71 results about "Corynebacterium sp" patented technology

The present invention provides a protein variant, a Corynebacterium genus microorganism comprising the protein variant, and a method for producing L-lysine using the microorganism of the present disclosure.

The present application provides: a microorganism with enhanced lipoate protein ligase activity; a composition for producing histidine comprising the microorganism; and a method for producing histidine, the method comprising a step for culturing the microorganism.

One embodiment of the present invention provides a psicose epimerase expression cassette comprising a polynucleotide encoding a psicose epimerase and a promoter operably linked thereto and modulating the expression of the psicose epimerase in a Corynebacterium strain. The promoter consists of a base sequence as shown in a sequence 1, a base sequence as shown in a sequence 9, a base sequence as shown in a sequence 10 or a base sequence as shown in a sequence 11. The psicose epimerase expression cassette disclosed by the embodiment of the invention is almost not started in a normal environment for culturing a recombinant corynebacterium strain, and does not induce growth inhibition of the recombinant corynebacterium strain. Therefore, the recombinant corynebacterium strain transformed by the psicose epimerase expression cassette of one embodiment of the present invention can normally grow and proliferate to the logarithmic phase, and stably and highly express psicose epimerase after the logarithmic phase.

The present application relates to a Corynebacterium sp. microorganism in which a foreign nicotinamide nucleotide transhydrogenase protein is expressed or a polynucleotide encoding the same is introduced, whereby the microorganism exhibits improved production capability of L-amino acids or derivatives thereof.

The present application relates to: a culture medium composition for microorganisms of Corynebacterium species, in which part of ammonium sulfate is replaced with a different ammonium-containing compound; and a method for producing a basic amino acid by using the culture medium composition.

This disclosure relates to compositions and methods using genetically modified bacteria that express superoxide dismutase (SOD) and catalase enzymes to reduce oxidative stress in the skin, and can be used for various skin conditions. In some embodiments of this disclosure, the genetically modified bacteria are Gram-positive bacteria, for example, of the genus Corynebacterium.

The invention provides a new application of the chlorine hydrozincite. The antibacterial agent according to the present invention is an antibacterial agent for at least one type of skin resident bacteria selected from the group consisting of Corynebacterium genus, Moraxella genus, and Malassezia genus, said antibacterial agent containing chlorine hydrozincite.

The present application relates to: a novel gluconate repressor variant, a polynucleotide comprising the variant of the present application, a microorganism of the genus Corynebacterium comprising the variant of the present application or the polynucleotide, and a method for producing L-arginine using the microorganism of the present application.

The present application relates to a recombinant microorganism of the genus Corynebacterium having an L-ornithine producing ability, comprising an amino acid transporter of the LysE / ArgO family derived from a Shewanella strain or a polynucleotide encoding an amino acid transporter of the LysE / ArgO family.

The present invention relates to a Corynebacterium sp. strain with enhanced histidine production ability and introduced galactose utilization ability, and a method for producing histidine from seaweed using same. The transformed Corynebacterium sp. strain of the present invention exhibits excellent histidine production ability through the enhancement of the galactose utilization and histidine production pathways, thereby producing amino acids on the basis of an eco-friendly process. Additionally, since galactose obtained from the degradation of carrageenan, a major component of seaweed, is utilized, the invention provides the advantage of utilizing seaweed as a biomass resource.

The present disclosure relates to: a protein variant; a polynucleotide encoding the protein variant; a Corynebacterium genus microorganism comprising at least one selected from the group consisting of the protein variant and the polynucleotide; and a method for producing L-isoleucine using the microorganism.

One embodiment of the present invention provides a promoter which is characterized by comprising a base sequence represented by sequence 6 or a base sequence represented by sequence 27, and which regulates the expression of psicose epimerase in a Corynebacterium strain. The novel promoter provided by the invention can be used for constitutive high expression of a target protein, especially an enzyme, in a corynebacterium strain. For example, when using a recombinant Corynebacterium strain transformed with an expression vector comprising a novel promoter of the present invention, psicose epimerase can be economically mass-produced or psicose can be economically mass-produced from fructose.

The present invention relates to a Corynebacterium sp. mutant microorganism producing L-glutamic acid and a method of producing L-glutamic acid using the same, and more specifically, to a novel NADP-dependent malic enzyme variant involved in the L-glutamic acid biosynthetic pathway, a polynucleotide, and a transformant, as well as a method of producing L-glutamic acid using the same. The NADP-dependent malic enzyme variant according to the present invention is obtained by substituting one or more amino acids in the amino acid sequence constituting NADP-dependent malic enzyme to change the enzymatic activity of the NADP-dependent malic enzyme, and a recombinant microorganism comprising the NADP-dependent malic enzyme variant is capable of efficiently producing L-glutamic acid.

The present disclosure relates to a Corynebacterium sp. microorganism for producing glutamate-based amid acids, and a method for producing glutamate-based amino acids using the microorganism.

The present application relates to a Corynebacterium genus microorganism into which an exogenous soluble pyridine nucleotide transhydrogenase is introduced, and a method for producing L-tryptophan using the same.

The present invention relates to a novel bacterium of the genus Corynebacterium, useful for cosmetic application. A method for screening anti-aging substances is also provided.

The present disclosure relates to a Corynebacterium genus microorganism in which an exogenous nicotinamide nucleotide transhydrogenase protein or a polynucleotide encoding the same is expressed, whereby the microorganism exhibits improved productivity of an L-amino acid or a derivative thereof.

