12 results about "Sodium periodate" patented technology

This invention discloses a composite hydrogel based on a polysaccharide-based hybrid dual network, its preparation method, and its applications, belonging to the field of marine polysaccharide technology. Based on the important role of amorphous calcium phosphate, a precursor in biomineral formation, in mineralization, this invention prepares a multifunctional composite hydrogel with wet bonding, antibacterial, and remineralization functions. This composite hydrogel can achieve rapid and convenient repair of enamel demineralization. This invention prepares oxidized sodium alginate via an alcohol-aqueous phase using the sodium periodate method. Sodium alginate reacts with carboxymethyl chitosan and dopamine through a Schiff base reaction to form dynamic imine bonds, thus preparing an in-situ self-crosslinking hydrogel. Simultaneously, amorphous calcium phosphate is introduced for secondary crosslinking, preparing a dense dual-network composite hydrogel. The composite hydrogel prepared by this invention has an interconnected three-dimensional porous structure, stable mechanical properties, and uniformly dispersed amorphous calcium phosphate in the form of nanospheres. The composite hydrogel prepared by this invention provides an integrated strategy with clinical translational potential for orthodontic enamel demineralization, with broad market prospects.

This invention discloses a method for preparing a self-healing, antibacterial dynamic hydrogel and its coating application. The method includes: 1. Reacting konjac glucomannan with sodium periodate to achieve aldehyde functionalization, and mixing it with sodium alginate powder to prepare a precursor polymer solution A; 2. Mixing an acylhydrazide or hydroxylamine small molecule crosslinking agent with an aminoglycoside drug to prepare an amino crosslinking agent solution B, and preparing a calcium salt ionic crosslinking agent solution C; 3. Mixing the three solutions and allowing them to stand to obtain a hydrogel. The application involves coating a hydrogel mixture solution onto a biodegradable metal surface after preparing a polyethyleneimine auxiliary layer and then gelling it. This invention utilizes aldehyde-functionalized oxidized konjac glucomannan and two crosslinking agents to form acylhydrazone, oxime, and imine bond networks, endowing the hydrogel with self-healing, self-responsive, and long-term antibacterial properties. The hydrogel of this invention improves the biocompatibility, antibacterial properties, and stability of biodegradable metal substrates, making it suitable for biodegradable implantation applications.

The present application provides a sericin / guar gum / polyvinyl alcohol (PVA) composite gel and its application as a fever-reducing patch. For the first time, sericin, cationic guar gum and PVA are used as a composite matrix, and sodium periodate and copper sulfate are introduced simultaneously. Through the precise assignment and synergistic effect of functional units, the problems of microbial contamination and insufficient high-temperature stability are systematically solved. The composite gel prepared by the present application has the advantages of initial adhesion (instant fixation), environmental stability (resistant to heat 42℃ / resistant to cold 0℃), good sustained cooling effect and skin safe pH (4.5-7.0), and is very suitable for clinical application.

The application discloses a method for preparing nanocellulose based on guanidinium sulfamate low eutectic solvent, and belongs to the field of modified nanocellulose materials. Firstly, in a certain temperature, water is used as a reaction medium, sodium periodate is used as an oxidant, and lithium chloride is used as a catalyst to oxidize cellulose into dialdehyde cellulose DAC. Secondly, a guanidinium sulfamate-choline chloride binary eutectic solvent or a guanidinium sulfamate-glycerol binary eutectic solvent is configured, and then DAC is added into the two kinds of eutectic solvents respectively. DAC is swollen in the two kinds of eutectic solvents and reacts with guanidinium sulfonic acid groups to graft guanidinium sulfonic acid groups. In the process, the cellulose is swollen in the solvent and the surface charge density is increased, which promotes the subsequent ultrasonic nanocrystallization process, and the guanidinium sulfonic acid group nanocellulose with high transparency and good flame retardant effect is successfully prepared. The application has the advantages of simple operation, low cost, effective reduction of energy loss in the nanocrystallization process of fibers, good flame-retardant modification effect on nanocellulose, environmental friendliness of the used eutectic solvent, and facilitation of industrial production and application of the guanidinium sulfonic acid group nanocellulose and guanidinium sulfonic acid group nanocellulose membrane.

The application discloses a three-dimensional cell scaffold based on a leaf vein of nandina domestica and a preparation method and application thereof, relates to the technical field of biomedical materials and tissue engineering, and discloses the following steps: taking the leaf vein of nandina domestica as a base material, and preparing the scaffold through alkali boiling, sodium periodate selective oxidation and amino-silica / chitosan composite modification. The scaffold retains the three-dimensional structure of the natural leaf vein completely, and significantly improves the cell compatibility of the material. Cell experiments prove that the scaffold has no cytotoxicity, can support the three-dimensional growth of mesenchymal stem cells and PC12 cells and the like with high survival rate, and effectively promotes cell proliferation. The method is simple, green, environmentally-friendly and low in cost, and the obtained scaffold has wide application prospects in the fields of tissue engineering, regenerative medicine and drug screening and the like.

The application belongs to the technical field of dressings and relates to a dressing for promoting healing of a wound of a diabetic foot and a preparation method thereof.The preparation method comprises the following steps: dissolving methacrylated gelatin and a photoinitiator in PBS to obtain solution A; dispersing sodium alginate in anhydrous ethanol, adding deionized water and sodium periodate, and reacting to obtain aldehyde-modified sodium alginate; dissolving the aldehyde-modified sodium alginate in PBS to obtain solution B; adding a tannin acid derivative to solution B, and then adding solution A and stirring; and curing under light to obtain the dressing.The dressing has precise microenvironment response characteristics, can realize on-demand release of H2S according to physiological indexes specific to a wound of a diabetic foot, has a high-efficiency anti-inflammatory effect, can improve local microcirculation and promote blood vessel and tissue neogenesis, and can accelerate healing of a wound of a diabetic foot.

