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Macrocyclic compounds as HCV entry inhibitors

A technology of compounds and inhibitors, applied in the field of new compounds of formula I, can solve the problem that the degree of correlation between viruses and cellular factors is not fully understood, etc.

Inactive Publication Date: 2015-10-21
BRISTOL MYERS SQUIBB CO
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The extent to which disease progression is related to viral and cellular factors is not fully understood

Method used

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  • Macrocyclic compounds as HCV entry inhibitors
  • Macrocyclic compounds as HCV entry inhibitors
  • Macrocyclic compounds as HCV entry inhibitors

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Embodiment Construction

[0034] Unless expressly stated otherwise elsewhere in this application, the following terms have the following meanings. "H" means hydrogen, including isotopes thereof, such as deuterium. "Halogen" means fluorine, chlorine, bromine or iodine. "Alkyl" means a straight or branched chain alkyl group consisting of 1-6 carbons. "Alkenyl" means a straight or branched chain alkyl group consisting of 2 to 6 carbons having at least one double bond. "Cycloalkyl" means a single ring system consisting of 3-8 carbons. "Alkylene" means a straight or branched chain divalent alkyl group. "Alkenylene" means a straight or branched divalent alkyl group having at least one double bond. "Cycloalkylene" means a divalent cycloalkane moiety consisting of 3 to 7 carbons and includes gem-divalencies (eg, 1,1-cyclopropanediyl) as well as non-gem-divalencies (eg, 1 ,4-cyclohexanediyl). "Alkylidinyl" means a divalent alkene substituent in which the divalence occurs on the same carbon of the alkene. ...

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Abstract

Compounds of Formula I, including pharmaceutically acceptable salts thereof, are set forth, in addition to compositions and methods of using these compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Patent Application 61 / 761,868, filed February 7, 2013, which is hereby incorporated by reference. technical field [0003] The present invention relates to novel compounds of formula I, including pharmaceutically acceptable salts thereof, which have anti-hepatitis C virus (HCV) activity and are useful for treating HCV-infected patients. The invention also relates to compositions and methods of using these compounds. Background technique [0004] An estimated 170 million people worldwide are chronically infected with hepatitis C virus (HCV), with 3 to 4 million infected in the United States alone (Boyer, N. and Marcellin, P.J. Hepatology. 2000, 32:98-112; Alter, M.J. et al. Engl. J. Med. 1999, 341:556-562). Before the mid-1990s, blood transfusion with infected blood products was the main route of HCV infection. After the introduction of blood screening methods, infec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D498/08C07D498/18C07D498/22A61K31/53A61P31/12
CPCC07D498/08C07D498/18C07D498/22A61K31/53A61K31/551C07D498/20A61P1/16A61P31/12A61P31/14A61P43/00A61K45/06
Inventor 汪涛张钟兴尹志伟孙力强E·麦尔赵倩P·M·斯科拉
Owner BRISTOL MYERS SQUIBB CO
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