17 results about "Inflammation Process" patented technology

A personal system to collect and remove electromagnetic radiation (EMR) and excess magnetic and voltage fields from a human body includes portable and non-portable embodiments that, when applied to skin, can causes EMR fields to be drawn out of the body toward a magnet before which the wave is split into separate electrical and the magnetic fields at the surface of the containers. Extraneous magnetic fields coming from the body are absorbed into the magnetic field of the internal magnet while simultaneously donating electrons and creating electrical current within the body to reduce oxidative stress inflammation. A portable handheld system includes a fanny / back pack, a revised standard insulated conductive grounding cord and a specialized cap for mobile use of standard grounding equipment. The system includes more high-powered non-portable similarly functioning EMR-removing vacuum-like booster instruments and protective wearable outer gear.

The present invention relates to the field of medicine and provides pharmaceutical compositions comprising one or more isolated amino acid sequences comprising or consisting solely of SEQ ID NO: 3 and / or SEQ ID NO: 1 and / or SEQ ID NO: 2, kits and conjugates comprising one or more of the aforementioned amino acid sequences. Furthermore, the present invention relates to the use of the pharmaceutical compositions, kits and conjugates of the present invention as medicaments, in particular in the treatment of infectious diseases or inflammatory conditions associated with infectious diseases or inflammatory diseases associated with the presence of products derived from infectious pathogens. The present invention also provides a device for selectively binding and separating at least one component from an aqueous solution, the device comprising one or more of the aforementioned amino acid sequences. [Selection diagram] None

The invention relates to the fields of therapy and drug delivery. It is based on an unexpected finding that a combination of an oligonucleotide-based medicament with a saponin component comprising a penta-cyclic triterpene saponin of a 12,13-dehydrooleanane aglycone core, not only does not appear to be associated with oligonucleotide medicament-induced nephrotoxic effects after systemic administration in vivo, but also that it allows the oligonucleotide-based medicament to enter and act on its nucleic acid target inside of the kidney cells instead of remaining unproductively trapped in renal subcellular compartments or being eliminated into the urine via the renal glomerular filtration system. In line with this finding, herein disclosed are therapeutic combinations, compositions, and formulations, as well as methods of treatment involving their administration, which comprise an oligonucleotide-based medicament that acts on an intracellular nucleic acid target in the kidney cells and / or in the cells of the spleen, being the other blood filtering organ in addition to the kidney, and a saponin component that enables the effective release of said medicament inside of these cells, thus allowing its use at a much lower and safer dose. The provision of the presented herein therapeutic combinations enables effective modulation of gene expression in the kidney and / or spleen cells and, therefore, it opens not only new treatment options for kidney diseases, in particular those involving inflammation and / or splenomegaly, but also for diseases of other organs which affect or are affected by the pathological processes happening in the kidneys and / or in the spleen, in particular being inflammatory processes.

The present invention relates to a composition comprising a combination of at least two cosmetic active agents, said combination of active agents preventing or reducing the loss of proteostasis, preventing or reducing micro-inflammatory processes, preventing cellular senescence, and preventing or reducing mitochondrial dysfunction and / or stimulating mitochondrial energy metabolism in skin cells The invention also relates to the cosmetic use of such a composition for increasing the longevity of skin cells and skin tissues, for preventing or reducing the loss of proteostasis, preventing or reducing micro-inflammatory processes, preventing cellular senescence and preventing or reducing mitochondrial dysfunction and / or stimulating mitochondrial energy metabolism, in skin cells. Finally, the invention relates to a nontherapeutic cosmetic process for caring for keratin materials comprising the topical application of such a composition.

The application discloses a gynecological micro-ecological detection system based on AI multi-modal fusion, and belongs to the technical field of gynecological micro-ecological detection. The system comprises a data acquisition module, a standardization module and a micro-ecological output unit. The data acquisition module acquires immunofluorescence signals, gram staining morphological characteristics and dry chemical indexes. The data acquisition module is connected to the standardization module. The standardization module comprises a pre-processing unit for pre-processing collected data. The standardization module is connected with a data classification unit for data classification. The data classification unit is connected to a heterologous data normalization processing unit. The gynecological micro-ecological detection system based on AI multi-modal fusion can realize accurate evaluation of gynecological micro-ecology, construct a dynamic model of microbial community parameters, realize inflammation process quantification, generate a visual micro-ecological atlas through three-dimensional space mapping, and output inflammation types and overall micro-ecological evaluation.

