43results about How to "Prevent postoperative infection" patented technology

The invention discloses a polylactic acid-based composite material surgical medical film and a preparation method thereof. By adopting electrostatic spinning equipment and exploring proper technological parameters, different types of polylactic acid-based composite material macromolecular fiber thin films are finally formed and are applied to the field of biomedicine. In addition, by regulating and controlling composition of a macromolecular composite material system and thickness of an electro-spinning thin film, the surgical medical film which has good flexibility, high tensile strength, controllable degradation rate as well as excellent waterproof, antibacterial and air permeable performances is obtained finally. The surgical medical film is applicable to the field of various biomedicines such as healing film, wound surface dressing and anti-adhesion medicine; the medical film not only can be better adhered to tissues and avoid biotoxicity, but also can effectively promote transmission functions of blood, nutrients and growth factors in a human body due to the nature of semipermeable membrane. The process of the invention is simple and environment-friendly; the preparation method is easy to operate, low in cost, applicable to large-scale production and good in controllability, and is expected to be widely applied to various medical fields.

The invention discloses a polyether ketone ketone-based composite, a composition, a restoration, a preparation method and application thereof. The polyether ketone ketone-based raw material composition comprises the following components: the mass ratio of the polyether ketone ketone powder and the silicon nitride powder, the polyether ketone ketone powder and the silicon nitride powder is (1-3): (2-4), and the D50 particle diameter of the silicon nitride is 0.5-3.5 micrometres. The polyether ketone ketone-based composite disclosed by the invention has the advantages of promoting osteogenesis and biocompatibility, thereby promoting the adhesion, proliferation and differentiation of osteoblasts. The bone restoration can inhibit infection after being implanted into an organism, promote new bone regeneration, and ensure long-term stability of the implant. The preparation method of the polyether ketone ketone-based composite provided by the invention is simple and easy to operate, and the preparation process of the polyether ketone ketone-based composite can be adjusted according to the clinical requirement, so that the bone restoration with different shapes, specifications and mechanical properties can be prepared.

The invention discloses a bone repair material composition, a bone repair material and a preparation method and application of the bone repair material. The bone repair material composition comprisesa bone cement component and curing liquid, wherein the bone cement comprises magnesium oxide, calcium hydrophosphate, sodium dihydrogen phosphate and hydroxyapatite, and the curing liquid is a sodiumphytate aqueous solution. The bone repair material disclosed by the invention is simple to prepare and proper in coagulation time, has good biocompatibility, osteogenesis and degradability, can be directly injected into a bone defect part, has anti-osteoporosis performance and has an obvious osteogenesis effect.

The present invention relates to a bone repair material composition comprising a bone cement component and nano silicon nitride, wherein the bone cement component comprises magnesium oxide and sodiumdihydrogen phosphate, and the weight ratio of the nano silicon nitride to the bone cement component is 1: (1.5-9). The bone repair material prepared according to the invention has dual effects of resisting infection and promoting bone growth, not only inhibits bacterial adhesion, but also promotes adhesion and proliferation of osteoblasts, and can play a role in resisting infection and improving bony combination between an implant and a host bone after being implanted into a body.

The invention discloses a preparation method of an anti-infective biological active coating on the surface of a 3D printed porous titanium stent. The method comprises the following steps: (1) preparing a porous titanium stent by using a 3D printing technology; (2) performing surface pretreatment by a sand blasting process, and then conducting annealing process treatment to form a smooth surface state on the surface of the porous titanium stent; (3) immersing the porous titanium stent in a sodium hydroxide solution for shaking; (4) rinsing the stent with deionized water or distilled water for several times, immersing the stent in the distilled water and a dilute hydrochloric acid solution respectively, then drying, heating up, keeping the temperature for a certain period of time and coolingthe stent with a furnace at room temperature; (5) preparing a simulated body fluid, adding vancomycin to the simulated body fluid, soaking the porous titanium stent in the simulated body fluid for shaking at constant temperature and obtaining the hydroxyapatite anti-infective bioactive coating with the vancomycin on the surface of the porous titanium stent. According to the method, the osseointegration, bone conduction and osteoinductive properties of the porous titanium stent can be significantly improved to achieve the purpose of preventing postoperative infection.

The invention discloses a preparation method of a multifunctional GTR gradient barrier membrane. The multifunctional GTR gradient barrier membrane is prepared by a solvent pouring method. The method comprises specific steps as follows: preparing hollow carbonated hydroxyapatite; mixing the hollow carbonated hydroxyapatite with polylysine and agarose, and then preparing the multifunctional GTR gradient barrier membrane by the solvent pouring method. The invention also discloses an application of the multifunctional GTR gradient barrier membrane in regeneration of periodontal tissue and long-term antibiosis in oral environments. The process is simple, the requirement of ideal GTR barrier membrane can be met, the multifunctional GTR gradient barrier membrane can be prepared simply and conveniently by the method on a large scale, the prepared gradient barrier membrane can effectively prevent postoperative infection and promote repair of periodontal defect tissue after being applied to GTRoperation.

The invention provides an antibacterial heat conducting coating. The antibacterial heat conducting coating is characterized in that the antibacterial heat conducting coating comprises graphene oxide and antibacterial peptide, wherein the mass ratio of the graphene oxide to the antibacterial peptide is (1:25)-(1:75). The antibacterial heat conducting coating can reduce the postoperative infection phenomenon of organ transplantation, provide a stable internal environment for organs and have a good market prospect and a high value on social benefit.