221 results about "Diseases skin" patented technology

The invention relates to the technical field of skin disease diagnosis, and discloses an AI auxiliary decision support system for skin disease diagnosis, which integrates an image acquisition module, an image analysis module and a comprehensive analysis and diagnosis decision module. A high-definition image of the skin of a patient is obtained through high-precision skin photographing equipment, and a training data set is formed by combining basic information of the patient. A deep learning algorithm is utilized to train a skin disease recognition model and an illness state evaluation model, and accurate recognition of skin disease types and objective evaluation of severity are realized. And the comprehensive analysis module fuses output of the two models, constructs a fusion decision model and provides comprehensive diagnosis suggestions. And the diagnosis decision module is used for generating a disease type judgment and illness state evaluation report based on the trained model in combination with real-time image data so as to effectively assist doctors in making decisions. The accuracy, the efficiency and the popularization degree of skin disease diagnosis are improved, and complex and changeable diagnosis requirements in clinical practice are met.

Camera and / or other sensor analysis of skin, used to diagnose and monitor health conditions. A computer, receiving skin data from a user, where the skin data is images and / or other data of the skin. The computer processes the skin data identify skin conditions, their status, and to compare the skin data with information indicative of health conditions that are not skin diseases. This can be done by finding similar skin data to other data received from other people who have specified health conditions and / or by looking for changes from previous images. The skin data can be captured by a smart phone camera (alone or with digital peripheral attachments) or a dedicated capture device such as a periscope, one way mirror, or cubicle. An augmented reality marking system can be used to mark areas on the user's skin to compare against other previous skin images and / or data.

The invention discloses lactobacillus plantarum DACN128 which is preserved in the China Center for Type Culture Collection, the preservation number of the lactobacillus plantarum DACN128 is CCTCC NO: M20241337, and the lactobacillus plantarum DACN128 has a remarkable effect of inhibiting pathogenic malassezia, can be applied to prevention and treatment of skin diseases caused by excessive propagation of malassezia such as seborrheic dermatitis, characteristic dermatitis and psoriasis, and has a good application prospect. The application range of the plant lactobacillus DACN128 is expanded, the utilization value of the plant lactobacillus DACN128 is improved, and a new thought is brought to preparation of related daily washing products for removing dandruff and treating fungal infectious dermatitis.

The invention discloses a cationic super-deformation liposome capable of realizing gene transdermal transfection as well as preparation and application of the cationic super-deformation liposome, and belongs to the field of gene transdermal delivery. Materials such as low-molecular-weight polyethyleneimine, lipidosome and Tween 80 are adopted, and the components are safe and simple; polyethyleneimine is used as a conjugation carrier of the gene to improve the binding capacity of the gene, liposome is used as a delivery carrier to improve the skin delivery capacity of the gene, and Tween 80 is used for improving the stability and transdermal transfection capacity of the carrier again, so that non-invasive targeted transdermal delivery of the gene is realized; in vitro stability is high, gene degradation can be effectively inhibited, and meanwhile in vitro cell experiments, high transfection efficiency and low toxicity are achieved; the cationic super-deformed liposome can successfully realize high-efficiency transdermal penetration of the gene and effectively promote transfection expression of the gene in the skin at the same time, a new idea is provided for gene delivery, and the advantage of treating skin diseases through non-invasive delivery of the gene is expected to be fully exerted.

Provided are methods and composition for treating skin barrier functions and associated disorders. Formulated compositions may be applied on human skin to maintain a desired skin surface pH over an extended period of time without irritating the skin. Maintaining the desired surface pH aids in treatment of eczema, in addition to other skin conditions.

The instant disclosure relates to lipid particles that harbor cationic lipids, the particles found to be capable of delivering associated cargoes - particularly nucleic acid cargoes when formulated as nucleic acid-lipid particles - intracellularly to skin tissue cells when administered topically to a subject. The instant disclosure provides compositions comprising such lipid particles, optionally in association with a therapeutic agent (e.g., a therapeutic mRNA and / or nucleic acid controller system), as well as methods and kits for delivering a lipid particle-associated therapeutic agent and / or for treating or preventing a disease or disorder, e.g., a skin disease or disorder, in a subject, using one or more lipid particle compositions provided herein.