The invention belongs to the technical field of fluorescent probes, and particularly relates to a near-infrared fluorescent probe for carbon monoxide monitoring in an inflammation process as well as a preparation method and application of the near-infrared fluorescent probe. Based on a donor-receptor system of dicyanoisofuranone and 2-mercaptoaniline, a compound containing benzothiazole, dicyanomethylene and allyl carbonate diester is prepared as a near-infrared probe, and a sensing mechanism is based on palladium-mediated allyl carbonate connecting bond breakage and release of high fluorophore, so that a remarkable fluorescence opening effect is generated. Visual monitoring of fluctuation of the carbon monoxide level in the zebra fish inside and outside the organism under inflammation stimulation is achieved, and a reliable tool is provided for studying in-vivo distribution and physiological functions of carbon monoxide.

Cosmetic composition for skin cell longevity The present invention relates to a composition comprising a combination of at least two cosmetic active agents, said combination of active agents preventing epigenetic modifications, preventing or reducing the loss of proteostasis, preventing or reducing micro- inflammatory processes, and preventing or reducing mitochondrial dysfunction and / or stimulating mitochondrial energy metabolism in skin cells The invention also relates to the cosmetic use of such a composition for increasing the longevity of skin cells and skin tissues, preventing epigenetic modifications, preventing or reducing the loss of proteostasis, preventing or reducing micro-inflammatory processes, and preventing or reducing mitochondrial dysfunction and / or stimulating mitochondrial energy metabolism, in skin cells. Finally, the invention relates to a nontherapeutic cosmetic process for caring for keratin materials comprising the topical application of such a composition.

The invention relates to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating atherosclerosis as well as a preparation method and application thereof. The invention provides a traditional Chinese medicine composition for preventing and / or treating atherosclerosis. The traditional Chinese medicine composition is prepared from the following raw materials: rhizoma zingiberis, cassia twig, radix salviae miltiorrhizae, caulis spatholobi, semen persicae, rhizoma chuanxiong, rhizoma atractylodis macrocephalae, poria cocos, fructus crataegi, medicated leaven, rhizoma atractylodis and rhizoma acori graminei. The traditional Chinese medicine composition provided by the invention has the effects of warming yang, activating blood, tonifying spleen and reducing phlegm, is mainly used for treating atherosclerosis caused by yang deficiency, blood stasis, spleen deficiency and phlegm stagnation, and is preferably suitable for a subclinical stage. Researches find that the traditional Chinese medicine composition regulates polarization of macrophages and inhibits development of an inflammation process by inhibiting a JAK2 / STAT3 signal channel, so that the progress of AS is relieved. The traditional Chinese medicine composition provided by the invention provides a safe and effective traditional Chinese medicine early intervention scheme convenient for long-term application for huge SAS people.

The present invention relates to a process for preparation of compositions comprising human umbilical cord blood plasma and a designed specific culture medium to grow these cells in specific conditions.The compositions of the present invention are rich in regenerative factors derived from mesenchymal stem cells and together with other designed culture medium factors and processes, are useful in tissue regeneration processes and for preservation, conservation and expansion of mesenchymal stem cells. In fact, the present invention allows a better therapeutic option compared to traditional cell transplantation, as it can benefit from the local tissue response to the secreted molecules without the difficulties and complications associated to the engraftment of the allo- or xeno-transplanted mesenchymal stem cells.Therefore, the present invention is in the field of cell-based therapies for skeletal disorders, such as joint disorders, disorders of connective tissue, bone diseases, osteoporosis, and other damaged tissues, and for modulating the inflammatory process related to tissue regeneration as well.

