Polyether ketone ketone-based composite, composition, restoration, preparation method and application thereof

A polyetherketone ketone-based, composite material technology, applied in the field of medical biomaterials, can solve the problems of poor antibacterial performance and low biological activity, etc.

Active Publication Date: 2019-01-04
上海禾麦医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem solved by the present invention is to overcome the defects of low biological activity and poor antibacterial performance of bone

Method used

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  • Polyether ketone ketone-based composite, composition, restoration, preparation method and application thereof
  • Polyether ketone ketone-based composite, composition, restoration, preparation method and application thereof
  • Polyether ketone ketone-based composite, composition, restoration, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Mix 4.6kg D50 silicon nitride powder with a particle size of 2.5μm and 5.4kg D50 polyetherketone ketone powder with a particle size of 20μm uniformly to obtain a mixed powder; then pour the mixed powder into absolute ethanol, ultrasonically clean and disperse, and then Dry in an oven at 80°C, pour it into deionized water, ultrasonically clean and disperse, and then place it in an oven at 80°C for drying to obtain a polyetherketone ketone-based raw material composition; The polyetherketone ketone-based composite material is obtained by hot pressing and sintering in a heating mold; the hot pressing temperature is 356° C.; the pressure is 3 MPa; and the hot pressing holding time is 40 minutes.

Embodiment 2

[0075]Mix 7.2kg D50 silicon nitride powder with a particle size of 2μm and 2.8kg D50 polyetherketone ketone powder with a particle size of 15μm uniformly to obtain a mixed powder; then the mixed powder is melted and blended with a twin-screw extruder at high temperature and extruded. After granulation, the master batch of polyetherketone ketone-based composite material was obtained, and the temperature of melt extrusion was 390° C.; the pressure of the twin-screw extruder was 90MPa. The polyetherketone ketone-based composite material masterbatch is injection-molded in an injection molding machine to obtain a polyetherketone-ketone-based composite material; the injection molding temperature is 390° C.; and the injection molding pressure is 110 MPa.

Embodiment 3

[0077] Mix 4.6g of D50 silicon nitride powder with a particle size of 3μm and 5.4g of polyetherketone ketone powder with a D50 particle size of 25μm; then pour the mixed powder into absolute ethanol, ultrasonically clean and disperse, and then place it at 80°C drying in an oven, pouring into deionized water, ultrasonically cleaning and dispersing, and then drying in an oven at 80°C to obtain a polyetherketone ketone-based raw material composition; cold-pressing and sintering the polyetherketone ketone-based raw material composition After molding, a polyetherketone ketone-based composite material is obtained; wherein, the heating rate of the sintering furnace is 2°C / min; the sintering temperature is 360°C; and the sintering holding time is 2 hours.

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Abstract

The invention discloses a polyether ketone ketone-based composite, a composition, a restoration, a preparation method and application thereof. The polyether ketone ketone-based raw material composition comprises the following components: the mass ratio of the polyether ketone ketone powder and the silicon nitride powder, the polyether ketone ketone powder and the silicon nitride powder is (1-3): (2-4), and the D50 particle diameter of the silicon nitride is 0.5-3.5 micrometres. The polyether ketone ketone-based composite disclosed by the invention has the advantages of promoting osteogenesis and biocompatibility, thereby promoting the adhesion, proliferation and differentiation of osteoblasts. The bone restoration can inhibit infection after being implanted into an organism, promote new bone regeneration, and ensure long-term stability of the implant. The preparation method of the polyether ketone ketone-based composite provided by the invention is simple and easy to operate, and the preparation process of the polyether ketone ketone-based composite can be adjusted according to the clinical requirement, so that the bone restoration with different shapes, specifications and mechanical properties can be prepared.

Description

technical field [0001] The invention relates to the field of medical biological materials, in particular to a polyetherketone ketone-based composite material, a composition, a prosthesis, a preparation method and an application. Background technique [0002] With the aging of the population and the increase in trauma among young and middle-aged people, bone repair materials have become one of the biomedical materials with the greatest clinical demand. There are millions of patients with bone tissue defects every year, but the currently widely used orthopaedic fixation materials and bone defect repair materials have the problem of poor biological activity. Looking for better bone tissue regeneration and repair materials is the frontier and hotspot of biomedical materials research. [0003] At present, the commonly used bone repair materials on the market are mainly divided into three categories: metal materials, bioceramics / bioglasses and polymer materials. Metal materials,...

Claims

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Application Information

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IPC IPC(8): C08L61/16C08K3/34A61L27/18A61L27/54A61L27/56
CPCA61L27/18A61L27/54A61L27/56A61L2300/216A61L2300/404A61L2430/02C08K3/34C08K2201/003C08L61/16
Inventor 魏杰吴涵汤亭亭潘泳康沈学宁王德强王雪红杨立利
Owner 上海禾麦医学科技有限公司
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