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Postoperative anti-adhesion membrane material and method for preparing same

An anti-adhesion film and lactic acid technology, applied in the field of biomedical materials, can solve the problems of unsatisfactory performance and high cost of the anti-adhesion film material, and achieve the effects of preventing adhesion, low equipment requirements and reducing bleeding

Inactive Publication Date: 2014-08-06
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a preparation method of postoperative anti-adhesion membrane material, which solves the problems of unsatisfactory performance and high cost of the existing postoperative anti-adhesion membrane material

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: The preparation method of this postoperative anti-adhesion film material, the specific operation steps are as follows:

[0024] (1) Mix the dilute lactic acid solution with sodium carboxymethyl cellulose and stir to dissolve it fully to obtain sodium lactic acid solution of carboxymethyl cellulose, wherein the dilute lactic acid solution is prepared by mixing lactic acid and distilled water with a volume ratio of 1:100 Obtain, the mixing ratio of lactic acid and sodium carboxymethyl cellulose is that 1ml lactic acid mixes with 0.5g sodium carboxymethyl cellulose;

[0025] (2) Add glycerol to carboxymethyl cellulose sodium lactic acid solution, mix well and add konjac glucomannan to stir well, wherein the volume ratio of glycerol to carboxymethyl cellulose sodium lactic acid solution is 1:200 , the amount of konjac glucomannan added is 0.5 g of konjac glucomannan added to every 100 ml of carboxymethylcellulose sodium lactic acid solution;

[0026] (3) Heat...

Embodiment 2

[0029] Embodiment 2: The preparation method of this postoperative anti-adhesion film material, the specific operation steps are as follows:

[0030] (1) Mix the dilute lactic acid solution with sodium carboxymethyl cellulose, stir to dissolve it fully, and obtain a sodium lactic acid solution of carboxymethyl cellulose, wherein the dilute lactic acid solution is prepared by mixing lactic acid and distilled water with a volume ratio of 1:300 Obtain, the mixing ratio of lactic acid and sodium carboxymethyl cellulose is that 1ml lactic acid mixes with 0.1g sodium carboxymethyl cellulose;

[0031] (2) Add glycerol to carboxymethyl cellulose sodium lactic acid solution, mix well and add konjac glucomannan and stir well, wherein the volume ratio of glycerol to carboxymethyl cellulose sodium lactic acid solution is 1:600 , the amount of konjac glucomannan added is 1g of konjac glucomannan added to every 100ml carboxymethylcellulose sodium lactic acid solution;

[0032] (3) Heat the ...

Embodiment 3

[0035] Embodiment 3: The preparation method of this postoperative anti-adhesion film material, the specific operation steps are as follows:

[0036](1) Mix the dilute lactic acid solution with sodium carboxymethyl cellulose, stir to dissolve it fully, and obtain a sodium lactic acid solution of carboxymethyl cellulose, wherein the dilute lactic acid solution is prepared by mixing lactic acid and distilled water with a volume ratio of 1:400 Obtain, the mixing ratio of lactic acid and sodium carboxymethyl cellulose is that 1ml lactic acid mixes with 0.3g sodium carboxymethyl cellulose;

[0037] (2) Add glycerol to carboxymethylcellulose sodium lactic acid solution, mix well and add konjac glucomannan and stir thoroughly, wherein the volume ratio of glycerol to carboxymethylcellulose sodium lactic acid solution is 1:800 , the amount of konjac glucomannan added is 3g of konjac glucomannan added to every 100ml carboxymethylcellulose sodium lactic acid solution;

[0038] (3) Heat t...

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Abstract

The invention discloses a post-operative anti-adhesion film material and a preparation method thereof. It belongs to the technical field of biomedical materials. The invention uses degradable biological materials such as konjac glucomannan and carboxymethyl cellulose with good biocompatibility. Sodium is the basic raw material, and the two are mixed to prepare a mixed sol. The modified sol is obtained through acid solution modification and microwave technology, and then the konjac glucomannan / carboxymethyl cellulose sodium composite is prepared by tape casting. Degradable membrane material to prevent adhesion after surgery. The degradation rate of the membrane material can be controlled by the double cross-linking degree of konjac glucomannan and carboxymethyl cellulose sodium. Not only the preparation process is simple and the cost is low, but also the Degradable membrane materials have good biomechanical properties. Cell experiments and animal experiments show that this membrane material can be widely used in the body and is an ideal degradable postoperative anti-adhesion material.

Description

technical field [0001] The invention relates to a postoperative anti-adhesion film material and a preparation method thereof, belonging to the technical field of biomedical materials. Background technique [0002] Adhesions are abnormal structures where fibrous bands of connective tissue join together with adjacent tissues or organs. Adhesion formation is universal, and it is reported that 50% to 100% of abdominal and pelvic surgeries can lead to different degrees of adhesions. Clinically serious complications caused by adhesions include intestinal obstruction, infertility, and chronic pelvic pain, which increase the difficulty of reoperation and the potential for further complications. Therefore, the prevention of postoperative adhesions is a very important topic in the surgical field. Clinically, the physical barrier effect of anti-adhesion materials is generally used to prevent the occurrence of adhesion symptoms. Various anti-adhesion materials currently studied have ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J7/12C08J5/18C08J3/28C08L1/26C08L5/02A61L31/06A61L31/16
Inventor 陈庆华李音颜廷亭冷崇燕
Owner KUNMING UNIV OF SCI & TECH
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