50 results about "Corynebacterium sp" patented technology

The present application provides: a microorganism with enhanced lipoate protein ligase activity; a composition for producing histidine comprising the microorganism; and a method for producing histidine, the method comprising a step for culturing the microorganism.

The present application relates to a Corynebacterium sp. microorganism in which a foreign nicotinamide nucleotide transhydrogenase protein is expressed or a polynucleotide encoding the same is introduced, whereby the microorganism exhibits improved production capability of L-amino acids or derivatives thereof.

The present application relates to: a culture medium composition for microorganisms of Corynebacterium species, in which part of ammonium sulfate is replaced with a different ammonium-containing compound; and a method for producing a basic amino acid by using the culture medium composition.

This disclosure relates to compositions and methods using genetically modified bacteria that express superoxide dismutase (SOD) and catalase enzymes to reduce oxidative stress in the skin, and can be used for various skin conditions. In some embodiments of this disclosure, the genetically modified bacteria are Gram-positive bacteria, for example, of the genus Corynebacterium.

The invention provides a new application of the chlorine hydrozincite. The antibacterial agent according to the present invention is an antibacterial agent for at least one type of skin resident bacteria selected from the group consisting of Corynebacterium genus, Moraxella genus, and Malassezia genus, said antibacterial agent containing chlorine hydrozincite.

The present disclosure relates to: a protein variant; a polynucleotide encoding the protein variant; a Corynebacterium genus microorganism comprising at least one selected from the group consisting of the protein variant and the polynucleotide; and a method for producing L-isoleucine using the microorganism.

The present invention relates to a Corynebacterium sp. mutant microorganism producing L-glutamic acid and a method of producing L-glutamic acid using the same, and more specifically, to a novel NADP-dependent malic enzyme variant involved in the L-glutamic acid biosynthetic pathway, a polynucleotide, and a transformant, as well as a method of producing L-glutamic acid using the same. The NADP-dependent malic enzyme variant according to the present invention is obtained by substituting one or more amino acids in the amino acid sequence constituting NADP-dependent malic enzyme to change the enzymatic activity of the NADP-dependent malic enzyme, and a recombinant microorganism comprising the NADP-dependent malic enzyme variant is capable of efficiently producing L-glutamic acid.

The present disclosure relates to a Corynebacterium sp. microorganism for producing glutamate-based amid acids, and a method for producing glutamate-based amino acids using the microorganism.

The present application relates to a Corynebacterium genus microorganism into which an exogenous soluble pyridine nucleotide transhydrogenase is introduced, and a method for producing L-tryptophan using the same.

The present disclosure relates to a Corynebacterium genus microorganism in which an exogenous nicotinamide nucleotide transhydrogenase protein or a polynucleotide encoding the same is expressed, whereby the microorganism exhibits improved productivity of an L-amino acid or a derivative thereof.

The present invention relates to a Corynebacterium sp. mutant microorganism producing L-glutamic acid and a method of producing L-glutamic acid using the same, and more specifically, to a novel oxidoreductase variant involved in the L-glutamic acid biosynthetic pathway, a polynucleotide, and a transformant, as well as a method of producing L-glutamic acid using the same. The oxidoreductase variant according to the present invention is obtained by substituting one or more amino acids in the amino acid sequence constituting oxidoreductase to change the enzymatic activity of the oxidoreductase, and a recombinant microorganism comprising the oxidoreductase variant is capable of efficiently producing L-glutamic acid.

The present disclosure relates to a microorganism of the genus Corynebacterium having an improved ability to produce L-amino acids or derivatives thereof, and in which a foreign nicotinamide nucleotide transhydrogenase protein is expressed or a polynucleotide encoding the same is introduced.

The present invention relates to a microorganism of the genus Corynebacterium with improved L-lysine production capacity and a method for producing L-lysine using the same. The microorganism of the genus Corynebacterium has enhanced activity of glucose-promoting diffusion transporters and glucokinase, thereby improving the production yield of L-lysine compared to the parent strain or cases where glucose-promoting diffusion transporters or glucokinase are enhanced alone.

