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Preparation method of anti-infective biological active coating on surface of 3D printed porous titanium stent

A 3D printing and bioactive technology, applied in coatings, pharmaceutical formulations, drug delivery, etc., can solve the problems of easy infection, implant failure, poor osseointegration, etc., and achieve the effect of preventing infection

Inactive Publication Date: 2019-04-16
刘昕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Porous titanium metal is a biologically inert material with poor osseointegration performance, and it is difficult to quickly grow together with the surrounding bone tissue; at the same time, the implant is prone to infection during the implantation process, which will also cause the implant to loosen and eventually implant fail

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Using medical-grade Ti6Al4V metal powder as the base material, the porous titanium stent is manufactured by 3D printing. The porous titanium stent has an interconnected internal structure with a porosity of 75%, a pore size of 500 μm, and a beam size of 200 μm. The compressive strength is 120 MPa, and the elastic modulus is 3.5 GPa.

[0023] The raw material is medical-grade Ti6Al4V spherical powder with a purity of ≥99.99 wt% and a particle size of 15 μm-45 μm.

[0024] The preparation method of the above-mentioned porous titanium stent comprises the following steps:

[0025] (1) Use drawing software to design and obtain the .stl format file of the three-dimensional geometric model of the porous titanium scaffold; the 3D printing process of the porous titanium scaffold is: merge the titanium metal parameter package with the .stl file in the Building Processing interface, and obtain the porous titanium in The .mtt format file recognizable in the 3D printer equipment, t...

Embodiment 2

[0031] Using medical-grade Ti6Al4V metal powder as the base material, the porous titanium stent is manufactured by 3D printing. The porous titanium stent has an interconnected internal structure with a porosity of 75%, a pore size of 500 μm, and a beam size of 200 μm. The compressive strength is 120 MPa, and the elastic modulus is 3.5 GPa.

[0032] The raw material is medical-grade Ti6Al4V spherical powder with a purity of ≥99.99 wt%, and a particle size of 15 μm-45 μm.

[0033] The preparation method of the above-mentioned porous titanium stent comprises the following steps:

[0034] (1) Use drawing software to design and obtain the .stl format file of the three-dimensional geometric model of the porous titanium scaffold; the 3D printing process of the porous titanium scaffold is: merge the titanium metal parameter package with the .stl file in the Building Processing interface, and obtain the porous titanium in The .mtt format file recognizable in the 3D printer device, the...

Embodiment 3

[0040] Using medical-grade Ti6Al4V metal powder as the base material, the porous titanium scaffold is manufactured by 3D printing. The porous titanium scaffold has an interconnected internal structure with a porosity of 75%, a pore size of 500 μm, and a beam size of 200 μm , compressive strength 120 MPa, elastic modulus 3.5 GPa.

[0041] The raw material is medical-grade Ti6Al4V spherical powder with a purity of ≥99.99 wt%, and a particle size of 15 μm-45 μm.

[0042] The preparation method of the above-mentioned porous titanium stent comprises the following steps:

[0043] (1) Use drawing software to design and obtain the .stl format file of the three-dimensional geometric model of the porous titanium scaffold; the 3D printing process of the porous titanium scaffold is: merge the titanium metal parameter package with the .stl file in the Building Processing interface, and obtain the porous titanium in The .mtt format file recognizable in the 3D printer device, the .mtt forma...

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Abstract

The invention discloses a preparation method of an anti-infective biological active coating on the surface of a 3D printed porous titanium stent. The method comprises the following steps: (1) preparing a porous titanium stent by using a 3D printing technology; (2) performing surface pretreatment by a sand blasting process, and then conducting annealing process treatment to form a smooth surface state on the surface of the porous titanium stent; (3) immersing the porous titanium stent in a sodium hydroxide solution for shaking; (4) rinsing the stent with deionized water or distilled water for several times, immersing the stent in the distilled water and a dilute hydrochloric acid solution respectively, then drying, heating up, keeping the temperature for a certain period of time and coolingthe stent with a furnace at room temperature; (5) preparing a simulated body fluid, adding vancomycin to the simulated body fluid, soaking the porous titanium stent in the simulated body fluid for shaking at constant temperature and obtaining the hydroxyapatite anti-infective bioactive coating with the vancomycin on the surface of the porous titanium stent. According to the method, the osseointegration, bone conduction and osteoinductive properties of the porous titanium stent can be significantly improved to achieve the purpose of preventing postoperative infection.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a method for preparing an anti-infection bioactive coating on the surface of a 3D printed porous titanium stent. Background technique [0002] Bone defect is a common orthopedic disease in clinical practice. It is mainly caused by trauma, tumor removal, and congenital malformation. Small-sized bone defects can heal on their own, while larger-sized bone defects are usually difficult to heal automatically and require bone grafting. Or tissue engineering methods for treatment. Among them, the tissue engineering method is considered to be the most promising research direction for the treatment of bone defects. The tissue engineering technology consists of three elements: scaffold materials, growth factors and cells. Scaffold materials mainly include metal materials, inorganic non-metal materials, polymer materials and their composite materials, among which metal materials have be...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/32A61L27/28A61L27/06A61L27/54A61L27/56B33Y80/00
CPCA61L27/06A61L27/28A61L27/32A61L27/54A61L27/56A61L2300/252A61L2300/406A61L2400/18A61L2420/02A61L2420/04A61L2420/08B33Y80/00
Inventor 刘昕刘洋
Owner 刘昕
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