproof assembly. Waterproof in a condition where the base component and the waterproof component are superimposed;

The invention relates to an anti-OX40L / IL-31R alpha bispecific antibody and an application thereof. Specifically, the invention provides a bispecific antibody simultaneously targeting OX40L and IL-31R alpha for the first time, and the bispecific antibody is used for treating skin diseases such as specific dermatitis (AD) and the like. The anti-OX40L / IL-31R alpha bispecific antibody provided by the invention simultaneously has high binding activity to OX40L and IL-31R alpha, can synergistically regulate and control pathogenic T cells, effectively inhibits pruritus while treating diseases for a long time, and gives a better treatment experience feeling to patients. The bispecific antibody disclosed by the invention has an application prospect in the aspect of treating skin diseases.

The invention relates to an application of an indole base compound or a pharmaceutically acceptable salt of the indole base compound and a pharmaceutically acceptable carrier in preparation of a medicine or a skin care product for treating or preventing high HMGB1 (High Mobility Group Box 1) type skin diseases, the indole base compound comprises at least one functional group of quaternary ammonium cations, amino groups or amino groups containing substituent groups; the HMGB1 type skin disease is marked by an increase in the level of high mobility group protein B1 (HMGB1) or is abnormal in signal path. According to the present invention, the N37 residue of the HMGB1 can be specifically bound, the pathological release of the N37 residue from the cell nucleus to the cytoplasm can be accurately blocked, the physiological functions of the N37 residue in the nucleus and the like are not affected, and the potential side effect of the existing broad-spectrum HMGB1 inhibitor is overcome.

Cosmetic composition comprising an endolysin and hydrophobic silica aerogel particles. The present invention relates to a composition, particularly a cosmetic one, comprising, in a physiologically acceptable medium, at least one endolysin, in particular an endolysin derived from a Staphylococcus aureus phage, and at least some hydrophobic silica aerogel particles. It also relates to the use of such a composition to prevent and / or treat a skin disorder related to colonization by Staphylococcus aureus in an individual in need, and in particular to prevent and / or treat acne and / or eczema in an individual in need, and a non-therapeutic cosmetic method for the care of keratinous materials, in particular skin, comprising at least one step of topical application of such a composition to said keratinous materials.

Provided herein is, inter alia, a hydrogel composition and methods for the treatment of skin conditions such as eczema, dandruff, and acne. The compositions comprise a synergistic blend of active ingredients including salts of carnosine, salts of carnitine, and cyclodextrin, which are formulated to be maintained in solution. The compositions disclosed herein are capable of altering gene expression related to skin health and can be manufactured through a method that involves forming carnosine and / or carnitine salts and combining them with cyclodextrin in solution.

Cosmetic composition comprising an endolysin derived from a Staphylococcus aureus phage and an aromatic alcohol. The present invention relates to a composition, particularly a cosmetic one, comprising, in a physiologically acceptable medium, at least one endolysin derived from a Staphylococcus aureus phage and at least one aromatic alcohol of formula (I). It also relates to the use of such a composition to prevent and / or treat a skin disorder related to colonization by Staphylococcus aureus in an individual in need, and in particular to prevent and / or treat acne and / or eczema in an individual in need, and a non-therapeutic cosmetic method for the care of keratinous materials, particularly skin, comprising at least one step of topical application of such a composition to said keratinous materials. Figure for abstract: None