Preparation method of highly antibacterial alginate dressing

An antibacterial and alginate technology, which is applied in wet spinning, pharmaceutical formulations, medical science, etc., can solve the problems of antibacterial alginate dressings, decreased mechanical properties, and loose bonding of alginate dressings, so as to avoid secondary Reduce bleeding, promote wound healing, and relieve pain

Inactive Publication Date: 2017-04-26
孙祎
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem mainly solved by the present invention: the existing composite prepared alginate dressings are not closely combined, and the chitosan, silver ions, nano ions and other substances with antibacterial function are easy to fall off in the process of packaging, transportation and use, resulting in The antibacterial and mechanical properties of alginate dressings have the defects that a kind of preparation method of alginate dressings with high antibacterial properties is provided. The present invention uses sodium periodate to oxidize sodium alginate to obtain oxidized sodium alginate with high antibacterial properties. And silver nitrate, zinc nitrate, trisodium citrate solution, etc. are mixed to prepare silver-zinc antibacterial agent, then dopamine hydrochloride is compounded with oxidized sodium alginate, adhered to the surface of oxidized sodium alginate through dopamine polymerization reaction, and passed polydopamine For the reduction and chelation of silver and zinc ions, the silver and zinc ions are evenly loaded on the surface of oxidized sodium alginate by the method of in-situ reduction of silver and zinc ions to make spinning solution, which is then vacuum degassed and then spun and solidified. Stretching, washing with water, winding, drying, and then making a dressing with acupuncture, you can get a highly antibacterial alginate dressing. The alginate dressing prepared by the present invention has excellent hemostatic and antibacterial effects, and good hygroscopicity and swelling , can effectively protect the wound, speed up the wound healing, and the dressing fibers are closely combined, the mechanical properties are good, the replacement is convenient, and the secondary damage caused by the replacement of the dressing is avoided, which has a wide application prospect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0018]First weigh 5g of sodium alginate, add it to 200mL of deionized water, stir at 300r / min for 10min, then add 5mL of sodium periodate solution with a mass fraction of 5%, and oxidize it in a dark place for 20h, then add 1.0mL of ethylene glycol alcohol, continue to stir and react for 10min to obtain a mixed solution; then add 10g of sodium chloride and 200mL of absolute ethanol to the above mixed solution in sequence, stir at 500r / min for 20min, let stand for 1h and filter, add the filter residue to 200mL of deionized water And stir until it is completely dissolved, then add 200mL of absolute ethanol, let it stand for precipitation, repeat the above precipitation and filtration operation twice, then transfer to a vacuum drying oven, and dry at 30°C for 8 hours to obtain oxidized sodium alginate for later use; Weigh 0.01g of silver nitrate and 0.01g of zinc nitrate, add them into 180mL of deionized water, and stir at 300r / min for 20min, then dropwise add 20mL of a mass fract...

example 2

[0021] First weigh 5g of sodium alginate, add 220mL of deionized water, stir at 350r / min for 13min, then add 5mL of sodium periodate solution with a mass fraction of 5%, and oxidize it in a dark place for 22h, then add 1.1mL of ethylene glycol alcohol, continue to stir and react for 13min to obtain a mixed solution; then add 11g of sodium chloride and 220mL of absolute ethanol to the above mixed solution in sequence, stir at 550r / min for 25min, let it stand for 1h and then filter, add the filter residue to 250mL of deionized water And stir until it is completely dissolved, then add 220mL of absolute ethanol, let it stand for precipitation, repeat the above precipitation and filtration operation twice, then transfer to a vacuum drying oven, and dry at 35°C for 9 hours to obtain oxidized sodium alginate for later use; Weigh 0.01g of silver nitrate and 0.02g of zinc nitrate, add them into 190mL of deionized water, and stir at 350r / min for 25min, then dropwise add 25mL of a mass fr...

example 3

[0024] First weigh 6g of sodium alginate, add it to 240mL of deionized water, stir at 400r / min for 15min, then add 6mL of 5% sodium periodate solution, and oxidize it in a dark place for 24h, then add 1.2mL of ethylene glycol Alcohol, continue to stir and react for 15 minutes to obtain a mixed solution; then add 10 g of sodium chloride and 240 mL of absolute ethanol to the above mixed solution in sequence, stir at 600 r / min for 30 min, let it stand for 2 hours and filter, add the filter residue to 300 mL of deionized water And stir until it is completely dissolved, then add 240mL of absolute ethanol, let stand to precipitate, repeat the above precipitation and filtration operation 3 times, then transfer to a vacuum drying oven, and dry at 40°C for 10 hours to obtain oxidized sodium alginate for later use; Weigh 0.02g of silver nitrate and 0.03g of zinc nitrate, add them into 200mL of deionized water, and stir at 400r / min for 30min, then add dropwise 30mL of a mass fraction of 3...

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Abstract

The invention discloses a preparation method of a highly antibacterial alginate dressing, and belongs to the technical field of preparation of medical dressings. The preparation method comprises the following steps: oxidizing sodium alginate by virtue of sodium periodate, and mixing silver nitrate, zinc nitrate, a trisodium citrate solution and the like so as to obtain a silver-zinc antibacterial agent; then, combining dopamine hydrochloride and the oxidized sodium alginate, wherein the dopamine hydrochloride is attached to the surface of the oxidized sodium alginate through a dopamine polymerization reaction, and on the basis of reducing and chelating effects of the dopamine on silver and zinc irons, silver and zinc are uniformly loaded on the surface of the oxidized sodium alginate by virtue of a method of conducting in-situ reduction on the silver and zinc irons, so that a spinning solution is prepared; and conducting vacuum deaerating, spinning, coagulating, stretching, rinsing, rolling and drying, and making the dressing by virtue of a needle punching technology, so that the highly antibacterial alginate dressing is obtained. The alginate dressing prepared by the invention is excellent in hemostatic and antibacterial effects, the alginate dressing is good in hygroscopic swelling performance and the alginate dressing is capable of effectively protecting wounds and accelerating healing speed of the wounds; and dressing fibers are closely combined, and the alginate dressing is relatively good in mechanical performance and convenient to change.

Description

technical field [0001] The invention discloses a preparation method of a highly antibacterial alginate dressing, which belongs to the technical field of preparation of medical dressings. Background technique [0002] Human skin can not only stabilize the internal environment of the human body, but also prevent the invasion of bacteria and microorganisms. When the skin is injured and the homeostasis of the internal environment is broken, medical dressings, as a medical wound healing material, can provide the necessary protection to the human body and reduce the degree of harm. Before the skin recovers, a good medical dressing can temporarily play a part of the skin covering function and provide favorable conditions for wound healing. [0003] The application of alginate fiber in medical dressings originated from wet therapy. In 1962, Winter found that wounds healed faster in a humid environment than in a dry environment, thus changing the traditional theory of wound healing....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/46A61L15/44A61L15/64A61L15/28A61L15/26A61L15/18D01D5/06D04H3/105
CPCA61L15/46A61L15/18A61L15/26A61L15/28A61L15/44A61L15/64A61L2300/102A61L2300/104A61L2300/404A61L2300/412A61L2400/04D01D5/06D04H3/105C08L5/04C08L79/04
Inventor 孙祎宋豪薛蕾
Owner 孙祎
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