The invention relates to a recombinant collagen with anti-inflammatory and soothing effects and application thereof. The heavy collagen is a recombinant human VII type collagen, and is obtained by repeating a short amino acid sequence GLPGAKGEKGAPGGL for 30 times. The recombinant collagen is not easy to degrade in the purification process, and the purity of the recombinant collagen can reach 90% or above through simple hollow ultrafiltration; moreover, the recombinant collagen can regulate release of key cell factors such as TNF-alpha, IL-1beta, IL-6 and IL-10 in the skin inflammation process or limit the effect of the key cell factors, so that the recombinant collagen has the anti-inflammatory and soothing effects.

The present invention includes novel molecules and methods for using the same to treat Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising: identifying a subject in need of treatment for at least one of AUD, SUD, pain, or a proinflammatory disorder; and providing the subject with an effective amount of a modified minocycline to ameliorate or eliminate the AUD, SUD, pain, or proinflammatory disorder and that has reduced, or no, antimicrobial activity, wherein the modified tetracycline has a formula, e.g., or the modified doxycycline, minocycline, and tigecycline and their tautomerized structures, where the R-groups shown in the minocycline example above could be different combination of halogen, acetyl ester, methyl ester, and diacetal.

The invention relates to a new method for in vitro production of BK-RiV-forte nanoparticles, which enables a higher yield of particulate compositions. The produced BK-RiV-forte nanoparticles differ in their composition from known BK-RiV particles. The BK-RiV-forte nanoparticles produced by the new method increase the diversity of the T cell repertoire and find a wide range of applications in medicine, for example in the treatment of septic diseases as well as wounds, tumours, strokes and inflammatory processes of all kinds.

The invention is applicable to the technical field of traditional Chinese medicine powder for treating arthralgia and provides traditional Chinese medicine powder for treating arthralgia and a preparation method thereof, and the traditional Chinese medicine powder for treating arthralgia comprises the following substances in parts by mass: 8-12 parts of tripterygium wilfordii, 4-6 parts of ligusticum wallichii, 8-12 parts of salvia miltiorrhiza, 1.6-2.4 parts of mirabilite and 4-6 parts of rheum officinale. According to the traditional Chinese medicine steeping powder for treating arthralgia and the preparation method of the traditional Chinese medicine steeping powder, the traditional Chinese medicine steeping powder takes four mechanisms of immunoregulation, anti-inflammation, blood circulation activation and detumescence as a core, accurate strike on the pathological link of rheumatoid arthritis is formed, triptolide in tripterygium wilfordii can inhibit T cell overactivity and block the start of autoimmune response, and the curative effect is good. Ligustrazine improves joint local microcirculation disturbance by expanding microvessels and inhibiting platelet aggregation, tanshinone has a strong anti-oxidation effect and can remove excessive oxygen free radicals generated in the inflammation process and relieve synovial cell damage, and sodium sulfate in mirabilite can promote absorption of inflammatory exudates in articular cavities and relieve swelling.

The invention relates to an H2O2 / hypoxia dual-response sectional drug delivery system based on a microneedle structure, which is used for treating burn wounds. The system comprises a soluble microneedle matrix containing sodium percarbonate, H2O2 response microspheres embedded in microneedles and functional components encapsulated in the microspheres. The H2O2 response microspheres are formed by crosslinking polyvinyl alcohol and 1, 4-phenylenediboronic acid through boric acid ester bonds, and a MnO2 nano material with catalase-like activity and hypoxia response drug-loaded micelles formed by self-assembly of nitroimidazole modified hyaluronic acid are encapsulated in the microspheres. After the micro-needle is applied to a burn wound, hydrogen peroxide generated in situ by sodium percarbonate triggers the microspheres to break and release functional components, and MnO2 catalyzes oxygen generation to promote diffusion of drugs to deep tissues; then, under the hypoxic microenvironment formed in the inflammation process, the micelles are discombined to release the medicine, and segmented and sequential medicine delivery is achieved. The invention can break through the physical barrier of the burn wound, improve the deep drug delivery efficiency and reduce the times of dressing change, and is suitable for continuous treatment of the burn wound.