The invention relates to a multi-modal skin disease analysis method based on deep learning, and relates to the technical field of auxiliary diagnosis. A photoacoustic imaging device is used for scanning, a dermatoscope is used for shooting a skin disease affected part, and photoacoustic imaging data and a skin image of the affected part are obtained; aligning the photoacoustic image with a skin image, filling according to a skin image space, and combining with the skin image to obtain multi-modal skin data; constructing and pre-training a skin analysis model based on the multi-modal skin data; the pre-trained skin analysis model analyzes the collected multi-modal skin data to obtain a skin disease analysis result. The multi-modal skin data is constructed, multivariate data support is provided, and it is ensured that disease analysis is accurate and reliable. The skin analysis model extracts different scales of skin image feature maps and photoacoustic imaging feature maps so as to cover correlation between different sizes of features and different specifications of skin diseases; the other modal data is used to reinforce the own modal, and the two modal features are better combined; and the interpretability is high.

The invention discloses a programmable full-spectrum skin video medical microscope, which belongs to the technical field of microscope detection, and comprises three cameras which are arranged on a camera mainboard side by side, one camera is a common camera, and the other two cameras are multispectral cameras; the light source can emit light with various wavelengths and is detachably mounted on the supporting seat; and the light path transmission unit is positioned between the light source and the cameras and is mounted on the supporting seat so as to transmit light emitted by the light source to the three cameras or one of the three cameras. The full-spectrum video medical microscope capable of programmably adjusting the receiving wavelength is provided by integrating a photoelectric technology and an artificial intelligence technology, so that various different application requirements from clinic to scientific research and spectrum requirements required by diagnosis of different skin disease spectrums are met; the method is suitable for detection and evaluation of skin with problems such as skin cancer, skin inflammation, skin quality and scalp.

The invention belongs to the technical field of veterinary drug preparations, and particularly relates to a compound external ointment for treating parasites of dogs and cats and skin tinea and a preparation method, the compound external ointment comprises the following components by mass percent: 2%-12% of selamectin, 3%-20% of imidacloprid, 0.5%-2% of terbinafine hydrochloride, 2%-12% of dipropylene glycol monomethyl ether, 10%-50% of isopropanol, 9%-45% of polyethylene glycol 400 and the balance of water. The adhesive is prepared from, by weight, 9%-45% of polyethylene glycol 3350, 5%-15% of caprylic / capric polyethylene glycol glyceride, 1%-8% of oleyl alcohol, 0.5%-5% of dimeticone, 0.01%-0.1% of butylated hydroxytoluene and 1%-5% of cassava starch polymethylsesquioxane. The preparation method comprises the following steps: uniformly stirring the selamectin, the imidacloprid, the terbinafine hydrochloride and the mixed solvent, then mixing with the matrix (the polyethylene glycol 400 and the polyethylene glycol 3350 are heated and uniformly mixed in advance), the emulsifier and other components, and homogenizing. The compound selamectin ointment prepared by the invention can realize accurate administration at the edge of the auricle of an animal, and not only can ensure that the medicine is fully absorbed, but also can improve the compliance of animal administration; the composition not only can expel parasites in a broad spectrum, but also has broad-spectrum antifungal activity, and can prevent and treat a plurality of skin diseases of pets.

1. The name of the product of this design: Red light therapy box (portable and foldable). 2. Purpose of the product with this design: to generate red light to irradiate the skin, thereby promoting wound healing and treating skin diseases. 3. The design key point of this appearance design product lies in the shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

A method of operation of a compute system includes: qualifying a patient image for analyzing a suspected skin condition; detecting a skin area in the patient image; segmenting the skin area into a segmented image including the suspected skin condition; cropping the segmented image to form a cropped image including the suspected skin condition at a center of the cropped image; analyzing the suspected skin condition to identify a skin disease result and a disease subclass from the cropped image; and assembling a disease identification display including the patient image, a skin disease indication, an image match score, and the disease subclass for displaying on a device.

The present invention relates to skin moisturizing external compositions containing a ceramide, a cholesterol, and a fatty acid, and more particularly, to skin moisturizing external compositions capable of preventing skin troubles such as atopy by forming a dense lamellar structure, which is an intercellular lipid structure, and improving the skin barrier, and may include a ceramide having long-chain fatty acids, a cholesterol, a long-chain fatty acid, and purified water as active ingredients.

