28 results about "Inflammation Process" patented technology

The present invention relates to a method for preparing a coating composition comprising an anti-infective agent for the controlled release of said anti-infective agent, and to a coating composition or coated substrate obtainable by said method. Such coating compositions are particularly useful in the dental field for the treatment or prevention of inflammatory processes, such as mucositis or peri-implantitis, preferably peri-implantitis.

To provide a novel tetracycline derivative having reduced antimicrobial activity for use in treating disorders of the central nervous system.SOLUTION: Provided are novel molecules comprising a modified tetracycline molecule including Deamino Diacetyl Minocycline, Methyl Ether Minocycline, Ethyl Ether Minocycline, Propyl Ether Minocycline, Butyl Ether Minocycline, Butyl Ether Monoacetyl Minocycline, Butyl Ether Diacetyl Minocycline, Butyl Ether Triacetyl Minocycline, or Butyl Ether Tetra Acetyl Minocycline, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, and tautomers thereof, and methods for using the same to treat Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders.SELECTED DRAWING: None

A personal system to collect and remove electromagnetic radiation (EMR) and excess magnetic and voltage fields from a human body includes portable and non-portable embodiments that, when applied to skin, can causes EMR fields to be drawn out of the body toward a magnet before which the wave is split into separate electrical and the magnetic fields at the surface of the containers. Extraneous magnetic fields coming from the body are absorbed into the magnetic field of the internal magnet while simultaneously donating electrons and creating electrical current within the body to reduce oxidative stress inflammation. A portable handheld system includes a fanny / back pack, a revised standard insulated conductive grounding cord and a specialized cap for mobile use of standard grounding equipment. The system includes more high-powered non-portable similarly functioning EMR-removing vacuum-like booster instruments and protective wearable outer gear.

The present invention relates to the field of medicine and provides pharmaceutical compositions comprising one or more isolated amino acid sequences comprising or consisting solely of SEQ ID NO: 3 and / or SEQ ID NO: 1 and / or SEQ ID NO: 2, kits and conjugates comprising one or more of the aforementioned amino acid sequences. Furthermore, the present invention relates to the use of the pharmaceutical compositions, kits and conjugates of the present invention as medicaments, in particular in the treatment of infectious diseases or inflammatory conditions associated with infectious diseases or inflammatory diseases associated with the presence of products derived from infectious pathogens. The present invention also provides a device for selectively binding and separating at least one component from an aqueous solution, the device comprising one or more of the aforementioned amino acid sequences. [Selection diagram] None

The invention relates to the fields of therapy and drug delivery. It is based on an unexpected finding that a combination of an oligonucleotide-based medicament with a saponin component comprising a penta-cyclic triterpene saponin of a 12,13-dehydrooleanane aglycone core, not only does not appear to be associated with oligonucleotide medicament-induced nephrotoxic effects after systemic administration in vivo, but also that it allows the oligonucleotide-based medicament to enter and act on its nucleic acid target inside of the kidney cells instead of remaining unproductively trapped in renal subcellular compartments or being eliminated into the urine via the renal glomerular filtration system. In line with this finding, herein disclosed are therapeutic combinations, compositions, and formulations, as well as methods of treatment involving their administration, which comprise an oligonucleotide-based medicament that acts on an intracellular nucleic acid target in the kidney cells and / or in the cells of the spleen, being the other blood filtering organ in addition to the kidney, and a saponin component that enables the effective release of said medicament inside of these cells, thus allowing its use at a much lower and safer dose. The provision of the presented herein therapeutic combinations enables effective modulation of gene expression in the kidney and / or spleen cells and, therefore, it opens not only new treatment options for kidney diseases, in particular those involving inflammation and / or splenomegaly, but also for diseases of other organs which affect or are affected by the pathological processes happening in the kidneys and / or in the spleen, in particular being inflammatory processes.