The present invention relates to a Corynebacterium sp. mutant microorganism producing L-glutamic acid and a method of producing L-glutamic acid using the same, and more specifically, to a novel oxidoreductase variant involved in the L-glutamic acid biosynthetic pathway, a polynucleotide, and a transformant, as well as a method of producing L-glutamic acid using the same. The oxidoreductase variant according to the present invention is obtained by substituting one or more amino acids in the amino acid sequence constituting oxidoreductase to change the enzymatic activity of the oxidoreductase, and a recombinant microorganism comprising the oxidoreductase variant is capable of efficiently producing L-glutamic acid.

The present disclosure relates to a microorganism of the genus Corynebacterium having an improved ability to produce L-amino acids or derivatives thereof, and in which a foreign nicotinamide nucleotide transhydrogenase protein is expressed or a polynucleotide encoding the same is introduced.

The present invention relates to a microorganism of the genus Corynebacterium with improved L-lysine production capacity and a method for producing L-lysine using the same. The microorganism of the genus Corynebacterium has enhanced activity of glucose-promoting diffusion transporters and glucokinase, thereby improving the production yield of L-lysine compared to the parent strain or cases where glucose-promoting diffusion transporters or glucokinase are enhanced alone.

The present invention relates to a microorganism belonging to the genus Corynebacterium and having improved L-lysine production capacity, and a method for producing L-lysine using the same, the microorganism being capable of producing L-lysine by enhancing the activity of a glucose-promoting diffusion transporter and a glucokinase. Therefore, the production yield of L-lysine can be improved compared with the condition of enhancing the parent strain, the glucose promoting diffusion transporter or the glucokinase alone.

To provide a novel evaluation method related to the barrier function of the scalp, to provide a method for selecting scalp and hair cosmetics, to provide a screening method, to provide a method for producing scalp and hair cosmetics, to provide scalp and hair cosmetics, and to provide an evaluation support tool.SOLUTION: The degree of the barrier function in the scalp of a subject to be evaluated is evaluated based on at least one of the following indicators: an indicator of bacterial diversity in the scalp bacterial flora of a subject to be evaluated; an indicator of the number of bacteria in the scalp bacterial flora of a subject to be evaluated that includes at least Corynebacterium bacteria; and an indicator of the proportion of bacteria in the scalp bacterial flora of a subject to be evaluated that includes at least Corynebacterium bacteria. Or, at least any one of the above indicators is evaluated based on the degree of the barrier function in the scalp of a subject to be evaluated.SELECTED DRAWING: Figure 3

The present disclosure relates to a microorganism of the genus Corynebacterium in which the activity of fumarate hydratase is enhanced, and a method for producing L-amino acids using same. The microorganism of the genus Corynebacterium with enhanced fumarate hydratase exhibits increased production capability of L-amino acids such as L-arginine, L-citrulline, L-ornithine, O-acetylhomoserine, L-homoserine, and L-histidine, compared to a parent strain in which the fumarate hydratase is not enhanced, and the microorganism with enhanced fumarate hydratase can be widely used for the production of L-amino acids.

This application relates to a composition for preventing, improving, or treating gastrointestinal diseases comprising a strain of the genus Corynebacterium, a culture thereof, and threonine. Since the composition according to this application has been confirmed to have excellent anti-Helicobacter pylori efficacy in cell experiments, efficacy in improving gastrointestinal diseases in animal experiments, and efficacy in the synthesis of gastric mucus, the composition may be used as a pharmaceutical composition for preventing or treating gastrointestinal diseases, as a feed for preventing or improving gastric ulcers, or as a feed composition.

The present application relates to: a Corynebacterium genus microorganism having an L-amino acid producing ability, into which an NAD-dependent isocitrate dehydrogenase protein derived from Streptococcus mutans or a polynucleotide encoding the same is introduced; a method for producing an L-amino acid, the method comprising a step of culturing the microorganism in a culture medium; a composition for producing an L-amino acid, the composition comprising the microorganism, a culture of the microorganism, a fermentation product of the microorganism, or a combination of two or more thereof; and to the use of said microorganism in the production of L-amino acids.

The present disclosure relates to a method for producing a glutamic acid-based amino acid, the method comprising culturing, in a culture medium, a Corynebacterium genus microorganism having a glutamic acid-based amino acid producing ability in which the activity of a protein comprising the amino acid sequence of SEQ ID NO: 1 is weakened as compared to its endogenous activity; a composition for producing glutamic acid-based amino acids, comprising the microorganism, a culture of the microorganism, a fermentation product of the microorganism, or a combination of two or more thereof; and to the use of said microorganism in the production of glutamic acid-based amino acids.

The present application relates to an L-arginine-producing microorganism in which a protein comprising the amino acid sequence of SEQ ID NO:1 is attenuated, and a method for producing L-arginine using the same.

Described herein are compositions, methods, kits and devices for the treatment and / or prevention of a wide spectrum of disease conditions. In particular, bacterial populations described herein are live, purified bacteria for the modulation, restoration and / or promotion of the microbiome in the upper respiratory tract of a subject, including the nasal cavity, to promote health. Such bacterial populations may include single or multiple strains for bacteria. The multiple strains of bacteria may be strains from the same or different species, including species of Corynebacterium and / or Dolosigranulum pigrum.

The present application provides a culture medium composition for a Corynebacterium genus microorganism in which a portion of ammonium sulfate is replaced with another ammonium-containing compound, and a method for producing a basic amino acid using the same.

The present disclosure relates to a novel bifunctional glutamate N-acetyltransferase / amino-acid acetyltransferase variant, a Corynebacterium sp. microorganism comprising the variant, and a method for producing glutamate-based amino acids, comprising the step of culturing the microorganism.