This invention belongs to the field of biomedical materials technology, specifically relating to a photocrosslinked dual-network hydrogel that promotes skin wound healing and its preparation method. Glycidyl methacrylate is added dropwise to an aqueous solution of ε-polylysine to obtain methacrylated polylysine. An aqueous solution of hyaluronic acid and an aqueous solution of sodium periodate are mixed under light-protected conditions and stirred to obtain oxidized hyaluronic acid. The methacrylated polylysine solution and the oxidized hyaluronic acid solution are mixed and vortexed until homogeneous to obtain a mixed solution. This mixed solution is injected into a mold and cured under ultraviolet light to obtain the photocrosslinked dual-network hydrogel. The dual-network hydrogel of this invention not only effectively solves the contradiction between mechanical strength and biocompatibility that is difficult to achieve simultaneously in traditional single-network hydrogels, but also integrates multiple healing mechanisms through functional complementarity between components.

The application relates to the technical field of medicine synthesis, and discloses a synthesis method of N-Boc-vinylglycine methyl ester and isomerate, which comprises the following steps: L-N-tert-butoxycarbonylmethionine methyl ester is prepared by taking L-methionine methyl ester hydrochloride as raw material; L-N-tert-butoxycarbonyl-4-methylsulfinylbutyric acid methyl ester is synthesized by taking L-N-tert-butoxycarbonylmethionine methyl ester and sodium periodate as raw material; and compound 13 is obtained by reacting L-N-tert-butoxycarbonyl-4-methylsulfinylbutyric acid methyl ester and 1,2,4-trimethylbenzene at 180-190 DEG C for 6-8 h; the Boc protection methionine is directly eliminated in the application, and unnecessary complicated steps are reduced; N-Boc-vinylglycine methyl ester is synthesized in high yield and high selectivity by taking N-Boc-methionine methyl ester sulfoxide as raw material, removing low-boiling-point by-products methylsulfinic acid by evaporation and accurately controlling the reaction temperature; and the structural formula of the compound 13 is as follows:

This invention relates to a polymeric probe for assessing sialylation levels in vivo. It uses a dendritic polymer with alkyne-terminated branches as a carrier, and its surface is simultaneously modified with galactose, cyanidin 5 fluorescent dye, and folic acid. The detection protocol involves subcutaneously injecting the prepared polymeric probe into the tumor region of tumor-bearing mice. Folic acid-mediated targeted endocytosis allows the polymeric probe to enter the tumor cells. In vivo sialylates bind sialic acid to the galactose terminal of the polymeric probe. Sodium periodate is used to oxidize the sialic acid terminal in mouse tumor tissue sections to form an aldehyde group, which is then further coupled with an acylhydrazide fluorescein molecule. Fluorescence signals from cyanidin 5 and fluorescein are simultaneously collected using fluorescence microscopy, and the fluorescence intensity of fluorescein in the superimposed region of the two fluorescence signals is obtained using software, which can then be used to assess the sialylation level of the tumor tissue.

The application discloses a preparation method and application of a chitosan / 3,4-dihydroxybenzaldehyde injectable hydrogel, and the injectable hydrogel is prepared by the following steps: first, preparing chitosan acetic acid solution, 3,4-dihydroxybenzaldehyde solution and sodium periodate solution respectively by using acetic acid solution and water; then, mixing the chitosan acetic acid solution and the 3,4-dihydroxybenzaldehyde solution, and adding the sodium periodate solution into the mixture and mixing; and finally, preparing the hydrogel by standing and cross-linking at 37 DEG C. The hydrogel is prepared by cross-linking chitosan and 3,4-dihydroxybenzaldehyde, the raw materials are simple and non-toxic, the hydrogel has good adhesion and slow release, the reaction condition is mild, no chemical cross-linking agent, photo initiator or enzyme needs to be introduced, no expensive and complex equipment is needed, the cost is low, the effect is remarkable, and the hydrogel can be used as an injectable gel drug delivery system for tumor treatment.

The application discloses a shrimp paste freshness real-time visual detection method, comprising the following steps: step 1, preparing a cellulose nanocrystal water suspension, adding sodium periodate and carrying out a reaction in the dark, after the reaction is completed, the reaction liquid is purified by dialysis and filtered by a filter membrane, and a dialdehyde cellulose nanocrystal film forming liquid is obtained; step 2, pouring the dialdehyde cellulose nanocrystal film forming liquid into a culture dish, and naturally drying to obtain a light blue responsive structural color film; step 3, placing the film in a packaging box containing shrimp paste and sealing, and real-time detecting the freshness of the shrimp paste. The method establishes a signal sensing mechanism of 'biogenic amine release -> Schiff base specific reaction -> pitch change -> structural color red shift', realizes nondestructive, in-situ, real-time and visual precise monitoring of the freshness of the shrimp paste, and solves the problems of high cost, complex operation, low accuracy and inability to real-time detection in the prior art.

The application discloses a self-healing and injectable photocrosslinking double-network hydrogel and a preparation method thereof. The preparation method comprises the following steps: firstly, glycidyl methacrylate solution is used to perform methacryl modification on silk fibroin; then, sodium periodate solution is used to make dextran perform an oxidation reaction to generate oxidized dextran; and finally, a double-network hydrogel is formed through Schiff base crosslinking reaction between amino groups in the modified silk fibroin and aldehyde groups in the oxidized dextran. The double-network hydrogel prepared by the method has a more compact structure, and thus, the double-network hydrogel has a series of excellent performances, such as safety, injectability, good adhesion, good mechanical properties, self-healing property and drug release performance after drug loading.