The present invention relates to a composition comprising a combination of at least two cosmetic active agents, said combination of active agents preventing or reducing the loss of proteostasis, preventing or reducing micro-inflammatory processes, preventing cellular senescence, and preventing or reducing mitochondrial dysfunction and / or stimulating mitochondrial energy metabolism in skin cells The invention also relates to the cosmetic use of such a composition for increasing the longevity of skin cells and skin tissues, for preventing or reducing the loss of proteostasis, preventing or reducing micro-inflammatory processes, preventing cellular senescence and preventing or reducing mitochondrial dysfunction and / or stimulating mitochondrial energy metabolism, in skin cells. Finally, the invention relates to a nontherapeutic cosmetic process for caring for keratin materials comprising the topical application of such a composition.

The invention discloses a reagent composition for constructing an acute inflammation model and a construction method. In the invention, local slow release of TNF-alpha is realized through the temperature-sensitive hydrogel, the limitation of traditional systemic administration is broken through, the gradient diffusion characteristic of inflammatory factors in a focus area is restored, and model distortion caused by excessive activation of systemic immune response is avoided. The stepped delivery of the lipopolysaccharide, the prostaglandin E2 analogue and the IL-1beta histamine aerosol effectively covers key pathological links such as vascular permeability change, neutrophil infiltration, oxidative stress and the like through multi-channel synergistic amplification of an inflammation cascade effect. Dynamic balance maintenance of the active oxygen scavenger significantly improves the stability of the model, ensures that the inflammation process is controllable and reversible, provides a reliable window period for drug testing, and real-time fluorescence monitoring and end-point multi-index joint inspection form a closed-loop verification system, so that dynamic migration characteristics of inflammation can be captured, the end damage degree can be quantified, and the accuracy of drug detection is improved. And a complete data link from a process to a result is provided for mechanism research.

The inventions relate to medical equipment and characterize a ventilated ozonizing drainage and lavage kit, and a drainage catheter, an aspirator and an ozonator contained in said kit, as well as a method for the prophylaxis and treatment of destructive inflammatory processes. The inventions are intended to provide reliable thorough long-term atraumatic active and passive drainage, as well as ease of use.

The application discloses a gynecological micro-ecological detection system based on AI multi-modal fusion, and belongs to the technical field of gynecological micro-ecological detection. The system comprises a data acquisition module, a standardization module and a micro-ecological output unit. The data acquisition module acquires immunofluorescence signals, gram staining morphological characteristics and dry chemical indexes. The data acquisition module is connected to the standardization module. The standardization module comprises a pre-processing unit for pre-processing collected data. The standardization module is connected with a data classification unit for data classification. The data classification unit is connected to a heterologous data normalization processing unit. The gynecological micro-ecological detection system based on AI multi-modal fusion can realize accurate evaluation of gynecological micro-ecology, construct a dynamic model of microbial community parameters, realize inflammation process quantification, generate a visual micro-ecological atlas through three-dimensional space mapping, and output inflammation types and overall micro-ecological evaluation.

The present invention relates to a polyhydroxylated chiral carbon-based nanometric cluster derived from plant-based materials called Micronized Vegetal Carbon NCN (NITE Carbon Nano Cluster - NITE NCN Pet) for use in a method of treatment, preventive and / or adjuvant to the curative process, of diseases and / or disorders characterized by inflammatory processes on an oxidative basis, such as those observed in musculoskeletal and / or osteoarticular diseases and / or disorders, in a mammal in need thereof. The present invention also relates to a feed ingredient comprising said polyhydroxylated chiral carbon-based nanometric cluster derived from plant-based materials called Micronized I Carbon NCN (NITE Carbon Nano Cluster - NITE NCN Pet) for use in a method of treatment, preventive and / or adjuvant to the curative process, of diseases and / or disorders of the musculoskeletal and / or osteoarticular system, in a mammal in need thereof.

