A kind of chitosan gel hemostatic material and preparation method thereof
A technology of chitosan gel and hemostatic material is applied in the field of biological materials and gel preparation, which can solve the problems of physiological toxicity and unsatisfactory hemostatic effect, and achieves a short hemostasis time, good self-healing ability and strong adaptability. Effect
Active Publication Date: 2016-04-27
BEIJING UNIV OF CHEM TECH
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Problems solved by technology
[0003] The general principle of traditional hemostatic materials is to enrich platelets by charge or to bind tissue to stop bleeding. Due to some defects in this kind of materials, the hemostatic effect is not ideal, and there are still some characteristics of physiological toxicity.
Method used
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Effect test
Embodiment 1
[0020] Take 3 chitosan solutions with a volume concentration of 3.0 mg / mL, add 1 volume concentration of 10.0 mg / mL of DF-PEG and a mixed solution of 300 U / mL thrombin, mix and react at room temperature for 2 minutes, and obtain chitosan hydrocoagulation glue.
Embodiment 2
[0022] Take 3 chitosan solutions with a volume concentration of 3.0 mg / mL, add 1 volume concentration of 10.0 mg / mL of DF-PEG and a mixed solution of 300 U / mL thrombin, mix and react at room temperature for 2 minutes, and obtain chitosan hydrocoagulation Gel, freeze-dried to obtain xerogel.
Embodiment 3
[0024] Take 3 chitosan solutions with a volume concentration of 3.0 mg / mL, add 1 volume concentration of 10.0 mg / mL of DF-PVA and 300 U / mL thrombin mixed solution, mix and react at room temperature for 2 minutes, and obtain chitosan hydrocoagulation glue.
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Abstract
The invention relates to a chitosan gel haemostatic material and a preparation method thereof. The chitosan gel haemostatic material is compounded of chitosan, a cross-linking agent and thrombin. The chitosan gel haemostatic material disclosed by the invention is good in biocompatibility and biodegradability; hydrogel is excellent in mucous membrane viscosity and self-adaptability, and has functions of quickly stopping blooding in body, promoting wound healing and releasing thrombin slowly so as to prevent secondary blooding caused by postoperative motion; meanwhile, the haemostatic material has characteristics of bacteria resistance and bacteriostasis and is capable of effectively preventing wound infection.
Description
technical field [0001] The invention belongs to the technical field of biological materials and gel preparation, and relates to a chitosan gel hemostatic material and a preparation method thereof. Background technique [0002] In recent years, many studies have shown that in the first aid treatment of sudden accidents, trauma hemostasis during surgery, especially in the rescue of wounded people in war, it is very important for patients to effectively and quickly stop bleeding locally. Rapid hemostasis materials can effectively reduce casualties. According to the mechanism of hemostasis, people currently use four methods to stop bleeding: one is to promote vasoconstriction, reduce capillary permeability, reduce blood flow, and promote the coagulation process at damaged blood vessels. The second is to increase the number of platelets, enhance their aggregation and adhesion, and promote the release of coagulation active substances from platelets to achieve the purpose of hemos...
Claims
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IPC IPC(8): A61K38/43A61L15/28A61L15/42A61L15/44C08J3/075C08L5/08
Inventor 王兴李永三
Owner BEIJING UNIV OF CHEM TECH