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Thermosetting medical carrier composition with mucosa adsorption

A composition and thermosetting technology, applied in the field with almost no side effects, can solve the problems of unsatisfactory form of use, convenience and drug delivery effect, etc.

Inactive Publication Date: 2003-08-13
PHARMA POWER BIOTEC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] Looking at the various topical drug delivery systems that have been disclosed in this technology, the form of use, convenience and drug delivery effects are still unsatisfactory.

Method used

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  • Thermosetting medical carrier composition with mucosa adsorption
  • Thermosetting medical carrier composition with mucosa adsorption
  • Thermosetting medical carrier composition with mucosa adsorption

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 11

[0064] Pluronic F-127 (PF-127) is a polymer with reverse thermal gelation. According to Schmolka (Schmolka IR.Artificial skin.I.Preparation and properties of pluronic F-127 gels for treatment of burns, Journal of Biomedical Materials Research.6(6):571-82, 1972) early reports and recent results of other research teams (1.Morishita M.Barichello JM.Takayama K.Chiba Y.Tokiwa S.Nagai T., Pluronic F-127 gels incorporating highly purified unsaturated fatty acids for buccaldelivery of insulin, International Journal of Pharmaceutics.212(2):289-93, 200l; 2.El-Kattan AF.Asbill CS.Kim N.Michniak BB., Effect of formulation variables on the percutaneous permeation of ketoprofen from gel formulations, Drug Delivery: Journal of Delivery & Targeting of Therapeutic Agents.7(3):147- 53, 2000; 3. Onuki Y. Morishita M. Takayama K. Tokiwa S. Chiba Y. Isowa K. Nagai T., In vivo effects of highly purified docosahexaenoic acid on rectalinsulin absorption, International Journal of Pharmaceuticals. 198(...

Embodiment 14

[0072] Samples and operating conditions are as described in Example 1.1 and Example 1.2. The square mark represents the temperature rise test, and the triangle mark represents the temperature drop test. The concentration of PF-127 was fixed at 25% w / w, and different concentrations of Carbopol 941 were added, and the average value was taken after each repetition three times. The test results are shown in Table 4 and Figure 4 .

[0073] 25% w / w PF-127

Embodiment 22

[0077] The fluorescence spectrum after smearing 10 mg of ALA, the colloid solution system is 25% PF127, and the buccal pouch tissue is treated with DMBA (9,10-dimethyl-1,2-benzanthracene). Figure 7a For smearing ALA side; Figure 7b It is the control side without application of ALA. Observing the change of the fluorescence intensity measured by smearing shows that the fluorescence intensity reaches the highest peak in the 3rd hour. However, in the corresponding unsmeared test, there was also a fluorescence intensity comparable to that of the smeared test within 5 hours; the main reason is that PF-127 failed to effectively control ALA to the smeared part. Example 2.2 Hamster cheek fossa test of PpIX fluorescence effect after adding ALA

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Abstract

A medicinal carrier composition suitable for the locally transferring bioactive compound, especially the 5-aminolaevulinic acid (ALA) for photodynamic diagnosing or therapy, contains mucosa adhering polymer and thermoresponsive polymer.

Description

technical field [0001] The present invention aims to develop a pharmaceutical carrier composition that is convenient to use, has good drug delivery effect and has almost no side effects. It mainly includes mucoadhesive polymers and thermosetting polymers. Local delivery of bioactive compounds, especially compounds that can be used in photodynamic diagnosis or therapy, such as 5-aminolevulinic acid (ALA for short), or used to fix the action site of bioactive compounds. Background technique [0002] The ultimate goal of using chemical drugs to treat or diagnose diseases is to deliver an appropriate concentration of drug molecules or their derivatives to the desired site of action of the patient, and to avoid adverse side effects while obtaining therapeutic or diagnostic effects. Patients with diseases such as skin cancer, oral cancer, laryngeal tumors, oral leukoplakia and other mucosal diseases are especially in need. [0003] The pharmaceutical effect of a drug (including t...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K9/70A61K31/195A61K41/00A61K47/10A61K47/32A61K49/00
CPCA61K9/006A61K9/7015A61K49/0063A61K49/0021A61K9/0043A61K41/0061A61K47/10A61K47/32A61K31/195A61P35/00
Inventor 蔡翠敏
Owner PHARMA POWER BIOTEC
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