The invention belongs to the technical field of fluorescent probes, and particularly relates to a near-infrared fluorescent probe for carbon monoxide monitoring in an inflammation process as well as a preparation method and application of the near-infrared fluorescent probe. Based on a donor-receptor system of dicyanoisofuranone and 2-mercaptoaniline, a compound containing benzothiazole, dicyanomethylene and allyl carbonate diester is prepared as a near-infrared probe, and a sensing mechanism is based on palladium-mediated allyl carbonate connecting bond breakage and release of high fluorophore, so that a remarkable fluorescence opening effect is generated. Visual monitoring of fluctuation of the carbon monoxide level in the zebra fish inside and outside the organism under inflammation stimulation is achieved, and a reliable tool is provided for studying in-vivo distribution and physiological functions of carbon monoxide.

Cosmetic composition for skin cell longevity The present invention relates to a composition comprising a combination of at least two cosmetic active agents, said combination of active agents preventing epigenetic modifications, preventing or reducing the loss of proteostasis, preventing or reducing micro- inflammatory processes, and preventing or reducing mitochondrial dysfunction and / or stimulating mitochondrial energy metabolism in skin cells The invention also relates to the cosmetic use of such a composition for increasing the longevity of skin cells and skin tissues, preventing epigenetic modifications, preventing or reducing the loss of proteostasis, preventing or reducing micro-inflammatory processes, and preventing or reducing mitochondrial dysfunction and / or stimulating mitochondrial energy metabolism, in skin cells. Finally, the invention relates to a nontherapeutic cosmetic process for caring for keratin materials comprising the topical application of such a composition.

The invention relates to the technical field of biological medicines, in particular to application of beta-aminoisobutyric acid in preparation of a preparation for treating animal mastitis. The invention discloses application of beta-aminoisobutyric acid in preparation of a preparation for treating animal mastitis. The beta-aminoisobutyric acid provided by the invention is derived from the posterior intestine content of the healthy saanen milk goat with the lowest somatic cell count in the milk obtained by large group screening. According to the present invention, the proliferation efficiency of dairy cow mammary epithelial cells can be significantly promoted, and the expression of the related proteins involved in the endoplasmic reticulum protein quality control pathway can be promoted in the LPS-induced dairy cow mammary epithelial cell inflammation model so as to enhance the folding efficiency of the proteins during the inflammation process; the removal of mistakenly folded and unfolded proteins is accelerated, and finally, the concentration of proinflammatory cytokines is reduced, and the concentration of anti-inflammatory cytokines is increased, so that the inflammatory phenotype is relieved.

The invention relates to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating atherosclerosis as well as a preparation method and application thereof. The invention provides a traditional Chinese medicine composition for preventing and / or treating atherosclerosis. The traditional Chinese medicine composition is prepared from the following raw materials: rhizoma zingiberis, cassia twig, radix salviae miltiorrhizae, caulis spatholobi, semen persicae, rhizoma chuanxiong, rhizoma atractylodis macrocephalae, poria cocos, fructus crataegi, medicated leaven, rhizoma atractylodis and rhizoma acori graminei. The traditional Chinese medicine composition provided by the invention has the effects of warming yang, activating blood, tonifying spleen and reducing phlegm, is mainly used for treating atherosclerosis caused by yang deficiency, blood stasis, spleen deficiency and phlegm stagnation, and is preferably suitable for a subclinical stage. Researches find that the traditional Chinese medicine composition regulates polarization of macrophages and inhibits development of an inflammation process by inhibiting a JAK2 / STAT3 signal channel, so that the progress of AS is relieved. The traditional Chinese medicine composition provided by the invention provides a safe and effective traditional Chinese medicine early intervention scheme convenient for long-term application for huge SAS people.