The present invention discloses an application of LCE5A as a target in the preparation of a drug for treating inflammatory skin diseases including psoriasis, wherein the LCE5A is mainly expressed on the epidermis; the present invention confirms through a series of experiments that LCE5A can effectively alleviate imiquimod-induced psoriasis-like skin inflammation in mice. The protein can significantly improve the barrier function of mouse skin, inhibit the release of proinflammatory factors and reduce the infiltration of inflammatory cells by regulating the proliferation and differentiation of keratinocytes. This provides important experimental support for the use of LCE5A in the preparation of drugs for skin diseases caused by skin barrier damage, as well as the development of functional skin care products. The experimental results clearly show that LCE5A exhibits significant therapeutic effects in a mouse psoriasis-like inflammation model, and its effect is safe and stable. The protein has a simple extraction and purification process, has good industrial production potential, and lays a solid foundation for clinical application.

The invention belongs to the technical field of washing products, and particularly relates to sulfur acarus-killing liquid soap and a preparation method thereof. 100% of the shampoo comprises the following raw materials by weight: 10 to 12% of a surfactant, 0.2 to 0.5% of a humectant, 0.2 to 0.5% of isothiazolinone, 0.1 to 0.2% of essence, 1.2 to 2.2% of sulfuric acid, 1.2 to 2.2% of polyvinyl alcohol, 0.1 to 0.3% of a compound traditional Chinese medicine extract, 0.02 to 0.04% of shea butter, 1.2 to 3.2% of butanediol, 0.3 to 1% of an emulsifier, 0.01 to 0.04% of a eucommia bark extract, 0.05 to 0.1% of sodium hydroxide, and the balance of deionized water. The sulfur acarus-killing liquid perfumed soap effectively reduces skin problems by inhibiting reproduction of bacteria and acarus; sulfur has strong bacteriostatic and acarus killing effects, can kill acarus on the surface of skin, and reduces skin problems caused by the acarus. The traditional Chinese medicine composition has the effects of diminishing inflammation and resisting bacteria, and has a good curative effect on skin diseases such as contact dermatitis, seborrheic dermatitis and solar eruption.

1. Name of the product of this design: Ultraviolet light therapy pen (CN‑308P II). 2. Purpose of the product of this design: UV irradiation treatment for skin diseases such as vitiligo, psoriasis, pityriasis rosea, eczema, etc. 3. Key points of the design of this product: The combination of shape and pattern. 4. The picture or photo that best illustrates the key points of the design: Stereoscopic picture.

The present disclosure provides crystalline forms of the compound having formula (I): (I), wherein the crystalline forms are crystalline Forms A, B, C, E, F, and H, each of which is characterized by an X-ray powder diffraction (XRPD) pattern. The present disclosure also provides methods for preparing crystalline forms, in particular Form A. The present disclosure further provides methods of treating various skin disorders using the crystalline forms of the disclosure or a pharmaceutical composition thereof.

The invention belongs to the technical field of microorganisms, and particularly relates to a staphylococcus epidermidis H62-3 metabolite gel preparation as well as a preparation method and application thereof. The staphylococcus epidermidis H62-3 metabolite gel preparation improves skin erythema and scale symptoms of a psoriasis mouse model, remarkably reduces the skin lesion thickness, can reduce the mRNA expression level of inflammatory factors interleukin-17A, interleukin-17F and interleukin-23 at the skin lesion of the psoriasis mouse model, and can be used for treating psoriasis. The compound has a prospect of being developed into drugs for treating inflammatory dermatosis. The staphylococcus epidermidis H62-3 metabolite gel preparation disclosed by the invention is used for improving a psoriasis mouse model, and a new thought for safely and effectively treating inflammatory skin diseases by external use of viable bacteria metabolite is provided.

The present invention relates to: a Bacillus subtilis HKtulip001 (accession no. KCTC15331BP) strain, a culture thereof, a lysate thereof, or an extract thereof; and a use thereof. The strain according to the present invention has excellent skin barrier improvement, pruritus amelioration, moisturization, and wrinkle amelioration effects, and also has a high total polyphenol content, and thus can be effectively utilized for skin condition improvement purposes.

