A kind of preparation method and application of multifunctional GTR gradient barrier film

Abstract

The invention discloses a preparation method of a multifunctional GTR gradient barrier film. The multifunctional GTR gradient barrier film is prepared by using a solvent casting method. The specific steps are as follows: preparing hollow carbonated hydroxyapatite; making the hollow carbonated hydroxyapatite The multifunctional GTR gradient barrier membrane was prepared by solvent casting after mixing stone and polylysine with agarose. The invention also discloses its application in periodontal tissue regeneration and long-term antibacterial in oral environment. The process of the present invention is simple, and can meet the requirements of an ideal GTR barrier film. The method can be used to prepare a multifunctional GTR gradient barrier film in a simple and large-scale manner. The prepared gradient barrier film can effectively prevent postoperative infection when used in GTR surgery, and at the same time Promote the repair of periodontal defect tissue.

Description

technical field [0001] The invention relates to a construction method of an oral GTR gradient barrier membrane and its biological application. In particular, it relates to a preparation method based on an asymmetric agarose hydrogel film loaded with polylysine and hydroxyapatite and its use in oral cavity guided tissue regeneration to achieve periodontal tissue regeneration and oral environment Antibacterial for a long time. Background technique [0002] Chronic periodontitis is a chronic infectious disease that occurs in the periodontal supporting tissue, causing the absorption and destruction of alveolar bone, and is the main cause of tooth loss in adults. Bacterial plaque is the initiating factor of chronic periodontitis, and is most closely related to the occurrence and development of chronic periodontitis. The traditional method of treating periodontitis is basic periodontal treatment, including supragingival scaling, subgingival scaling, root planing and drug treatme...

AI Technical Summary

Problems solved by technology

And it has the advantages of good histocompatibility, low antigenicity, strong toughness, and easy operation, but it does not have good osteoinduction and conductivity, the manufacturing process is complicated, and the price is relatively expensive

And because the oral cavity is a bacterial environment, in the process of periodontal tissue regeneration and healing, it is easy to make the wound pollution and oral microbial adhesion exposed to the oral environment, resulting in a significant reduction in wound infection or the formation of new periodontal attachments, but at present GTR barrier membrane materials on the market have no antibacterial ability, and postoperative oral bacterial infection is one of the main reasons for the failure of GTR surgery

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