The present invention relates to a process for preparation of compositions comprising human umbilical cord blood plasma and a designed specific culture medium to grow these cells in specific conditions.The compositions of the present invention are rich in regenerative factors derived from mesenchymal stem cells and together with other designed culture medium factors and processes, are useful in tissue regeneration processes and for preservation, conservation and expansion of mesenchymal stem cells. In fact, the present invention allows a better therapeutic option compared to traditional cell transplantation, as it can benefit from the local tissue response to the secreted molecules without the difficulties and complications associated to the engraftment of the allo- or xeno-transplanted mesenchymal stem cells.Therefore, the present invention is in the field of cell-based therapies for skeletal disorders, such as joint disorders, disorders of connective tissue, bone diseases, osteoporosis, and other damaged tissues, and for modulating the inflammatory process related to tissue regeneration as well.

The invention relates to a recombinant collagen with anti-inflammatory and soothing effects and application thereof. The heavy collagen is a recombinant human VII type collagen, and is obtained by repeating a short amino acid sequence GLPGAKGEKGAPGGL for 30 times. The recombinant collagen is not easy to degrade in the purification process, and the purity of the recombinant collagen can reach 90% or above through simple hollow ultrafiltration; moreover, the recombinant collagen can regulate release of key cell factors such as TNF-alpha, IL-1beta, IL-6 and IL-10 in the skin inflammation process or limit the effect of the key cell factors, so that the recombinant collagen has the anti-inflammatory and soothing effects.

The invention discloses a gynecological micro-ecology detection system based on AI multi-modal fusion, and belongs to the technical field of gynecological micro-ecology detection. Comprising a data acquisition module, a standardization module and a micro-ecological output unit, wherein the data acquisition module is used for acquiring an immunofluorescence signal, gram staining morphological characteristics and dry chemical indexes; the data acquisition module is connected to the standardization module, and the standardization module comprises a pre-processing unit for pre-processing acquired data; the data classification unit is connected with the pre-processing unit and used for data classification, and the data classification unit is connected to the heterologous data normalization processing unit. According to the gynecological micro-ecology detection system based on AI multi-modal fusion, precise evaluation of gynecological micro-ecology can be achieved, a dynamic model of microbial community parameters is constructed, and the detection accuracy is improved. The inflammation process quantification is realized; a visual micro-ecological map is generated through three-dimensional space mapping, and inflammation types and micro-ecological overall evaluation are output.

The present invention includes novel molecules and methods for using the same to treat Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising: identifying a subject in need of treatment for at least one of AUD, SUD, pain, or a proinflammatory disorder; and providing the subject with an effective amount of a modified minocycline to ameliorate or eliminate the AUD, SUD, pain, or proinflammatory disorder and that has reduced, or no, antimicrobial activity, wherein the modified tetracycline has a formula, e.g., or the modified doxycycline, minocycline, and tigecycline and their tautomerized structures, where the R-groups shown in the minocycline example above could be different combination of halogen, acetyl ester, methyl ester, and diacetal.

The present invention relates generally to a method of formulation of cannabidiol (CBD) a potential anti-inflammatory drug derived from lemon peel (d-limonene). More, particularly, the present invention relates to the enhancement of lipid soluble CBD into water soluble form in order to improve the formulation of the active component while apply in human for medication. The present invention further provides the therapeutic application of the new formulation which either neutralize and / or decreases the capability of the production of cytokines by activated immune cells during inflammatory process and hence alleviate the sufferings of illness like COVID-19 caused by SARSCOV2.

The invention relates to a new method for in vitro production of BK-RiV-forte nanoparticles, which enables a higher yield of particulate compositions. The produced BK-RiV-forte nanoparticles differ in their composition from known BK-RiV particles. The BK-RiV-forte nanoparticles produced by the new method increase the diversity of the T cell repertoire and find a wide range of applications in medicine, for example in the treatment of septic diseases as well as wounds, tumours, strokes and inflammatory processes of all kinds.

The inventions relate to medical equipment and characterize a ventilated ozonizing drainage and lavage kit, and a drainage catheter, an aspirator and an ozonator contained in said kit, as well as a method for the prophylaxis and treatment of destructive inflammatory processes. The inventions are intended to provide reliable thorough long-term atraumatic active and passive drainage, as well as ease of use.

