Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Compounds for the treatment of hepatitis c

A compound and alkyl technology, applied in the field of novel formula I compounds, can solve the problems of viral RNA reduction and decline

Inactive Publication Date: 2011-10-05
BRISTOL MYERS SQUIBB CO
View PDF5 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When treated with the compound as a single agent, viral RNA levels decreased briefly during dosing and then rebounded, but decreased more substantially when combined with standard-of-care forms of interferon and ribavirin

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compounds for the treatment of hepatitis c
  • Compounds for the treatment of hepatitis c
  • Compounds for the treatment of hepatitis c

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0300] The abbreviations used in this application are defined as follows: "1×" is once, "2×" is twice, "3×" is three times, "°C" is degrees Celsius, "eq" is equivalent, "g" is grams, " mg" is milligram, "L" is liter, "mL" is milliliter, "μL" is microliter, "N" is normal concentration, "M" is molar concentration, "mmol" is millimole, and "min" is minute , "h" is hours, "rt" is room temperature, "RT" is retention time, "atm" is atmospheric pressure, "psi" is pounds per square inch, "conc." is concentrated, "sat" or "sat' d" is saturated, "MW" is molecular weight, "mp" is melting point, "ee" is enantiomeric excess, "MS" or "Mass Spec" is mass spectrum, "ESI" is electrospray ionization mass spectrum, "HR" is high resolution, "HRMS" is high resolution mass spectrometry, "LCMS" is liquid chromatography / mass spectrometry, "HPLC" is high pressure liquid chromatography, "RP HPLC" is reverse phase HPLC, "TLC" or " tlc " is thin-layer chromatography, " NMR " is nuclear magnetic resonanc...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
purityaaaaaaaaaa
wavelengthaaaaaaaaaa
fluorescence wavelengthaaaaaaaaaa
Login to View More

Abstract

The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Application 61 / 096,005, filed September 11,2008. technical field [0003] The present invention relates to novel compounds of formula I, including their salts, which are active against hepatitis C virus (HCV) and are useful in the treatment of patients infected with HCV. The invention also relates to compositions and methods of using these compounds. Background technique [0004] Hepatitis C virus (HCV) is a major human pathogen that infects approximately 170 million people worldwide - roughly five times the number infected by human immunodeficiency virus type 1 . A substantial fraction of these HCV-infected individuals develop severe progressive liver disease, including cirrhosis and hepatocellular carcinoma (Lauer, G.M. et al., N. Engl. J. Med., 345:41-52 (2001)) . [0005] HCV is a positive-strand RNA virus. Based on a comparison of the deduced amino acid seq...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/84C07D405/04C07D405/10C07D405/12C07D407/12C07D409/12C07D413/10C07D413/12C07D417/10C07D417/12C07D453/00C07D491/10A61K31/14A61P31/14
CPCC07D491/10C07D413/12C07D409/12C07D413/10C07D453/00C07D407/12C07D405/10C07D307/84C07D417/10C07D405/12C07D417/12C07D405/04A61P31/12A61P31/14A61P31/16
Inventor 杨革新凯尔.E.帕塞拉约翰.A.本德布莱特.R.贝诺凯瑟琳.A.格兰特-扬韩迎皮亚塞纳.赫瓦瓦萨姆约翰.F.卡多安德鲁.妮科尔
Owner BRISTOL MYERS SQUIBB CO
Features
  • Generate Ideas
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com