Nanostructures for treating cancers and other conditions

A nanostructure, cancer technology, applied in metabolic diseases, allergic diseases, medical preparations containing active ingredients, etc., can solve the problems of large structure size, wide size distribution, short stability, etc.

Inactive Publication Date: 2014-12-24
NORTHWESTERN UNIV
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  • Abstract
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  • Application Information

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Problems solved by technology

However, some of these methods often result in structures with relatively large dimensions, broad size distributions, and / or short stability

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  • Nanostructures for treating cancers and other conditions
  • Nanostructures for treating cancers and other conditions
  • Nanostructures for treating cancers and other conditions

Examples

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Embodiment Construction

[0197] This example demonstrates the use of synthetic nanostructures such as HDL-NPs to treat cancers such as SR-B1 expressing cancers.

[0198] Functional biomimetic high-density lipoprotein nanoparticles (HDL-NPs) are described as a potential therapy for B-cell lymphoma. The HDL-NPs appear to act through their ability to target type B-1 scavenger receptors (SR-B1) and their functional ability to mask cholesterol. Thus, the HDL-NPs are surface chemical mimics of spherical HDL; however, the gold nanoparticle template used to control the size and shape of the HDL-NPs occupies some space in the particle normally reserved for esterified cholesterol. Thus, like native HDL, HDL-NP takes up SR-B1 but provides very little cholesterol to the cell. At the same time, HDL-NP masks free cellular cholesterol on its surface. The data here demonstrate that HDL-NP targets SR-B1 expressed by B-cell lymphoma cell lines, maximizes cholesterol efflux when compared to native HDL, and induces apo...

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Abstract

Nanostructures, compositions and methods for treating cancers and other conditions are provided. In some cases, the nanostructures and / or compositions may be used to treat cancers or other diseases or conditions at least in part by controlling cholesterol metabolism in cells. The nanostructures and compositions may be used, for example, to control cholesterol influx and / or efflux in cells. In some cases, the nanostructures or compositions may be used to kill the cells. Examples of cancer cells that may be affected by the nanostructures and compositions described herein include those having scavenger receptor type B-I (SR-B1), B-cell lymphoma cells, non-Hodgkin's lymphoma cells, melanoma cells and / or others. In some embodiments, the nanostructures may be mimics of natural high-density lipoprotein (HDL).

Description

[0001] Cross-References to Related Applications [0002] This application claims priority to US Provisional Application No. 61 / 601,706, filed February 22, 2012, the disclosure of which is incorporated herein by reference in its entirety. technical field [0003] The present invention generally relates to nanostructures for the treatment of cancer and other conditions. Background technique [0004] Nanostructures, including liposomal nanostructures, are currently used in applications such as drug delivery, gene delivery, and diagnostics. There are various methods for preparing such nanostructures, for example, liposomal nanostructures are formed by techniques including lipoprotein / conjugate synthesis and sonication of mixtures of amphiphilic liposome components. However, some of these methods often result in structures with relatively large dimensions, broad size distributions, and / or short stability. Therefore, there is a need for nanostructures with small size, controlled...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/16A61K38/17A61K45/06A61K9/51A61K33/00A61P35/00A61P37/00A61P3/00
CPCA61K47/6923A61K47/6929A61K38/1709A61K45/06A61K33/00A61P35/00A61P37/00A61P3/00A61P43/00A61K9/5123A61K9/14A61K47/02
Inventor C·S·萨克森M·G·达米安诺张恒K·M·麦克马洪杨朔L·I·乔丹A·T·K·辛
Owner NORTHWESTERN UNIV
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