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Compounds for the treatment of hepatitis c

A compound and alkyl technology, applied in the field of novel formula I compounds, can solve the problems of viral RNA reduction and decline

Inactive Publication Date: 2011-10-05
BRISTOL MYERS SQUIBB CO
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

When treated with the compound as a single agent, viral RNA levels decreased briefly during dosing and then rebounded, but decreased more substantially when combined with standard-of-care forms of interferon and ribavirin

Method used

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  • Compounds for the treatment of hepatitis c
  • Compounds for the treatment of hepatitis c
  • Compounds for the treatment of hepatitis c

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Embodiment Construction

[0300] The abbreviations used in this application are defined as follows: "1×" is once, "2×" is twice, "3×" is three times, "°C" is degrees Celsius, "eq" is equivalent, "g" is grams, " mg" is milligram, "L" is liter, "mL" is milliliter, "μL" is microliter, "N" is normal concentration, "M" is molar concentration, "mmol" is millimole, and "min" is minute , "h" is hours, "rt" is room temperature, "RT" is retention time, "atm" is atmospheric pressure, "psi" is pounds per square inch, "conc." is concentrated, "sat" or "sat' d" is saturated, "MW" is molecular weight, "mp" is melting point, "ee" is enantiomeric excess, "MS" or "Mass Spec" is mass spectrum, "ESI" is electrospray ionization mass spectrum, "HR" is high resolution, "HRMS" is high resolution mass spectrometry, "LCMS" is liquid chromatography / mass spectrometry, "HPLC" is high pressure liquid chromatography, "RP HPLC" is reverse phase HPLC, "TLC" or " tlc " is thin-layer chromatography, " NMR " is nuclear magnetic resonanc...

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Abstract

The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Application 61 / 096,005, filed September 11,2008. technical field [0003] The present invention relates to novel compounds of formula I, including their salts, which are active against hepatitis C virus (HCV) and are useful in the treatment of patients infected with HCV. The invention also relates to compositions and methods of using these compounds. Background technique [0004] Hepatitis C virus (HCV) is a major human pathogen that infects approximately 170 million people worldwide - roughly five times the number infected by human immunodeficiency virus type 1 . A substantial fraction of these HCV-infected individuals develop severe progressive liver disease, including cirrhosis and hepatocellular carcinoma (Lauer, G.M. et al., N. Engl. J. Med., 345:41-52 (2001)) . [0005] HCV is a positive-strand RNA virus. Based on a comparison of the deduced amino acid seq...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/84C07D405/04C07D405/10C07D405/12C07D407/12C07D409/12C07D413/10C07D413/12C07D417/10C07D417/12C07D453/00C07D491/10A61K31/14A61P31/14
CPCC07D491/10C07D413/12C07D409/12C07D413/10C07D453/00C07D407/12C07D405/10C07D307/84C07D417/10C07D405/12C07D417/12C07D405/04A61P31/12A61P31/14A61P31/16
Inventor 杨革新凯尔.E.帕塞拉约翰.A.本德布莱特.R.贝诺凯瑟琳.A.格兰特-扬韩迎皮亚塞纳.赫瓦瓦萨姆约翰.F.卡多安德鲁.妮科尔
Owner BRISTOL MYERS SQUIBB CO
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