The invention belongs to the field of skin care and skin disease treatment, and provides a skin care composition and application thereof, and the skin care composition is in a liquid form and comprises recombinant collagen and glycolic acid. The specific low-concentration glycolic acid in the skin care composition disclosed by the invention ensures the mild keratin metabolism capability; the recombinant collagen with high transdermal property can quickly permeate into the deep layer of the skin, and can immediately provide a repairing raw material for the skin while the glycolic acid acts, so that discomforts such as redness and stabbing pain are remarkably relieved, and synchronous skin care and repairing is realized.

Select substituted lysine and branched amino acid salts, compositions containing the same and the use of the foregoing in treating the adverse physiological effects of various diseases, especially skin diseases; in mitigating the effects of aging and environmental factors on skin; and in improving and rejuvenating skin.

METHODS FOR GEOLOCATION-BASED SKIN SCIENCE-BASED ENVIRONMENTAL EXPOSURE METRICS Methods for communicating the risk of skin conditions due to exposure to sunlight and environmental conditions to individuals. These methods leverage geolocation and environmental data to provide guidance and enable consumers to make informed decisions regarding outdoor activities, healthcare, and skincare. A photopollution metric is a function of the ultraviolet index (UVI) and the level of a pollutant such as particulate matter (PM) and allows for the communication of an individual's risk of exposome-induced skin conditions based on environmental exposure. Figure for abstract: none

This disclosure relates to compositions and methods using genetically modified bacteria that express superoxide dismutase (SOD) and catalase enzymes to reduce oxidative stress in the skin, and can be used for various skin conditions. In some embodiments of this disclosure, the genetically modified bacteria are Gram-positive bacteria, for example, of the genus Corynebacterium.

The invention belongs to the technical field of skin disease treatment and medicine, and particularly relates to an external pharmaceutical composition for treating atopic dermatitis and a preparation method and application thereof. The medicine composition is liquid medicine composed of blumea balsamifera oil, perfoliote knotweed herb and piper cubeba extract and is specially used for treating the atopic dermatitis (AD). According to the composition, the blumea balsamifera oil is innovatively used as a main component and cooperates with the perfoliote knotweed herb and the piper cubeba extract to form an efficient treatment scheme, and the curative effect of the composition is remarkably superior to that of a traditional method for singly using the blumea balsamifera oil. Experiments prove that the composition can effectively improve the skin barrier function, regulate immune disorder, reduce the levels of serum IgE and TSLP and inflammatory factors IL-4 and IFN-gamma, and reduce inflammatory cell infiltration, so that the AD symptom is relieved, and the recurrence rate is reduced.

The present invention relates generally to maqui berry for use in the treatment or prevention of skin diseases, wherein maqui berry may be the primary natural active ingredient. Particular embodiments as disclosed herein find application in, inter alia, the prophylaxis and the treatment of skin diseases, in particular, dermatitis, atopic dermatitis (neurodermatitis), dermatitis solaris, eczema, hand eczema, lichen planus, lupus erythematosus, psoriasis, urticaria, itching, scabies, age spot, freckles and dry / atopic skin of humans. In particular, the present invention relates to the use of maqui berry extract in the manufacture of a medicament or dietary supplement for use in treating or preventing said skin diseases or defects.

The invention belongs to the technical field of biological medicines, and particularly relates to application of a marine small molecule peptide and an active variant thereof in preparation of a medicine for treating skin diseases, the marine small molecule peptide and the active variant thereof can effectively inhibit keratinocyte pan apoptosis induced by TNF-alpha and IFN-gamma, the formation of a PANoptosome complex is blocked through a multi-target synergistic effect, and the effect of treating the skin diseases is achieved. The oxidative stress is reduced, and mitochondria is stabilized, so that a skin inflammatory cell death network is inhibited from the source. The variant has the same high sequence as the peptide, retains the activity of inhibiting cell pan-apoptosis, and has enhanced stability, skin permeability, in vivo half-life or efficacy. Based on the action mechanism, the peptide and the variant thereof can be used for preparing medicines for preventing and treating intractable skin diseases such as epidermis necrolysis, psoriasis, atopic dermatitis, skin lupus erythematosus and lichen planus. The invention also provides a composition containing the peptide or the variant thereof, and dosage forms comprise an external preparation and an injection.

