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Biomedical material with porous calcium phosphate-chitosan composite coating

A biomedical material, porous calcium phosphate technology, applied in coatings, medical science, prostheses, etc., can solve problems such as chitosan compounding, to enhance tissue repair ability, improve safety and success rate, and promote osteoarthritis The effect of growth

Active Publication Date: 2014-04-16
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Most of the bioactive coatings implanted on the surface of bioengineering device materials have a dense structure, and chitosan cannot be effectively compounded on the surface of the bioactive coating

Method used

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  • Biomedical material with porous calcium phosphate-chitosan composite coating
  • Biomedical material with porous calcium phosphate-chitosan composite coating
  • Biomedical material with porous calcium phosphate-chitosan composite coating

Examples

Experimental program
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Effect test

preparation example Construction

[0057] The invention provides a preparation method for directly compounding water-soluble chitosan surface layer on the surface of a porous calcium phosphate coating. The method is based on plasma spraying to prepare a porous calcium phosphate coating, and directly compound water-soluble chitosan on the surface of the porous coating. surface layer of chitosan.

[0058]The specific operation steps are:

[0059] A preparation of porous calcium phosphate coating

[0060] According to the calcium-phosphorus molar ratio of hydroxyapatite, tricalcium phosphate, etc., add the diammonium hydrogen phosphate aqueous solution with a molar concentration of 1.2-3.6 mol / L dropwise to calcium nitrate with a molar concentration of 1-3 mol / L under constant stirring In the aqueous solution, keep the reaction liquid at 30-90°C, control its pH at 9-12 with ammonia water with a concentration of 10% to 30% by mass percentage, leave it standing for 5-15 minutes after the reaction, and then age for ...

Embodiment 1

[0066] Composite chitosan coating on the hydroxyapatite coating of embodiment one powder plasma spraying

[0067] Direct use of hydroxyapatite powder. Through plasma spraying equipment, powder nozzles are used for spraying, atmospheric plasma spraying equipment is used, and finally a coating is formed on the biomedical metal substrate with a spraying thickness of 120 microns. The surface morphology of the coating was observed by scanning electron microscopy. SEM photo see Figure II . Chitosan was dissolved in ultrapure water with a concentration of 100g / L, and the coated sample was soaked in the chitosan aqueous solution under sterile conditions for 24 hours, and then air-dried for 12 hours in an ultra-clean bench. The early antibacterial performance of its composite coating (chitosan concentration 100g / L) is compared with the porous calcium phosphate-chitosan composite coating (chitosan concentration 100g / L) (MTT method for the detection of the proliferation of Staphyloco...

Embodiment 2

[0068] Embodiment two compound chitosan coating on the hydroxyapatite coating of liquid plasma spraying

[0069] Press Ca 10 (PO 4 ) 6 (OH) 2 The molar ratio of calcium to phosphorus (1.67), under constant stirring, the diammonium hydrogen phosphate aqueous solution with a molar concentration of 2.8mol / L is added dropwise to the calcium nitrate aqueous solution with a molar concentration of 2.4mol / L, and the reaction solution is kept at 70°C. Ammonia water with a concentration of 25% by mass was used to control the pH at 10.5, and after the reaction, it was allowed to stand for 10 minutes, and then aged for 24 hours to obtain a hydroxyapatite suspension with a solid content of 34% for use. Using plasma spraying equipment, the nozzle adopts an atomizing nozzle, and the liquid plasma spraying method is used. After the droplets in the precursor liquid are broken, refined, evaporated, sintered, and melted, a coating is finally formed on the biomedical metal substrate. The spray...

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Abstract

The invention belongs to the field of biomedical materials, and particularly relates to a biomedical material with good antibacterial, hemostatic and osteogenic activities and a porous calcium phosphate-chitosan composite coating, and a preparation method thereof. The preparation method comprises the following steps of: firstly, preparing a porous calcium phosphate coating by using plasma spraying; and secondly, directly compounding a water-soluble chitosan surface layer on the surface of the porous coating by a soaking method, a dropping method and the like. Thus, the prepared biomedical material not only can play a good role in resisting bacteria and stopping bleeding in early days after an operation, but also can minimize potential adverse effects of surface bioactivity and osteogenic performance of an implant. The biomedical material has a simple process and a low production cost, can endow an implantation appliance with two additional effects of stopping bleeding and stopping bleeding, can greatly improve the safety and the success rate of the existing implantation appliance, and alleviating pains of patients.

Description

technical field [0001] The invention relates to a preparation method of a porous calcium phosphate-chitosan composite coating with excellent antibacterial, hemostatic and osteogenic activities, and belongs to the technical field of biomedical material preparation. Background technique [0002] Biomedical materials are new high-tech materials used to repair or replace diseased tissues and organs of living organisms or enhance their functions. They generally refer to biomedical material implants that repair and replace teeth and bones. Existing dental implants, artificial joints and other implanted devices use titanium alloys with good mechanical properties as the substrate, and then carry out surface modification and deposit calcium phosphate coatings to improve their biological activity. With the aging society and the improvement of human health requirements, higher requirements are put forward for bioactive coating materials for hard tissue repair and replacement. In addit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/34A61L27/32A61L27/40
Inventor 吴方何静宋磊黄涛甘露田志立顾忠伟
Owner SICHUAN UNIV
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