5results about How to "Reduce lipid accumulation" patented technology

This invention relates to a lipid-lowering synbiotic, its preparation method, and its application, belonging to the field of egg-laying hen farming technology. The lipid-lowering synbiotic of this invention comprises the following components in parts by weight: 3-85 parts of traditional Chinese medicine extract, 1-25 parts of probiotics, 3-30 parts of prebiotics, 1-16 parts of enzyme preparation, and 4-55 parts of dietary therapy components. This synbiotic not only significantly improves the lipid metabolism of laying hens but also significantly prolongs the peak egg-laying period, increases the egg production rate, reduces cholesterol content in egg yolks, promotes calcium and phosphorus absorption, and reduces the paralysis rate in laying hens. It comprehensively improves the economic benefits of egg-laying hen farming.

The invention belongs to the technical field of pharmacotherapeutics, and particularly relates to application of timosaponin BII in preparation of a medicine for preventing and treating alcoholic liver injury. A novel KEAP1-NRF2 inhibitor-TBII is found through a virtual screening method, TBII and KEAP1 protein have high affinity, and experiments verify that TBII can reduce the protein level of KEAP1 in vivo and improve protein expression of NRF2 and downstream targets NQO1 and GCLC of NRF2. It is proved that TBII can protect the liver function by inhibiting increase of AST and ALT content, oxidative stress and lipid accumulation of the liver are reduced, and TBII has the potential to become a medicine for treating ethanol-induced liver injury.

This invention belongs to the fields of biomedical materials and colloid chemistry, and discloses a structurally remodeled egg yolk low-density lipoprotein biomimetic liposome and its application in regulating cholesterol metabolism. The method includes extracting and purifying natural egg yolk low-density lipoprotein; selectively removing endogenous cholesterol by adding β-cyclodextrin under alkaline conditions; adding a phytosterol ethanol solution to the cholesterol-removed low-density lipoprotein dispersion, followed by incubation and dialysis purification to obtain the biomimetic liposome. The obtained biomimetic liposome uses partially cholesterol-removed egg yolk low-density lipoprotein as its structural framework, with phytosterols embedded in its phospholipid monolayer and lipid core interface. This biomimetic liposome can inhibit cholesterol micelle formation, reduce cholesterol absorption, promote macrophage cholesterol efflux, and inhibit macrophage foam formation. It can be used to prepare cholesterol metabolism regulating materials, functional delivery systems, and dietary supplement products.

The invention discloses an application of a mulberry flavonol extract in preparation of a hypoglycemic drug, and belongs to the technical field of biology. According to the application of the mulberry flavonol extract in the preparation of the hypoglycemic drug, an insulin resistance model is established by utilizing HepG2 cells, and the mulberry flavonol extract acts on IR-HepG2 cells; the influence of the mulberry flavonol extract on cell glucose consumption, glycogen synthesis, glycometabolism, lipid metabolism, oxidative stress and glycolysis key enzyme gene expression quantity is analyzed, and the insulin resistance improving effect of the mulberry flavonol extract is verified from the cell level.

The present invention relates to the field of microbial technology, and in particular to a strain of animal-associated Lactobacillus LA-1, a microbial preparation and an application thereof. Animal Lactobacillus ) LA‑1 has been deposited in the General Microbiology Center of China National Committee for the Preservation of Microbiological Cultures on September 27, 2024, with the deposit address at No. 3, Yard No. 1, Beichen West Road, Chaoyang District, Beijing, and the deposit number is CGMCC No. 32098. Animal-associated Lactobacillus LA‑1 has the effect of significantly reducing cholesterol content and bile salt hydrolase activity, and can inhibit α-glucosidase activity, has a high fatty acid absorption rate, is safe and sensitive to commonly used antibiotics, can relieve obesity, reduce blood lipids and liver lipid accumulation, relieve liver lipid degeneration and fat hypertrophy, has the effect of protecting the liver and enhancing liver function, and has good application prospects in the preparation of functional products.