Biocolloid hemostatic prepared by aldehyde-modified sodium alginate and amine-modified gelatine

Abstract

The invention relates to a biocolloid hemostatic prepared by aldehyde-modified sodium alginate and amine-modified gelatine. Sodium alginate and gelatine as raw materials; according to ratio, aldehyde-modified sodium alginate solution with the concentration of 5-25% and the same volume of amine-modified gelatine solution with the concentration of 5-40% are mixed; sodium alginate is modified by aldehyde through sodium periodate oxidation; and then gel is obtained by mixing with gelatine modified by ethanediamine. The adopted gelatine and sodium alginate are safe and stable, have good biocompatibility and can be absorbed and degraded by organism. Gel is rapidly formed through Schiff base reaction of aldehyde-modified sodium alginate and amine-modified gelatine, and the gel has the same gel-forming time as fibrin glue but better adhesion property and adhesion strength, can be acted on any part of body through simple local spraying or injection, and can be used as substitute product of fibrin glue.

Description

technical field [0001] The present invention relates to a kind of biological glue type hemostatic agent of aldehyde-modified sodium alginate and amine-modified gelatin, specifically, it is the biological glue-type soft tissue hemostatic agent which is composed of aldehyde-modified sodium alginate and amine-modified gelatin, through The chemical reaction of the groups contained in the two materials quickly gels and stops the bleeding. Background technique [0002] With the rapid development of modern science and technology, surgical operation techniques have undergone revolutionary changes. Hemostasis is one of the cores of basic surgical techniques, and surgical operations on any part of the human body almost without exception involve bleeding and hemostasis. In the past, the traditional instrumental hemostasis technology has been abandoned due to the disadvantages of complicated operation and large trauma. Therefore, it is expected and paid attention to the emergence of a ...

AI Technical Summary

Problems solved by technology

Iwata et al. reported that water-soluble carbodiimide-crosslinked PLGA-gelatin bioglue and PLGA-gelatin bioglue modified by N-hydroxysuccinimide can rapidly form a gel when the two materials are mixed together And it is firmly bonded to soft tissue. However, due to the release of urea derivatives or N-hydroxysuccinimide during the formation of the gel, it may cause systemic or local biological reactions [Iwata H, Matsuda S, Mitsuhashi K, Itoh E, Ikada Y. A novel surgical glue composed of gelatin and N-hydroxysuccinimide activated poly(L-glutamic acid): Part 1.Synthesis of activated poly(L-glutamic acid) and its gelation with gelatin. Biomaterials: Vol.19, 1998, pp.1869-1876]