The present invention relates to a microorganism belonging to the genus Corynebacterium and having improved L-lysine production capacity, and a method for producing L-lysine using the same, the microorganism being capable of producing L-lysine by enhancing the activity of a glucose-promoting diffusion transporter and a glucokinase. Therefore, the production yield of L-lysine can be improved compared with the condition of enhancing the parent strain, the glucose promoting diffusion transporter or the glucokinase alone.

To provide a novel evaluation method related to the barrier function of the scalp, to provide a method for selecting scalp and hair cosmetics, to provide a screening method, to provide a method for producing scalp and hair cosmetics, to provide scalp and hair cosmetics, and to provide an evaluation support tool.SOLUTION: The degree of the barrier function in the scalp of a subject to be evaluated is evaluated based on at least one of the following indicators: an indicator of bacterial diversity in the scalp bacterial flora of a subject to be evaluated; an indicator of the number of bacteria in the scalp bacterial flora of a subject to be evaluated that includes at least Corynebacterium bacteria; and an indicator of the proportion of bacteria in the scalp bacterial flora of a subject to be evaluated that includes at least Corynebacterium bacteria. Or, at least any one of the above indicators is evaluated based on the degree of the barrier function in the scalp of a subject to be evaluated.SELECTED DRAWING: Figure 3

The present disclosure relates to a microorganism of the genus Corynebacterium in which the activity of fumarate hydratase is enhanced, and a method for producing L-amino acids using same. The microorganism of the genus Corynebacterium with enhanced fumarate hydratase exhibits increased production capability of L-amino acids such as L-arginine, L-citrulline, L-ornithine, O-acetylhomoserine, L-homoserine, and L-histidine, compared to a parent strain in which the fumarate hydratase is not enhanced, and the microorganism with enhanced fumarate hydratase can be widely used for the production of L-amino acids.

This application relates to a composition for preventing, improving, or treating gastrointestinal diseases comprising a strain of the genus Corynebacterium, a culture thereof, and threonine. Since the composition according to this application has been confirmed to have excellent anti-Helicobacter pylori efficacy in cell experiments, efficacy in improving gastrointestinal diseases in animal experiments, and efficacy in the synthesis of gastric mucus, the composition may be used as a pharmaceutical composition for preventing or treating gastrointestinal diseases, as a feed for preventing or improving gastric ulcers, or as a feed composition.

The present application relates to: a Corynebacterium genus microorganism having an L-amino acid producing ability, into which an NAD-dependent isocitrate dehydrogenase protein derived from Streptococcus mutans or a polynucleotide encoding the same is introduced; a method for producing an L-amino acid, the method comprising a step of culturing the microorganism in a culture medium; a composition for producing an L-amino acid, the composition comprising the microorganism, a culture of the microorganism, a fermentation product of the microorganism, or a combination of two or more thereof; and to the use of said microorganism in the production of L-amino acids.

The present disclosure relates to a method for producing a glutamic acid-based amino acid, the method comprising culturing, in a culture medium, a Corynebacterium genus microorganism having a glutamic acid-based amino acid producing ability in which the activity of a protein comprising the amino acid sequence of SEQ ID NO: 1 is weakened as compared to its endogenous activity; a composition for producing glutamic acid-based amino acids, comprising the microorganism, a culture of the microorganism, a fermentation product of the microorganism, or a combination of two or more thereof; and to the use of said microorganism in the production of glutamic acid-based amino acids.

The present application relates to an L-arginine-producing microorganism in which a protein comprising the amino acid sequence of SEQ ID NO:1 is attenuated, and a method for producing L-arginine using the same.

The present application provides a culture medium composition for a Corynebacterium genus microorganism in which a portion of ammonium sulfate is replaced with another ammonium-containing compound, and a method for producing a basic amino acid using the same.

The present disclosure relates to a novel bifunctional glutamate N-acetyltransferase / amino-acid acetyltransferase variant, a Corynebacterium sp. microorganism comprising the variant, and a method for producing glutamate-based amino acids, comprising the step of culturing the microorganism.