The invention relates to the human protein Family with sequence similarity 118 member B (FAM118B). In particular, the present invention relates to the activation, or the inhibition of the activity or effect provided by FAM118B, for modulating the inflammatory response. In particular, it is provided the use of activator of FAM118B, or an activator of the biological effects provided by FAM118, for inducing, sustaining, or enhancing an inflammatory process, in particular an inflammatory process associated with a cancer, a bacterial infection, or a viral infection. In particular, it is also provided the use of an inhibitor of FAM118B, or an inhibitor of the biological effects provided by FAM118B, for inhibiting, or reducing an inflammatory process, more particularly for inducing the resolution of an inflammatory process.

The invention is applicable to the technical field of traditional Chinese medicine powder for treating arthralgia and provides traditional Chinese medicine powder for treating arthralgia and a preparation method thereof, and the traditional Chinese medicine powder for treating arthralgia comprises the following substances in parts by mass: 8-12 parts of tripterygium wilfordii, 4-6 parts of ligusticum wallichii, 8-12 parts of salvia miltiorrhiza, 1.6-2.4 parts of mirabilite and 4-6 parts of rheum officinale. According to the traditional Chinese medicine steeping powder for treating arthralgia and the preparation method of the traditional Chinese medicine steeping powder, the traditional Chinese medicine steeping powder takes four mechanisms of immunoregulation, anti-inflammation, blood circulation activation and detumescence as a core, accurate strike on the pathological link of rheumatoid arthritis is formed, triptolide in tripterygium wilfordii can inhibit T cell overactivity and block the start of autoimmune response, and the curative effect is good. Ligustrazine improves joint local microcirculation disturbance by expanding microvessels and inhibiting platelet aggregation, tanshinone has a strong anti-oxidation effect and can remove excessive oxygen free radicals generated in the inflammation process and relieve synovial cell damage, and sodium sulfate in mirabilite can promote absorption of inflammatory exudates in articular cavities and relieve swelling.

The invention relates to an H2O2 / hypoxia dual-response sectional drug delivery system based on a microneedle structure, which is used for treating burn wounds. The system comprises a soluble microneedle matrix containing sodium percarbonate, H2O2 response microspheres embedded in microneedles and functional components encapsulated in the microspheres. The H2O2 response microspheres are formed by crosslinking polyvinyl alcohol and 1, 4-phenylenediboronic acid through boric acid ester bonds, and a MnO2 nano material with catalase-like activity and hypoxia response drug-loaded micelles formed by self-assembly of nitroimidazole modified hyaluronic acid are encapsulated in the microspheres. After the micro-needle is applied to a burn wound, hydrogen peroxide generated in situ by sodium percarbonate triggers the microspheres to break and release functional components, and MnO2 catalyzes oxygen generation to promote diffusion of drugs to deep tissues; then, under the hypoxic microenvironment formed in the inflammation process, the micelles are discombined to release the medicine, and segmented and sequential medicine delivery is achieved. The invention can break through the physical barrier of the burn wound, improve the deep drug delivery efficiency and reduce the times of dressing change, and is suitable for continuous treatment of the burn wound.

This invention teaches a targeted apheresis device that contains a plurality of different immobilized binding agents that can simultaneously target and bind out multiple proinflammatory factors belonging to three distinct proinflammatory systems: These systems are 1) proinflammatory factors that bind to the cell membrane; 2) the complement system; and 3) proinflammatory cytokines. This invention teaches a unique targeted apheresis device to remove a) C-Reactive Protein (CRP); and b) complement C1q; and c) Tumor Necrosis Factor (TNF); and optionally d) one or more other complement components, and / or one or more other proinflammatory cytokines. In one embodiment of this invention the targeted apheresis device is modified such that it will remove blood leukocytes in addition to removing CRP, C1q and TNF. Removing both cellular and humoral proinflammatory factors will further inhibit the harmful inflammatory process that occurs in many diseases and following tissue injury.