Application of a compound in preparing anti-virus medicament

An anti-AIDS and drug technology, used in drug delivery, antiviral agents, pharmaceutical formulations, etc., can solve problems such as anti-HIV virus CypA inhibitors that have not been reported yet
CN100502879CInactive Publication Date: 2009-06-24FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
FUDAN UNIV
Publication Date
2009-06-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the technical field of chemical industry, in particular to a preparation method and application of micromolecule compound with HIV resisting activity. CyPA is able to combine with the Gag polymer protein in HIV-1. Silence or inhibit the activity of CypA with RNAi technology and disturb the replication of virus. The micromolecule compound in the invention refers to a CyPA inhibitor that has the effect of resisting HIV-1 virus. Besides, as the micromolecule compound is designed while aiming at cellular target, the invention is not easy to develop drug resistance, thus meeting the demands of lifetime medication for AIDS patients. Therefore, the micromolecule compound in the invention, which can be developed as a new type anti-AIDS drug, provides a new means for treating and curing AIDS.
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Description

technical field

[0001] The invention relates to the fields of chemical industry and medicine, and relates to the application of a compound in the preparation of anti-AIDS drugs. Background technique

[0002] Cycliphilins (CyPs) are ubiquitously distributed intracellular proteins that are highly conserved in plants, bacteria, and mammals. They were originally discovered as cellular receptors for cyclosporin A. Cyclosporin A (Cyclosporin A, CsA) is a cyclic polypeptide containing 11 amino acids isolated from fungal metabolites. As an immunosuppressant drug, it is often used clinically to treat rejection and autoimmune system after organ transplantation. disease. There are more than 130 isomers of CyPs that have been discovered and cloned [GalatA, Metcalfe SM. Peptidyl proline cis-trans iso-merases. Prog Biophys Molec Biol, 1995; 63: 67.], which constitute the Cyclophilins family. CyPs has peptide prolyl cis-trans isomerase (PPIase) activity, catalyzes the protein folding pro...

Claims

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