The present disclosure relates to: a Corynebacterium genus microorganism having an L-tryptophan-producing ability, into which a pyruvate-phosphate dikinase derived from foal foal xylose or a polynucleotide encoding the same is introduced; a method for producing L-tryptophan, comprising a step of culturing the microorganism in a culture medium; a composition for producing L-tryptophan comprising the microorganism, a culture product of the microorganism, a fermentation product of the microorganism, or a combination of two or more thereof; and the use of said microorganism for the production of L-tryptophan.

The present invention relates to a microorganism belonging to the genus Corynebacterium having improved L-citrulline or L-arginine production capacity and a method for producing L-citrulline or L-arginine using the same, the microorganism belonging to the genus Corynebacterium having improved L-citrulline or L-arginine production capacity, the activity of glutamine synthetase, aspartate transaminase, and carbamyl phosphate synthetase being enhanced, so that the L-citrulline or L-arginine production capacity can be increased compared to the prior art, and a method for producing L-citrulline or L-arginine production capacity can be improved. And the production yield of the L-citrulline or the L-arginine can be improved.

The present application relates to a novel promoter and a method for producing a target substance using the same, and more particularly, to a novel polynucleotide having promoter activity, a vector gene carrying the same, and a microorganism of Corynebacterium sp. anchoring the same, and a method for producing a target substance using the same.

The present invention relates to a mutant strain of the genus Corynebacterium having improved L-alanine productivity due to radiation-induced mutation compared to a parent strain, a method for producing the same, and a method for producing L-alanine using the same. The mutant strain of the genus Corynebacterium has improved L-alanine productivity compared to the parent strain, and thus, L-alanine can be produced with high efficiency and high yield using the strain.

The present invention relates to a recombinant microorganism with improved glycerol utilization ability and a glycerol utilization method using same and, in particular, to: a recombinant microorganism of the genus Corynebacterium, which has improved glycerol utilization ability by using a gene involved in the use of glycerol derived from a heterologous strain; and a glycerol utilization method using same. The recombinant microorganism of the present invention is a recombinant microorganism with improved glycerol utilization ability, in which the glycerol conversion pathway operates more efficiently, thereby providing a recombinant microorganism which can facilitate the production of products via the glycerol conversion pathway and is useful for mass production.

The present invention relates to a method for detecting a nucleic acid of a target microorganism from a sample collected from skin by using a nucleic acid of Corynebacterium spp. or Cutibacterium spp. as an endogenous internal control nucleic acid, and a composition for nucleic acid amplification used in the method. The endogenous internal control according to the present invention is present in the sample from the beginning, thereby eliminating the inconvenience of having to add same separately after sample collection, and can be used as an internal control for the sample collection process, an internal control for the nucleic acid extraction process, and an internal control for the nucleic acid amplification process. In addition, by using the nucleic acid of Corynebacterium spp. or Cutibacterium spp. as an endogenous internal control, it is possible to detect the presence or absence of a target microbial nucleic acid in a sample collected from skin with high accuracy by minimizing false negative and false positive determinations.

The present invention relates to a Corynebacterium sp. mutant microorganism producing L-glutamic acid and a method of producing L-glutamic acid using the same, and more specifically, to a novel deoxyribose-phosphate aldolase variant involved in the L-glutamic acid biosynthetic pathway, a polynucleotide, and a transformant, as well as a method of producing L-glutamic acid using the same. The deoxyribose-phosphate aldolase variant according to the present invention is obtained by deleting one or more amino acids in the amino acid sequence constituting deoxyribose-phosphate aldolase to change the enzymatic activity of the deoxyribose-phosphate aldolase, and a recombinant microorganism comprising the deoxyribose-phosphate aldolase variant is capable of efficiently producing L-glutamic acid.

The present disclosure relates to: a Corynebacterium genus microorganism having an L-tryptophan producing ability, into which a ribose-phosphate pyrophosphate kinase derived from Bacillus subtilis or a polynucleotide encoding the same has been introduced; a method for producing L-tryptophan comprising culturing the microorganism in a culture medium; a composition for producing L-tryptophan comprising the microorganism, a culture of the microorganism, a fermentation product of the microorganism, or a combination of two or more thereof; and the use of the microorganism for the production of L-tryptophan.