The present invention relates to a multimodal skin disease analysis method based on deep learning, and relates to the field of auxiliary diagnosis technology. The present invention uses a photoacoustic imaging device to scan, and a dermatoscope to photograph the affected area of the skin disease to obtain photoacoustic imaging data and skin images of the affected area; aligns the photoacoustic imaging with the skin image, fills the space according to the skin image, and then combines it with the skin image to obtain multimodal skin data; constructs and pre-trains a skin analysis model based on multimodal skin data; the pre-trained skin analysis model analyzes the collected multimodal skin data to obtain skin disease analysis results. The present application constructs multimodal skin data, provides multivariate data support, and ensures that disease analysis is accurate and reliable. The skin analysis model extracts skin image feature maps and photoacoustic imaging feature maps of different scales to cover the association between features of different sizes and skin diseases of different specifications; uses another modality data to strengthen its own modality to better combine the two modality features; and has strong interpretability.

A method of producing a rapamycin-containing composition for treating skin disease, which comprises the steps of dissolving rapamycin in an ethanol-containing solvent, adding a gelling and / or thickening agent to the resulting rapamycin-containing solution, and adjusting the pH of the resulting rapamycin-containing composition to 5.5 to 6.1 with triethanolamine or tris(hydroxymethyl)aminomethane (TRIS) is provided. A method of inhibiting degradation of rapamycin in a rapamycin-containing composition for treating skin diseases, wherein the method comprises the step of adjusting the pH of the composition to 5.5 to 6.1 with triethanolamine or tris(hydroxymethyl)aminomethane is also provided. A rapamycin-containing composition for treating skin diseases comprising (i) rapamycin, (ii) carboxylic acid-containing aqueous polymer, and (iii) at least one pH adjuster selected from triethanolamine and tri(hydroxymethyl)aminomethane, having a pH of 5.5 to 6.1 is also provided. The carboxylic acid-containing polymer may be carboxy vinyl polymer (carbomer), carboxymethyl cellulose or carboxyethyl cellulose. The skin disease may be dermatitis, contact dermatitis, psoriasis, atopic dermatitis, seborrheic dermatitis, nummular eczema, vitiligo, keloids, autosensitised dermatitis, stasis dermatitis, sebaceous deficiency eczema, skin tumours of tuberous sclerosis, and skin tumours of Recklinghausen’s disease. Preferred topical gels comprise rapamycin, carboxy vinyl polymer (carbomer), ethanol, water and either triethanolamine or tris(hydroxymethyl)aminomethane.

The invention provides bacillus mojavensis and belongs to the technical field of microorganisms. The preservation number of the bacillus mojavensis VT275 is CGMCC (China General Microbiological Culture Collection Center) No.29974. The bacillus mojavensis VT275 can be used for effectively inhibiting common skin pathogenic bacteria and food-borne pathogenic bacteria, such as staphylococcus aureus, methicillin-resistant staphylococcus aureus, staphylococcus epidermidis, listeria monocytogenes, shigella, enterococcus faecalis and the like. The bacillus mojavensis VT275 disclosed by the invention can be used for preventing or treating skin diseases such as specific dermatitis or controlling food-borne infection, and has a good application prospect in the fields of medicines, cosmetics, edible microorganisms, feed microorganisms and the like.

The application belongs to the technical field of medicines, and specifically provides application of Phanginin A in preparation of medicines for preventing and / or treating skin diseases. The skin diseases include atopic dermatitis and skin epidermal barrier damage. The application finds that Phanginin A can reduce atopic dermatitis lesion scores, improve atopic dermatitis skin pathological thickening and inflammatory cell infiltration, reduce spleen inflammatory response, inhibit volume increase, promote thymus function recovery, down-regulate expression of atopic dermatitis related inflammatory factors IL-6 and TNF-alpha, and can be used for preventing and / or treating atopic dermatitis. In addition, the application also finds that Phanginin A can promote keratinocyte scratch healing, and can be used for repairing skin epidermal barrier damage.

The invention provides a quantitative analysis system and method for skin lesion of skin diseases, an image acquisition unit photographs a diseased skin part and transmits the photographed image to an image processing unit, and the image processing unit performs positioning detection and image segmentation on the photographed image and transmits a positioning detection result and an image segmentation result to a quantitative analysis unit; the quantitative analysis unit is used for automatically analyzing the shape and color of the skin lesion. Based on the system, accurate quantitative analysis can be performed on the skin lesion, and the system has the advantages of wide application range, convenience in operation and high precision.